Review
Polymer Science
Minal Thacker, Ching-Li Tseng, Feng-Huei Lin
Summary: Vitreoretinal surgeries are used to treat various ocular diseases, with different tamponade agents having their own advantages and disadvantages, yet an ideal long-term substitute has not been discovered.
Article
Medicine, General & Internal
Gerardo Garcia-Aguirre, Andree Henaine-Berra, Guillermo Salcedo-Villanueva
Summary: This study used dynamic ultra-widefield infrared confocal scanning laser ophthalmoscopy to analyze the appearance of vitreous opacities. The most common cause of vitreous floaters was posterior vitreous detachment, and the severity of opacities was correlated with age.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Mengyu Liao, Yunli Huang, Jiaxing Wang, Xiangda Meng, Yuanyuan Liu, Jinguo Yu, Hua Yan
Summary: Intravitreal triamcinolone acetonide (TA) administration after posterior vitreous detachment (PVD) during pars plana vitrectomy (PPV) can effectively improve the final visual outcomes and prevent postoperative complications in patients with severe proliferative diabetic retinopathy (PDR).
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Andrzej Grzybowski, Chen Shtayer, Stephen G. Schwartz, Elad Moisseiev
Summary: An analysis of the top 100 most cited papers on retinal detachment revealed that the majority were from the USA and published in ophthalmology journals, covering a range of clinical trials and animal/laboratory studies. This study provides unique insights into influential contributions in RD research and management over the past 55 years.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Vishal Balasubramanian Swaminathan, Mirataollah Salabati, Rachel Israilevich, Eli Cehelyk, Raziyeh Mahmoudzadeh, Joshua H. Uhr, Marc J. Spirn, Michael A. Klufas, Sunir J. Garg, Jason Hsu
Summary: This study aimed to compare anatomical and functional outcomes of acute-onset and delayed-onset rhegmatogenous retinal detachments (RDs) following acute posterior vitreous detachment (PVD). The results showed that the delayed RD group had higher rates of retinal reattachment and single surgery anatomic success (SSAS) at 3 months after RD repair. However, there was no significant difference in visual function outcomes between the two groups at 6 months, 12 months, and the final follow-up.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemical Research Methods
Chang Sun, Yangkun Cao, Jin-Mao Wei, Jian Liu
Summary: This study introduces an autoencoder-based method AEFS to predict drug-target interactions with spatial consistency constraints, maintaining the consistency between chemical properties and functions of drugs. Experimental comparisons show that AEFS is more robust for imbalanced data and performs significantly better in DTI prediction. Case studies further demonstrate its ability to discover latent DTIs.
Article
Biochemical Research Methods
Oda Helene Schiotz, Christoph J. O. Kaiser, Sven Klumpe, Dustin R. Morado, Matthias Poege, Jonathan Schneider, Florian Beck, David P. Klebl, Christopher Thompson, Juergen M. Plitzko
Summary: This study introduces an enhanced lift-out technique, Serial Lift-Out, which improves sample preparation efficiency and contextual information by preparing multiple sections from single transfers. Applying this technique to Caenorhabditis elegans L1 larvae, the researchers successfully resolved the ribosome structure and a subregion of the microtubule, demonstrating the potential of Serial Lift-Out in the study of multicellular molecular anatomy.
Review
Ophthalmology
Andrzej Grzybowski, Piotr Kanclerz
Summary: Early vitreoretinal surgical techniques aimed to treat eye disorders, with methods and technologies playing a significant role in the development of the field.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Joseph C. Galley, Scott A. Hahn, Megan P. Miller, Brittany G. Durgin, Edwin K. Jackson, Sean D. Stocker, Adam C. Straub
Summary: In the study, it was found that reduced renal blood flow activates the RAAS system, leading to renovascular hypertension. Ang II was shown to affect sGC expression through an AT(1) receptor-FoxO transcription factor mechanism, both in vivo and in vitro. This up-regulation of sGC led to increased downstream cGMP signaling, suggesting a protective mechanism to improve renal blood flow in the uninjured contralateral renal artery.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tobias Auel, Lara Paula Scherke, Stefan Hadlich, Susan Mouchantat, Michael Grimm, Werner Weitschies, Anne Seidlitz
Summary: The behavior of intravitreal dosage forms in vivo is usually studied through animal experiments during preclinical development. However, the use of in vitro vitreous substitutes (VS) for preclinical investigations has not been sufficiently explored. This study compared the distribution of a contrast agent in hyaluronic acid agar gels and polyacrylamide gels with that in ex vivo porcine vitreous using magnetic resonance imaging. The results showed that while both gels could not completely represent the porcine vitreous body, the distribution in the polyacrylamide gel was similar. On the other hand, the distribution in the hyaluronic acid agar gel was much faster. Anatomical features such as the lens and interfacial tension could also affect the distribution, making it difficult to reproduce using in vitro VS.
Article
Pharmacology & Pharmacy
Jose Hurst, Annekatrin Rickmann, Nele Heider, Christine Hohenadl, Charlotte Reither, Andreas Schatz, Sven Schnichels, Kai Januschowski, Martin S. Spitzer
Summary: The study demonstrated that highly viscously thiol-modified cross-linked hyaluronate showed good biocompatibility in rabbit eyes, making it a promising potential as a vitreous substitute over 6 months.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Dominik Buschmann, Veronika Mussack, James Brian Byrd
Summary: EVs are membrane nanovesicles secreted from living cells which have potential therapeutic activity and are being explored as drug delivery vehicles in preclinical investigations and early clinical trials. However, progress in EV-based drug delivery is hindered by heterogeneity of sample types and methods, as well as a persistent lack of standardization, validation, and comprehensive reporting.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Engineering, Biomedical
Joseph D. Phillips, Eileen S. Hwang, Denise J. Morgan, Christopher J. Creveling, Brittany Coats
Summary: Vitreoretinal mechanics play a crucial role in retinal trauma and various sight-threatening diseases. However, the understanding of the mechanics at the vitreoretinal interface is limited, and further research is needed to fill the knowledge gaps in this field. Studying the structure and function of vitreoretinal adhesion can provide valuable insights into disease treatments.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Ophthalmology
Damian Jaggi, Thanoosha Nagamany, Andreas Ebneter, Marion Munk, Sebastian Wolf, Martin Zinkernagel
Summary: The long-term outcomes of treating patients with neovascular age-related macular degeneration (nAMD) using a treat-and-extend (T&E) regimen were reported. The results showed that the initial increase in visual acuity was maintained over a period of 4 years without the need for an initial loading phase. The treatment intervals could also be extended, and the functional outcomes were comparable to those of large controlled studies.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ting Zhang, Zhirong Wang, Limei Sun, Songshan Li, Li Huang, Chengxi Liu, Chonglin Chen, Xiaoling Luo, Bilin Yu, Xiaoyan Ding
Summary: This study described novel vitreoretinal microstructural findings in patients with mild Familial Exudative Vitreoretinopathy (FEVR) using ultra-wide-field scanning laser ophthalmoscopy and UWF optical coherence tomography. A novel anatomical change named Temporal Mid-Peripheral Vitreoretinal Interface Abnormality (TEMPVIA) was identified in FEVR patients, and its clinical significance was validated with high sensitivity and specificity. Additionally, unrecognized clinical changes in FEVR were discovered, enriching our understanding of the disease's pathogenesis. TEMPVIA is suggested as a useful biomarker in the screening strategy for mild FEVR.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Claes H. Dohlman, Fabiano Cade, Caio V. Regatieri, Chengxin Zhou, Fengyang Lei, Alja Crnej, Mona Harissi-Dagher, Marie-Claude Robert, George N. Papaliodis, Dongfeng Chen, James V. Aquavella, Esen K. Akpek, Anthony J. Aldave, Kimberly C. Sippel, Donald J. D'Amico, Jan G. Dohlman, Per Fagerholm, Liqiang Wang, Lucy Q. Shen, Miguel Gonzalez-Andrades, James Chodosh, Kenneth R. Kenyon, C. Stephen Foster, Roberto Pineda, Samir Melki, Kathryn A. Colby, Joseph B. Ciolino, Demetrios G. Vavvas, Shigeru Kinoshita, Reza Dana, Eleftherios I. Paschalis
Article
Ophthalmology
Kiyohito Totsuka, Takashi Ueta, Takatoshi Uchida, Murilo F. Roggia, Suguru Nakagawa, Demetrios G. Vavvas, Megumi Honjo, Makoto Aihara
EXPERIMENTAL EYE RESEARCH
(2019)
Article
Cell & Tissue Engineering
Ahmad Al-Moujahed, Bo Tian, Nikolaos E. Efstathiou, Eleni K. Konstantinou, Mien Hoang, Haijiang Lin, Joan W. Miller, Demetrios G. Vavvas
STEM CELL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Jong-Jer Lee, Kenji Ishihara, Shoji Notomi, Nikolaos E. Efstathiou, Takashi Ueta, Daniel Maidana, Xiaohong Chen, Yasuhiro Iesato, Alberto Caligiana, Demetrios G. Vavvas
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Editorial Material
Ophthalmology
Demetrios G. Vavvas, David Sarraf, SriniVas R. Sadda, Dean Eliott, Justis P. Ehlers, Nadia K. Waheed, Yuki Morizane, Taiji Sakamoto, Miltiadis Tsilimbaris, John B. Miller
Article
Multidisciplinary Sciences
Fengyang Lei, Naiwen Cui, Chengxin Zhou, James Chodosh, Demetrios G. Vavvas, Eleftherios I. Paschalis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Letter
Multidisciplinary Sciences
Fengyang Lei, Naiwen Cui, Chengxin Zhou, James Chodosh, Demetrios G. Vavvas, Eleftherios I. Paschalis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Ophthalmology
Jonathan B. Lin, Omar A. Halawa, Deeba Husain, Joan W. Miller, Demetrios G. Vavvas
Summary: Lipid-rich drusen are essential in age-related macular degeneration (AMD), and altered lipid metabolism may play a role in the pathogenesis of AMD. There is evidence of the association of lipid homeostasis gene polymorphisms, metabolomics studies, and altered serum lipid profiles with AMD. Statins, which are used for dyslipidemia and reducing cardiovascular risk, may potentially treat AMD. However, more research is needed.
Article
Cell Biology
Zhen Yu, Nikolaos E. Efstathiou, Victor S. M. C. Correa, Xiaohong Chen, Kenji Ishihara, Yasuhiro Iesato, Toshio Narimatsu, Dimitrios Ntentakis, Yanyun Chen, Demetrios G. Vavvas
Summary: The study reveals that RIPK3 plays a critical role in UVA-induced cell death in CE, suggesting its potential as a protective target for CECs.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Zhen Yu, Victor S. M. C. Correa, Nikolaos E. Efstathiou, Henar Albertos-Arranz, Xiaohong Chen, Kenji Ishihara, Yasuhiro Iesato, Toshio Narimatsu, Dimitrios Ntentakis, Demetrios G. Vavvas
Summary: This study investigated the effects of UVA on photoreceptor injury and the involvement of RIPK1 and RIPK3 signaling molecules in programmed cell death. The results suggest that UVA-induced cell death is mainly mediated by RIPK3 through necroptosis, as well as increased oxidative stress leading to apoptosis. Additionally, RIPK3 inhibition can suppress UVA-induced cell death, reduce oxidative stress, and attenuate DNA fragmentation.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Daniel E. Maidana, Lucia Gonzalez-Buendia, Joan W. Miller, Demetrios G. Vavvas
Summary: Recent evidence suggests that modulating the RIPK3 pathway can improve the survival of transplanted cells and aid in the repair of degenerated retinas. Simultaneous inhibition of RIPK3 in both the donor and host can maximize the survival of transplanted cells. Additionally, targeting RIPK3 in the immune system can protect both donor and host retinal cells. These findings highlight the potential of immunomodulatory and neuroprotective strategies targeting RIPK3 in the regenerative therapy of photoreceptor transplantation.
Review
Ophthalmology
Dimitrios P. Ntentakis, Victor San Martin Carvalho Correa, Anastasia Maria Ntentaki, Eleni Delavogia, Toshio Narimatsu, Nikolaos E. Efstathiou, Demetrios G. Vavvas
Summary: Diabetic retinopathy (DR) is the leading cause of blindness in the working population of the USA, and its long-term management requires effective glycemic control. Seven anti-diabetic classes have been introduced in the past two decades, but their effects on DR have not been thoroughly studied. A systematic review of the literature revealed that newer anti-diabetic drugs have neutral effects on DR progression, with some differences in specific drugs and type 2 diabetes populations. Further investigation and assessment are recommended.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Cell Biology
Chengxin Zhou, Fengyang Lei, Mirja Mittermaier, Bruce Ksander, Reza Dana, Claes H. Dohlman, Demetrios G. Vavvas, James Chodosh, Eleftherios I. Paschalis
Summary: Limbal stem cell (LSC) deficiency is a common and severe complication after chemical injury to the eye. This study reveals that LSC damage is mediated by immune cell mediators, even without direct injury to LSCs. Elevated pH in the anterior chamber triggers uveal stress, release of inflammatory cytokines, and subsequent LSC damage and death.
Article
Pharmacology & Pharmacy
Chengxin Zhou, Fengyang Lei, Jyoti Sharma, Pui-Chuen Hui, Natalie Wolkow, Claes H. Dohlman, Demetrios G. Vavvas, James Chodosh, Eleftherios I. Paschalis
Summary: This study developed a thermosensitive drug delivery system (DDS) for sustained delivery of TNF-alpha and VEGF inhibitors to the eye, aiming to provide a clinically feasible and practical therapy for multiocular protection following ocular injury. The study found that the subconjunctival administration of the dual anti-TNF-alpha/anti-VEGF DDS achieved sustained delivery of antibodies to ocular tissues for 3 months, preventing corneal neovascularization and improving corneal re-epithelialization, while reducing immune cell infiltration and preventing damage to the retina and optic nerve. This therapeutic approach has the potential to significantly improve outcomes for severe ocular injuries and retinal vascular diseases.
Article
Cell Biology
Daniel E. Maidana, Lucia Gonzalez-Buendia, Sara Pastor-Puente, Afsar Naqvi, Eleftherios Paschalis, Andrius Kazlauskas, Joan W. Miller, Demetrios G. Vavvas
Summary: Photoreceptor cell degeneration and immune cell infiltration are two major events in retinal degeneration. This study identified neutrophils and monocytes as the predominant peripheral immune cell populations infiltrating the detached retina, and targeted depletion of these immune cells showed neuroprotective effects on photoreceptor cells.
CELL DEATH & DISEASE
(2023)
