Article
Oncology
Keiichiro Mori, Vidit Sharma, Eva M. Comperat, Shun Sato, Ekaterina Laukhtina, Victor M. Schuettfort, Benjamin Pradere, Mehdi Kardoust Parizi, Pierre I. Karakiewicz, Shin Egawa, Derya Tilki, Stephen A. Boorjian, Shahrokh F. Shariat
Summary: This study assessed prognostic differences in PC patients with GG 4 treated with RP and found considerable heterogeneity within GG 4, suggesting that primary and secondary Gleason patterns should be considered for stratifying high-risk PC patients after RP.
Article
Urology & Nephrology
Alberto Martini, Alae Touzani, Jean-Baptiste Beauval, Alain Ruffion, Jonathan Olivier, Anis Gasmi, Charles Dariane, Matthieu Thoulouzan, Eric Barret, Laurent Brureau, Gilles Crehange, Gaelle Fiard, Mathieu Gauthe, Raphaele Renard-Penna, Guilhem Roubaud, Paul Sargos, Mathieu Roumiguie, Marc-Olivier Timsit, Romain Mathieu, Arnauld Villers, Morgan Roupret, Gaelle Fromont, Guillaume Ploussard
Summary: This study evaluated the prognostic role of sub-categories of ISUP 4 prostate cancer on final pathology, and assessed the tumor architecture prognostic role for predicting biochemical recurrence after radical prostatectomy.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Multidisciplinary Sciences
Hwanik Kim, Gyoohwan Jung, Jin Hyuck Kim, Seok-Soo Byun, Sung Kyu Hong
Summary: PHI can predict GS upgrading in ISUP GG 1 & 2, in conjunction with PIRADS lesions >= 4. PHI alone can also evaluate the likelihood of high-risk PCa after surgery.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Masayuki Tomioka, Chiemi Saigo, Keisuke Kawashima, Natsuko Suzui, Tatsuhiko Miyazaki, Shinichi Takeuchi, Makoto Kawase, Kota Kawase, Daiki Kato, Manabu Takai, Koji Iinuma, Keita Nakane, Tamotsu Takeuchi, Takuya Koie
Summary: This study aimed to predict GG upgrading after robot-assisted RP (RARP), and found that BMI and NLR might be significantly correlated with GG upgrading for RARP specimens compared with NB specimens. This may have potential benefits for decision-making and treatment modalities selection for newly diagnosed patients with PCa.
Article
Endocrinology & Metabolism
Christoph Wurnschimmel, Mike Wenzel, Francesco Chierigo, Rocco S. Flammia, Keiichiro Mori, Zhe Tian, Shahrokh F. Shariat, Fred Saad, Alberto Briganti, Nazareno Suardi, Carlo Terrone, Michele Gallucci, Felix K. H. Chun, Derya Tilki, Markus Graefen, Pierre I. Karakiewicz
Summary: In GGG IV RP patients, the presence of biopsy GP 5 + 3 is associated with significantly higher CSM compared to GP 4 + 4 or 3 + 5. However, in GGG IV EBRT patients, no significant CSM differences according to GP were observed.
Article
Oncology
Felix Preisser, Nuowei Wang, Raisa S. Abrams-Pompe, Felix K-H Chun, Markus Graefen, Hartwig Huland, Derya Tilki
Summary: In radical prostatectomy, organ-confined prostate cancer with Gleason grade group 4-5 is rare but associated with worse oncologic outcomes, including biochemical recurrence, metastasis, death, and cancer-specific death.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Urology & Nephrology
Shulin Wu, Adam S. Feldman, Michelle M. Kim, Sharron X. Lin, Kristine M. Cornejo, Mukesh G. Harisinghani, Douglas M. Dahl, Chin-Lee Wu
Summary: This study aims to evaluate the Gleason grade discrepancy between biopsy techniques (transperineal/transrectal approaches or multiparametric magnetic resonance imaging [mpMRI] targeted biopsy/standard template biopsies) and radical prostatectomy specimens. The results showed that the combination of SBx and TBx can provide better GG concordance and lower upgrading rate.
Article
Oncology
Lamont J. Wilkins, Jeffrey J. Tosoian, Chad A. Reichard, Debasish Sundi, Weranja Ranasinghe, Ridwan Alam, Zeyad Schwen, Chandana Reddy, Mohammed Allaf, John W. Davis, Brian F. Chapin, Ashley E. Ross, Eric A. Klein, Yaw A. Nyame
Summary: Black and White men with high-grade prostate cancer at diagnosis showed similar oncologic outcomes when managed by primary radical prostatectomy. Our findings suggest that racial disparities in prostate cancer mortality are not related to differences in the efficacy of extirpative therapy.
Article
Medicine, General & Internal
Vincenzo Fiorentino, Maurizio Martini, Marco Dell'Aquila, Teresa Musarra, Ersilia Orticelli, Luigi Maria Larocca, Ernesto Rossi, Angelo Totaro, Francesco Pinto, Niccolo Lenci, Valerio Di Paola, Riccardo Manfredi, Pier Francesco Bassi, Francesco Pierconti
Summary: Biopsy proven Gleason score is crucial in determining treatment modalities for prostate cancer, but may underestimate the score at radical prostatectomy. Studies show a strong association between the volume ratio of biopsies in the tumor area and the corresponding tumor volume at radical prostatectomy with Gleason score agreement.
Article
Oncology
Johan Bengtsson, Erik Thimansson, Erik Baubeta, Sophia Zackrisson, Pia Charlotte Sundgren, Anders Bjartell, Despina Flondell-Site
Summary: This study aimed to investigate the correlation between ADC and ADC ratio compared to tumor aggressiveness determined by a histopathological examination. The results showed no correlation between ADC and ISUP grade and no predictive value for tumor aggressiveness could be determined. These findings contradict previous research in the field.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Oleksii A. Iakymenko, Isabella Lugo, Laurence M. Briski, Ivan Nemov, Sanoj Punnen, Deukwoo Kwon, Alan Pollack, Radka Stoyanova, Dipen J. Parekh, Merce Jorda, Mark L. Gonzalgo, Oleksandr N. Kryvenko
Summary: Both GP4% and TV are independent predictors of adverse pathological stage and margin status at RP. However, the risks for adverse outcomes associated with GP4% are marginal, while those for TV are strong.
Article
Urology & Nephrology
Mykyta Kachanov, Lars Budaeus, Dirk Beyersdorff, Pierre I. Karakiewicz, Zhe Tian, Fabian Falkenbach, Derya Tilki, Tobias Maurer, Guido Sauter, Markus Graefen, Sami-Ramzi Leyh-Bannurah
Summary: Combining targeted biopsy alone and combined with systematic biopsy, along with quantitative Gleason grading of biopsy specimen, accurately detects low levels of GP 4 and helps identify patients suitable for active surveillance.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Oncology
Baoling Zhang, Shangrong Wu, Yang Zhang, Mingyu Guo, Ranlu Liu
Summary: This study investigated the risk factors of Gleason score upgrading (GSU) after radical prostatectomy (RP) in a Chinese cohort. The results showed that clinical stage >= T2c, the number of positive cores <3, and lower positive rate of biopsy were identified as risk factors of GSU. This information may guide clinicians in accurately judging the biopsy pathological grading and formulating treatment strategies.
Article
Pathology
Won Jin Cho, Jung-Soo Pyo, Nae Yu Kim, Dong-Wook Kang
Summary: The present study aimed to investigate the clinicopathological implications of histological mapping in radical prostatectomy specimens. The results showed significant correlations between positive surgical margin (PSM) and the largest tumor dimension, tumor volume, tumor surface area, and proportion of the tumor in the histological mappings. These histological parameters can be useful for interpreting PSM after radical prostatectomy.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Keiichiro Mori, Vidit Sharma, Eva M. Comperat, Shun Sato, Ekaterina Laukhtina, Victor M. Schuettfort, Benjamin Pradere, Reza Sari Motlagh, Hadi Mostafaei, Fahad Quhal, Mehdi Kardoust Parizi, Mohammad Abufaraj, Pierre I. Karakiewicz, Shin Egawa, Derya Tilki, Stephen A. Boorjian, Shahrokh F. Shariat
Summary: This study evaluated the prognostic differences among various Gleason scores in patients with Grade group 4 prostate cancer. Different Gleason scores within Grade group 4 were significantly associated with biochemical recurrence, but not with prostate cancer-specific or all-cause mortality. Patients with Gleason score 5 + 3 had a higher risk of Gleason score upgrading.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Meeting Abstract
Oncology
Vidya Sankar Viswanathan, Nathaniel Braman, Priyanka Reddy, Siddharth Kunte, Jame Abraham, Alberto J. Montero, Anant Madabhushi
Article
Gastroenterology & Hepatology
Prathyush Chirra, Anamay Sharma, Kaustav Bera, H. Matthew Cohn, Jacob A. Kurowski, Katelin Amann, Marco-Jose Rivero, Anant Madabhushi, Cheng Lu, Rajmohan Paspulati, Sharon L. Stein, Jeffrey A. Katz, Satish E. Viswanath, Maneesh Dave
Summary: Radiomic features extracted from magnetic resonance enterography are associated with the need for surgery in Crohn's disease patients at risk of complications, and when combined with clinical variables and radiological assessment, they can accurately predict the time to surgery.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Oncology
Shayan Monabbati, Patrick Leo, Kaustav Bera, Claire W. Michael, Behtash G. Nezami, Aparna Harbhajanka, Anant Madabhushi
Summary: This study used computational image analysis to predict the presence of pancreatic and biliary tract adenocarcinoma on digitized brush cytology specimens. By extracting nuclear morphological and texture features and training machine learning classifiers, the researchers successfully improved the sensitivity and specificity of diagnosis.
Article
Computer Science, Artificial Intelligence
Yufei Zhou, Can Koyuncu, Cheng Lu, Rainer Grobholz, Ian Katz, Anant Madabhushi, Andrew Janowczyk
Summary: Deep learning performs well in computational pathology tasks but struggles with domain shift on whole slide images generated at external test sites. To address this, researchers propose using off-target organs from the test site for calibration, effectively mitigating the domain shift and improving the robustness of the model for skin cancer classification.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Mohd Shuaib, Kumari Sunita Prajapati, Sanjay Gupta, Shashank Kumar
Summary: In this study, it was found that Withaferin A (WA) can exert an anticancer effect on triple-negative breast cancer cells by modulating the expression of miRNA. The results showed that WA up-regulated the expression of miR-181c-5p and down-regulated the expression of miR-1275, among other miRNAs. These miRNAs were found to affect the expression of cancer-associated genes and signaling pathways. Additionally, co-treatment of WA and miR-181c-5p mimic inhibited cell growth, induced apoptosis, and regulated the expression of genes involved in cell cycle and apoptosis.
Article
Oncology
Robert Serafin, Can Koyuncu, Weisi Xie, Hongyi Huang, Adam K. Glaser, Nicholas P. Reder, Andrew Janowczyk, Lawrence D. True, Anant Madabhushi, Jonathan T. C. Liu
Summary: Previous studies have shown that computational analysis of 2D histology images can improve prognostication of prostate cancer outcomes. This study expands on previous work by exploring the prognostic value of 3D shape-based nuclear features in prostate cancer. The results suggest that these features are associated with cancer aggressiveness and could be valuable for decision-support tools.
JOURNAL OF PATHOLOGY
(2023)
Editorial Material
Oncology
Smit Brahmbhatt, Herta H. H. Chao, Shiv Verma, Sanjay Gupta
Review
Oncology
Shashank Kumar, Mohd Shuaib, Abdullah F. AlAsmari, Faleh Alqahtani, Sanjay Gupta
Summary: Guanine nucleotide-binding protein-like 3 (GNL3) and proliferation-associated protein 2G4 (PA2G4) are overexpressed in several human cancers, including prostate cancer, and could serve as prognostic biomarkers of clinical significance in prostate cancer. Prostate cancer is a common disease in males and lacks reliable biomarkers for prognosis. In this review, the function of GNL3 and PA2G4 is highlighted, and their potential as prognostic biomarkers in prostate cancer is discussed.
Review
Oncology
Jeppe Thagaard, Glenn Broeckx, David B. Page, Chowdhury Arif Jahangir, Sara Verbandt, Zuzana Kos, Rajarsi Gupta, Reena Khiroya, Khalid Abduljabbar, Gabriela Acosta Haab, Balazs Acs, Guray Akturk, Jonas S. Almeida, Isabel Alvarado-Cabrero, Mohamed Amgad, Farid Azmoudeh-Ardalan, Sunil Badve, Nurkhairul Bariyah Baharun, Eva Balslev, Enrique R. Bellolio, Vydehi Bheemaraju, Kim R. M. Blenman, Luciana Botinelly Mendonca Fujimoto, Najat Bouchmaa, Octavio Burgues, Alexandros Chardas, Maggie U. Cheang, Francesco Ciompi, Lee A. D. Cooper, An Coosemans, German Corredor, Anders B. Dahl, Flavio Luis Dantas Portela, Frederik Deman, Sandra Demaria, Johan Dore Hansen, Sarah N. Dudgeon, Thomas Ebstrup, Mahmoud Elghazawy, Claudio Fernandez-Martin, Stephen B. Fox, William M. Gallagher, Jennifer M. Giltnane, Sacha Gnjatic, Paula Gonzalez-Ericsson, Anita Grigoriadis, Niels Halama, Matthew G. Hanna, Aparna Harbhajanka, Steven N. Hart, Johan Hartman, Soren Hauberg, Stephen Hewitt, Akira Hida, Hugo M. Horlings, Zaheed Husain, Evangelos Hytopoulos, Sheeba Irshad, Emiel A. M. Janssen, Mohamed Kahila, Tatsuki R. Kataoka, Kosuke Kawaguchi, Durga Kharidehal, Andrey Khramtsov, Umay Kiraz, Pawan Kirtani, Liudmila L. Kodach, Konstanty Korski, Aniko Kovacs, Anne-Vibeke Laenkholm, Corinna Lang-Schwarz, Denis Larsimont, Jochen K. Lennerz, Marvin Lerousseau, Xiaoxian Li, Amy Ly, Anant Madabhushi, Sai K. Maley, Vidya Manur Narasimhamurthy, Douglas K. Marks, Elizabeth S. McDonald, Ravi Mehrotra, Stefan Michiels, Fayyaz ul Amir Afsar Minhas, Shachi Mittal, David A. Moore, Shamim Mushtaq, Hussain Nighat, Thomas Papathomas, Frederique Penault-Llorca, Rashindrie D. Perera, Christopher J. Pinard, Juan Carlos Pinto-Cardenas, Giancarlo Pruneri, Lajos Pusztai, Arman Rahman, Nasir Mahmood Rajpoot, Bernardo Leon Rapoport, Tilman T. Rau, Jorge S. Reis-Filho, Joana M. Ribeiro, David Rimm, Anne Roslind, Anne Vincent-Salomon, Manuel Salto-Tellez, Joel Saltz, Shahin Sayed, Ely Scott, Kalliopi P. Siziopikou, Christos Sotiriou, Albrecht Stenzinger, Maher A. Sughayer, Daniel Sur, Susan Fineberg, Fraser Symmans, Sunao Tanaka, Timothy Taxter, Sabine Tejpar, Jonas Teuwen, E. Aubrey Thompson, Trine Tramm, William T. Tran, Jeroen van Der Laak, Paul J. van Diest, Gregory E. Verghese, Giuseppe Viale, Michael Vieth, Noorul Wahab, Thomas Walter, Yannick Waumans, Hannah Y. Wen, Wentao Yang, Yinyin Yuan, Reena Md Zin, Sylvia Adams, John Bartlett, Sibylle Loibl, Carsten Denkert, Peter Savas, Sherene Loi, Roberto Salgado, Elisabeth Specht Stovgaard
Summary: The clinical significance of tumor-immune interaction in breast cancer has been established. Tumor-infiltrating lymphocytes (TILs) have emerged as predictive and prognostic biomarkers for patients with triple-negative and HER2-positive breast cancer. The use of machine learning (ML) to automatically evaluate TILs has shown promising results. However, there are challenges in implementing this in trial and routine clinical management, including technical slide issues, ML and image analysis aspects, data challenges, and validation issues.
JOURNAL OF PATHOLOGY
(2023)
Review
Oncology
David B. Page, Glenn Broeckx, Chowdhury Arif Jahangir, Chowdhury Jahangir, Sara Verbandt, Rajarsi R. Gupta, Jeppe Thagaard, Reena Khiroya, Zuzana Kos, Khalid Abduljabbar, Gabriela Acosta Haab, Balazs Acs, Jonas S. Almeida, Isabel Alvarado-Cabrero, Farid Azmoudeh-Ardalan, Sunil Badve, Nurkhairul Bariyah Baharun, Enrique R. Bellolio, Vydehi Bheemaraju, Kim R. M. Blenman, Luciana Botinelly Mendonca Fujimoto, Octavio Burgues, Maggie Chon U. Cheang, Francesco Ciompi, Lee A. D. Cooper, An Coosemans, German Corredor, Flavio Luis Dantas Portela, Frederik Deman, Sandra Demaria, Sarah N. Dudgeon, Mahmoud Elghazawy, Scott Ely, Claudio Fernandez-Martin, Susan Fineberg, Stephen B. Fox, William M. Gallagher, Jennifer M. Giltnane, Sacha Gnjatic, Paula Gonzalez-Ericsson, Anita Grigoriadis, Niels Halama, Matthew G. Hanna, Aparna Harbhajanka, Alexandros Hardas, Steven N. Hart, Johan Hartman, Stephen Hewitt, Akira Hida, Hugo M. Horlings, Zaheed Husain, Evangelos Hytopoulos, Sheeba Irshad, Emiel A. M. Janssen, Mohamed Kahila, Tatsuki R. Kataoka, Kosuke Kawaguchi, Durga Kharidehal, Andrey Khramtsov, Umay Kiraz, Pawan Kirtani, Liudmila L. Kodach, Konstanty Korski, Aniko Kovacs, Anne-Vibeke Laenkholm, Corinna Lang-Schwarz, Denis Larsimont, Jochen K. Lennerz, Marvin Lerousseau, Xiaoxian Li, Amy Ly, Anant Madabhushi, Sai K. Maley, Vidya Manur Narasimhamurthy, Douglas K. Marks, Elizabeth S. McDonald, Ravi Mehrotra, Stefan Michiels, Fayyaz ul Amir Afsar Minhas, Shachi Mittal, David A. Moore, Shamim Mushtaq, Hussain Nighat, Thomas Papathomas, Frederique Penault-Llorca, Rashindrie D. Perera, Christopher J. Pinard, Juan Carlos Pinto-Cardenas, Giancarlo Pruneri, Lajos Pusztai, Arman Rahman, Nasir Mahmood Rajpoot, Bernardo Leon Rapoport, Tilman T. Rau, Jorge S. Reis-Filho, Joana M. Ribeiro, David Rimm, Anne-Vincent Salomon, Manuel Salto-Tellez, Joel Saltz, Shahin Sayed, Kalliopi P. Siziopikou, Christos Sotiriou, Albrecht Stenzinger, Maher A. Sughayer, Daniel Sur, Fraser Symmans, Sunao Tanaka, Timothy Taxter, Sabine Tejpar, Jonas Teuwen, E. Aubrey Thompson, Trine Tramm, William T. Tran, Jeroen van Der Laak, Paul J. van Diest, Gregory E. Verghese, Giuseppe Viale, Michael Vieth, Noorul Wahab, Thomas Walter, Yannick Waumans, Hannah Y. Wen, Wentao Yang, Yinyin Yuan, Sylvia Adams, John Mark Seaverns Bartlett, Sibylle Loibl, Carsten Denkert, Peter Savas, Sherene Loi, Roberto Salgado, Elisabeth Specht Stovgaard, Guray Akturk, Najat Bouchmaa
Summary: Modern histologic imaging platforms combined with machine learning methods offer new opportunities for studying the spatial distribution of immune cells in the tumor microenvironment. However, there is currently no standardized method for describing or analyzing spatial immune cell data, and most previous spatial analyses have been simplistic. In this review, two approaches (raster versus vector-based) for reporting and analyzing spatial data are outlined, along with a summary of reported spatial immune cell metrics and their prognostic associations in various cancers. Two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, are also discussed, along with potential research opportunities to improve the clinical utility of these spatial biomarkers.
JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Abhishek Midya, Amogh Hiremath, Jacob Huber, Vidya Sankar Viswanathan, Danly Omil-Lima, Amr Mahran, Leonardo K. Bittencourt, Sree Harsha Tirumani, Lee Ponsky, Rakesh Shiradkar, Anant Madabhushi
Summary: The objective of this study was to quantify radiomic changes in prostate cancer progression on serial MRI among patients on active surveillance and evaluate their association with pathologic progression on biopsy. The study found that delta radiomics were more strongly associated with upgrade events compared to other clinical variables, and the combination of delta radiomics with baseline clinical variables showed the strongest association with biopsy upgrade prediction.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Mohammadhadi Khorrami, Vidya Sakar Viswanathan, Priyanka Reddy, Nathaniel Braman, Siddharth Kunte, Amit Gupta, Jame Abraham, Alberto J. Montero, Anant Madabhushi
Summary: Imaging texture biomarkers before and after CDK4/6i therapy can predict early response and overall survival in MBC patients with liver metastases. Radiomic features can predict a lack of response earlier than standard anatomic/RECIST 1.1 assessment, highlighting the need for further study and clinical validation.
Article
Pathology
Chuheng Chen, Cheng Lu, Vidya Viswanathan, Brandon Maveal, Bhunesh Maheshwari, Joseph Willis, Anant Madabhushi
Summary: This study uses computer-extracted histomorphometric features to identify the primary site of origin for liver metastases. It found that features related to nuclear and peri-nuclear shape were the most important in classifying different metastatic tumors. Additionally, attention maps generated by a deep learning network can provide a composite feature similarity heat map between primary tumors and their associated metastases.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Article
Computer Science, Interdisciplinary Applications
Zelin Zhang, Sara Arabyarmohammadi, Patrick Leo, Howard Meyerson, Leland Metheny, Jun Xu, Anant Madabhushi
Summary: This article introduces a segmentation model based on conditional generative adversarial network for efficient segmentation of myeloblasts from slides of AML patients. Through validation experiments, it is confirmed that this method has better segmentation performance than other deep learning models, and prognostic models for predicting the risk of recurrence in AML patients have been constructed using the segmentation results.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2024)
Article
Urology & Nephrology
Yijiang Chen, Jarcy Zee, Andrew R. Janowczyk, Jeremy Rubin, Paula Toro, Kyle J. Lafata, Laura H. Mariani, Lawrence B. Holzman, Jeffrey B. Hodgin, Anant Madabhushi, Laura Barisoni
Summary: Computational image analysis enables quantification of PTC attributes and the discovery of a previously unrecognized PTC biomarker (aspect ratio) associated with clinical outcome.