Creation and Initial Characterization of Isogenic Helicobacter pylori CagA EPIYA Variants Reveals Differential Activation of Host Cell Signaling Pathways

CagA Phosphorylation in Helicobacter pylori-Infected B Cells Is Mediated by the Nonreceptor Tyrosine Kinases of the Src and Abl Families

(2016) Linda M. Krisch et al.   INFECTION AND IMMUNITY

Helicobacter pylori Diversity and Gastric Cancer Risk

(2016) Timothy L. Cover   mBio

Nutrition andHelicobacter pylori: Host Diet and Nutritional Immunity Influence Bacterial Virulence and Disease Outcome

(2016) Kathryn P. Haley et al.   Gastroenterology Research and Practice

Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b

(2016) Hiroko Nishikawa et al.   Scientific Reports

The CagA toxin of Helicobacter pylori: abundant production but relatively low amount translocated

(2016) Luisa F. Jiménez-Soto et al.   Scientific Reports

Helicobacter pylori-induced epithelial-mesenchymal transition, a potential role of gastric cancer initiation and an emergence of stem cells

(2015) Yoon Jin Choi et al.   CARCINOGENESIS

Helicobacter pyloriCagA protein induces factors involved in the epithelial to mesenchymal transition (EMT) in infected gastric epithelial cells in an EPIYA- phosphorylation-dependent manner

(2015) Ioanna S. Sougleri et al.   FEBS Journal

Composition, structure and function of theHelicobacter pylori cagpathogenicity island encoded type IV secretion system

(2015) Steffen Backert et al.   Future Microbiology

Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein

(2015) Nobumi Suzuki et al.   Scientific Reports

Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis

(2015) Lisa Nagase et al.   Scientific Reports

A Specific A/T Polymorphism in Western Tyrosine Phosphorylation B-Motifs Regulates Helicobacter pylori CagA Epithelial Cell Interactions

(2015) Xue-Song Zhang et al.   PLoS Pathogens

CD44 Plays a Functional Role in Helicobacter pylori-induced Epithelial Cell Proliferation

(2015) Nina Bertaux-Skeirik et al.   PLoS Pathogens

Helicobacter pyloritargets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells

(2014) Lydia E Wroblewski et al.   GUT

Helicobacter pylori Promotes Epithelial–Mesenchymal Transition in Gastric Cancer by Downregulating Programmed Cell Death Protein 4 (PDCD4)

(2014) Han Yu et al.   PLoS One

H. pylori virulence factor CagA increases intestinal cell proliferation by Wnt pathway activation in a transgenic zebrafish model

(2013) J. T. Neal et al.   Disease Models & Mechanisms

Helicobacter pylori generates cells with cancer stem cell properties via epithelial–mesenchymal transition-like changes

(2013) E Bessède et al.   ONCOGENE

Presence of Terminal EPIYA Phosphorylation Motifs in Helicobacter pylori CagA Contributes to IL-8 Secretion, Irrespective of the Number of Repeats

(2013) Konstantinos S. Papadakos et al.   PLoS One

Helicobacter pylori Initiates a Mesenchymal Transition through ZEB1 in Gastric Epithelial Cells

(2013) Jessica Baud et al.   PLoS One

A Mutagenesis Method for the Addition and Deletion of Highly Repetitive DNA Regions: The Paradigm of EPIYA Motifs in thecagAGene ofHelicobacter pylori

(2012) Konstantinos S. Papadakos et al.   HELICOBACTER

c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains

(2012) Doreen Mueller et al.   JOURNAL OF CLINICAL INVESTIGATION

Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling

(2011) Kenji Kikuchi et al.   MICROBES AND INFECTION

Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoprotein

(2010) Masanori Hatakeyama   CANCER SCIENCE

Helicobacter pylori Exploits Host Membrane Phosphatidylserine for Delivery, Localization, and Pathophysiological Action of the CagA Oncoprotein

(2010) Naoko Murata-Kamiya et al.   Cell Host & Microbe

The Versatility of Helicobacter pylori CagA Effector Protein Functions: The Master Key Hypothesis

(2010) Steffen Backert et al.   HELICOBACTER

Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation

(2009) Masato Suzuki et al.   Cell Host & Microbe

Polymorphism in the CagA EPIYA Motif Impacts Development of Gastric Cancer

(2009) K. R. Jones et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A Single Nucleotide Change Affects Fur-Dependent Regulation of sodB in H. pylori

(2009) Beth M. Carpenter et al.   PLoS One

The Complete Genome Sequence of Helicobacter pylori Strain G27

(2008) D. A. Baltrus et al.   JOURNAL OF BACTERIOLOGY

Functional association between the Helicobacter pylori virulence factors VacA and CagA

(2008) R. H. Argent et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Differences in Helicobacter pylori CagA tyrosine phosphorylation motif patterns between western and East Asian strains, and influences on interleukin-8 secretion

(2008) R. H. Argent et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

(2008) N. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Transgenic Drosophila Model Demonstrates That the Helicobacter pylori CagA Protein Functions as a Eukaryotic Gab Adaptor

(2008) Crystal M. Botham et al.   PLoS Pathogens

Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells

(2003) Steffen Backert et al.   MOLECULAR MICROBIOLOGY