Article
Medicine, Research & Experimental
Rasha M. S. M. Mohamed, Enssaf Ahmad Ahmad, Bothina H. F. Omran, Amr T. Sakr, Islam A. A. E-H Ibrahim, Mona F. Mahmoud, Mostafa E. El-Naggar
Summary: This study investigated the role of a and 13-adrenergic receptors (13ARs) in the dexamethasone-induced nephrotoxicity and found that blocking either a1ARs or 13ARs can effectively protect against the nephrotoxicity. However, the combined blocking of a1ARs and 13ARs does not enhance the renal protective effects.
Article
Neurosciences
Zong-qing Zhao, Xiu-jie Wu, Yan-hao Cheng, Yun-fei Zhou, Xi-meng Ma, Jian Zhang, Xue-yuan Heng, Fan Feng
Summary: The study demonstrated that TROAP plays an oncogenic role in glioma by activating the Wnt/beta-Catenin signaling pathway, leading to cell proliferation, migration, invasion, and poor prognosis. Inhibition of TROAP or downstream targets of Wnt/beta-Catenin pathway could reverse the tumor-promoting effects, suggesting TROAP as a potential novel target for glioma therapy.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Immunology
Ruqing Gao, Xiaoqiang Zheng, Aimin Jiang, Wangxiao He, Tianya Liu
Summary: The tumor-specific biomimetic Wnt pathway suppressor CM-CA effectively inhibits the Wnt/β-catenin signaling pathway and cellular proliferation in lung adenocarcinoma, leading to significant tumor growth inhibition. CM-CA also promotes T cell infiltration and enhances the immune response within tumor tissues.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Chun Tang, Xuehui Wang, Changle Ji, Wenfang Zheng, Yunhe Yu, Xiaochong Deng, Xiqian Zhou, Lin Fang
Summary: The study demonstrated that miR-640 suppresses the tumorigenesis of breast cancer cells by regulating the Wnt/β-catenin signaling pathway, making it a potential novel target for targeted therapy in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Environmental Sciences
Xueming Xu, Yimei Pan, Liqin Zhan, Yi Sun, Sichuan Chen, Jianlin Zhu, Lingfeng Luo, Wenchang Zhang, Yuchen Li
Summary: This study found that 2,5-hexanedione can cause cell cycle arrest in ovarian granulosa cells (GCs), with the Wnt/beta-catenin signaling pathway playing a critical role. The study also investigated the expression changes of mRNA and miRNA and the functions of related genes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biotechnology & Applied Microbiology
Ben Yang, Fengling Wang, Gang Zheng
Summary: This study investigated the role of TMEM119 in breast cancer progression and found that TMEM119 overexpression is associated with poor survival in patients. Knockdown of TMEM119 reduced stemness marker expression. RNA-sequencing and Co-IP experiments confirmed the relationship between TMEM119 and Wnt/beta-catenin signaling pathway.
Article
Agriculture, Multidisciplinary
Hui Zhao, Shun Tang, Qiu Tao, Tianqi Ming, Jiarong Lei, Yuanjing Liang, Yuhui Peng, Minmin Wang, Maolun Liu, Han Yang, Shan Ren, Haibo Xu
Summary: Overwhelming evidence supports the role of the Wnt/beta-catenin signaling pathway in colorectal cancer (CRC) pathogenesis. Ursolic acid (UA), a pentacyclic triterpenoid found in various fruits and plants, has shown potent anticancer activity against CRC, although its mechanism of action is not fully understood. This study aimed to investigate the effects of UA on CRC and its impact on the Wnt/beta-catenin signaling pathway. The study demonstrated that UA significantly inhibited proliferation, migration, and clonality, induced apoptosis, and arrested the cell cycle in CRC cells. Moreover, UA suppressed tumor growth, improved pathological features, induced apoptosis, and arrested the cell cycle in CRC tissue, by diminishing the Wnt/beta-catenin signaling pathway. These findings suggest that UA has the potential to inhibit the malignant phenotype of CRC by attenuating the Wnt/beta-catenin signaling axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Yinan Hu, Qi Wang, Jun Yu, Qing Zhou, Yanhan Deng, Juan Liu, Lei Zhang, Yongjian Xu, Weining Xiong, Yi Wang
Summary: This study reveals the involvement of ACP5 in the initiation and progression of pulmonary fibrosis. Acp5 deficiency protects mice from lung injury and fibrosis, and the upregulation of Acp5 by TGF-beta 1 enhances β-catenin signaling, promoting fibroblast differentiation, proliferation, and migration. Furthermore, treatment with Acp5 siRNA or inhibitor can reverse established lung fibrosis.
NATURE COMMUNICATIONS
(2022)
Article
Environmental Sciences
Eman A. Mohamed, Hebatalla Ahmed, Heba S. Zaky, Amira M. Badr
Summary: This study aimed to investigate the protective effect of boswellic acids (BA) against aluminum-induced Alzheimer's disease, through modulation of the Wnt/beta-catenin pathway. The results showed that BA significantly improved learning and memory impairments induced by aluminum treatment, reduced acetylcholinesterase levels and amyloid-beta expression, suppressed tumor necrosis factor-alpha and interleukin-1 beta expression, inhibited lipid peroxidation, and increased total antioxidants in the brain. BA also modulated the expression of brain-derived neurotrophic factor, pGSK-3 beta (Ser 9), and beta-catenin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Medicinal
Lin Li, Li-Li Yang, Song-Lin Yang, Run-Qing Wang, Hui Gao, Zhu-Ying Lin, Yi-Yi Zhao, Wei-Wei Tang, Rui Han, Wen-Ju Wang, Ping Liu, Zong-Liu Hou, Ming-Yao Meng, Li-Wei Liao
Summary: Andrographolide (ADE) has been found to inhibit tumor growth and progression by suppressing tumor-associated macrophage (TAM) polarization through the Wnt5a signaling pathway. This discovery highlights the potential of ADE as a therapeutic agent for triple-negative breast cancer.
PHYTOTHERAPY RESEARCH
(2022)
Article
Reproductive Biology
Zhijie Zheng, Yingfang Guo, Yonghui Zheng, Haichong Wu
Summary: This study demonstrates that miR-92b plays a protective role in LTA-induced endometritis by targeting FZD10 and reducing the production of pro-inflammatory cytokines, thus alleviating uterine injury.
Article
Immunology
Mengjiao Zhang, Dongmei Yang, Honggang Yu, Qing Li
Summary: miR-497 is downregulated in inflammatory diseases but not in IBD. The study found that miR-497 can inhibit gut inflammation by suppressing the NF-kappa B pathway and cytokine release.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tao Xueqin, Mei Jinhong, Huang Yuping
Summary: INHBA is highly expressed in breast cancer cells and acts as an oncogene by activating the Wnt/beta-catenin pathway, providing a potential therapeutic target for the treatment of breast cancer.
Article
Biochemistry & Molecular Biology
Yalan Dong, Heng Fan, Zhe Zhang, Feng Jiang, Mingyue Li, Haifeng Zhou, Weina Guo, Zili Zhang, Zhenyu Kang, Yang Gui, Zhexing Shou, Junyi Li, Rui Zhu, Yu Fu, Alexey Sarapultsev, Huafang Wang, Shanshan Luo, Ge Zhang, Desheng Hu
Summary: In this study, the therapeutic effect and mechanism of berberine (BBR) in treating DSS-induced colitis were investigated. It was found that BBR can reduce colon inflammation, regulate the abundance and composition of bacteria, restore the broken chemical and epithelial barriers, and modulate the expression of various immune factors. The protective effect of BBR was also observed through the enhancement of the Wnt/beta-catenin pathway. These findings suggest that BBR serves as a potential gut microbiota modulator and mucosal barrier protector for UC prevention and therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)