Article
Cell Biology
Guanzheng Liu, Jiefeng Yu, Runqiu Wu, Lin Shi, Xu Zhang, Wanhong Zhang, Xiaomin Zhong, Yifeng Wang, Huan Li, Yang Shen, Changyong Wu, Rutong Yu, Mingshan Niu, Xuejiao Liu
Summary: The study identified a potential therapeutic strategy by inducing UPR in GBM cells through UBA1 inhibition. This approach showed significant anti-tumor effects in animal models, with a greater impact on GBM stem cells, and highlighted GRP78 as a potential molecular marker for personalized treatment targeting UBA1.
CELL DEATH & DISEASE
(2021)
Article
Clinical Neurology
Juanjuan Luo, Pei Liu, Chunjiao Lu, Wanping Bian, Dongsheng Su, Chenchen Zhu, Shaolin Xie, Yihang Pan, Ningning Li, Wei Cui, De-Sheng Pei, Xiaojun Yang
Summary: The molecular pathogenesis of glioblastoma is critical for human gliomagenesis, with RTK/Ras/PI3K, RB, and TP53 pathways playing key roles. Using transgenic zebrafish with single or multiple gene deletions, researchers induced gliomagenesis and found that nf1 mutation alone had low efficiency, but combined deletions of nf1;tp53 and rb1;tp53 resulted in higher tumor incidences with advanced histology. Bioinformatics analysis revealed alterations in critical pathways like RTK/Ras/PI3K, cell cycle, and focal adhesion, highlighting their importance in gliomagenesis initiation and development. Tumors in zebrafish models showed significant similarities to human gliomas, and temozolomide treatment effectively suppressed gliomagenesis, mimicking responses seen in clinical glioma treatment. This study provides a potential tool for genetically studying gliomagenesis and screening targeted anti-tumor compounds for glioma treatment.
Article
Clinical Neurology
Juanjuan Luo, Pei Liu, Chunjiao Lu, Wanping Bian, Dongsheng Su, Chenchen Zhu, Shaolin Xie, Yihang Pan, Ningning Li, Wei Cui, De-Sheng Pei, Xiaojun Yang
Summary: The research indicates that combined deletions of nf1, tp53, and rb1 genes in zebrafish greatly promote gliomagenesis, with these glioma models showing relevance to temozolomide treatment.
Article
Oncology
Zhe Tang, Patrick G. Pilie, Chuandong Geng, Ganiraju C. Manyam, Guang Yang, Sanghee Park, Daoqi Wang, Shan Peng, Cheng Wu, Guang Peng, Timothy A. Yap, Paul G. Corn, Bradley M. Broom, Timothy C. Thompson
Summary: ATR inhibitors in prostate cancer can activate immune pathways and induce cell autophagy, and when combined with anti-PD-L1 therapy, can result in a synergistic effect, providing therapeutic responses for CRPC patients.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Eva Ari Wahyuni, Chin-Yuan Yii, Hsiao-Lan Liang, Yueh-Hsia Luo, Sheng-Hua Yang, Pei-Yi Wu, Wei-Lun Hsu, Chung-Yi Nien, Ssu-Ching Chen
Summary: Selenocystine (SeC) has been identified as a novel compound with broad-spectrum anticancer activity. It selectively induces cytotoxicity and genotoxicity against HepG2 hepatoma cell line. SeC suppresses DNA homologous recombination repair and generates reactive oxygen species (ROS), leading to DNA damage and apoptosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Roxana Deleanu, Laura Cristina Ceafalan, Anica Dricu
Summary: Recent studies have uncovered surprising levels of cell diversity in the human brain, revealing complex cellular hierarchies and signaling pathways in neural cells. It has been found that brain tumor cells share properties with neural stem and progenitor cells, suggesting potential for therapeutic interventions by targeting relevant signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Zhonghui Bai, Kun Jia, Guilan Chen, Xinjun Liao, Zigang Cao, Yangqi Zhao, Chunping Zhang, Huiqiang Lu
Summary: Exposure to CBZ induced severe hepatotoxicity in zebrafish by promoting lipid accumulation, generating excessive ROS production, and inhibiting the Wnt/beta-catenin signaling pathway. These findings highlight the environmental concerns associated with CBZ exposure.
ENVIRONMENTAL POLLUTION
(2021)
Article
Medicine, Research & Experimental
Chuanhong Zhong, Bei Tao, Fangli Tang, Xiaobo Yang, Tangming Peng, Jian You, Kaiguo Xia, Xiangguo Xia, Ligang Chen, Lilei Peng
Summary: Cancer development, especially in glioma, involves complex interactions between extracellular matrix components, such as type I collagen and fibronectin, and signaling pathways like PI3K/AKT/SOX2 and CDC42/YAP-1/NUPR1/Nestin. Inhibiting the integrin alpha v beta 3 pathway shows promise in suppressing tumor growth and reducing cancer relapse, providing new insights for potential glioma therapy strategies.
Article
Biophysics
Yao Wang, Jing He, Junwei Zhang, Nihui Zhang, Yong Zhou, Fang Wu
Summary: The current design scheme on anti-cancer materials focuses on tuning the mechanical properties of materials and inducing apoptosis in cancer cells through the Rho/ROCK signaling pathway. The study proposes that tuning cell motility could be another important approach to modifying the tumor microenvironment and inducing tumor apoptosis. RGD-modified substrates were used to regulate cell motility, and the effect of motility on tumor cell apoptosis and the involvement of the Wnt signaling pathway were examined. The findings suggest that RGD modification can effectively tune the motility of cancer cells, while high RGD concentration can suppress cell migration and increase the apoptosis rate. The activation of the Wnt-beta-catenin pathway further confirms the critical role of the Wnt pathway in motility-regulated apoptosis of tumor cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Endocrinology & Metabolism
Lichao Zhang, Shaoxia Zi
Summary: This study demonstrates that parthenolide inhibits cell viability and induces apoptosis in melanoma cells through the inhibition of the PI3K/AKT signaling pathway. It may serve as an adjuvant therapy.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Oncology
Mariam Markouli, Dimitrios Strepkos, Kostas A. Papavassiliou, Athanasios G. Papavassiliou, Christina Piperi
Summary: Epigenetic mechanisms play a role in regulating key metabolic pathways in glioblastoma cells, increasing their heterogeneity and plasticity. These mechanisms have the potential to be targeted for therapy and improving treatment strategies.
Article
Cell Biology
Alhaji H. Janneh, Mohamed Faisal Kassir, F. Cansu Atilgan, Han Gyul Lee, Megan Sheridan, Natalia Oleinik, Zdzislaw Szulc, Christina Voelkel-Johnson, Hung Nguyen, Hong Li, Yuri K. Peterson, Elisabetta Marangoni, Ozge Saatci, Ozgur Sahin, Michael Lilly, Carl Atkinson, Stephen Tomlinson, Shikhar Mehrotra, Besim Ogretmen
Summary: This study reveals how oncogenic sphingosine 1-phosphate (S1P) metabolism activates C3 complement and induces NLRP3/inflammasome activation, enhancing cell migration/metastasis. Furthermore, activation of the S1PR1/C3/PPIL1/NLRP3 signaling axis is associated with metastatic melanoma, and targeting this axis can prevent lung colonization/metastasis.
Article
Chemistry, Multidisciplinary
Ru Wang, Bo Yang, Beibei Zhang, Qinqin Zhang, Bing Cao, Jufang Jia, Meng Liu, Pengli Guo, Yuhan Zhang, Xiaokun Li, Xiaoke Zheng, Weisheng Feng
Summary: In this study, a new amide alkaloid, ZYL-01, was synthesized and found to inhibit melanoma cell proliferation and migration by inducing cell apoptosis through inhibiting the STAT3 signaling pathway.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ruye Ma, Dandan Yu, Yu Peng, Hongfei Yi, Yingcong Wang, Taofang Cheng, Bingqing Shi, Guang Yang, Weiming Lai, Xiaosong Wu, Ye Lu, Jumei Shi
Summary: Resveratrol showed anti-tumor effects against multiple myeloma (MM) by promoting apoptosis and autophagy, leading to inhibition of cell viability and colony formation in MM cell lines U266, RPMI-8226, and NCI-H929. The involvement of autophagy in the anti-MM activity of resveratrol was confirmed, suggesting that resveratrol may be a potential therapeutic strategy for MM treatment.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Cell Biology
Hyun-Ji Cho, Jeong-A Hwang, Eun Jae Yang, Eok-Cheon Kim, Jae-Ryong Kim, Sung Young Kim, Young Zoon Kim, Sang Chul Park, Young-Sam Lee
Summary: In this study, it was found that Nintedanib can be used as a new senolytic agent, selectively inducing the death of senescent cells. It achieves drug-induced death by inhibiting the STAT3 pathway and reduces the number of senescent cells and collagen deposition.
CELL DEATH & DISEASE
(2022)
Article
Neurosciences
Xia Lei, Hanxia Li, Min Li, Qiwei Dong, Huayang Zhao, Zongyong Zhang, Baoliang Sun, Leilei Mao
Summary: In this study, it was found that by activating the Nrf2 pathway, CDDO-EA can exert neuroprotective effects against ischemic injury, improving neurological function after cerebral ischemia, reducing infarct size and neuronal apoptosis, and modulating microglia/macrophage polarization towards an anti-inflammatory M2 phenotype.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Ping Li, Chao Yu, Fan-Shuo Zeng, Xiaoyan Fu, Xiao-Jing Yuan, Qin Wang, Cundong Fan, Bao-Liang Sun, Qiang-San Sun
Summary: The study found that Lic-A significantly attenuated CCI-induced neuropathic pain by inhibiting microglia activation and inflammatory response. This suggests that Lic-A may be a potential drug for treating neuropathic pain.
NEUROCHEMICAL RESEARCH
(2021)
Article
Clinical Neurology
Jing-yi Sun, Shi-jun Zhao, Hong-bin Wang, Ya-jun Hou, Qiong-jie Mi, Ming-feng Yang, Hui Yuan, Qing-bin Ni, Bao-liang Sun, Zong-yong Zhang
Summary: Excessive glutamate leading to excitotoxicity can worsen brain damage after SAH, and the drug ifenprodil, as a non-competitive antagonist of NMDA receptor, shows promise in improving long-term neurological deficits by attenuating neuronal death, calcium overload, BBB damage, and cerebral edema.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Kun Wang, Qian Wang, Qinghao Li, Zhaoqiang Zhang, Jing Gao, Cundong Fan, Baoliang Sun, Qingbin Ni
Summary: The study demonstrated that WIN inhibits proliferation, migration, and invasion of U251 human glioma cells by inducing ROS-dependent DNA damage and dysfunction of the VEGF-AKT/FAK signal axis, leading to apoptosis. These findings suggest a potential therapeutic application of WIN in glioblastoma treatment.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Dongdong Sun, Zekun Wang, Pu Zhang, Chenyang Yin, Jingyuan Wang, Yu Sun, Ying Chen, Weiyun Wang, Baoliang Sun, Cundong Fan
Summary: The novel ruthenium-loaded palmitoyl ascorbate-modified mesoporous silica (Ru@SiO2-PA) showed enhanced growth inhibition and apoptosis induction in cancer cells while displaying super selectivity between cancer cells and normal cells. Real-time imaging confirmed its accumulation in the cell nucleus and tumor xenografts, with no observed side effects, suggesting its potential for safe clinical applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Cell Biology
Lei Zhang, Cundong Fan, Hua-Chen Jiao, Qian Zhang, Yue-Hua Jiang, Jie Cui, Yang Liu, Yong-Hao Jiang, Juan Zhang, Meng-Qi Yang, Yan Li, Yi-Tao Xue
Summary: This study confirmed that Calycosin can alleviate doxorubicin-induced cardiotoxicity and pyroptosis, possibly by inhibiting the activation of the NLRP3 inflammasome.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Chemistry, Multidisciplinary
Yu Sun, Pu Zhang, Yuqing Li, Yajun Hou, Chenyang Yin, Zekun Wang, Ziyu Liao, Xiaoyan Fu, Man Li, Cundong Fan, Dongdong Sun, Liang Cheng
Summary: Mitochondrial dysfunction and oxidative damage are important mechanisms of myocardial ischemia-reperfusion injury. Designing gold-selenium nanostructures with targeting capabilities can attenuate cellular damage and oxidative stress, improving myocardial function through the regulation of MAPK and PI3K/AKT pathways.
Article
Medicine, Research & Experimental
Ya-jun Hou, Dawei Li, Weiqi Wang, Leilei Mao, Xiaoyan Fu, Baoliang Sun, Cundong Fan
Summary: This study evaluated the anticancer effects and mechanism of NT157 against human glioma growth, and found that NT157 alone inhibited glioma cell growth by regulating cell cycle, promoting apoptosis, and inducing DNA damage and dysfunction of signaling pathways. Combined treatment with TRAIL further enhanced apoptosis by upregulating DR5 and inducing DNA damage.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Zekun Wang, Pu Zhang, Chenyang Yin, Yuqing Li, Ziyu Liao, Chenhao Yang, Hang Liu, Weiyun Wang, Cundong Fan, Dongdong Sun, Liang Cheng
Summary: Irreversible bacterial resistance and impenetrable biofilms have made conventional antibiotic therapy ineffective. However, antibiotic carbon nanodots (CDs) have been found to exhibit potent antibacterial activity. In this study, kanamycin-sulfate-derived carbon nanodots (KCDs) were shown to inhibit the activity of Staphylococcus aureus beta-ketoacyl-acp synthase III (FabH) through molecular docking. Additionally, a multifunctional hydrogel (CG-KCDs) self-assembled into injectable, self-healing, and antibiofilm structures with enhanced antibacterial activity under laser irradiation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ming-feng Yang, Sheng-yao Sun, Hai-guang Lv, Wei-qi Wang, Han-xia Li, Jing-yi Sun, Zong-yong Zhang
Summary: In this study, we found that the phosphorylation level of Erk1/2 was significantly increased in the cerebrospinal fluid of SAH patients and in the cerebrospinal fluid and basal cortex of rats. Treatment with RAH could reduce the phosphorylation level of Erk1/2, improve neurological deficits in rats after SAH, and protect the blood-brain barrier from damage.
Review
Biochemistry & Molecular Biology
Qi Wang, Jingyi Sun, Tian Chen, Siyu Song, Yajun Hou, Lina Feng, Cundong Fan, Mingquan Li
Summary: Alzheimers disease is a neurodegenerative disorder with a rapidly increasing mortality rate. Regulation of cell death plays a crucial role in maintaining homeostasis, and studies have found that ferroptosis, pyroptosis, and cuproptosis are closely related to the development of Alzheimers disease.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Jingyuan Wang, Zekun Wang, Yuqing Li, Yajun Hou, Chenyang Yin, Endong Yang, Ziyu Liao, Cundong Fan, Lisandra L. Martin, Dongdong Sun
Summary: A multifunctional double selenium nanosphere (CLNDSe) was designed and prepared, which showed targeted delivery to the blood brain barrier (BBB) by modifying A(2A)AR agonist. This novel strategy may ameliorate Alzheimer's disease by inhibiting neural ferroptosis.
Article
Chemistry, Multidisciplinary
Zekun Wang, Nana Yang, Yajun Hou, Yuqing Li, Chenyang Yin, Endong Yang, Huanhuan Cao, Gaofei Hu, Jing Xue, Jialei Yang, Ziyu Liao, Weiyun Wang, Dongdong Sun, Cundong Fan, Lemin Zheng
Summary: Cardiovascular disease is the leading cause of death globally. Reperfusion therapy is crucial for patient survival after a heart attack but can contribute to myocardial ischemia/reperfusion injury (MI/RI). Nitric oxide (NO) has potential for treating MI/RI, but its oxidation by reactive oxygen species (ROS) leads to secondary cardiomyocyte damage. In this study, L-arginine-loaded selenium-coated gold nanocages modified with a peptide exhibit enhanced targeting of cardiomyocytes and improved imaging capabilities. The administration of these nanocages effectively inhibits cell damage and apoptosis, restores mitochondrial function, and regulates NO signaling, ultimately attenuating MI/RI in rats.
Article
Medicine, Research & Experimental
Chenyang Yin, ZeKun Wang, Chunxue Dai, Bangjia Yang, Weiyun Wang, Endong Yang, Feng Guo, Cundong Fan, Pu Zhang, Jikui Sun, Dongdong Sun
Summary: This study proposes a new strategy to enhance the effectiveness of photodynamic therapy (PDT) and photothermal therapy (PTT) for tumor treatment by utilizing a hybrid of photosynthetic bacteria/photosensitizer/photothermal agent to generate oxygen through photosynthesis. The combination of photosensitizer and photothermal agent with photosynthetic bacteria effectively enhances their accumulation in tumor tissues, and the oxygen produced through photosynthesis is converted to reactive oxygen species (ROS) to further enhance the therapeutic effect.
Review
Biochemistry & Molecular Biology
Qi Wang, Jingyi Sun, Tian Chen, Siyu Song, Yajun Hou, Lina Feng, Cundong Fan, Mingquan Li
Summary: Alzheimer's disease, the most common form of dementia, is characterized by progressive cognitive dysfunction in elderly individuals. Regulatory cell death, including ferroptosis, pyroptosis, and cuproptosis, has been found to be closely related to the occurrence and development of AD. Understanding the molecular mechanisms of these processes may lead to potential therapeutic targets for AD.
ACS CHEMICAL NEUROSCIENCE
(2023)