Article
Neuroimaging
Michael J. Firbank, Katrina daSilva Morgan, Daniel Collerton, Greg J. Elder, Jehill Parikh, Kirsty Olsen, Julia Schumacher, Dominic Ffytche, John-Paul Taylor
Summary: This study investigated structural brain changes in patients with Charles Bonnet Syndrome (CBS) using magnetic resonance imaging (MRI). The findings suggest that there are cortical and subcortical effects associated with sight loss, but structural changes alone cannot explain the occurrence of visual hallucinations. CBS may be related to changes in connectivity or excitability in brain networks linked to vision.
NEUROIMAGE-CLINICAL
(2022)
Article
Psychiatry
Lomelin-Lopez Diana, Jaime Carmona-Huerta, J. Guillermo Patino, Aldana-Lopez Alejandro, Durand-Arias Sol
Summary: Charles Bonnet Syndrome (CBS) presents with visual hallucinations and preserved reality judgment, often associated with alterations in the optic pathway. Atypical clinical presentations may indicate underlying structural pathologies in the central nervous system, necessitating a thorough evaluation for optimal diagnosis and treatment. In this case, a frontal tumor lesion adjacent to the olfactory groove and compression of the optic chiasm led to visual hallucinations and depressive symptoms, highlighting the importance of considering basic structural pathologies in cases of isolated visual hallucinations.
Article
Cell Biology
Andrea Piarulli, Jitka Annen, Ron Kupers, Steven Laureys, Charlotte Martial
Summary: This study revealed specific changes in electrical brain activity in CBS patients during visual hallucinations, including alterations in power and connectivity between different brain areas, changes in network properties, and increased signal complexity. These findings suggest that the emergence of hallucinations in CBS may be related to disruptions in the visual cortex and core cortical regions involved in attention and default mode networks.
Review
Ophthalmology
Yousif Subhi, Diana Chabane Schmidt, Daniella Bach-Holm, Miriam Kolko, Amardeep Singh
Summary: The prevalence of Charles Bonnet Syndrome (CBS) in patients with glaucoma varies depending on different factors such as age, gender, and visual acuity. The existing literature has limitations and more studies are needed to gain a better understanding of CBS among patients with glaucoma.
ACTA OPHTHALMOLOGICA
(2021)
Article
Behavioral Sciences
Timothy Lawn, Dominic Ffytche
Summary: Hallucinations are perceptual experiences in the absence of external stimuli, shared features between eye-disease and Parkinson's disease. Structural changes in the cerebellum have been linked to visual hallucinations, independent of specific mechanisms. Lower GMV in cerebellar lobule VIII and IX/VII was observed in hallucinators, with PD patients showing more significant reductions in Crus 1 GMV. Additionally, PD patients exhibited lower WMV in the medulla in relation to hallucinations.
Article
Ophthalmology
Katrina daSilva Morgan, Julia Schumacher, Daniel Collerton, Sean Colloby, Greg J. Elder, Kirsty Olsen, Dominic H. Ffytche, John-Paul Taylor
Summary: This study investigated the potential therapeutic benefits and tolerability of inhibitory transcranial direct current stimulation (tDCS) in treating visual hallucinations in patients with CBS. The results showed that tDCS of the visual cortex significantly reduced the frequency of visual hallucinations, especially in individuals with higher occipital excitability prior to stimulation. The treatment was found to be feasible and without significant side effects.
Article
Ophthalmology
Patty P. A. Dhooge, Rob J. Teunisse, Bart Liefers, Stanley Lambertus, Nathalie M. Bax, Carel B. Hoyng, Johannes R. M. Cruysberg, B. Jeroen Klevering
Summary: The prevalence of Charles Bonnet syndrome (CBS) in Dutch patients with Stargardt disease (STGD1) was found to be 8.4%, with a higher proportion of female patients. CBS was not associated with age or retinal pigment epithelium atrophy, but was associated with lower social functioning and visual impairment.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Marta Isabel Martinez-Sanchez, Gema Bolivar
Summary: This case report describes a 78-year-old man with Charles Bonnet syndrome as the initial presentation of occipital infarction, despite preserved visual acuity. The patient experienced visual hallucinations of flowers and fruits intermittently for two months, which improved over time without any specific treatment. It is important to consider Charles Bonnet syndrome in patients with non-disturbing visual hallucinations, even in the presence of good visual acuity.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Vesna Tepsic Ostojic, Zagorka Gojkovic, Bratislav Zivic
Summary: Charles Bonnet syndrome is a condition characterized by complex visual hallucinations due to visual impairment, with retention of insight. It is often misdiagnosed as psychosis or early stages of dementia, and is underreported by patients due to fear of being diagnosed with a mental illness.
VOJNOSANITETSKI PREGLED
(2023)
Article
Medicine, General & Internal
Francisco J. Somoza-Cano, Ahmed Abuyakoub, Faris Hammad, Jasmin Jaber, Abdul Rahman Al Armashi
Summary: Charles Bonnet syndrome is a clinical entity characterized by visual hallucinations in patients with declining visual acuity and no underlying neuropsychiatric disorder. Clinical suspicion and reassurance are crucial for adequate patient care when encountering such cases.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Ophthalmology
Trine Lomo, Amardeep Singh, Dorothea Peters
Summary: Charles Bonnet syndrome can occur in glaucoma patients with preserved visual acuity, where patients may experience vivid hallucinations while maintaining insight into their unreal nature. Awareness of this relation is important for clinicians to enhance communication with patients.
ACTA OPHTHALMOLOGICA
(2021)
Article
Clinical Neurology
Hanako Sasaki, Yasunori Fujimoto, Hiroyuki Ima, Yu Kageyama
Summary: A 74-year-old man presented with complex visual hallucinations, with MRI showing a right occipital falx meningioma. FDG-PET imaging revealed hypometabolism in the right primary and secondary visual cortices, and hypermetabolism in the ventral visual pathway.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Psychiatry
Charmi Balsara, Alexander Shahin, Niharika Baviriseaty, Richard Czuma, Gregory A. Sullivan
Summary: Charles Bonnet syndrome is a disorder of visual hallucinations that occurs in psychologically normal patients with ocular disease or damage to visual pathways. The cause of CBS is not fully understood and it is often triggered by conditions such as age-related macular degeneration. Visual disturbances, including decreased visual acuity, visual field deficits, and visual hallucinations, are common symptoms.
JOURNAL OF PSYCHIATRIC PRACTICE
(2022)
Article
Psychiatry
Arda Karagol
Summary: The prevalence of CBS in younger patients was found to be 17.9%, which is consistent with the medical literature. Patients with CBS may experience negative emotions related to their hallucinations, and inquiring about this symptom during clinical examination could be the first step in helping these individuals.
PSYCHIATRIA DANUBINA
(2021)
Article
Medicine, General & Internal
Ricardo Irizarry, Ariel Sosa Gomez, Jean Tamayo Acosta, Leonel Gonzalez Diaz
Summary: This paper discusses the neuropsychiatric sequelae associated with traumatic brain injuries and presents a case of visual hallucinations consistent with Charles Bonnet syndrome.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)