Review
Biochemistry & Molecular Biology
Masahiro Horita, Colin Farquharson, Louise A. Stephen
Summary: This review summarizes the differential expression patterns and functional roles of the miR-29 family in diseases such as osteoarthritis, osteoporosis, cardiorenal, and immune disease, highlighting their therapeutic potential. Further research is needed to identify the precise mechanisms of the miR-29 family in these diseases and their potential in therapeutics.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Meng-Nan Liu, Gang Luo, Wan-Jiao Gao, Si-Jin Yang, Hua Zhou
Summary: miR-29 plays a crucial role in cardiovascular disease (CVD), particularly in maintaining arterial integrity and regulating atherosclerosis. Studies have shown the potential of miR-29 as a potential marker for prevention, treatment, and prognostic observation in CVD.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Neurosciences
Betul Ozdilek, Berna Demircan
Summary: The study found that miR-29c expression levels were significantly higher in Turkish Parkinson's disease patients, suggesting it may be a potential diagnostic biomarker. miR-195 showed a significant positive correlation with age, while miR-29a had a significant negative correlation with UPDRS total score.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Masoumeh Amirian, Amir Masoud Jafari-Nozad, Majid Darroudi, Tahereh Farkhondeh, Saeed Samarghandian
Summary: Accumulating evidence has shown the significant role of miR-29 in human malignancies, particularly breast cancer (BC). MiR-29 acts as a tumor suppressor by targeting multiple signaling pathways and transcripts, but it can also promote BC progression through gene and transcription factor targeting. The conflicting roles of miR-29 in BC may be attributed to its regulatory roles dependent on the environment and signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Michele Salemi, Giovanna Marchese, Giuseppe Lanza, Filomena I. I. Cosentino, Maria Grazia Salluzzo, Francesca A. Schillaci, Giovanna Maria Ventola, Angela Cordella, Maria Ravo, Raffaele Ferri
Summary: Parkinson's disease (PD) is a neurodegenerative synucleinopathy with an unclear molecular pathomechanism. This study analyzed miRNAs on peripheral blood mononuclear cells from 30 participants to identify differentially expressed miRNAs in PD compared to healthy controls. The study also explored the pathways influenced by these miRNAs and their potential association with PD susceptibility. Several dysregulated miRNAs and their putative targets were identified, suggesting their potential as diagnostic markers and outcome measures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Soheil Madadi, Massoud Saidijam, Bahram Yavari, Meysam Soleimani
Summary: miR-106b may be a promising serum biomarker for early diagnosis of Alzheimer's disease.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Clinical Neurology
Tommaso Schirinzi, Henri Zenuni, Piergiorgio Grillo, Roberta Bovenzi, Gisella Guerrera, Francesca Gargano, Massimo Pieri, Sergio Bernardini, Nicola Biagio Mercuri, Luca Battistini, Giulia Maria Sancesario
Summary: This study found that there were no quantitative differences in serum biomarker levels between Parkinson's disease patients and control subjects. However, only Parkinson's disease patients showed associations between levels of tau and amyloid-beta-42 in inter-fluids (serum-CSF). In addition, the serum content of tau protein was inversely correlated with cognitive performance.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lorenzo Agostino Citterio, Roberta Mancuso, Simone Agostini, Mario Meloni, Mario Clerici
Summary: The etiology of Parkinson's disease is still unclear, but it is likely to involve both genetic and environmental factors. Studies have found dysregulated microRNA expression, specifically increased levels of miR-7-1-5p and miR-223-3p in the serum of Parkinson's patients, suggesting that these microRNAs could potentially serve as diagnostic biomarkers.
Article
Multidisciplinary Sciences
Elisa Zago, Alessandra Dal Molin, Giovanna Maria Dimitri, Luciano Xumerle, Chiara Pirazzini, Maria Giulia Bacalini, Maria Giovanna Maturo, Tiago Azevedo, Simeon Spasov, Pilar Gomez-Garre, Maria Teresa Perinan, Silvia Jesus, Luca Baldelli, Luisa Sambati, Giovanna Calandra-Buonaura, Paolo Garagnani, Federica Provini, Pietro Cortelli, Pablo Mir, Claudia Trenkwalder, Brit Mollenhauer, Claudio Franceschi, Pietro Lio, Christine Nardini
Summary: This study aims to investigate the relevance of microRNAs as biomarkers of Parkinson's Disease within the ageing framework. The down-regulation of hsa-miR-144-3p in early Parkinson's Disease patients and its involvement in the regulation of coagulation were consistently observed.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Yanyan Jiang, Jing Chen, Yunchuang Sun, Fan Li, Luhua Wei, Wei Sun, Jianwen Deng, Yun Yuan, Zhaoxia Wang
Summary: The combination of salivary miR-29a-3p and miR-29c-3p shows potential as a diagnostic biomarker for idiopathic PD. The expression level of miR-29a-3p in PD patients was significantly lower than ET patients, but higher than MSA patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Matthew Shew, Helena Wichova, Madeleine St Peter, Athanasia Warnecke, Hinrich Staecker
Summary: Meniere's disease patients exhibit unique miRNA expression profiles in both perilymph and serum, with miRNA-1299 being validated as downregulated in both serum and perilymph of Meniere's patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Yukichi Takada, Tatsuki Shibuta, Mayu Hatano, Kenichi Sato, Mari Koga, Ayaka Ishibashi, Tetsuhiro Harada, Takashi Hisatomi, Hanae Shimura, Noriyasu Fukushima, Kamonlak Leecharoenkiat, Supat Chamnanchanunt, Saovaros Svasti, Suthat Fucharoen, Tsukuru Umemura
Summary: Circulating microRNAs are useful biomarkers for hemolysis. The study found that blood drawing and pre-analytical modifications can lead to significant increases in RBC-related miRNAs, but these modifications do not interfere with the clinical utility of RBC-derived miRNAs as biomarkers for hemolytic diseases, such as anemia. Serum miR-451a was significantly elevated in patients with hemolytic anemia more than the levels of pre-analytical modification, suggesting its potential as a biomarker for this condition.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Mi Xiong, Qian Qian, Xue Liang, You-Dong Wei
Summary: In this study, we recruited 40 PD patients and 35 HC as controls. Serum LCN2 levels were not significantly increased in PD patients compared with HC. There was no significant difference in LCN2 levels between patients at early and advanced stage of PD, as well as between cognitively impaired PD patients, PD patients with normal cognition, and HC. Moreover, LCN2 had no correlation with disease duration, UPDRS III score, and MoCA score.
NEUROLOGICAL SCIENCES
(2022)
Article
Behavioral Sciences
Liwei Shen, Xiaoli Yang, Wenmei Lu, Weijie Chen, Xiaofei Ye, Danhong Wu
Summary: Abnormal blood pressure regulation is a common feature of autonomic dysfunction in Parkinson's disease patients. This study found significant differences in circadian blood pressure rhythm between different disease stages and subtypes of PD patients, with reverse dipping being more common in advanced PD patients. 24-hour ambulatory blood pressure monitoring is crucial for evaluating blood pressure alterations in PD patients and clinicians should be vigilant about reverse dipping to prevent serious clinical events.
BRAIN AND BEHAVIOR
(2022)
Article
Biochemistry & Molecular Biology
Fengyao Yan, Dan-Qian Chen, Jijun Tang, Ying-Yong Zhao, Yan Guo
Summary: Controlling blood pressure is crucial for curbing kidney function decline and reducing the risk of cardiovascular disease in chronic kidney disease (CKD) patients. Ten metabolites that have significant associations with blood pressure were identified, and their quantitative importance was verified.
Article
Radiology, Nuclear Medicine & Medical Imaging
Feng-Tao Liu, Jia-Ying Lu, Xin-Yi Li, Xiao-Niu Liang, Fang-Yang Jiao, Jing-Jie Ge, Ping Wu, Gen Li, Bo Shen, Bin Wu, Yi-Min Sun, Yu-Hua Zhu, Jian-Feng Luo, Tzu-Chen Yen, Jian-Jun Wu, Chuan-Tao Zuo, Jian Wang
Summary: This study aimed to investigate the distribution patterns and regional vulnerability of tau pathology in patients with PSP using F-18-Florzolotau PET imaging, and to devise a novel image-based staging system. The findings showed that F-18-Florzolotau PET imaging can effectively capture the distribution patterns and regional vulnerability of tau pathology in PSP patients. The F-18-Florzolotau modified staging system holds promise for early tracking of tau deposition in living brains.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Letter
Clinical Neurology
Xin-Yi Li, Fang-Yang Jiao, Rui-Xin Yao, Zi-Zhao Ju, Ming-Jia Chen, Jing-Jie Ge, Gen Li, Yi-Min Sun, Ping Wu, Jian-Jun Wu, Tzu-Chen Yen, Chuantao Zuo, Jian Wang, Jia-Ying Lu, Feng-Tao Liu
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Yilin Tang, Ling Li, Tianyu Hu, Fangyang Jiao, Linlin Han, Shiyu Li, Zhiheng Xu, Yun Fan, Yimin Sun, Fengtao Liu, Tzu-Chen Yen, Chuantao Zuo, Jian Wang
Summary: This study describes the results of F-18-florzolotau PET/CT imaging in patients with PDD. The findings showed significantly increased uptake of F-18-florzolotau in the cortical regions of PDD patients, especially in the temporal lobe. Furthermore, there was a significant correlation between F-18-florzolotau uptake in the occipital lobe and cognitive impairment.
MOVEMENT DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Yun Fan, Yunpeng Sun, Wenbo Yu, Youqi Tao, Wencheng Xia, Yiqi Liu, Qinyue Zhao, Yilin Tang, Yimin Sun, Fengtao Liu, Qin Cao, Jianjun Wu, Cong Liu, Jian Wang, Dan Li
Summary: We amplified α-syn aggregates from PD patients and found that fibrils derived from late-stage PD patients are most potent in inducing endogenous a-syn aggregation, followed by mid-stage and pre-stage PD fibrils. Cryo-electron microscopy revealed significant differences in conformational species among samples from different clinical stages. Our study suggests potential conformational transitions of a-syn fibrils during the progression of PD.
Article
Neurosciences
Xin-Yi Li, Ming-Jia Chen, Xiao-Niu Liang, Rui-Xin Yao, Bo Shen, Bin Wu, Gen Li, Yi-Min Sun, Jian-Jun Wu, Feng-Tao Liu, Yu-Jie Yang, Jian Wang
Summary: This study aimed to test the effectiveness of the short Parkinson's Disease Questionnaire-8 (PDQ-8) in assessing quality of life (QoL) in patients with progressive supranuclear palsy (PSP), compared to the PSP-QoL and PDQ-39. The results showed that PDQ-8 is an easy, reliable, and valid tool to evaluate QoL in PSP patients.
JOURNAL OF PARKINSONS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Eunhee Choi, Xiao-Chen Bai
Summary: The insulin receptor (IR) is a type II receptor tyrosine kinase that plays crucial roles in metabolism, growth, and proliferation. Recent advances in cryo-electron microscopy have allowed the determination of IR structures with different numbers of bound insulin molecules, providing important insights into the activation mechanism of this receptor. This review summarizes the insulin-induced activation mechanism of IR, including the binding modes and functions of insulin at different sites, as well as the structural transitions necessary for IR activation. It also highlights key aspects of IR signaling activation and regulation and suggests future research directions to fill the remaining gaps in our understanding.
ANNUAL REVIEW OF BIOCHEMISTRY
(2023)
Article
Clinical Neurology
Feng-Tao Liu, Jia-Ying Lu, Xin-Yi Li, Fang-Yang Jiao, Ming-Jia Chen, Rui-Xin Yao, Xiao-Niu Liang, Zi-Zhao Ju, Jing-Jie Ge, Gen Li, Bo Shen, Ping Wu, Jiong Song, Ji Li, Yi-Min Sun, Jian-Jun Wu, Tzu-Chen Yen, Jian-Feng Luo, Qian-hua Zhao, Chuantao Zuo, Jian Wang
Summary: This study used F-18-florzolotau PET imaging technology to analyze the spatial distribution of tau pathology in the brains of patients with CBS, and found that compared to other neurodegenerative tauopathies, patients with CBS showed higher F-18-florzolotau signals in cortical and subcortical regions, and exhibited an asymmetric pattern of F-18-florzolotau uptake associated with motor severity.
MOVEMENT DISORDERS
(2023)
Article
Multidisciplinary Sciences
Guipeun Kang, Corey A. H. Allard, Wendy A. A. Valencia-Montoya, Lena van Giesen, Jeong Joo Kim, Peter B. B. Kilian, Xiaochen Bai, Nicholas W. W. Bellono, Ryan E. E. Hibbs
Summary: The study reveals that both octopus and squid have evolved cephalopod-specific chemotactile receptors (CRs) to sense their marine environments, with structural adaptations supporting the sensation of specific molecules suited to distinct physiological roles. Squid express ancient CRs more resembling nicotinic acetylcholine receptors, while octopuses exhibit a more recent expansion in CRs consistent with their elaborate 'taste by touch' sensory system. This study provides a foundation for understanding how adaptation of protein structure drives the diversification of organismal traits and behaviour.
Article
Biochemistry & Molecular Biology
Liwei Wang, Catherine Hall, Jie Li, Eunhee Choi, Xiao-chen Bai
Summary: The authors used cryo-EM to determine the structures of alkaline pH-induced insulin receptor-related receptor (IRR), revealing the mechanism of IRR activation by pH. Unlike other members of the insulin receptor family, IRR is activated by alkaline pH instead of ligand binding. Through mutagenesis and cellular assays, it was shown that the repulsion of pH-sensitive motifs disrupts the autoinhibited state of IRR and leads to a T-shaped active conformation. This study uncovers a novel pH-dependent activation mechanism of IRR, providing insights into its structure-function relationship.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Tian Xie, Guangjun Xu, Yun Liu, Bradley Quade, Weichun Lin, Xiao-chen Bai
Summary: MuSK is a receptor tyrosine kinase that is essential for the neuromuscular junction. Its activation requires both agrin and LRP4 coreceptors. This study presents the cryo-EM structure of the extracellular ternary complex of agrin/LRP4/MuSK, revealing how LRP4 recruits agrin and MuSK to activate MuSK receptor.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Shun Liu, Hua Chen, Yan Yin, Defen Lu, Guoming Gao, Jie Li, Xiao-Chen Bai, Xuewu Zhang
Summary: This study reveals that the nuclear protein BCCIP alpha binds to FAM46 and inhibits its PAP activity, thus affecting RNA stability. Structural analysis shows that BCCIP alpha, despite sharing most of the sequence with BCCIPII, adopts a unique fold completely different from BCCIPII. The unique fold of BCCIP alpha underlies its interaction with and functional regulation of FAM46.
Article
Biochemistry & Molecular Biology
Hongshan Zhang, Zhubing Shi, Edward J. Banigan, Yoori Kim, Hongtao Yu, Xiao-chen Bai, Ilya J. Finkelstein
Summary: This study provides direct evidence that CTCF binding polarity controls cohesin-mediated DNA looping and organization of the three-dimensional genome. It reveals that a specific motif of CTCF blocks cohesin translocation and DNA looping, and that CTCF polarity affects the compaction of DNA by cohesin. It also suggests that RNA-DNA hybrids may play a role in forming TAD boundaries and inhibiting DNA compaction by cohesin.
Review
Cell Biology
Xiao-chen Bai, Tamir Gonen, Angela M. Gronenborn, Anastassis Perrakis, Andrea Thorn, Jianyi Yang
Summary: Deciphering the intricate architecture of macromolecules is a formidable task, requiring a combination of empirical experimentation and artificial intelligence-based techniques. This Viewpoint discusses the key challenges and opportunities in this process.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Liwei Wang, Catherine E. Hall, Emiko Uchikawa, Dailu Chen, Eunhee Choi, Xuewu Zhang, Xiao-chen Bai
Summary: The researchers characterized insulin fibrils using cryo-EM and solved the structure of one fibril form. They designed several insulin mutants that can reduce fibrillation while maintaining the activity of insulin signaling, which may lead to more effective therapeutics for type 1 diabetes.
Article
Pediatrics
Yunlong Zhao, Ying Wang, Chao Liu, Yulin Jiang, Yandong Wei, Hua Meng, Shan Jian, Xiting Zhu, Lijian Pei, Xiaochen Bai, Feng Feng, Yan Lv, Xiya Zhou, Qingwei Qi, Jingna Li, Lishuang Ma
Summary: This study reports the experience of using ex utero intrapartum therapy (EXIT) in fetuses with congenital diaphragmatic hernia (CDH). The results show that EXIT can be performed safely in selected CDH neonates, leading to potentially better survival rates without causing more maternal complications.
WORLD JOURNAL OF PEDIATRIC SURGERY
(2022)