Review
Immunology
Vladimir Roudko, Cansu Cimen Bozkus, Benjamin Greenbaum, Aimee Lucas, Robert Samstein, Nina Bhardwaj
Summary: Defective DNA mismatch repair is associated with various cancer types, including Lynch syndrome which increases the risk of malignancy. MSI-H tumors can be treated with checkpoint inhibitors, but the response rates are not high.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Tomohiro Enokida, Alvaro Moreira, Nina Bhardwaj
Summary: Preventive cancer vaccines have shown promising results in targeting oncogenic viruses, such as HPV and HBV, but face challenges in eliminating established cancer. Ongoing research is also focusing on nonviral antigens to develop effective cancer-preventive vaccines.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Rong Bu, Abdul K. Siraj, Sandeep Kumar Parvathareddy, Kaleem Iqbal, Saud Azam, Zeeshan Qadri, Maha Al-Rasheed, Wael Haqawi, Mark Diaz, Khadija Alobaisi, Padmanaban Annaiyappanaidu, Nabil Siraj, Hamed AlHusaini, Osama Alomar, Ismail A. Al-Badawi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: This study investigated the frequency of LS in EC patients from Saudi Arabia and found that the prevalence of LS was low, with LLS being as common as LS in this population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jiayu Zhao, Yudi Xu, Sheng Ma, Yibo Wang, Zichao Huang, Haoyuan Qu, Haochen Yao, Yu Zhang, Guanglu Wu, Leaf Huang, Wantong Song, Zhaohui Tang, Xuesi Chen
Summary: A minimalist binary nanovaccine (BiVax) has been designed to integrate innate stimulating activity into the carrier to elicit robust antitumor immunity, showing promising results in inducing strong immune responses against tumor cells.
ADVANCED MATERIALS
(2022)
Article
Immunology
Di Cao, Yu Gao, Rong-xin Zhang, Fu-long Wang, Cong Li, Miao-qing Wu, Yi-fan Liu, Dan-dan Li, Gong Chen
Summary: This case report describes a Lynch syndrome patient who developed enlarged lymph nodes after treatment with PD-1 receptor inhibitor. However, surgical pathology examination did not find any cancer cells in these lymph nodes, allowing the preservation of the patient's reproductive organs. The patient successfully conceived and gave birth without any immune-related adverse events.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Xue Dong, Pei Pan, Jing-Jie Ye, Qiu-Ling Zhang, Xian-Zheng Zhang
Summary: The study demonstrates a bioactive vaccine platform using hybrid M13 phage and personal tumor antigens for efficient delivery of antigens and activation of immune response. The vaccine not only prevents tumor occurrence but also delays tumor growth, showing potential synergy with immune checkpoint blockade therapy.
Review
Biochemistry & Molecular Biology
Cristina Bayo, Gerhard Jung, Marta Espanol-Rego, Francesc Balaguer, Daniel Benitez-Ribas
Summary: Cancer vaccines aim to modulate the immune system to induce protective immune responses against cancer-related antigens. Administering cancer-preventive vaccination at early stages is seen as a potential way to increase clinical efficacy, as research begins to focus on these approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Chao Liu, Xue Liu, Xinchu Xiang, Xin Pang, Siyuan Chen, Yunming Zhang, En Ren, Lili Zhang, Xuan Liu, Peng Lv, Xiaoyong Wang, Wenxin Luo, Ningshao Xia, Xiaoyuan Chen, Gang Liu
Summary: This study presents a genetically engineered cell membrane nanovesicle for cancer immunotherapy. The nanovaccine, named ASPIRE, can improve antigen delivery to lymphoid organs and generate broad-spectrum T-cell responses that eliminate established tumors. This work provides a powerful vaccine formula that can directly activate both native T cells and exhausted T cells, suggesting a general strategy for personalized cancer immunotherapy.
NATURE NANOTECHNOLOGY
(2022)
Article
Oncology
Soyoun Rachel Kim, Alicia Tone, Raymond H. Kim, Matthew Cesari, Blaise A. Clarke, Lua Eiriksson, Tae L. Hart, Melyssa Aronson, Spring Holter, Alice Lytwyn, Manjula Maganti, Leslie Oldfield, Steven Gallinger, Marcus Q. Bernardini, Amit M. Oza, Bojana Djordjevic, Jordan Lerner-Ellis, Emily van de Laar, Danielle Vicus, Trevor J. Pugh, Aaron Pollett, Sarah E. Ferguson
Summary: The implementation of a navigated genetic program resulted in a high rate of genetic assessment in patients with endometrial or nonserous/nonmucinous ovarian cancer at risk for Lynch syndrome.
Article
Multidisciplinary Sciences
Abdul Khalid Siraj, Rong Bu, Tariq Masoodi, Sandeep Kumar Parvathareddy, Kaleem Iqbal, Wael Al-Haqawi, Hassan Al-Dossari, Saud Azam, Zeeshan Qadri, Padmanaban Annaiyappanaidu, Fouad Al-Dayel, Khawla Sami Al-Kuraya
Summary: RNF43 mutations are frequently found in Middle Eastern CRC, with a strong association with right-sided and sporadic MSI CRC, and no association with other clinical and pathological features.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Swetlana Ladigan-Badura, Deepak B. Vangala, Christoph Engel, Karolin Bucksch, Robert Hueneburg, Claudia Perne, Jacob Nattermann, Verena Steinke-Lange, Nils Rahner, Hans K. Schackert, Juergen Weitz, Matthias Kloor, Judith Kuhlkamp, Huu Phuc Nguyen, Gabriela Moeslein, Christian Strassburg, Monika Morak, Elke Holinski-Feder, Reinhard Buettner, Stefan Aretz, Markus Loeffler, Wolff Schmiegel, Christian Pox, Karsten Schulmann
Summary: Regular upper GI endoscopy surveillance for LS patients starting from the age of 30 can successfully detect gastric cancer in early stages, leading to more frequent diagnoses in early-stage disease compared to symptomatic diagnoses. The study emphasizes the importance of early detection through regular screenings.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Renato Brito Baleeiro, Peng Liu, Louisa S. Chard Dunmall, Carmela Di Gioia, Ai Nagano, Lauren Cutmore, Jun Wang, Claude Chelala, Lydon Wainaina Nyambura, Peter Walden, Nicholas Lemoine, Yaohe Wang
Summary: This study successfully identified immunogenic neoantigens and generated neoantigen-specific CD8+T cells capable of recognizing human triple-negative breast cancer cells. Using an oncolytic virus as a delivery system, the researchers demonstrated that vaccination with neoantigens can induce a specific CD8+T cell response, slow tumor growth, and increase survival in a mouse model of TNBC. This study provides a promising approach for the development of neoantigen-based immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Karolin Bucksch, Silke Zachariae, Aysel Ahadova, Stefan Aretz, Reinhard Buttner, Heike Goergens, Elke Holinski-Feder, Robert Hueneburg, Matthias Kloor, Magnus Knebel Doeberitz, Swetlana Ladigan-Badura, Gabriela Moeslein, Monika Morak, Jacob Nattermann, Huu Phuc Nguyen, Claudia Perne, Silke Redler, Ariane Schmetz, Verena Steinke-Lange, Harald Surowy, Deepak B. Vangala, Juergen Weitz, Markus Loeffler, Christoph Engel
Summary: This study aimed to characterize and compare the risks for adenoma and CRC in Lynch syndrome (LS), Lynch-like syndrome (LLS) and familial colorectal cancer type X (FCCX). The study found similar risks for colorectal adenomas, but different risks for first and metachronous CRC between the three risk groups, with CRC risk highest in LS, followed by LLS and lowest in FCCX. Male sex and a prevalent adenoma in the index colonoscopy were associated with a higher risk for incident adenoma and CRC.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Engineering, Environmental
Junyan Li, Yuanyuan Wu, Jian Xiang, Hairong Wang, Qi Zhuang, Ting Wei, Zhiqin Cao, Qingyang Gu, Zhuang Liu, Rui Peng
Summary: Scientists have synthesized F-PEI nanovaccine for mRNA delivery, which can induce dendritic cell maturation and trigger effective antigen presentation, leading to strong anti-tumor immune responses. This research provides a new tool for mRNA delivery, promising for personalized cancer vaccines as well as other mRNA-based immunotherapies.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Dixita Ishani Viswanath, Hsuan-Chen Liu, David P. Huston, Corrine Ying Xuan Chua, Alessandro Grattoni
Summary: Landmark successes in oncoimmunology have led to the development of cancer vaccines using biomaterials to enhance the host immune system against tumors. This review focuses on strategies to attract dendritic cells, activate them against tumor-specific antigens, and stimulate T cells in secondary lymphoid organs. Personalized cancer vaccines have the potential to generate long-term systemic immunity against patient- and tumor-specific antigens.
Article
Anthropology
Bharti Mittal, Vikal Tripathy, M. Aruna, A. G. Reddy, I. Thanseem, K. Thangaraj, Lalji Singh, B. M. Reddy
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2008)
Article
Multidisciplinary Sciences
Snigdha Majumder, Rakshit Shah, Jisha Elias, Yogesh Mistry, Karunakaran Coral, Priyanka Shah, Anand Kumar Maurya, Bharti Mittal, Jason K. D'Silva, Sakthivel Murugan, Lakshmi Mahadevan, Rekha Sathian, V. L. Ramprasad, Papia Chakraborty, Ravi Gupta, Amitabha Chaudhuri, Arati Khanna-Gupta