Article
Biochemistry & Molecular Biology
Xiao-Lin Zhuang, Jin-Jin Zhang, Yong Shao, Yaxin Ye, Chun-Yan Chen, Long Zhou, Zheng-bo Wang, Xin Luo, Bing Su, Yong-Gang Yao, David N. Cooper, Ben-Xia Hu, Lu Wang, Xiao-Guang Qi, Jiangwei Lin, Guo-Jie Zhang, Wen Wang, Nengyin Sheng, Dong-Dong Wu
Summary: By conducting large-scale comparative genomic, transcriptomic, and epigenomic analyses, we investigated the evolutionary changes of brain genes from ancestral primates to humans and provided a comprehensive listing of innovative genetic elements. The regulatory sequences associated with brain-expressed genes underwent rapid changes, particularly in the ancestor of the Simiiformes. Comparisons of primate and non-primate brain transcriptomic data revealed that these regulatory sequences may drive the high expression of certain genes in primate brains. Our study also demonstrated the recruitment of the primate-specific brain-biased gene BMP7 to regulate neuronal proliferation in the primate ventricular zone. These findings provide valuable insights into the genetic basis of human brain evolution and inherited diseases.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Immunology
Sonya Krishnan, Artur T. L. Queiroz, Amita Gupta, Nikhil Gupte, Gregory P. Bisson, Johnstone Kumwenda, Kogieleum Naidoo, Lerato Mohapi, Vidya Mave, Rosie Mngqibisa, Javier R. Lama, Mina C. Hosseinipour, Bruno B. Andrade, Petros C. Karakousis
Summary: Novel high-throughput approaches may improve the recognition of tuberculosis in HIV-infected individuals, especially in those with severely suppressed immune systems.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Aslihan Kurt-Kizildogan, Gozde Celik, Eser unsaldi, Servet Ozcan, Serife Ayaz-Guner, Gulay Ozcengiz
Summary: This study deciphers regulatory mechanisms in clavulanic acid biosynthesis and provides insights for enhancing CA yields through analyzing transcriptome and proteome alterations in an industrial overproducer strain.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Daniel Picard, Joerg Felsberg, Maike Langini, Pawel Stachura, Nan Qin, Jadranka Macas, Yvonne Reiss, Jasmin Bartl, Florian Selt, Romain Sigaud, Frauke-D. Meyer, Anja Stefanski, Kai Stuehler, Lucia Roque, Rafael Roque, Aleksandra A. Pandyra, Triantafyllia Brozou, Christiane Knobbe-Thomsen, Karl H. Plate, Alexander Roesch, Till Milde, Guido Reifenberger, Gabriel Leprivier, Claudia C. Faria, Marc Remke
Summary: Using a multi-omics approach, researchers identified two distinct molecular subtypes of pediatric brain tumor PA, namely Group 1 and Group 2. Group 1 was associated with younger age and worse prognosis, with enrichment of immune response pathways. On the contrary, Group 2 showed enrichment of neurotransmitter signaling pathways. This study provides insights for risk stratification and personalized treatment of PA patients.
ACTA NEUROPATHOLOGICA
(2023)
Article
Microbiology
Bart Cuypers, Pieter Meysman, Ionas Erb, Wout Bittremieux, Dirk Valkenborg, Geert Baggerman, Inge Mertens, Shyam Sundar, Basudha Khanal, Cedric Notredame, Jean-Claude Dujardin, Malgorzata A. Domagalska, Kris Laukens
Summary: Aneuploidy has a significant impact on the transcriptome, proteome, and metabolome of Leishmania donovani, leading to disruptions in stochiometric balances and metabolic differences between aneuploid strains. However, protein complex subunits and non-cytoplasmic proteins show attenuations in dosage effects. The differentially expressed proteins are enriched for those involved in protein metabolism. These findings suggest that aneuploidy in Leishmania can be adaptive and make it an attractive model for studying protein homeostasis in the context of aneuploidy.
Article
Oncology
Zhengqing Wan, Haofeng Xiong, Xian Tan, Tong Su, Kun Xia, Danling Wang
Summary: Oral squamous cell carcinoma (OSCC) is a common and deadly cancer. In this study, we identified potential biomarkers and therapeutic targets for OSCC through analyzing differentially expressed genes and methylation-regulated genes. Several hub genes were found to be significantly associated with survival in OSCC patients, suggesting their potential as therapeutic targets.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Wenzhu Guo, Jianhua Yang, Tianchen Huang, Dandan Liu, Qian Liu, Jingen Li, Wenliang Sun, Xingji Wang, Leilei Zhu, Chaoguang Tian
Summary: This study identified key enzymes involved in the starch saccharification process, including glucoamylase, alpha-amylase, and acid alpha-amylase, out of 29 glycoside hydrolases from the 6-day fermentation products of A. niger O1. Synergistic effects were observed among the components of glucoamylases cocktail, with an increase in alpha-amylase leading to improved efficiency of starch saccharification. Overexpression of acid alpha-amylase in strain O1 resulted in an increase in total glucoamylase activity.
BIOTECHNOLOGY FOR BIOFUELS
(2021)
Article
Multidisciplinary Sciences
Huiting Jiangzhou, Hang Zhang, Renliang Sun, Aamir Fahira, Ke Wang, Zhiqiang Li, Yongyong Shi, Zhuo Wang
Summary: The study identified molecular features and prognosis differences among subtypes of pan-GI cancers through multi-omics integration, highlighting the significance of multi-omics approach in pan-cancer research.
Article
Multidisciplinary Sciences
Ian Jones, Lucas Dent, Tomoaki Higo, Theodoros Roumeliotis, Maria Arias Garcia, Hansa Shree, Jyoti Choudhary, Malin Pedersen, Chris Bakal
Summary: Almost all living cells maintain size uniformity through successive divisions. Proteins that over and underscale with size can act as rheostats, which regulate cell cycle progression. This study provides one of the first demonstrations of size-scaling phenomena in cancer and how morphology influences the chemistry of the cell.
Article
Biology
Laura M. Doherty, Caitlin E. Mills, Sarah A. Boswell, Xiaoxi Liu, Charles Tapley Hoyt, Benjamin Gyori, Sara J. Buhrlage, Peter K. Sorger, Silke Hauf
Summary: This study establishes a knowledgebase of DUB activities, co-dependent genes, and substrates, utilizing targeted experiments and systematic mining of functional genomic databases. The findings provide insights into the important role of DUBs in regulating cellular activities and suggest their potential as therapeutic targets for cancer and other diseases.
Article
Genetics & Heredity
Minglong Cai, Tao Yuan, He Huang, Lan Gui, Li Zhang, Ziyuan Meng, Wenjuan Wu, Yujun Sheng, Xuejun Zhang
Summary: Vitiligo is a multifactorial polygenic disorder characterized by depigmented skin and hair. Genetic studies have identified new functional genes associated with vitiligo, as well as DNA methylation sites that are related to gene expression and disease risk. Colocalization analyses showed a shared genetic variant that alters DNA methylation and regulates gene expression, thereby influencing the risk of vitiligo.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Rong Li, Chao Guo, Xiao Lin, Ting Fung Chan, Min Su, Zhiyong Zhang, Keng Po Lai
Summary: Vitamin C supplementation reduces PFOA-induced liver damage by controlling signaling networks, suppressing linoleic acid metabolism, reducing thiodiglycolic acid, and elevating glutathione levels in the liver.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Microbiology
Kyunghun Min, Thomas F. Jannace, Haoyu Si, Krishna R. Veeramah, John D. Haley, James B. Konopka
Summary: The fungal pathogen Candida albicans can form hyphae in the absence of cAMP, due to mutations that improve growth through loss of the negative regulatory subunit BCY1. Deletion of large regions of chromosome 2's left arm can enhance hyphal morphogenesis in some mutants. Gene expression related to hyphal formation can be induced independently of cAMP.
Article
Cell Biology
Jingyun Zhang, Xiaoyi Sun, Xueqing Jia, Binggui Sun, Shijun Xu, Weiping Zhang, Zuyun Liu
Summary: This study explores the relationship between aging and Alzheimer's disease (AD) and identifies a gene module, including PBXIP1, that is significantly associated with various neuropathological traits of AD. The study also suggests the potential of using multi-omics data to investigate complex disease mechanisms.
Article
Environmental Sciences
Xuan Yu, Chunlan Mao, Simin Zong, Aman Khan, Wenxue Wang, Hui Yun, Peng Zhang, Toshiro Shigaki, Yitian Fang, Huawen Han, Xiangkai Li
Summary: A novel mechanism of azo dye degradation by a fungus was discovered in this study. The degradation process involved a self-redox process and mineralization of the metabolites into CO2 through catechol pathway and a glycolytic process. A novel decoloring enzyme Ord95 was identified through comparative transcriptome analysis, which hydrolyzed the dye into two key metabolites.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Applied
Qi Ma, Lan Zeng, Xiaoyun Liu, Qixin Zhuang, Jun Qian
Summary: This paper presents a high-efficiency catalysis method for the preparation of large-sized COF aerogels at room temperature, showing good mechanical properties and thermodynamic characteristics, which provides a new approach for industrial production of COF materials.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Chemistry, Physical
Yiqian Du, Jian Xu, Jiangyu Fang, Yantai Zhang, Xiaoyun Liu, Peiyuan Zuo, Qixin Zhuang
Summary: Researchers are focusing on improving the applicability of transition-metal carbon/nitride (MXene) shielding devices through integration with nanomaterials and polymers. By constructing an ultralight, conductive aerogel with strong interfacial interaction between MXene nanosheets and aramid nanofibers, the device shows excellent compressibility, superelasticity, and electromagnetic interference (EMI) shielding performance. Additionally, the aerogel has consistent thermal stability and flame retardant properties, making it suitable for various extreme conditions.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Materials Science, Multidisciplinary
Jinpeng Li, Junhao Jiang, Qilin Cheng, Zhongkai Cui, Xiaoyun Liu, Peiyuan Zuo, Qixin Zhuang
Summary: Poly(p-phenylene benzobisoxazole) (PBO) with excellent thermal stability was synthesized by the precursor method and prepared via solution casting, and one-dimensional Al2O3@NaNbO3 was introduced to improve the dielectric properties and breakdown strength. The nanocomposite with 3 vol% Al2O3@NaNbO3 showed the highest breakdown strength, increased energy density, and excellent thermal stability.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Q. Ma, X. Liu, H. Wang, Q. Zhuang, J. Qian
Summary: In this study, a new hydroxyl-containing imine-linked COF was converted into a benzoxazine-linked COF with improved antibacterial activity through a cyclization reaction. The efficiency of COF against Escherichia coli and Staphylococcus aureus was over 90%, while maintaining crystal and pore structure for drug delivery and release functions. Post-synthetic modifications have significant potential to enhance the properties and applications of COFs.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Wenjun Ma, Chuanhao Tang, Peng He, Xiaohan Wu, Zhong-Kai Cui, Shaoliang Lin, Xiaoyun Liu, Qixin Zhuang
Summary: This study develops a new morphological fabrication strategy for preparing compatible stealth nanomaterials. The growth of flake alpha-Fe2O3 (f-Fe2O3) on hollow mesoporous carbon spheres (HMCS) is achieved using a specific hydrothermal process. The introduction of f-Fe2O3 helps to lower infrared emissivity and improve high-frequency impedance matching. The performance of the material can be regulated by changing the constituent proportion in the hydrothermal suspension.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Pengtu Zhang, Xiaoyun Liu, Peiyuan Zuo, Puke Mi, Qixin Zhuang
Summary: By incorporating p-phenylenediamine-modified and L-ascorbic acid-reduced graphene oxide nanosheets into the polymer matrix, a composite material with significantly improved chemical functionalization and dispersity was obtained. The composite material has a high dielectric constant and breakdown strength, making it suitable for high-dielectric applications.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Xinhua Wang, You Yuan, Donglin Chen, Bowen Sun, Jun Qian, Xiaoyun Liu, Peiyuan Zuo, Yi Chen, Qixin Zhuang
Summary: This study investigates the effect of the flexible segment of polymer shells and inorganic shells on the dielectric properties. The results reveal that the intermediate polymer shell can limit carrier migration and decrease dielectric loss, while the double-layer structure improves the dielectric constant. Additionally, the energy density of the nanocomposite is significantly enhanced. Therefore, this research provides new insights for the design of hierarchical core-double shell nanoparticles and their derived polymer nanocomposite capacitors for high-energy-density storage applications.
ACS APPLIED NANO MATERIALS
(2023)
Article
Engineering, Chemical
Qi Ma, Xiaoyun Liu, Jun Qian, Qixin Zhuang
Summary: Recently, the development of high-selectivity porous materials, such as covalent organic frameworks (COFs), for sewage purification and rapid adsorption of heavy metals has attracted much attention. In this study, two novel COFs, DAA-TFPT-COF and PDA-TFPT-COF, containing triazine and carboxyl bifunctional groups, were developed. These COFs exhibited high specific surface areas and good metal ion adsorption properties, even in both acidic and alkaline environments, surpassing ordinary adsorption materials. The adsorption process within the COFs was confirmed to follow the Langmuir adsorption model and pseudo-second-order kinetic model. The electrostatic interactions and active affinity sites were identified as crucial factors in the strong adsorption effect of COFs, especially for DAA-TFPT-COF, which showed high partition coefficient and fast adsorption kinetics, making it an excellent candidate for metal ion adsorption.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yunyao Zhang, Xiaoyun Liu, Rui Yang, Qixin Zhuang
Summary: High-temperature-resistant benzoxazines have become a research hotspot in the aviation and aerospace field. The development of benzoxazines with high thermal stability and good processability is challenging, but this study proposes an effective method to achieve it. Different benzoxazines were analyzed and screened based on their heat resistance, processability, and curing performance. The method involves high-throughput design, property prediction, and computer-aided screening, and it can promote the research of high-performance thermosetting polymer materials with higher efficiency and lower cost compared to traditional trial-and-error approaches.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Physical
Chuanhao Tang, Wenjun Ma, Peng He, Yukang Zhou, Xiaoyun Liu, Peiyuan Zuo, Qixin Zhuang
Summary: Pyrolytic Prussian blue analogs (PBAs) combined with an amorphous carbon layer provide optimized microwave absorption (MA) performance through the formation of a yolk-shell structure. The amorphous carbon layer prevents collapse of PBAs and optimizes impedance matching. Experimental results and simulations show impressive MA properties, indicating that hierarchical and quantitative design can maximize MA capability.
Article
Nanoscience & Nanotechnology
Xinyao Ni, Jingyu Lin, You Yuan, Xinhua Wang, Peiyuan Zuo, Xiaoyun Liu, Qixin Zhuang
Summary: The development of high-performance antiferroelectric ceramics/polymeric materials with great thermal stability has attracted considerable interest due to their extensive use in efficient power sources and electronic devices. However, the poor processibility and weakened breakdown strength of dielectrics seriously restrict their high energy storage density and thermal stability. To overcome these challenges, the use of an organically modified high-aspect-ratio one-dimensional antiferroelectric ceramic is suggested, which can extend the breakdown path and improve the local electric field distribution, thus yielding high energy storage density.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Jiangyu Fang, Jian Xu, Xiaoyun Liu, Peiyuan Zuo, Zhong-Kai Cui, Qixin Zhuang
Summary: A three-phase composite aerogel interconnecting MXene, Ag nanowire, and carbon nanotube was prepared by freeze-drying, exhibiting high conductivity, excellent electromagnetic interference shielding performance, and enhanced compressive strength. This composite aerogel holds promise for applications in high-strength electromagnetic shielding materials.
ACS APPLIED NANO MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Xinhua Wang, Xinyao Ni, You Yuan, Jun Qian, Peiyuan Zuo, Xiaoyun Liu, Qixin Zhuang
Summary: This study proposes an innovative approach to reconstruct polymer chain structure by introducing a group with high temperature resistance, aiming to solve the failure issue in high-temperature applications. The method improves the energy storage performance of the polymer and shows potential for industrial applications.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Jinpeng Li, Junhao Jiang, Yi Chen, Xiaoyun Liu, Peiyuan Zuo, Qilin Cheng, Qixin Zhuang
Summary: A core-shell structured imide-polymer@barium titanate (BT) is designed, and a modulation strategy to optimize the dielectric behavior at the BT-polyetherimide (PEI) interface is proposed to manufacture a high-performance polymeric dielectric. Compared with BT-PEI, the modified BT-PEI nanocomposites exhibit improved comprehensive dielectric properties and breakdown strength, with the highest discharge energy density of 3.04 J cm(-3) and a charge-discharge efficiency of 89.25%. The prepared composite also possesses excellent thermal stability from 20 degrees C to 150 degrees C.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Materials Science, Multidisciplinary
Zhe Zhang, Peng He, Wenjun Ma, Peiyuan Zuo, Xiaoyun Liu, Qixin Zhuang
Summary: A novel and controllable selective etching strategy was reported to fabricate yolk-multishell mesoporous silica nanoparticles with high pore volume, low specific surface area, uniform diameter, and excellent monodispersity. The obtained nanocomposite films exhibited ultralow dielectric constant and maintained great stability over a wide temperature range.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)