Review
Nutrition & Dietetics
Eirini D. Basdeki, Anastasios Kollias, Panagiota Mitrou, Christiana Tsirimiagkou, Marios K. Georgakis, Antonios Chatzigeorgiou, Antonios Argyris, Kalliopi Karatzi, Yannis Manios, Petros P. Sfikakis, Athanase D. Protogerou
Summary: Our study found inconsistency in population characteristics and methodology among RCTs, which may have led to the lack of significant associations between different levels of daily sodium intake and systemic inflammation levels in humans. Suggestions for future RCTs include focusing on young healthy participants, having three arms of daily sodium intake levels, and an adequate intervention duration of 14 days.
Review
Cell Biology
Xiaotong Song, Hao Zhang, Fanxing Yin, Panpan Guo, Xiaocheng Yang, Jinzhu Liu, Yanshuo Han, Zhaozhou Ren
Summary: This meta-analysis and systematic review found that elevated neutrophil to lymphocyte ratio (NLR), C-reactive protein (CRP), and Glasgow prognostic score (GPS) are significantly associated with shortened overall survival in osteosarcoma patients, while CRP level is significantly associated with shortened disease-specific survival. However, lymphocyte to monocyte ratio (LMR) and platelet to lymphocyte ratio (PLR) are not statistically significant in predicting the prognosis of osteosarcoma.
MEDIATORS OF INFLAMMATION
(2021)
Review
Oncology
Li Wang, Xianfei Qin, Yu Zhang, Shouyu Xue, Xicheng Song
Summary: The aim of this study was to investigate the predictive value of systemic immune index (SII) and systemic inflammatory response index (SIRI) in the prognosis of patients with nasopharyngeal carcinoma. The results showed that SII and SIRI can be used as independent predictors to predict the prognosis and survival status of patients with nasopharyngeal carcinoma, and they have certain predictive accuracy. Therefore, SII and SIRI should be considered in studies that update survival risk assessment systems.
FRONTIERS IN ONCOLOGY
(2023)
Review
Pediatrics
Debjyoti Dhar, Treshita Dey, M. M. Samim, Hansashree Padmanabha, Aritra Chatterjee, Parvin Naznin, S. R. Chandra, K. Mallesh, Rutul Shah, Shahyan Siddiqui, K. Pratik, P. Ameya, G. Abhishek
Summary: This study systematically reviewed and analyzed the demographic profile, clinical characteristics, management strategies, prognosis, and pathophysiology of Multisystem Inflammatory Syndrome in Children associated with COVID-19. It found a male predilection, gastrointestinal and cardiac symptoms being prominent, and emphasized the importance of early diagnosis and treatment for a favorable outcome.
PEDIATRIC RESEARCH
(2022)
Review
Multidisciplinary Sciences
Kelly A. Baker, Timothy D. Miller, Frank E. Marino, Tegan E. Hartmann
Summary: This study examined the effects of acute and chronic exercise on inflammatory responses in individuals with inflammatory bowel disease (IBD) through a systematic review and meta-analysis. The results showed that exercise did not significantly affect inflammatory markers in IBD patients, but regular moderate exercise improved bowel symptoms.
Review
Medicine, General & Internal
Irene Castro, Pedro Carvalho, Nuno Vale, Teresa Monjardino, Joana Mourao
Summary: There is increasing evidence supporting the use of perioperative intravenous lidocaine infusion in surgical patients for its analgesic, opioid-sparing, and anti-inflammatory effects. This systematic review examined the impact of intravenous lidocaine infusion on postoperative anti-inflammatory status in patients undergoing elective surgery. The review found that lidocaine infusion significantly reduced IL-6 levels and other pro-inflammatory markers, providing support for its use as an anti-inflammatory strategy in elective surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Matthew Kheir, Vincent Dong, Victoria Roselli, Bushra Mina
Summary: This systematic review examines the utility of ultrasound methods in predicting non-invasive ventilation (NIV) outcomes. The findings suggest that lung ultrasound scores and diaphragm thickening fraction can accurately predict NIV failure, including the need for ICU-level care, invasive mechanical ventilation, and higher mortality rates.
FRONTIERS IN MEDICINE
(2023)
Review
Surgery
Francesca Savioli, Elizabeth S. Morrow, Ross D. Dolan, Laszlo Romics, Alison Lannigan, Joanne Edwards, Donald C. McMillan
Summary: Through a systematic review and meta-analysis, it was found that preoperative circulating markers of the systemic inflammatory response, such as NLR, dNLR, LMR, PLR, and CRP, may serve as prognostic markers in primary operable breast cancer.
BRITISH JOURNAL OF SURGERY
(2022)
Review
Oncology
Khalid El Bairi, Ouissam Al Jarroudi, Said Afqir
Summary: The umbrella systematic review assessed 17 meta-analyses on the association between biomarkers and epithelial ovarian cancer outcomes, showing that high NLR and PLR, as well as low LMR, are independent predictors of poor prognosis. Most studies were conducted by Chinese researchers, highlighting issues of low quality and lacking critical domains.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dermatology
Patrick P. G. Mulder, Hans J. P. M. Koenen, Marcel Vlig, Irma Joosten, Rob B. M. de Vries, Bouke K. H. L. Boekema
Summary: Burn injuries lead to immune response dysregulation and excessive inflammation. This systematic review highlights the changes in immune cell numbers and functions after burns, showing a prolonged inflammatory response. This research provides essential insights for improving burn care and outcomes.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Oncology
Muhammad Majdoub, Takafumi Yanagisawa, Fahad Quhal, Ekaterina Laukhtina, Markus von Deimling, Tatsushi Kawada, Pawel Rajwa, Alberto Bianchi, Maximilian Pallauf, Hadi Mostafaei, Marcin Chlosta, Benjamin Pradere, Pierre I. Karakiewicz, Manuela Schmidinger, Ronen Rub, Shahrokh F. Shariat
Summary: This meta-analysis summarizes research findings on the correlation between clinicopathological characteristics and post-surgery survival outcomes in non-metastatic renal cell carcinoma (RCC) patients. Several clinicopathological characteristics were associated with poor survival outcomes, while no features were predictive for late recurrence.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Rheumatology
Michael Hughes, Elisabetta Zanatta, Robert D. Sandler, Jerome Avouac, Yannick Allanore
Summary: This study found that despite the heterogeneity and scarcity of vascular disease in SSc, there have been significant improvements in various vascular complications over time, leading to improved survival rates for patients.
Review
Immunology
Xiaoyan Qian, Haizhu Chen, Yunxia Tao
Summary: This systematic review and meta-analysis investigated the association between various biomarkers and clinical outcomes in nasopharyngeal cancer patients treated with immune checkpoint inhibitors (ICIs). The analysis revealed that lower baseline plasma EBV DNA levels, decreased EBV DNA load during immunotherapy, and higher PD-L1 expression were associated with better treatment response. Lower baseline plasma EBV DNA levels were also linked to longer progression-free survival (PFS).
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Ghaith Mohsen, Annika Stroemer, Andreas Mayr, Andrea Kunsorg, Christian Stoppe, Maria Wittmann, Markus Velten
Summary: Initial evidence suggests that preoperative administration of omega-3 fatty acids can reduce postoperative inflammatory reaction. However, the effects of immunonutrition with omega-3 fatty acids on inflammatory response in abdominal surgery patients are still unclear. This study found no significant difference in inflammatory markers or postoperative length of hospital stay between the preoperative omega-3 fatty acids group and the control group.
Review
Health Care Sciences & Services
Lanlan Pang, Hengyu Liu, Zhidong Liu, Jinyu Tan, Long-Yuan Zhou, Yun Qiu, Xiaoqing Lin, Jinshen He, Xuehua Li, Sinan Lin, Subrata Ghosh, Ren Mao, Minhu Chen
Summary: Telemedicine intervention has shown promising results in improving the quality of life among adolescents with IBD and reducing clinic visits among patients with IBD.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Stephen T. McSorley, Jayne Digby, Danielle Clyde, Neil Cruickshank, Paul Burton, Louise Barker, Judith A. Strachan, Callum G. Fraser, Karen Smith, Craig Mowat, Jack Winter, Robert J. C. Steele
Summary: Symptomatic patients with f-Hb >= 10 mu g/g should undergo further investigation for CRC, while higher f-Hb concentrations could be used to triage for urgency during the COVID-19 recovery phase. Patients with f-Hb <10 mu g/g and without anaemia are very unlikely to be diagnosed with CRC and the majority need no further investigation.
COLORECTAL DISEASE
(2021)
Article
Oncology
Katrina A. Knight, Ioanna Drami, Donald C. McMillan, Paul G. Horgan, James H. Park, John T. Jenkins, Campbell S. D. Roxburgh
Summary: The study found that calcification of the aortoiliac vessels supplying the rectum (AC) was not associated with NACRT response in the examined cohorts. Larger contemporary cohorts are needed to better assess host determinants of NACRT response and develop predictive models to improve patient selection.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Mark S. Johnstone, Paul Burton, Georgios Kourounis, Jack Winter, Emilia Crighton, David Mansouri, Paul Witherspoon, Karen Smith, Stephen T. McSorley
Summary: The study investigated the association between FIT and CRC detection in symptomatic patients, finding that raised FIT levels were correlated with referral decisions and colonoscopy procedures. Age, gender, FIT levels, and anemia were identified as independent predictors of CRC.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Medical Laboratory Technology
Mark S. Johnstone, Gillian Miller, Grace Pang, Paul Burton, Georgios Kourounis, Jack Winter, Emilia Crighton, David Mansouri, Paul Witherspoon, Karen Smith, Stephen T. McSorley
Summary: An elevated f-Hb is independently associated with older age, deprivation, anticoagulants, rectal bleeding, advanced adenoma, non-advanced polyps, and IBD in symptomatic patients. Deprivation is associated with a raised f-Hb in the absence of pathology, which should be considered when utilizing FIT in symptomatic patients.
ANNALS OF CLINICAL BIOCHEMISTRY
(2022)
Article
Oncology
Josh McGovern, Ross D. Dolan, Richard J. Skipworth, Barry J. Laird, Donald C. McMillan
Summary: Cancer cachexia has traditionally been viewed as a nutritional syndrome, but recent research suggests that it may be primarily a manifestation of systemic inflammation. This has important implications for future treatment strategies.
BRITISH JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Mark S. Johnstone, Campbell MacLeod, Jayne Digby, Yassir Al-Azzawi, Grace Pang, Angus J. M. Watson, Judith Strachan, Craig Mowat, Stephen T. McSorley
Summary: This study aimed to investigate the prevalence of serial FITs in primary care and assess the risk of CRC in these patients. The study found that serial FITs accounted for 9.1% of all FIT results within a year, and the prevalence of CRC among symptomatic patients with serial FIT was lower than in single-FIT cohorts.
COLORECTAL DISEASE
(2022)
Article
Cell Biology
Suad A. K. Shamis, Jean Quinn, Elizabeth E. A. Mallon, Joanne Edwards, Donald C. McMillan
Summary: The prognostic significance of hypoxia markers in estrogen receptor-positive breast cancer patients was investigated. The expression of these markers was associated with clinicopathological parameters and disease-free survival.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2022)
Article
Oncology
P. G. Alexander, H. C. van Wyk, K. A. F. Pennel, J. Hay, D. C. McMillan, P. G. Horgan, C. S. D. Roxburgh, J. Edwards, J. H. Park
Summary: The Glasgow Microenvironment Score (GMS) is associated with the location of recurrence in colorectal cancer. Higher GMS categories (GMS 1 and 2) are associated with an increased risk of local and distant recurrence.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Josh McGovern, Ross D. Dolan, Claribel P. L. Simmons, Louise E. Daly, Aoife M. Ryan, Derek G. Power, Donogh Maguire, Marie T. Fallon, Barry J. Laird, Donald C. McMillan
Summary: This study found a relationship between serum LDH level, phenotypic/aetiologic diagnostic GLIM criteria, and survival in patients with advanced cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Health Care Sciences & Services
Bruna M. M. Rocha, Ross D. Dolan, Carlos E. Paiva, Josh McGovern, Bianca S. R. Paiva, Daniel D. Preto, Donald C. McMillan, Yara C. P. Maia, Barry J. Laird
Summary: This study compares prognostic factors in two international cohorts of patients with advanced cancer and establishes a prognostic framework for treatment. The study finds that despite geographical and socio-demographic differences, similar prognostic factors are associated with long-term survival in both the European and Brazilian cohorts.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Oncology
Leo R. Brown, Michael I. Ramage, Ross D. Dolan, Judith Sayers, Nikki Bruce, Lachlan Dick, Sharukh Sami, Donald C. McMillan, Barry J. A. Laird, Stephen J. Wigmore, Richard J. E. Skipworth
Summary: This study aimed to assess CT body composition in patients who had anastomotic leak post-oesophagectomy. The results showed that skeletal muscle index decreased and subcutaneous fat area increased following neoadjuvant treatment and anastomotic leak. Although tissue radiodensity and subcutaneous fat area normalized on late follow-up scans, skeletal muscle index remained below pre-treatment levels.
Article
Oncology
Randa Saeed, Josh McGovern, Hugo Bench, Ross D. Dolan, Donald C. McMillan, Almudena Cascales
Summary: This study analyzed the connection between prior treatment host/tumor characteristics and survival in advanced NSCLC patients receiving nivolumab as a second-line therapy. The study found that ECOG-PS and hypoalbuminemia were strongly associated with survival.
