Article
Biology
Hu Lei, Li Yang, Hanzhang Xu, Zhengting Wang, Xiangyun Li, Meng Liu, Yingli Wu
Summary: The study reveals that ubiquitin-specific protease 47 (USP47) regulates intestinal inflammation through de-ubiquitination of K63-linked poly-ubiquitination TRAF6 in intestinal epithelial cells. The down-regulation of USP47 aggravates the activation of the NF-kappa B signaling pathway, and it is closely associated with the development of inflammatory response.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chao Guo, Shuhuang Zhou, Weimin Yi, Pingzhou Yang, Ou Li, Jianming Liu, Chuang Peng
Summary: The study reveals that SOX9 can transcriptionally regulate MKLN1-AS and play an important role in hepatocellular carcinoma (HCC). SOX9 promotes cell viability, proliferation, invasion, and epithelial-mesenchymal transition (EMT) of HCC, and MKLN1-AS mediates these effects of SOX9.
BIOCHEMICAL GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Jung-Hwan Park, Minho Moon, Jong-Seok Kim, Sang-Muk Oh
Summary: The study demonstrated that TOPK upregulates EMT and invasion of nonsmall-cell lung cancer cells through HIF-1α/Snail axis and hypoxic signaling. TOPK positively regulates HIF-1α expression, leading to Snail expression, EMT, and invasion of cancer cells. TOPK acts as a critical mediator of hypoxia signaling in nonsmall-cell lung cancer development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Environmental Sciences
Yan Wang, Siling Li, Jing Zhao, Qiuyue Li, Chunjie Xu, Huihui Wu, Zhonghui Zhu, Lin Tian
Summary: The study revealed that partial EMT may be involved in the development of pulmonary fibrosis diseases, with Snail playing a critical role in the process. The process of EMT in epithelial cells promoted the differentiation of lung myofibroblasts, and this epithelial-mesenchymal crosstalk was mainly controlled by Snail.
Article
Medicine, Research & Experimental
Surya Kant Tripathi, Bijesh Kumar Biswal
Summary: This study demonstrated that high expression of SOX9 and beta-catenin is associated with poor prognosis in lung cancer patients, while upregulation of SOX9 is linked to gefitinib resistance through promoting the epithelial to mesenchymal transition process. Additionally, knocking down SOX9 can reverse gefitinib resistance in vitro.
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Urology & Nephrology
Yingfeng Shi, Min Tao, Hui Chen, Xiaoyan Ma, Yi Wang, Yan Hu, Xun Zhou, Jinqing Li, Binbin Cui, Andong Qiu, Shougang Zhuang, Na Liu
Summary: This study found that the aberrant expression of USP11 is related to tumor progression in kidney fibrosis. Inhibition of USP11 can attenuate pathological lesions and improve kidney function, suggesting its potential as a therapeutic strategy for patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Chemistry, Physical
Kamran Hosseini, Palina Trus, Annika Frenzel, Carsten Werner, Elisabeth Fischer-Friedrich
Summary: The study reveals that EMT can change the mechanical properties of skin epithelial cells in a cell-cycle dependent manner. Additionally, EMT can boost cellular proliferation and result in changes in the actin cortex. These changes are primarily dependent on the transcription factor snail, which is upregulated during EMT.
Article
Biochemistry & Molecular Biology
Yoshiko Hashimoto, Tomoko Tsuzuki-Nakao, Naoko Kida, Yoshiyuki Matsuo, Tetsuo Maruyama, Hidetaka Okada, Kiichi Hirota
Summary: The endometrium undergoes repeated changes during the menstrual cycle, and chronic endometritis can lead to implantation failure and miscarriage. In this study, the effects of inflammatory cytokines, hypoxia-inducible factor (HIF), and inflammation on endometrial epithelial cells were investigated. The results showed that pro-inflammatory factors and hypoxia activated HIF-1 and promoted epithelial-mesenchymal transition (EMT) in endometrial epithelial cells.
Article
Cell Biology
Chenqiang Jia, Zhuqing Zhang, Jun Tang, Mei-Chun Cai, Jingyu Zang, Kaixuan Shi, Yunheng Sun, Jie Wu, Hailei Shi, Weiping Shi, Pengfei Ma, Xiaojing Zhao, Zhuang Yu, Yujie Fu, Guanglei Zhuang
Summary: EMT gene signatures are positively correlated with GSDME levels in human cancers, and EMT plays a causal role in the reversible upregulation of GSDME. Core EMT-activating transcription factors ZEB1/2 directly drive the transcriptional activation of GSDME. Elevated GSDME in mesenchymally transdifferentiated derivatives can induce pyroptotic cell death and cytokine release upon exposure to antineoplastic drugs, suggesting therapeutic potential for mesenchymal malignancies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yun-Ju Lai, Chi-Hong Chao, Chun-Che Liao, Te-An Lee, Jung-Mao Hsu, Wen-Cheng Chou, Jyun Wang, Hsiang-Chi Huang, Shing-Jyh Chang, Yi-Ling Lin, Chia-Wei Li
Summary: The engagement of hACE2 and SARS-CoV-2 spike protein promotes virus spread, while inducing EMT phenotypic changes and stemness in breast cancer cells through Snail modulation. The spike protein S of SARS-CoV-2 is crucial in inducing EMT marker changes, and Snail upregulation is essential for the virus-mediated aggressive phenotype in cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Grazia Maugeri, Agata Grazia D'Amico, Salvatore Saccone, Concetta Federico, Daniela Maria Rasa, Rosario Caltabiano, Giuseppe Broggi, Salvatore Giunta, Giuseppe Musumeci, Velia D'Agata
Summary: The study shows that PACAP plays a role in regulating the hypoxic micro-environment, angiogenesis and EMT in GBM cells. By inhibiting specific pathways and molecules, PACAP can reduce invasiveness of GBM cells and interfere with VEGF release and vessel formation. This study provides new insights into the complex role of PACAP in GBM malignancy.
Article
Multidisciplinary Sciences
Rachel Erickson, Chang Huang, Cameron Allen, Joanna Ireland, Gwynne Roth, Zhongcheng Zou, Jinghua Lu, Bernard A. P. Lafont, Nicole L. Garza, Beniah Brumbaugh, Ming Zhao, Motoshi Suzuki, Lisa Olano, Joseph Brzostowski, Elizabeth R. Fischer, Homer L. Twigg, Reed F. Johnson, Peter D. Sun
Summary: Severe COVID-associated lung injury is complicated by a non-classical fibrin clotting mechanism induced by SARS-CoV-2-infected lung epithelial cells, which differs from other susceptible epithelial cells. This viral-induced coagulation mechanism requires thrombin but is independent of tissue factor and other classical plasma coagulation factors. Activation of prothrombin by infection-induced transmembrane serine proteases is involved in this process.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Ayalur Raghu Subbalakshmi, Sarthak Sahoo, Isabelle McMullen, Aaditya Narayan Saxena, Sudhanva Kalasapura Venugopal, Jason A. Somarelli, Mohit Kumar Jolly
Summary: Research shows that the transcription factor KLF4 can delay the onset of EMT by suppressing multiple EMT-TFs and promote a phenotypic shift towards a more epithelial state. KLF4 can also strengthen its influence on modulating EMT dynamics by inhibiting cell-state transitions at the epigenetic level.
Article
Cell Biology
Weiyu Wang, Yufan Ying, Haiyun Xie, Jiangfeng Li, Xueyou Ma, Liujia He, Mingjie Xu, Shiming Chen, Haixiang Shen, Xiangyi Zheng, Ben Liu, Xiao Wang, Liping Xie
Summary: Research shows miR-665's role in regulating SMAD3 and SNAIL genes in bladder cancer, making it a potential therapeutic target.
Article
Oncology
Jinyoung Suh, Do-Hee Kim, Eun-Hee Kim, Sin-Aye Park, Jong-Min Park, Jeong-Hoon Jang, Su-Jung Kim, Hye-Kyung Na, Nam-Doo Kim, Nam-Jung Kim, Young Ger Suh, Young-Joon Surh
Article
Biochemistry & Molecular Biology
Xiancai Zhong, Ha-Na Lee, Seung Hyeon Kim, Sin-Aye Park, Wonki Kim, Young-Nam Cha, Young-Joon Surh
Article
Biochemistry & Molecular Biology
Nam Ji Sung, Na Hui Kim, Na Young Bae, Hyo Sik Jo, Sin-Aye Park
BIOSCIENCE REPORTS
(2020)
Article
Immunology
Su Yeon Kim, Sunghye Heo, Seung Han Kim, Minji Kwon, Nam Ji Sung, A-Reum Ryu, Mi-Young Lee, Sin-Aye Park, Hyung-Sun Youn
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sujin Kim, Wonki Kim, Do-Hee Kim, Jeong-Hoon Jang, Su-Jung Kim, Sin-Aye Park, Hyunggu Hahn, Byung Woo Han, Hye-Kyung Na, Kyung-Soo Chun, Bu Young Choi, Young-Joon Surh
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Biochemistry & Molecular Biology
Athena Jessica Ong, Soma Saeidi, Ngo Hoang Kieu Chi, Su Jung Kim, Do-Hee Kim, Seung Hyeon Kim, Sin-Aye Park, Young-Nam Cha, Hye-Kyung Na, Young-Joon Surh
FREE RADICAL RESEARCH
(2020)
Article
Oncology
Sin-Aye Park, Nam Ji Sung, Bae-Jung Choi, Wonki Kim, Seung Hyeon Kim, Young-Joon Surh
BRITISH JOURNAL OF CANCER
(2020)
Article
Biochemistry & Molecular Biology
Na Hui Kim, Nam Ji Sung, Hyung-Sun Youn, Sin-Aye Park
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Juan-Yu Piao, Su-Jung Kim, Do-Hee Kim, Ji Hyun Park, Sin-Aye Park, Hyeong-jun Han, Hye-Kyung Na, Kichul Yoon, Ha-Na Lee, Nayoung Kim, Ki Baik Hahm, Young-Joon Surh
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Nam Ji Sung, Na Hui Kim, Young-Joon Surh, Sin-Aye Park
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Seung Hyeon Kim, Su-Jung Kim, Jeongmin Park, Yeonsoo Joe, So Eui Lee, Soma Saeidi, Xiancai Zhong, Seong Hoon Kim, Sin-Aye Park, Hye-Kyung Na, Hun Taeg Chung, Young-Joon Surh
Summary: Tumor-associated macrophages (TAMs) are important components of the tumor microenvironment and exhibit heterogeneity in phenotype, playing crucial roles in tumor development and progression. During chemotherapy, the phagocytic engulfment of tumor cell debris by TAMs may reduce the efficacy of chemotherapy.
Article
Biochemistry & Molecular Biology
Na Hui Kim, Nam Ji Sung, Seokwon Shin, Deok-Seon Ryu, Hyung-Sun Youn, Sin-Aye Park
Summary: Sauchinone, a lignan isolated from Saururus chinenesis, has been shown to inhibit the growth of breast cancer cells by attenuating the Akt-CREB-MMP13 pathway. Targeted inhibition of MMP13 by sauchinone represents a promising approach for the treatment of breast cancer.
BIOSCIENCE REPORTS
(2021)
Article
Oncology
Seung Hyeon Kim, Soma Saeidi, Xiancai Zhong, Shin-Young Gwak, Shrat Aklima Muna, Sin-Aye Park, Seong Hoon Kim, Hye-Kyung Na, Yeonsoo Joe, Hun Taeg Chung, Kyoung-Eun Kim, Wonshik Han, Young-Joon Surh
Review
Multidisciplinary Sciences
Sin-Aye Park, Young-Joon Surh
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2017)