Article
Multidisciplinary Sciences
Eui Jeong Han, Seo-Young Kim, Hee-Jin Han, Hyun-Soo Kim, Kil-Nam Kim, Ilekuttige Priyan Shanura Fernando, Disanayake Mudiyanselage Dinesh Madusanka, Mawalle Kankanamge Hasitha Madhawa Dias, Sun Hee Cheong, Sang Rul Park, Young Seok Han, Kyounghoon Lee, Ginnae Ahn
Summary: The methanol extract of Sargassum horneri showed protective effects against UVB-induced cellular damage in human keratinocytes by reducing intracellular ROS generation, inhibiting apoptosis, and modulating the expression of anti- and pro-apoptotic molecules. The extract also restored skin dryness and barrier disruption in UVB-exposed cells through the Nrf2/HO-1/NF-kappa B p65 signaling pathway. These findings suggest that Sargassum horneri extract may be useful for preventing UVB-induced skin damage.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Liping Zhang, Kai Wang, Shaoxin Liang, Junhan Cao, Mengke Yao, Ling Qin, Changfeng Qu, Jinlai Miao
Summary: In this study, a & zeta;-carotene-like compound (CLC) was synthesized through the expression of three genes in the carotenoid pathway of Antarctic moss in Escherichia coli. The CLC was found to enhance skin antioxidant capacity, reduce inflammation, and mitigate skin damage induced by UVB radiation. This research provides a foundation for the application of CLC in functional food and medicine for skin resistance against UVB damage.
Article
Chemistry, Medicinal
Jeongjin Park, Dakyung Kim, Minhee Lee, Sangshin Han, Woojin Jun, Hyun Mook Jung, Yean Kyoung Koo, Gwi Hwan Na, Sang Hun Han, Jehee Han, Ok-Kyung Kim
Summary: This study found that enzyme-treated caviar powder extract (CV) can protect keratinocytes against oxidative stress and inflammation induced by UVB irradiation by increasing antioxidant enzyme activities, elevating sphingomyelin and hyaluronic acid levels, and reducing inflammatory cytokine production.
Article
Biochemistry & Molecular Biology
Kai Wang, Yashan Deng, Yingying He, Junhan Cao, Liping Zhang, Ling Qin, Changfeng Qu, Hongmei Li, Jinlai Miao
Summary: This study investigated the effect of mycosporine-like amino acids (MAAs) extracted from Antarctic diatom Phaeodactylum tricornutum ICE-H on UVB-induced skin damage. The study found that these MAA components protected against UVB-induced skin damage by inhibiting ROS generation, relieving skin inflammation, and slowing down collagen degradation. This suggests that these MAA components could be effective cosmetic candidate molecules for the protection and therapy of UVB damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Tomohisa Yoshimura, Chika Manabe, Yuki Inokuchi, Chikako Mutou, Tohru Nagahama, Shigeru Murakami
Summary: This study showed that oral supplementation with taurine can suppress UVB-induced wrinkle formation by regulating moisture content in the epidermis, suggesting potential beneficial effects of taurine on skin aging.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Nanoscience & Nanotechnology
Carol Yousry, Mona M. Saber, Wessam H. Abd-Elsalam
Summary: This study aimed to develop and optimize a water-in-oil nanoemulsion loaded with collagen and/or vitamin C for skin protection against UV radiation. The optimized nanoemulsion showed good permeability and wound healing properties on skin cells and effectively protected the skin from UV damage in both in vitro and in vivo experiments. The mixture of collagen and vitamin C in the nanoemulsion had a more pronounced effect.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Medicinal
Mariam Zewail, Passent M. E. Gaafar, Nancy Abdel Hamid Abou Youssef, Merhan E. E. Ali, Mai F. F. Ragab, Miranda F. F. Kamal, Mohamed H. H. Noureldin, Haidy Abbas
Summary: The interest in bioactive compounds from natural sources has led to the development of the skin care industry. Spirulina, a microalga rich in nutrients and phytochemicals, has antioxidant, immunomodulatory, and anti-inflammatory activities. Spirulina-loaded bilosomes were designed as a novel drug delivery system for skin care, with good characteristics and safety profile.
Article
Biochemistry & Molecular Biology
Gayoung Park, Yan-Hong Cui, Seungwon Yang, Ming Sun, Emma Wilkinson, Haixia Li, Yuhan Blair Zhang, Jing Chen, Marc Bissonnette, Wenbin Lin, Yu-Ying He
Summary: Moderate low-dose UVB irradiation increases the activation of immune cells and promotes antitumor immunity, thus inhibiting tumor growth.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Dermatology
Liang Cao, Xueping Yue, Yonghui Zhao, Lixia Du, Zili Xie, Yi Yuan, Sha Zhang, Feng Li, Jing Feng, Hongzhen Hu
Summary: The study established a sunburn-related mouse model and found that TRPV1-positive dorsal root ganglion neurons are involved in broad-band UVB irradiation induced itch, while mast cells are not. Both genetic and pharmacological inhibition of TRPV1 function significantly alleviated the broad-band UVB irradiation-induced itch response.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Plant Sciences
Zhenzhuo Li, Rui Jiang, Chenxu Jing, Jianzeng Liu, Xiaohao Xu, Liwei Sun, Daqing Zhao
Summary: The study found that the ginseng oligosaccharide extract can effectively repair UVB-induced skin barrier damage, alleviate skin dryness, and desquamation symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liping Zhang, Shaoxin Liang, Zhi Zhang, Kai Wang, Junhan Cao, Mengke Yao, Ling Qin, Changfeng Qu, Jinlai Miao
Summary: This study demonstrated that CLC mitigates UVB-induced skin damage through anti-apoptotic and anti-inflammatory effects, up-regulating antioxidant pathways and suppressing signaling pathways. These findings highlight the potential of CLC as an important ingredient in cosmetics targeting anti-aging, skin brightening, and sunburn repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Rahul Kalippurayil Moozhipurath, Lennart Kraft
Summary: Studies indicate that UVB radiation plays a protective role in mitigating COVID-19 deaths in India, while the monsoon season may reduce this protective effect.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Rahul Kalippurayil Moozhipurath, Lennart Kraft
Summary: Research shows that UVB and lockdown measures independently reduce the death rate of COVID-19, but increasing severity of lockdown may diminish the protective role of UVB. Therefore, both lockdown severity and UVB exposure play a role in reducing COVID-19 deaths.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Hui-Jie Jia, Yuchen Ge, Jing Xia, Yi-ling Shi, Xiao-bo Wang
Summary: Belinostat (PXD101), a histone deacetylase inhibitor, effectively inhibits cellular senescence and skin photoaging by inhibiting the UVB-induced signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Xiao Cui, Yongshi Ma, Hong Wang, Jianfang Huang, Linlin Li, Jianbing Tang, Biao Cheng
Summary: The study demonstrated that pre- and post-treatment of PRP could reduce MDA content and increase antioxidant enzyme activities in UVB-damaged HaCaT cells. Additionally, PRP intervention promoted cell proliferation via PI3K/AKT pathway, suppressed the expression of gamma-H2AX, upregulated TIMP-1 expression while downregulating MMP expression levels in photoaged HaCaT cells, ultimately playing an anti-photoaging role.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Keita Takahashi, Shuichi Yanai, Shoko Takisawa, Nozomu Kono, Hiroyuki Arai, Yoichiro Nishida, Takanori Yokota, Shogo Endo, Akihito Ishigami
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Biochemistry & Molecular Biology
Maho Tsubota, Kenta Uebo, Koki Miki, Fumiko Sekiguchi, Akihiko Ishigami, Atsufumi Kawabata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Yohko Yamaguchi, Kohei Kaida, Yusuke Suenaga, Akihito Ishigami, Yoshiro Kobayashi, Kisaburo Nagata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Nutrition & Dietetics
Reina Saga, Takahiro Uchida, Yuka Takino, Yoshitaka Kondo, Hiroaki Kobayashi, Manabu Kinoshita, Daizoh Saitoh, Akihito Ishigami, Makoto Makishima
Summary: This study demonstrated that nutritionally sufficient vitamin C exerts a radioprotective effect against radiation-induced gastrointestinal syndrome, but has minimal impact on hematopoietic syndrome.
Article
Multidisciplinary Sciences
Yuta Doshida, Haruka Sano, Sadahiro Iwabuchi, Toshiro Aigaki, Masayuki Yoshida, Shinichi Hashimoto, Akihito Ishigami
Article
Biochemistry & Molecular Biology
Seulah Lee, Yeon Ji Suh, Seonguk Yang, Dong Geun Hong, Akihito Ishigami, Hangun Kim, Jae-Seoun Hur, Seung-Cheol Chang, Jaewon Lee
Summary: The study demonstrates that evernic acid (EA) has neuroprotective and anti-inflammatory effects, protecting neurons against MPP+-induced cell death, mitochondrial dysfunction, and oxidative stress, and reducing astroglial activation. In mouse models, EA ameliorated MPTP-induced symptoms of PD, including motor dysfunction, dopaminergic neuronal loss, and neuroinflammation in the nigrostriatal pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ayako Ohyama, Atsumu Osada, Hoshimi Kawaguchi, Izumi Kurata, Taihei Nishiyama, Tamaki Iwai, Akihito Ishigami, Yuya Kondo, Hiroto Tsuboi, Takayuki Sumida, Isao Matsumoto
Summary: Neutrophils and their extracellular traps are important in the pathogenesis of rheumatoid arthritis, with IL-6 enhancing neutrophil chemotaxis and NETosis in inflammatory joints, possibly being the source of citrullinated proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Ayami Sato, Yuka Takino, Tomohiro Yano, Koji Fukui, Akihito Ishigami
Summary: The study revealed that in SMP30-KO mice, vitamin C mainly spares vitamin E in the liver and heart, while vitamin E spares vitamin C in the kidneys. The interaction between vitamin C and vitamin E is likely to be tissue specific.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Multidisciplinary Sciences
Sarah Palko, Nicholas J. Saba, Elias Mullane, Benjamin D. Nicholas, Yosuke Nagasaka, Jayakrishna Ambati, Bradley D. Gelfand, Akihito Ishigami, Paola Bargagna-Mohan, Royce Mohan
Summary: Muller glia (MG) have been found to play a crucial role in reactive gliosis and are associated with retinal degenerative diseases. This study shows that MG citrullination is broadly conserved in various models and human tissues. The enzyme PAD4 is responsible for the citrullination, and endfeet are identified as a location where citrullination initiates and sustains in retinal degeneration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Yuta Doshida, Mitsuyo Itabashi, Takashi Takei, Yuka Takino, Ayami Sato, Wako Yumura, Naoki Maruyama, Akihito Ishigami
Summary: This study found lower plasma ascorbate levels in hemodialysis patients compared to non-hemodialysis-dependent CKD patients, with fluctuations before and after dialysis. After dialysis, there was a significant reduction in plasma ascorbate levels and an increase in DHA proportion.
Article
Biology
Shoko Takisawa, Yuka Takino, Jaewon Lee, Shuichi Machida, Akihito Ishigami
Summary: The study found that long-term vitamin C deficiency can cause muscle atrophy and deterioration in physical ability in both male and female mice. However, these effects can be completely restored with vitamin C supplementation. This highlights the importance of vitamin C in maintaining skeletal muscle function.
Article
Dentistry, Oral Surgery & Medicine
T. Yamaguchi, Y. Yamamoto, K. Egashira, A. Sato, Y. Kondo, S. Saiki, M. Kimura, T. Chikazawa, A. Ishigami, S. Murakami
Summary: Periodontal disease is caused by dysbiosis of the dental biofilm and the host inflammatory response. Oxidative stress, one of the major risk factors for periodontal disease, may contribute to disease progression through the inhibition of endotoxin tolerance.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
Masaki Takigawa, Hiroyuki Tanaka, Junichi Suwa, Tomoya Obara, Yohei Maeda, Mamoru Sato, Yoshitomo Shimazaki, Toshihisa Onoda, Akihito Ishigami, Toshihiro Ishii
Summary: The study aimed to investigate the therapeutic drug monitoring in FN patients when TEIC dosing was based on the population mean method. The results showed that the accuracy of predicting TEIC blood concentrations was good in FN patients, with slightly inferior prediction accuracy in patients with a Scr < 0.6 mg/dL and a neutrophil count < 100/mu L.
MEDICINA-LITHUANIA
(2023)
Article
Geriatrics & Gerontology
Yoshitaka Kondo, Hitoshi Aoki, Masato Masuda, Hiroki Nishi, Yoshihiro Noda, Fumihiko Hakuno, Shin-Ichiro Takahashi, Takuya Chiba, Akihito Ishigami
Summary: Nutritional requirements vary with life stage and the appropriate ratio of nutrients, especially proteins, for maintaining metabolic health in old age was investigated in mice. The moderate protein intake percentages of 25% and 35% were found to be necessary for maintaining metabolic health in middle-aged mice, similar to young mice.
Article
Multidisciplinary Sciences
Shoko Takisawa, Tomoko Funakoshi, Tomofumi Yatsu, Kisaburo Nagata, Toshiro Aigaki, Shuichi Machida, Akihito Ishigami
SCIENTIFIC REPORTS
(2019)
