Review
Pharmacology & Pharmacy
Lichao Hu, Mengyuan Ding, Weichun He
Summary: Epithelial-mesenchymal transition (EMT) is an important process in tissue fibrosis, and the Wnt/beta-catenin signaling pathway plays a crucial role in regulating tubular EMT, making it a potential therapeutic target for kidney fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Xiaohe Li, Xiaowei Liu, Ruxia Deng, Shaoyan Gao, Qiuyan Jiang, Rui Liu, Hailong Li, Yang Miao, Yunqian Zhai, Shanshan Zhang, Zhenzhen Wang, Yimeng Ren, Wen Ning, Honggang Zhou, Cheng Yang
Summary: Betulinic acid (BA) has shown anti-pulmonary fibrosis effect by suppressing the Wnt/beta-catenin pathway, inhibiting fibroblast activation, and decreasing the expression of Wnt target genes. In both in vitro and in vivo experiments, BA significantly reduced pulmonary fibrosis and myofibroblast activation.
Article
Pharmacology & Pharmacy
Hanshuo Zhu, Zheng Chen, Lin Shen, Tianchi Tang, Min Yang, Xuesheng Zheng
Summary: The study showed that LINC-PINT suppresses cell proliferation, invasion, and EMT in GBM by blocking Wnt/β-catenin signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Irina Giralt, Gabriel Gallo-Oller, Natalia Navarro, Patricia Zarzosa, Guillem Pons, Ainara Magdaleno, Miguel F. Segura, Constantino Sabado, Raquel Hladun, Diego Arango, Jose Sanchez de Toledo, Lucas Moreno, Soledad Gallego, Josep Roma
Summary: The study demonstrates the therapeutic potential of DKK-1 pharmaceutical inhibition in rhabdomyosarcoma, resulting in beta-catenin activation and modulation of focal adhesion kinase, with positive effects on myogenic marker expression and a reduction in proliferation and invasion. In addition, the chemical inhibitor WAY-262611 was able to impair tumor cell survival in vivo, suggesting DKK-1 as a potential molecular target for novel therapeutic strategies in RMS patients, especially those with high DKK-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Wenhao Liao, Yueqiang Wen, Jing Wang, Maoyuan Zhao, Shangbin Lv, Nianzhi Chen, Yuchen Li, Lina Wan, Qiao Zheng, Yu Mou, Ziyi Zhao, Jianyuan Tang, Jinhao Zeng
Summary: This study aims to investigate the role and potential mechanism of GA on gastric precancerous lesions (GPL), the key turning point of gastritis to gastric cancer, with the aim of delaying, blocking or reversing the dynamic overall process of inflammation-cancer transformation and thus blocking GPL to prevent the development of gastric cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Xiaoli Shi, Yunzhu Cen, Liying Shan, Lijie Tian, Endong Zhu, Hairui Yuan, Xiaoxia Li, Ying Liu, Baoli Wang
Summary: The study revealed that NDRG1 negatively regulated cell growth and modulated the differentiation of marrow stromal progenitor cells towards adipocytes, impacting the osteoblast differentiation. NDRG1 interacted with LRP6 and inactivated the canonical Wnt/beta-catenin signaling cascade in stromal progenitor cells. In vivo transfection of Ndrg1 siRNA prevented inactivation of Wnt signaling and improved osteoblasts reduction and fat accumulation in ovariectomized mice.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Environmental Sciences
Yangyang Tian, Jiarui Xia, Guo Yang, Chao Li, Yuanmeng Qi, Kai Dai, Chenchen Wu, Yonghua Guo, Wu Yao, Changfu Hao
Summary: We found that A2aR inhibits fibrosis and the EMT process in silicosis by regulating the Wnt/β-catenin pathway. Our study provides an experimental basis for elucidating the role of A2aR in the development of silicosis and offers new ideas for further exploration of interventions for silicosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Medicinal
Xingcai Zhang, Lifang Ye, Wan Tang, Yiqin Ji, Li Zheng, Yijun Chen, Qidong Ge, Changshun Huang
Summary: The study aimed to investigate the antifibrotic effects of mesenchymal stem cell microvesicles (MSC MVs) in acute respiratory distress syndrome (ARDS) and the underlying mechanisms. The results showed that MSC MVs significantly suppressed pathological progression of ARDS, reversed abnormal expression of epithelial-mesenchymal transition (EMT)-related proteins, and attenuated activation of the Wnt/β-catenin signaling pathway. These findings suggest that MSC MVs have the potential to ameliorate early pulmonary fibrosis associated with ARDS by regulating EMT and the Wnt/β-catenin signaling pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Chung-Te Liu, Shih-Chang Hsu, Hui-Ling Hsieh, Cheng-Hsien Chen, Chun-You Chen, Yuh-Mou Sue, Tso-Hsiao Chen, Yung-Ho Hsu, Feng-Yen Lin, Chun-Ming Shih, Yan-Ting Shiu, Po-Hsun Huang
Summary: This study found that mechanical disturbances activate the beta-catenin signaling pathway in AVF, causing the transition of endothelial cells to myofibroblasts and thickening of AVFs. Inhibiting the beta-catenin signaling pathway can help maintain AVF patency.
MOLECULAR MEDICINE
(2022)
Review
Genetics & Heredity
Giovanni Ligresti, Ahmed A. Raslan, Jeongmin Hong, Nunzia Caporarello, Marco Confalonieri, Steven K. Huang
Summary: Mesenchymal cells in the lung play a crucial role in development and are also implicated in the pathogenesis of fibrotic disorders, including idiopathic pulmonary fibrosis. These cells exhibit remarkable plasticity and can differentiate into activated myofibroblasts, which secrete high levels of extracellular matrix proteins and inflammatory cytokines. Understanding the different functions and actions of each mesenchymal cell subtype will provide insights into the development of fibrosis and potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Mei-Jen Hsieh, Ching-Chieh Weng, Yu-Chun Lin, Chia-Chen Wu, Li-Tzong Chen, Kuang-Hung Cheng
Summary: This study revealed the importance of the Wnt/β-catenin signaling pathway in pancreatic cancer, showing that loss of LKB1 affects cystadenoma development and that the beta-catenin inhibitor FH535 can effectively suppress LKB1 loss-driven cystadenoma and slow down pancreatic cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yue Zhu, Yujie Gan, Renrui Zou, Huanhuan Sha, Ya Lu, Yuan Zhang, Jifeng Feng
Summary: The study demonstrated that RNF128 inhibits cell proliferation and metastasis of CRC cells by regulating the Wnt/β-catenin signaling pathway.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Wen Bi, Mengyue Yang, Pengfei Xing, Tao Huang
Summary: This study investigated the association between miR-331-3p and OS development and identified MGAT1 as a target of miR-331-3p in OS. The results demonstrated that miR-331-3p acts as a tumor suppressor by inhibiting MGAT1 and related signaling pathways, leading to decreased proliferation and increased apoptosis in OS cells, as well as inhibited migration and invasion abilities.
Article
Cell Biology
Yanlin Cai, Yi Hu, Furong Yu, Wenjuan Tong, Shufen Wang, Shunliang Sheng, Jiayu Zhu
Summary: Globally, ovarian cancer ranks as the second most common cause of gynecologic-related cancer deaths among women, with a poor prognosis. Research has shown that downregulation of AHNAK in ovarian cancer cells can significantly inhibit cell growth and metastasis, partly by dampening the Canonical Wnt cascade. Therefore, AHNAK may serve as a biomarker and potential treatment target for ovarian cancer.
Article
Multidisciplinary Sciences
Morgane Le Rolle, Filippo Massa, Pam Siggers, Laurent Turchi, Agnes Loubat, Bon-Kyoung Koo, Hans Clevers, Andy Greenfield, Andreas Schedl, Marie-Christine Chaboissier, Anne-Amandine Chassot
Summary: This study shows that germ cell-intrinsic beta-catenin activity in mouse embryonic ovaries is essential for maintaining pluripotency and its repression is crucial for differentiation and meiosis entry. The interaction of beta-catenin with the pluripotent-associated factor POU5F1 in the nucleus is associated with germ cell pluripotency, and its exit from the nucleus correlates with germ cell differentiation. These findings highlight the role of beta-catenin as a central gatekeeper in ovarian differentiation and gametogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Jiwei Hou, Tan Ma, Honghui Cao, Yabing Chen, Cong Wang, Xiang Chen, Zou Xiang, Xiaodong Han
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Article
Cell Biology
Ling Chen, Jiwei Hou, Xiao Fu, Xiang Chen, Jiang Wu, Xiaodong Han
Article
Medicine, Research & Experimental
Honghui Cao, Xiang Chen, Jiwei Hou, Cong Wang, Zou Xiang, Yi Shen, Xiaodong Han
LABORATORY INVESTIGATION
(2020)
Article
Environmental Sciences
Haibo Jin, Bo Wang, Jiwei Hou, Tan Ma, Dan Qiao, Yingwen Miao, Jie Ding, Xiaodong Han
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2019)
Article
Cell Biology
Xiang Chen, Hongyang Xu, Jiwei Hou, Hui Wang, Yi Zheng, Hui Li, Hourong Cai, Xiaodong Han, Jinghong Dai
Article
Environmental Sciences
Tan Ma, Jiwei Hou, Yuan Zhou, Yusheng Chen, Jiayin Qiu, Jiang Wu, Jie Ding, Xiaodong Han, Dongmei Li
ENVIRONMENTAL HEALTH
(2020)
Article
Environmental Sciences
Xiannan Meng, Ling Zhang, Jiwei Hou, Tan Ma, Chun Pan, Yuan Zhou, Ruitong Han, Yuanzhen Ding, Haoran Peng, Zou Xiang, Dongmei Li, Xiaodong Han
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Environmental Sciences
Haibo Jin, Jiwei Hou, Xiannan Meng, Tan Ma, Bo Wang, Zhenyu Liu, Xiaoxuan Sha, Jie Ding, Xiaodong Han
Summary: MC-LR, a toxin produced by cyanobacterial, leads to decreased testosterone levels and apoptosis of GnRH neurons. Exposure to MC-LR increases intracellular ROS production and Ca2+ release, as well as activates ER stress and autophagy. Pre-treatment with ER stress inhibitor reduces apoptosis, while pre-treatment with autophagy inhibitor increases apoptosis in cells exposed to MC-LR.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Jiwei Hou, Jie Ji, Xiang Chen, Honghui Cao, Yi Tan, Yu Cui, Zou Xiang, Xiaodong Han
Summary: The study revealed the interaction between macrophages and fibrosis-associated alveolar epithelial cells, unveiling the mechanism of macrophage polarization and pulmonary fibrosis development, and suggesting Shh as a potential target for treating pulmonary fibrosis.
Article
Chemistry, Multidisciplinary
Qijian Ji, Jiwei Hou, Xueqing Yong, Guangming Gong, Mohd. Muddassir, Tianyu Tang, Jinbing Xie, Wenpei Fan, Xiaoyuan Chen
Summary: This study demonstrates the potential therapeutic target of inhibiting myofibroblast differentiation of LR-MSCs using micelles to deliver siRUNX1, as well as the synergistic effect of siRUNX1 and siGli1 loaded micelle system for PF therapy.
ADVANCED MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Yu Cui, Jie Ji, Jiwei Hou, Yi Tan, Xiaodong Han
Summary: By analyzing gene expression profiles of IPF and normal samples, 62 upregulated genes and 20 downregulated genes were identified, and relevant pathways associated with IPF were illustrated. Through protein-protein interaction network analysis, 11 key candidate genes were identified, potentially contributing to novel treatments for IPF.
Article
Biochemistry & Molecular Biology
Jie Ji, Jiwei Hou, Yunhui Xia, Zou Xiang, Xiaodong Han
Summary: The activation of NLRP3 inflammasome is elevated in fibrotic lungs, contributing to a better understanding of the pathogenesis of pulmonary fibrosis and revealing a potential therapeutic strategy for disorders associated with pulmonary fibrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Letter
Genetics & Heredity
Lingyi Liu, Yanru Yang, Xin Han, Jiwei Hou
FUNCTIONAL & INTEGRATIVE GENOMICS
(2022)
Article
Plant Sciences
Tong Zhao, Zhiruo Zhou, Shimei Zhao, Huiqi Wan, Honglin Li, Jiwei Hou, Jiaying Wang, Minyi Qian, Xu Shen
Summary: In this study, the role of GPR40 in pulmonary fibrosis (PF) was investigated using the GPR40 agonist Vin as a probe, and the potential of Vin in ameliorating PF in mice was explored. The results showed that pulmonary GPR40 expression was downregulated in PF patients and mice, and Vin-mediated GPR40 activation improved PF pathology. Therefore, pulmonary GPR40 activation may be a promising therapeutic strategy for PF, and Vin exhibits high potential in treating this disease.
Article
Medicine, Research & Experimental
Jiwei Hou, Qijian Ji, Jie Ji, Shenghong Ju, Chun Xu, Xueqing Yong, Xiaoxuan Xu, Mohd Muddassir, Xiang Chen, Jinbing Xie, Xiaodong Han
Summary: The development of a dual siRNA-loaded micelle delivery system targeting (myo)fibroblasts shows promising potential in inhibiting the progression of pulmonary fibrosis by suppressing (myo)fibroblast activation and promoting apoptosis. The micelles effectively deliver siRNA targeting NOX4 and PTPN13, leading to significant antifibrotic effects without causing damage to major organs in murine models.