Article
Oncology
Anja E. Eisenhardt, Zacharias Brugger, Ute Lausch, Jurij Kiefer, Johannes Zeller, Alexander Runkel, Adrian Schmid, Peter Bronsert, Julius Wehrle, Andreas Leithner, Bernadette Liegl-Atzwanger, Riccardo E. Giunta, Steffen U. Eisenhardt, David Braig
Summary: This study utilized a highly sensitive targeted next-generation sequencing approach to monitor tumor dynamics in synovial sarcoma patients. The detection of circulating tumor DNA (ctDNA) correlated with the presence of viable tumor tissue, allowing for non-invasive detection of tumor recurrence and monitoring of treatment response. The findings suggest that targeted NGS could be a valuable tool for the diagnosis and treatment of synovial sarcoma.
Article
Biochemistry & Molecular Biology
Yu-Jen Chen, Chia-Tien Hsu, Shang-Feng Tsai, Cheng-Hsu Chen
Summary: Chronic allograft dysfunction (CAD) is a major condition affecting long-term kidney graft survival. In this study, the correlation between plasma miR-21 and the severity of CAD was investigated. RNA sequencing was performed and differentially expressed miRNAs in CAD were identified. MiR-21-5p, miR-20a-5p, and miR-101-3p were found to be associated with the TGF-beta pathway and CAD. These findings may lead to the development of early prediction miRNA biomarkers and therapeutic tools for CAD in the field of kidney transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jaehoon Lee, Hee Seung Lee, Soo Been Park, Chanyang Kim, Kahee Kim, Dawoon E. Jung, Si Young Song
Summary: The study aimed to identify non-invasive miRNA markers for early pancreatic cancer diagnosis. A total of 39 miRNA markers were selected from blood serum samples to build a PC diagnosis model, which showed excellent performance in independent sample validation and differential expression in samples from PC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Xinmei Cai, Bilian Li, Wei Wei, Yanping Guan, Xue Bai, Min Huang, Yaying Huang, Lili Rong, Xingrong Song, Guoping Zhong
Summary: Our study showed that circulating miR-101-3p, miR-140-3p, and miR-30a-5p could serve as blood-based markers for predicting dexmedetomidine efficacy and safety in pediatric patients, with potential discriminatory ability between responders and non-responders, as well as patients with adverse effects.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Cecil J. Weale, Don M. Matshazi, Saarah F. G. Davids, Shanel Raghubeer, Rajiv T. Erasmus, Andre P. Kengne, Glenda M. Davison, Tandi E. Matsha
Summary: This study found that miR-1299, miR-126-3p, and miR-30e-3p are associated with prediabetes, with miR-126-3p showing higher diagnostic capability for prediabetes.
Article
Biochemistry & Molecular Biology
Shalini Das Gupta, Robert Ciszek, Mette Heiskanen, Niina Lapinlampi, Janne Kukkonen, Ville Leinonen, Noora Puhakka, Asla Pitkanen
Summary: The study identified plasma miR-9-3p and miR-136-3p as promising biomarker candidates for mTBI, showing potential for distinguishing mTBI patients with high sensitivity and specificity. Further validation in a larger patient population is needed to confirm their diagnostic utility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Dennis Gerloff, Stefanie Kewitz-Hempel, Gerd Hause, Jovine Ehrenreich, Linda Golle, Tim Kingreen, Cord Sunderkoetter
Summary: Extracellular vesicles (EVs) play an important role in intercellular communication, influencing the function and phenotype of different cell types within the tumor microenvironment and promoting tumor progression. This study identified miRNAs enriched in both melanoma cells and melanoma cell-derived EVs, and showed that these miRNAs were also elevated in serum-derived EVs of patients with metastatic melanoma, suggesting their potential as prognostic or diagnostic liquid biopsy markers in melanoma.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sofie Dinesen, Alisar El-Faitarouni, Nanna Lond Skov Frisk, Anja Elaine Sorensen, Louise Torp Dalgaard
Summary: Gestational diabetes mellitus (GDM) is a severe complication during pregnancy, and identifying potential biomarkers for its early detection is crucial. This study conducted a systematic review and meta-analysis to investigate miRNAs associated with GDM. The findings suggest that certain miRNAs show altered expression in GDM, indicating their potential as biomarkers for early GDM detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yang Su, Yuxi Sun, Yansong Tang, Hao Li, Xiaoyu Wang, Xin Pan, Weijing Liu, Xianling Zhang, Fenglei Zhang, Yawei Xu, Chunxi Yan, Sang-Bing Ong, Dachun Xu
Summary: The study identified miR-19b-3p as a valuable prognostic biomarker for AHF patients, indicating ventricular hypertrophy and correlating with echocardiographic indexes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Kodai Nakamura, Naomi Hiyake, Tomofumi Hamada, Seiya Yokoyama, Kazuki Mori, Kouta Yamashiro, Mahiro Beppu, Yasuaki Sagara, Yoshiaki Sagara, Tsuyoshi Sugiura
Summary: The study identified a combination of six microRNAs that could accurately distinguish oral squamous cell carcinoma (OSCC) from the control group with a higher degree of accuracy compared to traditional serum tumor markers like SCC-Ag. This specific microRNA panel may serve as a novel candidate biomarker for oral cancer diagnosis.
Article
Biochemistry & Molecular Biology
Xuezhong Liu, Lei Zhang
Summary: This study investigated the role of miR-92b-3p in the development of colon cancer (CC). Higher expression levels of miR-92b-3p and lower expression levels of Kruppel-like factor 3 (KLF3) were observed in CC tissues and cells. Inhibition of miR-92b-3p or overexpression of KLF3 reduced proliferation, invasion, and migration while inducing apoptosis of CC cells. KLF3 was validated as the target gene of miR-92b-3p. Depletion of KLF3 reversed the anti-tumor role of miR-92b-3p inhibition in CC cells. Therefore, miR-92b-3p promotes CC development by inhibiting KLF3, which may provide a novel target for future treatment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Oncology
Scott M. MacKenzie, Hannah Saunders, Josie C. van Kralingen, Stacy Robertson, Alexandra Riddell, Maria-Christina Zennaro, Eleanor Davies
Summary: Many patients are at increased risk of primary aldosteronism (PA) due to difficulties in accurate diagnosis. Circulating microRNAs are being explored as potential biomarkers for PA, but reproducibility of studies has been a challenge due to technical reasons.
Review
Oncology
Tim Nestler, Justine Schoch, Gazanfer Belge, Klaus-Peter Dieckmann
Summary: miR371 is a more sensitive and specific biomarker for testicular germ cell cancer than conventional serum markers. It shows potential for initial diagnosis, treatment monitoring, and follow-up. However, miR371 is not expressed in teratoma. Further studies are needed to determine its importance in detecting testicular tumor recurrences and residual tumors after chemotherapy.
Article
Immunology
Tahereh Donyavi, Farah Bokharaei-Salim, Hossein Bannazadeh Baghi, Khadijeh Khanaliha, Mahrokh Alaei Janat-Makan, Bahareh Karimi, Javid Sadri Nahand, Hamed Mirzaei, AliReza Khatami, Saba Garshasbi, Majid Khoshmirsafa, Seyed Jalal Kiani
Summary: This study aimed to identify specific miRNA profiles that can be used as biomarkers to differentiate acute COVID-19 cases, healthy individuals, and those in the post-acute phase. The results showed that miR-29a-3p, miR-146a-3p, and let-7b-3p were significantly elevated in COVID-19 patients compared to healthy individuals, with potential for high sensitivity and specificity in COVID-19 diagnosis and monitoring. MiR-29a-3p and miR-146a-3p also showed promise as biomarkers for distinguishing acute from post-acute phases of COVID-19.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)