Article
Biochemistry & Molecular Biology
Rong Cao, Lin Li, Wen Zhang, Jun Lu, Yu Wang, Qian Chen, Wentong Zhang, Mingming Chen, Liang Sheng, Keshu Cai, Guangxu Xu
Summary: The study found that melatonin only enhanced cognition when administered during the early pathological stages of TBI, with no effect in the late (chronic) stages. Furthermore, an increase in neuronal activity and inhibition of astrocyte reactivation were observed in cognition-related brain regions such as the medial prefrontal cortex and hippocampus.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian-Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez-Pinilla, Zhen Zhao
Summary: This study demonstrates that microvascular injury plays a key role in the pathogenesis of Alzheimer's disease after mild traumatic brain injury. Restoring vascular functions may be beneficial for patients with mild TBI and potentially reduce the risk of developing AD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Behavioral Sciences
Mohammed M. Alnawmasi, Jacinta A. Walz, Sieu K. Khuu
Summary: Visual attentional deficits are observed in patients with mild traumatic brain injury (TBI). In this study, the ability to orient visual attention (using endogenous and exogenous cues) was examined in TBI patients using a modified Posner visual search task. The results showed that TBI patients had impaired discrimination accuracy and were insensitive to the type of visual cue, suggesting deficits in both endogenous and exogenous visual attention. These findings highlight the attentional and cognitive difficulties that TBI patients may face in daily life.
Article
Endocrinology & Metabolism
Antoine Drieu, Anastasia Lanquetin, Paul Prunotto, Zuhal Gulhan, Swannie Pedron, Gloria Vegliante, Daniele Tolomeo, Sophie Serriere, Johnny Vercouillie, Laurent Galineau, Clovis Tauber, Bertrand Kuhnast, Marina Rubio, Elisa R. Zanier, Damien Levard, Sylvie Chalon, Denis Vivien, Carine Ali
Summary: This study investigates the relationship between cognitive dysfunction and neuro-inflammation caused by mild traumatic brain injury (TBI) using animal models and imaging techniques. The results show that even without evidence of brain contusion or bleeding, mild TBI can lead to persistent behavioral deficits and can be detected by PET imaging.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Chen-Mei Chen, Pei-Yu Gung, Yen-Chun Ho, Candra D. D. Hamdin, Shaw-Fang Yet
Summary: This study found that probucol can improve functional recovery and cognitive impairment after traumatic brain injury (TBI) by promoting neuroregeneration and neuronal remodeling. In addition, probucol exerts its neuroregenerative effects by increasing the expression of BDNF and activation of TrkB. Therefore, probucol may be a promising new drug for the treatment of TBI.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Ashfaq Ahmed Khan Malik, Waqas Ahmad, Farhan Younas, Haroon Badshah, Shatha Alharazy, Shafiq Ur Rehman, Muhammad Imran Naseer, Osama Yousef Muthaffar, Rehmatullah Achakzai, Ikram Ullah
Summary: Traumatic brain injury (TBI) is a major cause of mortality and a significant public health concern. This study investigated the neuroprotective effects of Troxerutin, a natural flavonoid, in a closed brain injury mouse model. The results demonstrated that pre-treatment with Troxerutin improved neurological functions, reduced brain edema, enhanced cognitive behavior, decreased Reactive Oxygen Species (ROS), and improved neuronal morphology and survival.
Article
Neurosciences
Jared A. Smith, Tyler Nguyen, Brittany C. Davis, Debomoy K. Lahiri, Takashi Hato, Alexander G. Obukhov, Fletcher A. White
Summary: This study aimed to investigate the peripheral innate immune response after repeated TBIs and repurpose the nonselective beta blocker propranolol as a novel mTBI therapy. The results showed significant changes in gene expression in bone marrow following drug alone, mTBI alone, and drug combined with mTBI. The findings suggest that a single dose propranolol injection may be a potential acute mTBI therapy.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Rodrigo G. Mira, Rodrigo A. Quintanilla, Waldo Cerpa
Summary: Traumatic brain injury (TBI) is brain damage caused by external forces. Mild TBI (mTBI) is the most common type of TBI and repeated mTBI increases the risk of neurodegenerative diseases. This study evaluated mitochondrial calcium dynamics in an mTBI mouse model using isolated hippocampal mitochondria. The findings showed that mTBI results in decreased mitochondrial membrane potential, increased basal matrix calcium levels, and increased NCLX protein levels.
Article
Neurosciences
Fernando da Silva Fiorin, Caroline Cunha do Espirito Santo, Raphael Santos do Nascimento, Angela Patricia Franca, Luiz Fernando Freire Royes
Summary: This study provides a detailed characterization of the behavioral deficits induced by mild fluid percussion injury (FPI). The results show that mild FPI leads to a decrease in sweet liquid consumption, reduced social interaction time, and long-term memory deficits.
NEUROSCIENCE LETTERS
(2024)
Article
Immunology
Esber S. Saba, Mona Karout, Leila Nasrallah, Firas Kobeissy, Hala Darwish, Samia J. Khoury
Summary: The study found that TBI leads to an increase in activated microglia, which is negatively correlated with spatial learning and memory abilities 35 days post-injury. The findings could help define therapeutic windows and improve patient outcomes.
CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mohammed M. Alnawmasi, Sieu K. Khuu
Summary: This study investigated the impact of TBI on the allocation and maintenance of visual attention to multiple moving targets using a multiple object tracking task. The results showed that patients with mild TBI had greater deficits in maintaining visual attention and detecting targets, particularly when the tracking load and distraction increased.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Shawn R. Eagle, Ava M. Puccio, Lindsay D. Nelson, Michael McCrea, Joseph Giacino, Ramon Diaz-Arrastia, William Conkright, Sonia Jain, Xiaoying Sun, Geoffrey Manley, David O. Okonkwo
Summary: Obesity is associated with higher symptomatology and blood inflammatory markers in recovery following mTBI. The study found that obese patients had higher concentrations of hsCRP and IL-6 at multiple time points after injury, as well as higher RPQ scores at 6 and 12 months.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Immunology
Dong Wang, Shishuang Zhang, Xintong Ge, Zhenyu Yin, Meimei Li, Mengtian Guo, Tianpeng Hu, Zhaoli Han, Xiaodong Kong, Dai Li, Jing Zhao, Lu Wang, Qiang Liu, Fanglian Chen, Ping Lei
Summary: This study found that repetitive mild traumatic brain injury (rmTBI) leads to changes in biomarker levels related to ferroptosis, and treatment with mesenchymal stromal cells (MSCs) can alleviate neuronal damage and improve cognitive function caused by rmTBI, partially through inhibiting ferroptosis.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Sathiya Sekar, Raja Solomon Viswas, Hajar Miranzadeh Mahabadi, Elahe Alizadeh, Humphrey Fonge, Changiz Taghibiglou
Summary: The study revealed a molecular link between PrPc and brain insulin resistance, showing that both single and repeated mild TBI can lead to reduced glucose uptake in mice brains, as well as motor and cognitive deficits, disrupting interactions between related proteins. This provides a new insight into the pathogenesis of brain injury, potentially leading to the development of new therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Tianyao Wang, Yujie Hu, Danni Wang, Jun Liu, Jiahua Sun, Chunxiao Wei, Hui Dai, Yao Li
Summary: This study revealed impaired verbal memory and language functions in patients with acute mTBI, possibly related to the damage in different subsegments of the AF tracts.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Biochemistry & Molecular Biology
Yan Yun, Yun Zhang, Chen Zhang, Liyan Huang, Shichuan Tan, Pin Wang, Carles Vilarino-Guell, Weihong Song, Xiulian Sun
Summary: The study reveals that RCAN1 is a novel RNA-binding protein, and its RNA aptamer can block RCAN1-induced inhibition of NFAT and NF-kappa B signaling pathways, reducing neuronal apoptosis and playing a neuroprotective role.
MOLECULAR PSYCHIATRY
(2021)
Article
Biotechnology & Applied Microbiology
Kaixin Qiu, Shuai Wang, Xin Wang, Fengting Wang, Yili Wu
BIOMED RESEARCH INTERNATIONAL
(2020)
Review
Clinical Neurology
Yuqing Wang, Debiao Liu, Xuezhi Li, Yan Liu, Yili Wu
Summary: This study suggests that the use of antidepressants may be a risk factor for the new onset of T2DM, particularly tricyclic antidepressants. The risk of T2DM increases in a linear trend with the duration of antidepressant use. Routine T2DM screening is recommended for antidepressant users.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Yan Liu, Song Yue, Xiaoran Hu, Jin Zhu, Zifan Wu, JianLi Wang, Yili Wu
Summary: This study found that specific factors such as suicidal ideation, quarreling with parents, insomnia, difficulty in concentrating during online learning, and anxious and depressed mood during lockdown were positively associated with depression and anxiety among children and adolescents after COVID-19 pandemic lockdown. Missing teachers was negatively associated with both depression and anxiety. Living in urban areas and not living with parents were positively associated with depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Editorial Material
Neurosciences
Keenan Sterling, Mengen Xing, Weihong Song
NEUROSCIENCE BULLETIN
(2022)
Review
Neurosciences
Lina Gao, Yun Zhang, Keenan Sterling, Weihong Song
Summary: Synaptic abnormalities are a key aspect of Alzheimer's disease, connecting pathological changes to cognitive impairment. Brain-derived neurotrophic factors are crucial in synaptic plasticity for learning and memory, and have potential as diagnostic biomarkers and therapeutic molecules for AD. The exact mechanisms underlying the effects of impaired BDNF signaling on AD are still unclear.
TRANSLATIONAL NEURODEGENERATION
(2022)
Review
Biochemistry & Molecular Biology
Lin Peng, Isabel Bestard-Lorigados, Weihong Song
Summary: Alzheimer's disease is a neurodegenerative disorder that severely impairs memory and cognition. It is characterized by Aβ deposition, tau tangles, synaptic abnormalities, and dysfunctions. Targeting the synapse and early treatment windows hold promise for finding effective treatments for AD patients.
MOLECULAR PSYCHIATRY
(2022)
Article
Environmental Sciences
Zhengkang Su, Kaiyu Guan, Yunbin Liu, Hai Zhang, Zhengwei Huang, Miaomiao Zheng, Ya Zhu, He Zhang, Weihong Song, Xi Li
Summary: The use of clinical psychoactive drugs can pose unpredictable threats to fetal development. Opicapone, a newly effective peripheral COMT inhibitor, is used for the treatment of Parkinson's disease and other dopamine-related disorders. However, the impact of opicapone on embryonic development is still unknown.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Juelu Wang, Peiye Chen, Bolang Hu, Fang Cai, Qin Xu, Sipei Pan, Yili Wu, Weihong Song
Summary: Alzheimer's disease (AD) and Parkinson's disease (PD) are age-related neurodegenerative disorders that cause specific neuronal loss in the cholinergic and dopaminergic systems, respectively. The mutations in APP(SWE) and SNCA(A53T) have been implicated in the pathology of AD and PD, promoting the generation of A beta and the aggregation of alpha-synuclein, respectively. We found that SDC3 and FGFRL1 genes were differentially expressed in cells carrying these mutations and their knockdown attenuated cell death induced by oxidative stress.
Review
Biochemistry & Molecular Biology
Jing Yao, Zhe Wang, Weihong Song, Yun Zhang
Summary: Neuroinflammation is a crucial pathological feature in neurological diseases, including Alzheimer's disease (AD). NLRP3, a member of the NLRs family, is primarily expressed in microglia and plays a significant role in inflammation by activating the NLRP3 inflammasome to release proinflammatory cytokines and cause pyroptosis. Recent studies have also highlighted the importance of neuronal NLRP3 in the pathogenesis of neurological disorders.
MOLECULAR PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Yi Xu, Hongshen Yang, Zhou Jin, Jian Xiang, Haiyun Xu, Yili Huang Pokay, Haibo Mao, Xugong Cai, Yili Wu, Deborah Baofeng Wang
Summary: This study evaluated the functionality and effectiveness of a digital mental health clinic (DMHC) in secondary schools in China. The DMHC provided accessible and free mental health services to students, addressing issues such as learning difficulties, interpersonal relationships, and emotional distress. The mini course videos on emotional assistance, personal growth, and family member relationships were highly popular among students. The DMHC also served as a crisis prevention and intervention tool, helping students at high risk for suicide and self-injury.
JMIR FORMATIVE RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Yun Zhang, Huaqiu Chen, Ran Li, Keenan Sterling, Weihong Song
Summary: Amyloid & beta; protein (A & beta;) is the main component of neuritic plaques in Alzheimer's disease. It has been considered as the molecular driver of Alzheimer's pathogenesis. The failures of A & beta;-targeted clinical trials have raised doubts about the amyloid cascade hypothesis, but recent successes have alleviated those doubts. This review discusses the evolution of the hypothesis, its application in Alzheimer's diagnosis and treatment, and the prospects for future research and development of A & beta;-targeted approaches.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
Review
Biochemistry & Molecular Biology
Yan Lian, Yu-Juan Jia, Joelyn Wong, Xin-Fu Zhou, Weihong Song, Junhong Guo, Colin L. Masters, Yan-Jiang Wang
Summary: This article analyzes key questions regarding the efficacy of Aβ targeting therapies and provides perspectives on early intervention, adequate Aβ removal, sufficient treatment period, and combinatory therapeutics. The success of recent clinical trials and lessons from previous trials provide critical evidence supporting the role of Aβ in AD pathogenesis.
MOLECULAR PSYCHIATRY
(2023)
Letter
Biochemistry & Molecular Biology
Xi Liu, Rongbo Che, Wenping Liang, Yun Zhang, Liyong Wu, Chao Han, Hong Lu, Weihong Song, Yili Wu, Zhe Wang
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)