Article
Polymer Science
Hitesh Chopra, Shabana Bibi, Sandeep Kumar, Muhammad Saad Khan, Pradeep Kumar, Inderbir Singh
Summary: In this study, chitosan/polyvinyl alcohol (PVA)-based hydrogel films loaded with honey were developed for potential wound healing applications. The films were evaluated for their physical and mechanical properties, as well as their antimicrobial performance against Staphylococcus aureus. The results demonstrated the potential of these films as wound dressings and suggested the need for further in vivo experiments to evaluate their clinical efficacy.
Article
Nanoscience & Nanotechnology
Saeed Ali Alsareii, Javed Ahmad, Ahmad Umar, Mohammad Zaki Ahmad, Abdul Aleem Mohammed, Alamri Abdulrahman Manaa, Mansour Yousef AlAsmari, Abdulhadi Mohamed Elbashir
Summary: More than 5 million people require medical attention annually due to burn-related injuries. This study evaluates the wound healing potential of chitosan gel containing hesperetin for burn wounds.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Review
Polymer Science
Siti Nor Najihah Yasin, Zulfahmi Said, Nadia Halib, Zulaiha A. Rahman, Noor Izzati Mokhzani
Summary: Excellent wound dressings should have crucial components such as high porosity, non-toxicity, high water absorption, and the ability to maintain a moist environment and promote wound healing. However, current wound dressings have limitations in antibacterial, anti-inflammatory, and antioxidant activity, frequent dressing changes, low biodegradability, and poor mechanical properties. Hydrogels, including natural, synthetic, or hybrid polymers, have shown potential as wound dressings by providing a moist environment, a protective barrier against infections, and pain relief. Honey-based hydrogel dressing, with its anti-inflammatory, antibacterial, and antioxidant properties, exhibits excellent characteristics including biodegradability, biocompatibility, cell proliferation, inhibition of bacterial growth, and accelerated wound healing. This review aims to showcase the potential of honey-based hydrogel dressings in wound healing applications and complement existing studies on their implementation.
Article
Pharmacology & Pharmacy
Saibhargav Narisepalli, Shubham A. Salunkhe, Deepak Chitkara, Anupama Mittal
Summary: This study developed a gelatin-based biodegradable hydrogel embedded with Asiaticoside polymeric nanoparticles (AST PNP) to enable sustained release of AST and enhance its therapeutic effects. The AST PNP demonstrated sustained release profile and enhanced intra-cellular uptake in fibroblasts, leading to significant proliferation and migration of fibroblasts and improved collagen biosynthesis. The application of AST PNP gel also showed improved wound healing efficacy in diabetic rats.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Emine Salva, Ahmet Enes Akdag, Saadet Alan, Sema Arisoy, Fatma Julide Akbuga
Summary: The 3D polymeric network structure of chitosan/hyaluronic acid/honey hydrogels, which imitates the extracellular matrix, promotes cell growth and differentiation and exhibits excellent wound-healing abilities. The hydrogels were characterized and their properties, such as water content, water uptake capacities, and porosity, were investigated. The addition of honey altered the interaction between chitosan and hyaluronic acid, resulting in changes in the hydrogel's properties. The honey-containing hydrogels showed decreased porosity and slightly decreased water-uptake capacity, but increased cell adhesion and proliferation. In vivo studies demonstrated that honey addition accelerated wound healing. These findings highlight the potential of honey-loaded chitosan-hyaluronic acid hydrogels in wound healing applications.
Article
Chemistry, Multidisciplinary
Minting Liu, Ying Chen, Qiang Zhu, Junjun Tao, Changming Tang, Huajun Ruan, Yunlong Wu, Xian Jun Loh
Summary: This study discovered that supercritical CO2 extracted pearl peptide hydrogels have the potential to promote wound healing. These hydrogels can increase skin fibroblast viability, enhance antioxidant stress resistance, promote tissue remodeling and angiogenesis, and significantly accelerate wound healing.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Vandiara Martins Moreira, Joandra Maisa da Silva Leite, Kaline de Araujo Medeiros, Karoll Moangella Andrade de Assis, Joyce Cordeiro Borges, Lucas Matheus Barreto Santana, Livia Maria Coelho de Carvalho Moreira, Larissa Pereira Alves, Tharcia Kiara Beserra de Oliveira, Joao Walter de Souza da Silveira, Dayanne Tomaz Casimiro da Silva, Bolivar Ponciano Goulart de Lima Damasceno
Summary: The study developed chitosan films associated with pentoxifylline for healing wounds. The films were prepared at two concentrations and evaluated for their structural characteristics, release properties, and wound healing effects in mice. Higher concentration of pentoxifylline in the films showed faster wound reduction, indicating the effectiveness of the combination of chitosan and pentoxifylline in promoting wound healing.
Article
Pharmacology & Pharmacy
Cheng Yang, Yuhui Chen, Hai Huang, Shicai Fan, Chengliang Yang, Liping Wang, Wenqiang Li, Wenxin Niu, Jianwen Liao
Summary: The ROS-sensitive hydrogel prepared in this study showed strong free radical scavenging ability, accelerated wound healing, and promoted tissue regeneration in experiments.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mohammad Taghi Khorasani, Alireza Joorabloo, Hassan Adeli, Peiman Brouki Milan, Moein Amoupour
Summary: The fabricated wound dressings developed in the study showed increased mechanical strength, enhanced therapeutic agent delivery, improved protein adsorption, and strong antibacterial activity, significantly accelerating wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Dermatology
Yuming Qiu, Xinxiang Sun, Xiaoli Lin, Wenying Yi, Jianye Jiang
Summary: Preparing hydrogels with high antibacterial properties and good biosafety for wound healing can be challenging, but the HMC-HA/AgNPs hydrogels synthesized by introducing silver nanoparticles have shown excellent antibacterial activities and biocompatibility in experiments.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Medicine, Research & Experimental
Hadi Samadian, Reza Vahidi, Majid Salehi, Hossein Hosseini-Nave, Arman Shahabi, Saeed Zanganeh, Mahla Lashkari, Seyedeh Mehrnaz Kouhbananinejad, Nariman Rezaei Kolarijani, Seyed Mohammad Amini, Majid Asadi-shekari, Mohamad Javad Mirzaei Parsa
Summary: The objective of this study was to evaluate the antibacterial and regenerative effects of a hydrogel nanocomposite containing pure natural zeolite integrated with alginate. Zeolites were characterized and integrated into alginate hydrogel, and the resulting hydrogel was tested for swelling, weight loss, antibacterial properties, hemocompatibility, and cell viability. In animal studies, the hydrogel nanocomposite accelerated wound healing compared to the control group.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
Article
Polymer Science
Doaa Alshora, Lubna Ashri, Rihaf Alfaraj, Ahlam Alhusaini, Raeesa Mohammad, Nawal Alanaze, Mohamed Ibrahim, Mohamed Badran, Mounir Bekhit, Shaikha Alsaif, Modhi Alagili, Rehab Ali, Adel Jreebi
Summary: This study aims to formulate a biofilm composed of silver sulfadiazine, chitosan, and sodium alginate, and evaluate its effectiveness in wound healing. The optimized formulation showed reasonable mechanical properties and significantly higher antibacterial activity compared to the blank biofilm. In vivo study demonstrated a 75% reduction in wound width with the formulated biofilm.
Article
Pharmacology & Pharmacy
Priya Patel, Ashish Thanki, Dhara Viradia, Pranav Shah
Summary: This study aimed to develop a silver sulfadiazine-loaded microsponge along with a honey-impelled hydrogel for improved burn wound healing activity. The microsponge was prepared by quasi-emulsion solvent diffusion method and formulation variables were optimized. The results showed that the microsponge-loaded hydrogel had increased medication retention ability, no skin irritation, low cytotoxicity, and better wound contraction compared to the commercial product.
CURRENT DRUG DELIVERY
(2023)
Article
Chemistry, Applied
Punnida Nonsuwan, Preeyaporn Plaimee Phiboonchaiyanan, Namon Hirun, Pakorn Kraisit
Summary: A Pul-derivative hydrogel was developed by introducing methacrylate groups and beta-cyclodextrin to improve mechanical properties and increase curcumin solubility. The hydrogel exhibited enhanced curcumin solubility, biocompatibility, and accelerated wound healing.
CARBOHYDRATE POLYMERS
(2023)
Article
Dermatology
Meiping Dong, Yi Mao, Zhiwei Zhao, Jinbo Zhang, Lipeng Zhu, Linlu Chen, Liexiang Cao
Summary: The development of a carbon-based composite injectable silk fibroin hydrogel as a multifunctional wound dressing has been shown to effectively promote wound healing, providing anti-bacterial properties, cell compatibility, sustained drug delivery, antioxidant effects, and self-healing abilities. This hydrogel also enhances tissue adhesion and burn wound regeneration, making it a promising option for quick burn wound therapy and prevention of bacterial infections in the wound microenvironment.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Muhammed Ossama, Rania M. Hathout, Dalia A. Attia, Nahed D. Mortada
Article
Multidisciplinary Sciences
Anil Bozdogan, Reham F. El-Kased, Vanessa Jungbluth, Wolfgang Knoll, Jakub Dostalek, Amal Kasry
ROYAL SOCIETY OPEN SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Noha Badawi, Khalid El-Say, Dalia Attia, Mohamed El-Nabarawi, Mohey Elmazar, Mahmoud Teaima
Article
Biotechnology & Applied Microbiology
Reham F. El-Kased, Noha M. Gamaleldin
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ayat M. Emad, Dalia M. Rasheed, Reham F. El-Kased, Dina M. El-Kersh
Summary: Medicinal plant extracts are an important source of innovative medications and healthcare products. This study focused on the antioxidant and antimicrobial activities of water extract and organic fractions of Egyptian celery. The results showed that the celery extract and dichloromethane fraction had the highest antioxidant potential, while both showed antimicrobial activities against certain bacteria.
Article
Pharmacology & Pharmacy
Caroline Lamie, Enas Elmowafy, Maha H. Ragaie, Dalia A. Attia, Nahed D. Mortada
Summary: Topical delivery of poorly water soluble and high-molecular-weight antifungal agents like itraconazole (ITZ) has been improved by the use of liposomes called ITZ aspasomes. These liposomes, encapsulated in a cream, enhance skin deposition of the drug. In clinical trials, the aspasomal cream containing 0.5% ITZ showed better efficacy in treating diaper dermatitis and tinea infections compared to creams containing 0.1% ITZ aspasomes or non-formulated ITZ. This suggests that ITZ aspasomal cream has potential for use in other dermal fungal infections.
Article
Multidisciplinary Sciences
Christina Medhat Naiim, M. M. Elmazar, Nagwa A. Sabri, Naglaa S. Bazan
Summary: This study compared the efficacy, safety, and cost-effectiveness between extended infusion and intermittent infusion of piperacillin/tazobactam in the treatment of gram-negative bacterial infections. The results demonstrated that extended infusion had shorter treatment duration and time to clinical success compared to intermittent infusion, and it was more cost-effective. Both regimens had comparable clinical and microbiological outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Doaa M. El-Atrees, Reham F. El-Kased, Ahmad M. Abbas, Mahmoud A. Yassien
Summary: This study investigated the potential application of six bacteriophages isolated from sewage samples in combating Enterococcus faecalis infections. The results showed that these phages exhibited promising antibiofilm activity against biofilm-forming Enterococcus faecalis and reduced bacterial adherence to urinary catheter surfaces.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Rania M. Yehia, Dalia A. Attia, Mohamed M. Elmazar, Mohamed A. El-Nabarawi, Mahmoud H. Teaima
Summary: This study investigated the use of microsponges as a carrier system for the drug Adapalene. The Plackett-Burman design was employed to identify key variables affecting the formulation of ADA-MS, with significant effects found for drug percentage, polymer type, and surfactant concentration. Furthermore, ADA-MS exhibited significant cytotoxicity against cell lines and enhanced antimicrobial activity.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biology
Reham F. El-Kased, Dina M. El-Kersh
Summary: The purpose of this study was to investigate the antimicrobial effects and preservative action of natural essential oils. Eight natural essential oils were tested against different types of microbes, and thyme oil showed the highest inhibitory effect. Concentration-dependent inhibition of growth was observed for all tested oils. Lemon grass, thyme, and Mentha virdis essential oils were found to be enriched with monoterpenes, exhibiting the strongest antimicrobial activity in pasteurized apple juice.
Article
Biochemistry & Molecular Biology
Claudia Roewer, Christian Ortmann, Andrei Neamtu, Reham F. El-Kased, Michael O. Glocker
Summary: Antibody-based point-of-care diagnostics are crucial in modern medicine. Understanding antibody recognition mechanisms is essential for improving test accuracy and precision, especially in life-threatening conditions like myocardial infarction. The ITEM-FOUR approach combines mass spectrometry and molecular dynamics simulations to determine the effects of amino acid polymorphisms on antibody binding. The study addresses the unsolved problem of antibody-based diagnostics for human cardiac Troponin I epitope.
Article
Chemistry, Multidisciplinary
Yomna A. Moussa, Mahmoud H. Teaima, Dalia Attia, Mohey M. Elmazar, Mohamed A. El-Nabarawi
Summary: GCBE-loaded SLNs were prepared to improve the bioavailability of green coffee bean extract (GCBE) by enhancing its intestinal absorption. The optimized SLNs exhibited small particle size, reasonably acceptable PDI, and high entrapment efficiency. The performance of the optimized GCBE-SLN was further evaluated using an ex vivo everted sac model, which showed improved intestinal permeation of GCBE and suggested the potential of oral GCBE-SLNs for enhancing the intestinal absorption of chlorogenic acid.
Article
Pharmacology & Pharmacy
Noha M. Badawi, Mona A. Elkafrawy, Rania M. Yehia, Dalia A. Attia
Summary: The study focused on designing and evaluating novel MTD loaded SLNs vaginal emulgel for BV treatment, showing improved therapeutic response and lower recurrence rate compared to the market product.
Article
Chemistry, Multidisciplinary
R. M. Abd-Elaziz, A. S. El-Tabl, M. M. Elmazar, M. M. Abd-Elwahed
EGYPTIAN JOURNAL OF CHEMISTRY
(2020)
