Article
Chemistry, Organic
Mingming Mao, Jia Li, Kang Dong, Rui-Peng Li, Xi Chen, Jian Liu, Shouchu Tang
Summary: We present a metal-free late-stage reductive C2 alkylation method for the synthesis of structurally complex peptides, utilizing readily available 1,3-dithianes. This protocol shows a broad substrate scope and excellent tolerance toward reactive functional groups.
Article
Nanoscience & Nanotechnology
Gulcihan Gulseren, Aytul Saylam, Antoine Marion, Salih Ozcubukcu
Summary: The introduction of fullerene nanocatalysts into biocatalysis represents a novel approach to mimic enzymatic activity, offering potential for the design of high-efficiency artificial nanocatalysts through self-assembled nanostructures.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Organic
Liangliang Song, Zhenwei Lv, Yan Li, Kui Zhang, Erik V. Van der Eycken, Lingchao Cai
Summary: In this study, a Rh(III)-catalyzed C-H activation/annulation reaction was developed for the diversification of Lys-based peptides, yielding a range of peptide-isoquinolone conjugates. This method offers racemization-free conditions, high atom and step economy, excellent chemo- and site-selectivity, and broad substrate scope. Furthermore, the peptide-isoquinolone conjugates demonstrate good fluorescent properties and show potential antifungal activity against crop and forest pathogenic fungi, with a particular conjugate exhibiting superior activity compared to the positive control.
Article
Chemistry, Organic
Narendra Dinkar Kharat, Chikkagundagal K. Mahesha, Kiran Bajaj, Rajeev Sakhuja
Summary: A Rh(III)-catalyzed [5+2] annulation reaction was performed to successfully synthesize oxepine-mounted tyrosine-based unnatural amino acids by reacting vinyl tyrosines with symmetrical and unsymmetrical internal alkynes. The chemical applicability of this strategy was demonstrated through the stapling of amino acid/peptide-appended alkynes with vinyl tyrosines, as well as the late stage functionalization of tyrosine-containing dipeptides and tripeptides with internal alkynes.
Article
Chemistry, Organic
Xianghua Tao, Guobin Ma, Yanhong Song, Yunrong Chen, Qun Qian, Deli Sun, Hegui Gong
Summary: A Ni-catalyzed reductive cross-coupling reaction has been developed for the synthesis of unnatural di- and tripeptides containing vinyl and aryl side chains, expanding the application of Ni-catalyzed reductive cross-coupling in the late-stage diversification of peptides.
Article
Astronomy & Astrophysics
Xiaoyi Hu, Deping Zhang, Yuanyuan Yang, Yang Chen, Liping Qin, Junfeng Zhen
Summary: The study investigated the chemical reactivity of fullerene cations with amino acid molecules, finding high efficiency in forming fullerene/amino acid cluster cations in the gas phase. The formation rate constants increased gradually with declining C-atom number of fullerene cations, reaching a plateau for smaller fullerene cations. Magic numbers of C-atom counts with enhanced chemical reactivity were identified, indicating the importance of ion-molecule reactions in the formation of complex fullerene-amino acid derivatives in the ISM.
ASTROPHYSICAL JOURNAL
(2021)
Article
Chemistry, Physical
C. Aguiar, M. Camps, N. Dattani, I. Camps
Summary: By functionalizing the surface of boron nitride nanotubes with hydroxyl and carboxyl organic groups, various effects such as changes in the electronic properties, magnetism, and electron density of the nanotubes can be produced. These changes can be used to control and modify the interaction between nanotubes and other molecules.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Organic
Narendra Dinkar Kharat, Sushma Naharwal, Disha Tank, Siva S. Panda, Kiran Bajaj, Rajeev Sakhuja
Summary: Pyridyloxy-directed Rh-(III)-catalyzed regioselective C3(Ar)-H alkenylation of protected tyrosines was achieved, leading to the synthesis of a series of maleimide-appended tyrosine-based unnatural amino acids. The strategy was further applied to peptide compounds with moderate reactivity.
Article
Chemistry, Multidisciplinary
Huazhong Liu, Qing An, Qian Deng, Jiexiu Ming, Han Xu
Summary: In this study, the interaction between methylene blue (MB) and graphene and h-BN was investigated through molecular simulations. It was found that both graphene and h-BN have strong adsorption capabilities for MB, suggesting potential applications in wastewater treatment and sensors.
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2023)
Article
Environmental Sciences
Mengmeng Wang, Hirofumi Akamatsu, Ismaila Dabo, Keiko Sasaki
Summary: This study investigates the effects of amino acids as simplified models of natural organic matters on the stability of hydrocalumite (Ca2Al-LDH) immobilizing selenium (SeO42-). The presence of amino acids was found to enhance the release of SeO42- from the LDH model, indicating a potential impact on the stability of selenate immobilized in hydrocalumite in cement disposal in the long term.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Physical
D. Kirk Lewis, Younghoon Oh, Luke Nambi Mohanam, Micha Wierzbicki, Nicole L. Ing, Lei Gu, Allon Hochbaum, Ruqian Wu, Qiang Cui, Sahar Sharifzadeh
Summary: Proteins are promising for bioelectronic devices due to their biocompatibility, flexibility, and chemical diversity. However, the electronic structure and conductivity of protein assemblies are not well-understood due to their structural and environmental complexity. This study shows that the full atomistic picture needs to be considered when predicting electronic properties of supramolecular protein complexes.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Multidisciplinary Sciences
Nikolaos Kaplaneris, Jongwoo Son, Lorena Mendive-Tapia, Adelina Kopp, Nicole D. Barth, Isaac Maksso, Marc Vendrell, Lutz Ackermann
Summary: Bioorthogonal diversification of peptides usually relies on impractical prefunctionalization methods. The authors have developed a manganese(I)-catalyzed C-H fluorescent labeling with BODIPY probes, which enables the development of activatable fluorophores for imaging cell function.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Anas Semghouli, Zsanett Benke, Attila M. Remete, Tamas T. Novak, Santos Fustero, Lorand Kiss
Summary: Novel functionalized azaheterocycles with multiple chiral centers have been successfully accessed from readily available norbornene beta-amino acids or beta-lactams through a stereocontrolled synthetic route, based on ring-opening metathesis (ROM) of the starting unsaturated bicyclic amino esters, followed by selective cyclization through ring-closing metathesis (RCM). The developed synthetic route preserved the configuration of the chiral centers determined by the structure of the starting norbornene beta-amino acids.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Materials Science, Multidisciplinary
Anh Thi Le, Thanh Binh Dinh, T. Anh Thu Do, Truong Giang Ho, Duy Manh Le, Minh Tan Man
Summary: The electronic properties and phonon dynamics of Cs2SnCl6 double perovskites were investigated through first-principles calculations combined micro-Raman scattering and optical spectroscopy. The findings show that the principal Raman peaks and fundamental vibrational modes are perfectly aligned. This research provides valuable information for basic research and practical applications of Cs2SnCl6 in emerging nanoelectronics.
Article
Chemistry, Organic
Ya-Ting Wen, Xiang-Tao Kong, Hong-Chao Liu, Cui-Tian Wang, Wan-Xu Wei, Bin Wang, Xue-Yuan Liu, Yong-Min Liang
Summary: An innovative 1,5-HAT cascade strategy has been proposed for nickel-catalyzed distal arylation via cross-electrophile coupling. It selectively activates the remote C(sp(3))-H bond through specific migration and uses Ar-I as the available electrophile for constructing the C(sp(3))-C(sp(2)) bond. The method shows broad applicability for benzylic and aliphatic N-fluorocarboxamides with yields up to 80%. Control experiments suggest that this reaction may be initiated by a radical process.