Article
Oncology
Mengjun Guo, Xiling Zhang
Summary: This study revealed that lncRNA MSTO2P promotes colorectal cancer progression through epigenetically silencing CDKN1A mediated by EZH2.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Mingkun Zhang, Liu Yang, Lan Hou, Xueyuan Tang
Summary: In this study, it was found that SNHG1 is significantly upregulated in breast cancer tissues and cells, and its high levels are closely associated with reduced survival rates in patients. Silencing of SNHG1 inhibited the proliferative, migratory, and invasive activity of breast cancer cells and enhanced their sensitivity to cisplatin. The mechanism involves SNHG1 interacting with EZH2 to epigenetically inhibit miR-381 expression, which in turn suppresses tumor progression and overcomes chemoresistance in breast cancer cells.
Article
Biochemistry & Molecular Biology
Jiyeon Lee, Ji-Hyun Hwang, Harim Chun, Wonjin Woo, Sekyung Oh, Jungmin Choi, Lark Kyun Kim
Summary: Research suggests that pseudogene-derived long non-coding RNAs may play a critical role in chemoresistance in hepatocellular carcinoma, with PLEKHA8P1 and its parental gene PLEKHA8 promoting tumor progression and affecting 5-FU-induced chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Xiang Ye, Xiaochen Liu, Min Gao, Li Gong, Fei Tian, Yangli Shen, Huili Hu, Gongping Sun, Yongxin Zou, Yaoqin Gong
Summary: Resistance to TMZ, the first-line chemotherapy drug for GBM and anaplastic gliomas, is a significant obstacle in clinical treatment, regulated by complex genetic and epigenetic networks. The upregulation of CUL4B in glioma patients correlates with disease progression, tumor recurrence, malignant subtype, and poor survival, indicating a role in TMZ resistance. Inhibition of CUL4B may be beneficial for overcoming resistance to TMZ in GBM cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Bing Lu, Jiatian Wei, Houhong Zhou, Jie Chen, Yuqing Li, Liefu Ye, Wei Zhao, Song Wu
Summary: Epigenetic dysregulation plays a role in bladder cancer. KDM2A, an important epigenetic regulator, is found to be upregulated in bladder cancer due to gene copy number gain and a super-enhancer. Knockdown of KDM2A suppresses the growth and invasion of bladder cancer cells and inhibits tumor growth. KDM2A suppresses RARRES3 expression through demethylation and the KDM2A/RARRES3 axis may be a promising therapeutic target for high-grade bladder cancer.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Xiaocong Lin, Guodan Li, Xiuwen Yan, Weiyu Fu, Jie Ruan, Hang Ding, Huajun Yu, Xiaoyi Chen, Liubo Lan, Yong Dai, Kai Pan, Xinguang Liu, Haitao Zhang
Summary: This study identifies lncRNA BC002811 as a critical regulator in the development and progression of gastric cancer. BC002811 is upregulated in GC tissues and cell lines and its high expression is associated with reduced overall survival in GC patients. BC002811 promotes GC cell proliferation, migration, invasion, and inhibits apoptosis in vitro, and accelerates tumor growth and metastasis in vivo. It upregulates MMP2 and MMP9 and promotes GC cell metastasis by downregulating PTEN expression and blocking SOX2 binding to the PTEN promoter.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Li-Hui Yang, Peng Du, Wei Liu, Li-Kun An, Jian Li, Wen-Yi Zhu, Shuo Yuan, Lei Wang, Lei Zang
Summary: In multiple myeloma, upregulated ANRIL is associated with poor survival and promotes cell proliferation and chemoresistance through EZH2-mediated epigenetic silencing of PTEN.
Article
Biochemistry & Molecular Biology
Yuan Guo, Yan-Rong Zhao, Huan Liu, Yang Xin, Jian-Zhi Yu, Yun-Jin Zang, Qing-guo Xu
Summary: The study identified EHMT2 as a critical factor in the development of hepatocellular carcinoma, showing that elevated EHMT2 expression promotes tumorigenesis and activates the Wnt-beta-catenin signaling pathway. EHMT2 was found to epigenetically silence the APC promoter through methylation, and the specific inhibitor UNC0642 demonstrated anti-tumorigenesis effects in HCC, suggesting it as a potential candidate for targeted drug therapy.
CELL AND BIOSCIENCE
(2021)
Article
Cell Biology
Jia Zhang, Kaisa Cui, Liuying Huang, Fan Yang, Shengbai Sun, Zehua Bian, Xue Wang, Chaoqun Li, Yuan Yin, Shengling Huang, Leyuan Zhou, Bojian Fei, Zhaohui Huang
Summary: SLCO4A1-AS1 is upregulated in colorectal cancer (CRC) and associated with poor prognosis. SLCO4A1-AS1 acts as a molecular scaffold to regulate the Hsp90/Cdk2/c-Myc axis and promote the growth of CRC.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Oncology
Chenyao Li, Sen Hong, Han Hu, Tao Liu, Guoqiang Yan, Di Sun
Summary: This study identified a novel lncRNA ELFN1-AS1 plays a crucial role in colorectal cancer, inhibiting tumor growth by restricting cell proliferation and promoting cell apoptosis. ELFN1-AS1 transcriptionally silenced TPM1 gene by recruiting EZH2 and FOXP1, thereby facilitating colorectal cancer progression.
MOLECULAR CANCER RESEARCH
(2022)
Article
Cell Biology
Chuan Zhang, Lu Wang, Chi Jin, Jiahui Zhou, Chaofan Peng, Yong Wang, Ziwei Xu, Dongsheng Zhang, Yuanjian Huang, Yue Zhang, Dongjian Ji, Wen Peng, Kangpeng Jin, Junwei Tang, Yifei Feng, Yueming Sun
Summary: Colorectal cancer is a common cancer worldwide, with liver metastasis being a key factor affecting prognosis. A study revealed that Lnc-LALC can regulate CRC cell metastasis ability by affecting DNA methylation status, highlighting its important role in CRLM.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Marta Codrich, Emiliano Dalla, Catia Mio, Giulia Antoniali, Matilde Clarissa Malfatti, Stefania Marzinotto, Mariaelena Pierobon, Elisa Baldelli, Carla Di Loreto, Giuseppe Damante, Giovanni Terrosu, Carlo Ennio Michele Pucillo, Gianluca Tell
Summary: The study focused on analyzing patient-derived colon organoids under different conditions to determine their ability to replicate the original tumor. Through integration of genomic, transcriptomic, and phosphoproteomic data, the researchers found that PDCOs faithfully recapitulated the patient's tumor at the molecular level, accumulating mutations over time that potentially mimic the evolution of the tumor.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Lijun Zhang, Liqun Xu, Xiaoyan Zhang, Ke Wang, Yingjun Tan, Gaozhi Li, Yixuan Wang, Tong Xue, Quan Sun, Xinsheng Cao, Ge Zhang, Zebing Hu, Shu Zhang, Fei Shi
Summary: This study reveals for the first time the role of the Atf7ip/Setdb1/Macrod2 axis in osteoblast proliferation under mechanical unloading, providing a potential protective strategy against unloading-induced bone loss.
Article
Immunology
Tingkai Fu, Yunxue Yang, Zhenxin Mu, Rongwei Sun, Xingang Li, Jun Dong
Summary: The study found that upregulation of LINC01410 in GBM cells promoted cell viability, while its silencing decreased viability. In TMZ-resistant GBM cells, increased expression of LINC01410 and drug resistance-related factors was observed, along with a decreased cell viability trend. However, silencing LINC01410 decreased the IC50 value, increased sensitivity and apoptosis in resistant cells, and led to upregulation of PTEN and downregulation of phosphorylated AKT.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ran Li, Qing Ruan, Jia Zheng, Butian Zhang, Hongliang Yang
Summary: This study demonstrated that LINC01116 plays a crucial regulatory role in doxorubicin resistance in osteosarcoma through the miR-424-5p axis. Inhibition of LINC01116 expression could alleviate drug resistance and potentially serve as a strategy to overcome chemoresistance in osteosarcoma.
FRONTIERS IN PHARMACOLOGY
(2021)
