期刊
SCIENTIFIC REPORTS
卷 7, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-017-13099-4
关键词
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资金
- Commission of the European Community, specific RTD Programme Quality of Life and Management of Living Resources, within the 5th Framework Programme [QLRT-2001-00389, QLK1-CT-2002-30582]
- 6th Framework Programme [007036 (FP6-007036)]
- European Union's Seventh Framework Programme Project EarlyNutrition [289346 (FP7-289346)]
- Horizon research and innovation programme DYNAHEALTH [633595]
- European Research Council Advanced Grant META-GROWTH (ERC-AdG) [322605]
- German Ministry of Education and Research, Berlin [01 GI 0825]
- University of Munich Innovative Research Priority Project MC-Health
- NHMRC Senior Research Fellowship
- NHMRC: EU project grant
- MCRI by the Victorian Operational Infrastructure support scheme
- European Research Council (ERC) [322605] Funding Source: European Research Council (ERC)
Adiposity and obesity result from the interaction of genetic variation and environmental factors from very early in life, possibly mediated by epigenetic processes. Few Epigenome-Wide-Association-Studies have identified DNA-methylation (DNAm) signatures associated with BMI and body composition in children. Body composition by Bio-Impedance-Analysis and genome-wide DNAm in whole blood were assessed in 374 pre-school children from four European countries. Associations were tested by linear regression adjusted for sex, age, centre, education, 6 WBC-proportions according to Houseman and 30 principal components derived from control probes. Specific DNAm variants were identified to be associated with BMI (212), fat-mass (230), fat-free-mass (120), fat-mass-index (24) and fat-freemass-index (15). Probes in genes SNED1(IRE-BP1), KLHL6, WDR51A(POC1A), CYTH4-ELFN2, CFLAR, PRDM14, SOS1, ZNF643(ZFP69B), ST6GAL1, C3orf70, CILP2, MLLT4 and ncRNA LOC101929268 remained significantly associated after Bonferroni-correction of P-values. We provide novel evidence linking DNAm with (i) altered lipid and glucose metabolism, (ii) diabetes and (iii) body size and composition in children. Both common and specific epigenetic signatures among measures were also revealed. The causal direction with phenotypic measures and stability of DNAm variants throughout the life course remains unclear and longitudinal analysis in other populations is required. These findings give support for potential epigenetic programming of body composition and obesity.
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