Editorial Material
Biochemistry & Molecular Biology
Camille Boudreau-Pinsonneault, Michel Cayouette
Summary: This study reveals that post-mitotic cell reprogramming can occur naturally in the developing fish retina, shedding light on the mechanism involved in the generation of cell diversity.
Review
Pharmacology & Pharmacy
Farahidah Mohamed, May K. Oo, Bappaditya Chatterjee, Batoul Alallam
Summary: This article provides a brief review of the history of supramolecular mesoporous silica nanoparticles (MSNs) and highlights the influencing factors affecting their morphology-porosity characteristics. It also presents the applications of MSNs as a next-generation drug delivery system, particularly in controlled release dosage forms via an oral drug delivery system.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yujung Chang, Junsang Yoo, Junyeop Kim, Yerim Hwang, Gayong Shim, Yu-Kyoung Oh, Jongpil Kim
Summary: The study found that magnetized graphene nanosheets facilitate direct lineage reprogramming of induced dopaminergic neurons, significantly enhancing neuron generation in mouse models of Parkinson's disease and effectively ameliorating PD symptoms.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Biomedical
Sarah Y. Neshat, Chun Hei Ryan Chan, Jawaun Harris, Osamah M. Zmily, Savannah Est-Witte, Johan Karlsson, Sydney R. Shannon, Manav Jain, Joshua C. Doloff, Jordan J. Green, Stephany Y. Tzeng
Summary: Immuno-oncology therapies aim to induce sustained tumor regression, but current methods are in need of improvement. An antigen-free method of cancer immunotherapy that stimulates the immune system without knowledge of neoantigens has been developed, along with a local delivery system to minimize systemic toxicity. A gene delivery nanoparticle platform has been engineered to reprogram the tumor microenvironment and activate cytotoxic lymphocytes, resulting in tumor regression and clearance.
Article
Cell & Tissue Engineering
Shijia Liuyang, Guan Wang, Yanglu Wang, Huanjing He, Yulin Lyu, Lin Cheng, Zhihan Yang, Jingyang Guan, Yao Fu, Jialiang Zhu, Xinxing Zhong, Shicheng Sun, Cheng Li, Jinlin Wang, Hongkui Deng
Summary: We have developed a robust and chemically defined reprogramming protocol that significantly shortens the induction time for generating human pluripotent stem cells from somatic cells. This protocol promotes cell proliferation and metabolic activities, leading to a more direct reprogramming process.
Article
Biochemical Research Methods
Liang Peng, Huarong Peng, Wei Li, Dongyuan Zhao
Summary: Functional mesoporous carbonaceous nanomaterials with large pores have wide accessibility and can transport chemicals efficiently in various fields including biomedical applications, gas separation, catalysis, sensing, and energy storage and conversion. The assembly of monomicelles, composed of block copolymers/surfactants and precursor species, has been used to control the nanostructure and mesoporosity of carbonaceous nanomaterials. This method allows for a high degree of control over the final product's structure, making it possible to shape the nanomaterial into unique nanostructures that are otherwise difficult to synthesize using conventional templating methods.
Article
Cell & Tissue Engineering
Yi Han Ng, Soham Chanda, Justyna A. Janas, Nan Yang, Yuko Kokubu, Thomas C. Sudhof, Marius Wernig
Summary: Differentiation of pluripotent stem cells can be achieved through signaling pathways activation or transcription factor programming, each with its own advantages and disadvantages. Research findings suggest that specific combinations of transcription factors can efficiently induce the generation of functional dopaminergic neurons.
Article
Chemistry, Multidisciplinary
Tianyu Li, Efrain E. Rodriguez
Summary: This study demonstrated the hydrothermal conversion of mesoporous TiO2 to mesoporous SrTiO3, with controlled pore size distribution and potential for high-temperature applications due to thermal stability.
CHEMICAL COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Mingxi Weng, Haoqing Hu, Matthew S. Graus, Daisylyn Senna Tan, Ya Gao, Shimiao Ren, Derek Hoi Hang Ho, Jakob Langer, Markus Holzner, Yuhua Huang, Guang Sheng Ling, Cora Sau Wan Lai, Mathias Francois, Ralf Jauch
Summary: Advanced strategies to convert cell types provide potential avenues for modeling cellular pathologies and developing therapies for neurological disorders. However, direct transdifferentiation of somatic cells into multipotent induced neural stem cells (iNSCs) is slow and inefficient, and it is unclear if cells go through a pluripotent state with full epigenetic reset. Our study reports the successful reprogramming of iNSCs from embryonic and aged mouse fibroblasts, as well as human blood, using an engineered version of Sox17 (eSox17(FNV)). This method efficiently drives iNSC reprogramming and shows promise in generating more authentic cell models for aging-associated neurodegenerative diseases.
Review
Chemistry, Multidisciplinary
Chun Xu, Chang Lei, Yue Wang, Chengzhong Yu
Summary: Dendritic mesoporous silica nanoparticles have attracted attention due to their wide applications, but the terminology used is ambiguous. This review provides a critical analysis of reported dendritic silica nanoparticles according to their structural classification, updating the understanding of their formation mechanisms and the control of structural parameters. The review also focuses on the applications of dendritic mesoporous nanoparticles in the biomedical field, offering new insights into the structure-property relationship.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Min Ji Son, Sang-Wha Lee
Summary: This study systematically evaluated the toxicity of mesoporous silica nanoparticles (MSNs) against Escherichia coli (E. coli), finding that residual cetyltrimethyl ammonium bromide (CTAB) affects bacterial mortality and functional decorations such as polydopamine and graphene oxide increase the antibacterial activity of MSNs.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Review
Biochemistry & Molecular Biology
Lulu Tian, Murad Al-Nusaif, Xi Chen, Song Li, Weidong Le
Summary: This review summarizes the molecular mechanism of transcription factors in the embryonic growth and maturation of meso-diencephalic dopaminergic (mdDA) neurons, as well as the progress in dopaminergic cell therapy dependent on the understanding of transcription factors in mdDA neuronal development. Researchers believe that a deeper understanding of the extrinsic and intrinsic factors that influence the fate and development of dopaminergic neurons in the midbrain could lead to a better strategy for Parkinson's disease cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Inorganic & Nuclear
Neha Benedicta Fernandes, Yogendra Nayak, Sanjay Garg, Usha Y. Nayak
Summary: The field of advanced nanotechnology offers a wide range of nanotheranostics for treating malignant tumors. Among them, Mesoporous Silica Nanoparticles (MSNs) combined with upconversion nanoparticles have gained prominence in biomedicine research due to their remarkable properties in drug targeting, bio-imaging, and photodynamic/photothermal therapy. MSNs have versatile pore sizes, high drug loading efficiency, and can be functionalized to enhance their applicability. This article focuses on MSN-based hybrid nanotheranostics and their designing strategies, characterization, applications, efficacy, limitations, biotoxicity, as well as current challenges and future perspectives.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Cell Biology
Haofei Wang, Yuchen Yang, Jiandong Liu, Li Qian
Summary: Direct reprogramming converts cells from one lineage into another without going through a pluripotent state, and it is a promising strategy for generating functional cells for therapeutic purposes. Recent advancements include using defined factors for lineage conversion, enhancing reprogrammed cell maturation, and addressing challenges in in vivo direct reprogramming for translational applications.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Review
Clinical Neurology
Yuan Yuan Zheng, Hui Xu, Yue Si Wang
Summary: Parkinson's disease is a neurodegenerative disease for which current drug and surgical treatments are not curative and are associated with high risks. Recent advances in cell reprogramming offer new prospects for Parkinson's disease treatment, including the creation of iPSCs, iDNs, and iNSCs. However, this article highlights the limitations of using iPSCs and iNSCs for Parkinson's disease treatment and explores the potential of directly reprogramming somatic cells into iDNs.
NEUROLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Cheng-Ta Lee, Min-Hua Kao, Wen-Hsien Hou, Yu-Ting Wei, Chin-Lin Chen, Cheng-Chang Lien
SCIENTIFIC REPORTS
(2016)
Article
Clinical Neurology
Yi-Ting Hsu, Ya-Gin Chang, Yu-Chao Liu, Kai-Yi Wang, Hui-Mei Chen, Ding-Jin Lee, Sung-Sen Yang, Chon-Haw Tsai, Cheng-Chang Lien, Yijuang Chern
MOVEMENT DISORDERS
(2019)
Article
Neurosciences
Yu-Ting Wei, Jei-Wei Wu, Chia-Wei Yeh, Hung-Chang Shen, Kun-Pin Wu, Imre Vida, Cheng-Chang Lien
Summary: VIP+ INs in the DG region of the hippocampus exhibit a high degree of morpho-physiological diversity, with their axons branching in different layers. These INs display variable intrinsic properties and discharge patterns without clear correlation with their morphologies. They show a long latency response to cortical inputs and selectively regulate inhibitory INs over glutamatergic principal neurons through disinhibition mechanisms.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Cell Biology
Kai-Yi Wang, Jei-Wei Wu, Jen-Kun Cheng, Chun-Chung Chen, Wai-Yi Wong, Robert G. Averkin, Gabor Tamas, Kazu Nakazawa, Cheng-Chang Lien
Summary: The study shows that increased activity of hippocampal mossy cells may reduce anxiety behaviors and could be a potential therapeutic target for anxiety disorders.
Article
Neurosciences
Wahab Imam Abdulmajeed, Kai-Yi Wang, Jei-Wei Wu, Musa Iyiola Ajibola, Irene Han-Juo Cheng, Cheng-Chang Lien
Summary: This study reveals the differential regulation of local and distant granule cell activity by mossy cells in the hippocampus, highlighting the distinct synaptic mechanisms involved. These findings provide new insights into the functional organization of hippocampal circuits.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)