期刊
SCIENTIFIC REPORTS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-14292-1
关键词
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资金
- MEXT/JSPS KAKENHI Grant [263395, 26293111, 16H01373, JP15K09766, JP15H05096]
- Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology (PRESTO) [16021031300]
- Ministry of Health, Labour and Welfare (MHLW)
- Research on Development of New Drugs, the Japan Agency for Medical Research and Development (AMED)
- Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries, and Food Industry
- Astellas Foundation for Research on Metabolic Disorders
- Suzuken Memorial Foundation
- Yamada Science Foundation
- [15H05790]
- [15H1155]
- [15K15417]
- Grants-in-Aid for Scientific Research [17K19655, 16H01373, 26293111, 15H05906, 15H05897, 16H05172, 16K15288] Funding Source: KAKEN
Psoriasis is a common, chronic inflammatory skin disease characterized by epidermal hyperplasia via the IL-23/IL-17 axis. Various studies have indicated the association between obesity and psoriasis, however, the underlying mechanisms remains unclarified. To this end, we focused on high-fat diet (HFD) in this study, because HFD is suggested as a contributor to obesity, and HFD-fed mice exhibit exacerbated psoriatic dermatitis. Using murine imiquimod (IMQ)-induced psoriasis and HFD-induced obesity models, we have revealed a novel mechanism of HFD-induced exacerbation of psoriatic dermatitis. HFD-fed mice exhibited aggravated psoriatic dermatitis, which was accompanied with increased accumulation of IL-17A-producing V gamma 4(+) gamma delta T cells in the skin. HFD also induced the increase of V gamma 4(+) gamma delta T cells in other organs such as skin draining lymph nodes, which preceded the increase of them in the skin. In addition, HFD-fed mice displayed increased expression of several gamma delta T cell-recruiting chemokines in the skin. On the other hand, ob/ob mice, another model of murine obesity on normal diet, did not exhibit aggravated psoriatic dermatitis nor accumulation of gamma delta T cells in the dermis. These results indicate that HFD is a key element in exacerbation of IMQ-induced psoriatic dermatitis, and further raise the possibility of HFD as a factor that links obesity and psoriasis.
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