Article
Robotics
Sebastien Briot, Alexandre Goldsztejn
Summary: This article focuses on defining singularity conditions for continuum parallel robots and providing an intuitive interpretation of the phenomena occurring at these singularities. It proves that some singularities occur when the robot potential energy has a local isovalue, separating stable configurations from unstable ones in the workspace. Additionally, robots can freely move along a given direction at these singularities under small perturbations.
IEEE TRANSACTIONS ON ROBOTICS
(2022)
Article
Engineering, Environmental
Keishi Ishida, Motoshi Furukawa, Masataka Kunitani, Rai Yamagiwa, Youhei Hiromori, Daisuke Matsumaru, Jianying Hu, Hisamitsu Nagase, Tsuyoshi Nakanishi
Summary: We developed a new short-term screening test using in vivo bioluminescence imaging to detect chemicals with estrogen-like effects. Our method is more sensitive and requires less time compared to traditional in vivo screening methods. Our results showed that our method could detect the estrogenic effects of BPA at doses below tolerable daily intakes, which traditional screening methods could not. Our study demonstrates that in vivo bioluminescence imaging is a highly effective tool for screening estrogenic chemicals and resolving the controversy about low-dose effects of endocrine-disrupting chemicals.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Hyo Won Lee, In-Jeong Lee, Soo-Jin Lee, Yu Rim Kim, Hwan Myung Kim
Summary: Lipid droplets (LDs) are lipid-abundant organelles that play important roles in cellular metabolic processes and are associated with various diseases related to lipid regulation. Researchers have developed a highly selective fluorescent tracker LD1 to monitor LD dynamics in live samples.
Article
Computer Science, Information Systems
Sung Wook Hwang, Deok Ha Kim, Jaehwan Park, Jong Hyeon Park
Summary: This paper presents a novel methodology for under-constrained cable-driven parallel robots (UCCDPRs) to find stable equilibrium configurations, generate feasible EE trajectories, and design input shapers for vibration suppression. The proposed method is verified through computer simulations and hardware experiments for its effectiveness and performance.
Article
Computer Science, Software Engineering
Toni Mancini, Igor Melatti, Enrico Tronci
Summary: This article presents a technique for parallel shortest simulation campaigns in HPC infrastructure, enabling efficient system-level verification tasks with reduced completion time.
IEEE TRANSACTIONS ON SOFTWARE ENGINEERING
(2023)
Article
Chemistry, Medicinal
Ryota Morimoto, Takumi Matsumoto, Mayuri Minote, Masayuki Yanagisawa, Ryotaro Yamada, Takefumi Kuranaga, Hideaki Kakeya
Summary: This article introduces improved LC-MS protocols for highly sensitive amino acid analysis and new labeling reagents, which contribute to enhancing our understanding of the structural basis of highly sensitive labeling reagents.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Engineering, Biomedical
Qinyi Zhao, Ming Zhu, Gongwei Tian, Cuiyuan Liang, Zhiyuan Liu, Jianping Huang, Qianheng Yuan Yu, Shuanglong Tang, Jianhui Chen, Xizheng Zhao, Qi Zeng, Chongshen Guo, Dianpeng Qi
Summary: Flexible electrode array is an important tool for communication between living tissues and external electronics. However, current advances in flexible neural microelectrodes are limited by high impedance and poor mechanical consistency. In this study, a highly sensitive and omnidirectionally stretchable polymeric electrode array (PEA) is introduced, which significantly reduces impedance and has good mechanical properties. The PEA is capable of withstanding mechanical loads and successfully recording electrophysiological signals from a rat. This research provides new insights for the practical application of flexible neural electrodes.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Analytical
Ji Sun Park, Sun-Ki Kim, Chang-Hyung Choi, Jong Pil Park, Kyeongsoon Park
Summary: The overproduction of hydrogen peroxide (H2O2) is closely associated with the progression of various diseases, making it an important diagnostic marker for in vivo molecular imaging. A novel Co2+-doped L012/magnesium peroxide-based chemiluminescence (CL) nanosystem (L-012/Co@MgO2) has been developed for visual detection and quantitative analysis of H2O2, which has potential applications in biosensing and bioimaging of H2O2.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Tianyi Li, Scott D. Soelberg, Zachary Taylor, Vigneshwar Sakthivelpathi, Clement E. Furlong, Jong-Hoon Kim, Sang-Gyeun Ahn, Peter D. Han, Lea M. Starita, Jia Zhu, Jae-Hyun Chung
Summary: This study developed an immunoresistive sensor on a polyethylene terephthalate (PET) film for simple, inexpensive, and highly sensitive COVID-19 screening. The sensor showed high sensitivity and specificity in detecting the spike protein of SARS-CoV-2. The developed film sensor has the potential to facilitate rapid COVID-19 screening.
Article
Ergonomics
Michel Hery, Marc Malenfer, Stephanie Devel, Catherine Levert
Summary: Introduction: Information and communication technologies play a significant role in the evolution of work, serving as tools for liberating humans from tedious tasks and intensifying work. Through foresight exercises and concrete examples, the authors outline possible trends for future changes and propose general principles for establishing a win-win policy.
JOURNAL OF SAFETY RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Xuan Chen, Huazheng Cao, Yan Huo, Jiaxin Song, Haohan Zou, Jing Li, Jie Hou, Yan Wang
Summary: This study analyzed and compared sensitive in vivo characteristics for screening early keratoconus using a multicenter, case-control design. The results showed significant differences in corneal biomechanical indices between early keratoconus and normal corneas, with A1 dArc length showing high discriminatory ability. The clinical application of corneal biomechanics, combined with corneal tomography, should be emphasized for the timely and accurate detection of early keratoconus.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Environmental
Baisong Yang, Wenhui Chen, Xiaohong Zhou, Fandong Meng, Chuyang Chen, Quan Liu, Qian Li, Xin Wang, Peng Xu, Yifeng Lei, Longjian Xue
Summary: In this study, a hydrogel sensor with enhanced mechanical properties, high defect-resistance, and high sensitivity is developed by anchoring silver nanowires in a composite hydrogel. The sensor exhibits high stability and sensitivity, and a sustainable strategy for utilizing food residues is proposed.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Multidisciplinary Sciences
Nathan J. VanDusen, Julianna Y. Lee, Weiliang Gu, Catalina E. Butler, Isha Sethi, Yanjiang Zheng, Justin S. King, Pingzhu Zhou, Shengbao Suo, Yuxuan Guo, Qing Ma, Guo-Cheng Yuan, William William Pu
Summary: The study utilized in vivo somatic Cas9 mutagenesis in mice to conduct a forward genetic screen for regulators of cardiomyocyte maturation, identifying transcriptional regulators such as RNF20 and RNF40. Mechanistic studies showed that these regulators control dynamic gene expression changes essential for cardiomyocyte maturation.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Electrical & Electronic
Ruka Wada, Hidetoshi Takahashi
Summary: This paper presents a method for enhancing MEMS-based acoustic sensors with a front-mounted parallel HR array, suitable for DP sensor-type elements. Experimental results show that the sensor with HRs has three times higher sensitivity at the resonant frequency, and achieves an acoustic pressure resolution of approximately 4 mPa.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Multidisciplinary Sciences
Hiroto Sugawara, Junta Imai, Junpei Yamamoto, Tomohito Izumi, Yohei Kawana, Akira Endo, Masato Kohata, Junro Seike, Haremaru Kubo, Hiroshi Komamura, Yuichiro Munakata, Yoichiro Asai, Shinichiro Hosaka, Shojiro Sawada, Shinjiro Kodama, Kei Takahashi, Keizo Kaneko, Hideki Katagiri
Summary: The authors establish a sensitive strategy to monitor the proliferation of targeted cell types in vivo in the same individuals, providing a new technical approach for biological and medical research.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Rebekka Schmitz, Wael Sabra, Philipp Arbter, Yaeseong Hong, Tyll Utesch, An-Ping Zeng
ENGINEERING IN LIFE SCIENCES
(2019)
Article
Chemistry, Medicinal
Philipp Nicolas Depta, Uwe Jandt, Maksym Dosta, An-Ping Zeng, Stefan Heinrich
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2019)
Article
Biotechnology & Applied Microbiology
Tyll Utesch, Wael Sabra, Christin Prescher, Julian Baur, Philipp Arbter, An-Ping Zeng
BIOTECHNOLOGY AND BIOENGINEERING
(2019)
Editorial Material
Biotechnology & Applied Microbiology
An-Ping Zeng, Ralf Takors, Thomas Bley
ENGINEERING IN LIFE SCIENCES
(2019)
Article
Biochemical Research Methods
Matthias Wurm, Sibel Ilhan, Uwe Jandt, An-Ping Zeng
ANALYTICAL BIOCHEMISTRY
(2019)
Article
Biochemical Research Methods
Xinyi Zhang, Mei Li, Yingying Xu, Jie Ren, An-Ping Zeng
JOURNAL OF BIOLOGICAL ENGINEERING
(2019)
Article
Biotechnology & Applied Microbiology
Johannes Moeller, Krathika Bhat, Kristoffer Riecken, Ralf Poertner, An-Ping Zeng, We Jandt
BIOTECHNOLOGY AND BIOENGINEERING
(2019)
Article
Biochemical Research Methods
Chuang Wang, Jie Ren, Libang Zhou, Zhidong Li, Lin Chen, An-Ping Zeng
ACS SYNTHETIC BIOLOGY
(2019)
Article
Biochemical Research Methods
Libang Zhou, Jie Ren, Zhidong Li, Jinglei Nie, Chuang Wang, An-Ping Zeng
ACS SYNTHETIC BIOLOGY
(2019)
Article
Agricultural Engineering
Philipp Arbter, Aakanksha Sinha, Julie Troesch, Tyll Utesch, An-Ping Zeng
BIORESOURCE TECHNOLOGY
(2019)
Review
Biochemical Research Methods
Yaeseong Hong, Jie Ren, Xinyi Zhang, Wei Wang, An-Ping Zeng
CURRENT OPINION IN BIOTECHNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Weigang Chen, Panpan Wang, Lixia Wang, Dalu Zhang, Mingzhe Han, Mingyong Han, Lifu Song
Summary: A new DNA barcode construction scheme combining cyclic block code and predetermined pseudo-random sequence is proposed in this study to address corrupted DNA barcodes, with a barcode identification scheme using cyclic shifting and dynamic programming to enhance accuracy in estimating insertion/deletion errors. The proposed method demonstrates an overall identification error rate lower than 10(-5) in scenarios with base mutation probability below 0.1, showing improved accuracy compared to traditional methods.
Article
Multidisciplinary Sciences
Weigang Chen, Mingzhe Han, Jianting Zhou, Qi Ge, Panpan Wang, Xinchen Zhang, Siyu Zhu, Lifu Song, Yingjin Yuan
Summary: The study on DNA digital storage introduces an alternative method for high-density and long-term stable information storage by designing and synthesizing an artificial chromosome that encodes images and videos. With a coding paradigm that tolerates errors and a stability demonstration through generational transmission, this approach provides potential for massive data distribution in an economically efficient manner.
NATIONAL SCIENCE REVIEW
(2021)
Review
Biotechnology & Applied Microbiology
Li-Fu Song, Zheng-Hua Deng, Zi-Yi Gong, Lu-Lu Li, Bing-Zhi Li
Summary: Significant progress has been made in large-scale de novo oligonucleotide synthesis based on phosphoramidite chemistry in recent decades, with a focus on applications such as de novo genome synthesis and DNA data storage. However, challenges remain in improving synthesis length, speed, cost, and throughput, which can be addressed by utilizing enzymatic methods. This review summarizes the current status of large-scale oligonucleotide synthesis technologies and discusses opportunities and challenges in de novo genome synthesis and DNA data storage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Lifu Song, Feng Geng, Zi-Yi Gong, Xin Chen, Jijun Tang, Chunye Gong, Libang Zhou, Rui Xia, Ming-Zhe Han, Jing-Yi Xu, Bing-Zhi Li, Ying-Jin Yuan
Summary: The study introduces a novel DNA strand assembly algorithm, DBGPS, that utilizes de Bruijn graph and greedy path search to tackle errors commonly encountered in DNA data storage. DBGPS demonstrates significant advantages in handling DNA breaks, rearrangements, and indels, and its robustness is demonstrated through various tests.
NATURE COMMUNICATIONS
(2022)