Article
Biochemistry & Molecular Biology
Michal Tomaszewski, Paulina Mertowska, Martyna Janczewska, Agnieszka Styczen, Sebastian Mertowski, Kamil Jonas, Ewelina Grywalska, Grzegorz Kopec
Summary: Pulmonary arterial hypertension (PAH) is a complex disorder where cytokines play a crucial role in deregulation of the immune system. This study found that PAH patients have abnormal immune function with decreased percentages of immune cell subpopulations and changes in cytokine concentration. Furthermore, significant differences were observed between PAH subtypes and immunological parameters, suggesting the important role of the immune system in the pathogenesis of PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Elisa Toppi, Laura Sireno, Micaela Lembo, Nerisa Banaj, Beatrice Messina, Sedigheh Golesorkhtafti, Gianfranco Spalletta, Paola Bossu
Summary: Homotaurine is a potential therapeutic compound for Alzheimer's disease (AD) and has anti-inflammatory properties. This study suggests that supplementation of homotaurine in patients with mild cognitive impairment (MCI) increases the levels of anti-inflammatory cytokines IL-10 and IL-33, while decreasing the levels of pro-inflammatory cytokine IL-18. The elevation of IL-10 and IL-33 is associated with improved episodic memory in treated patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Pingping Niu, Liqin Li, Yonggang Zhang, Zhongzhou Su, Binghao Wang, He Liu, Shehong Zhang, Sheng Qiu, Yuntao Li
Summary: Ischemic stroke is a significant cause of death and disability worldwide. Gender differences in stroke outcomes have been established, and the immune response after stroke plays a crucial role in patient outcomes. However, gender disparities lead to distinct immune metabolic tendencies that are closely related to immune regulation after stroke.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Maria Luisa Barcena, Sarah Jeuthe, Maximilian H. Niehues, Sofya Pozdniakova, Natalie Haritonow, Anja A. Kuehl, Daniel R. Messroghli, Vera Regitz-Zagrosek
Summary: The study revealed that male sex is associated with a higher incidence of cardiac fibrosis, stronger inflammation, and decreased cardiac function in autoimmune myocarditis, while females show an anti-inflammatory phenotype with better cardiac outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Hashim Islam, Garett S. Jackson, Jeff S. J. Yoon, Carolina Cabral-Santos, Fabio S. Lira, Alice L. Mui, Jonathan P. Little
Summary: There are sex-based differences in the anti-inflammatory function of IL-10 observed in ex vivo blood leukocytes, with males exhibiting larger changes in pSTAT3 levels and a more pronounced inhibition of TNF-alpha production by IL-10. These findings suggest that sex differences in IL-10 action may contribute to overall sex differences in immune function.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Clinical Neurology
Irene F. Ugidos, Cristiana Piston, Paula Korhonen, Mireia Gomez-Buda, Valeriia Sitnikova, Pamela Klecki, Lveta Stanova, Jukka Jolkkonene, Tarja Malm
Summary: Stroke is a leading cause of death worldwide with limited therapeutic options currently available. Research has shown that sex differences play a significant role in stroke treatment and outcomes, with sexual hormones and aging being key factors influencing these differences.
Article
Clinical Neurology
Helge Toft, Jorgen G. Bramness, Lars Lien
Summary: This study investigated the development of cytokines and depression symptoms in patients with comorbid depression and post-traumatic stress disorder (PTSD) over a one-year follow-up period. The results showed that certain inflammatory biomarkers in PTSD patients were similar to those in non-PTSD patients after one year, despite the level of depression remaining unchanged in the PTSD patients.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Biochemistry & Molecular Biology
Casado-Bedmar Maite, Maryline Roy, Viennois Emilie
Summary: Sexual dimorphism plays an important role in understanding diseases like inflammatory bowel disease (IBD), however, the specific role of sex in IBD remains unclear. This study investigates the sex-dependent differences and inflammatory susceptibility in a commonly used IBD mouse model. The findings reveal that female mice lacking the IL-10 gene are more prone to developing intestinal inflammation and exhibit dysbiosis compared to males, highlighting the importance of considering sex in experimental designs and personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Arianna Di Napoli, Daniele Greco, Giorgia Scafetta, Francesca Ascenzi, Alessandro Gulino, Luigi Aurisicchio, Fabio Santanelli Di Pompeo, Adriana Bonifacino, Enrico Giarnieri, John Morgan, Rita Mancini, Marshall E. Kadin
Summary: BI-ALCL is a rare peripheral T cell lymphoma commonly presenting as delayed peri-implant effusion, requiring cytological examination, CD30 immunostaining, and T-cell clonality assessment for diagnosis. A Th2-type cytokine profile characterized by high levels of IL-10, IL-13, and Eotaxin distinguishes BI-ALCL from reactive seromas, with an IL10/IL-6 ratio cutoff of 0.104 showing high specificity and sensitivity in identifying BI-ALCL effusions. This study identifies potential biomarkers for early screening of late seromas to aid in prompt BI-ALCL diagnosis.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Psychiatry
Jingqi He, Yisen Wei, Jinguang Li, Ying Tang, Junyu Liu, Zhangyin He, Risheng Zhou, Xingtao He, Honghong Ren, Yanhui Liao, Lin Gu, Ning Yuan, Xiaogang Chen, Jinsong Tang
Summary: This study compared serum IL-6 levels between TRS and PRS patients and explored potential sex differences in the association between TRS and IL-6 levels. The results showed that TRS patients had higher serum IL-6 levels, especially in females. The findings suggest that the inflammatory response system may play a role in the pathogenesis of TRS in a sex-dependent manner.
Review
Immunology
Lauren A. Zenewicz
Summary: Cytokines, including IL-22, play crucial roles in inflammation, with their activity regulated by factors like IL-22BP. IL-22BP, a soluble receptor homolog, binds to IL-22 with greater affinity, impacting the biological functions of IL-22, yet further research is needed to fully understand its role and regulation mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Christian Ulrich von Linstow, Sofie Mozart Hindkjaer, Pernille Vinther Nielsen, Matilda Degn, Kate Lykke Lambertsen, Bente Finsen, Bettina Hjelm Clausen
Summary: The study found that bone marrow cells can modulate the poststroke inflammation, benefiting poststroke outcomes, with TNF and IL-1Ra identified as key players in the defense response after tMCAo.
Article
Immunology
Xiaofei Xu, Errol Prens, Edwin Florencia, Pieter Leenen, Luis Boon, Patrick Asmawidjaja, Anne-Marie Mus, Erik Lubberts
Summary: The up-regulation of IL-19 and IL-24 induced by IL-17A in skin stromal cells contributes to keratinocyte proliferation. Depletion of IL-10 leads to increased expression of IL-23/IL-17 pathway related cytokines followed by significant up-regulation of IL-19 and IL-24.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jeremie Joffre, Erika Wong, Samira Lawton, Elliot Lloyd, Nina Nguyen, Fengyun Xu, Cristina Sempio, Lester Kobzik, Ivana Zlatanova, Mark Schumacher, Jost Klawitter, Hua Su, Katalin Rabl, Kevin Wilhelmsen, Che-Chung Yeh, Judith Hellman
Summary: This study reveals that OLDA has potent anti-inflammatory effects by activating the neuronal TRPV1 and modulating the systemic inflammatory response induced by endotoxemia and infection through a multicellular network.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Andrea Nieto-Veloza, Shan Hong, Matthew Reeder, Mee-Ja Sula, Doris H. D'Souza, Qixin Zhong, Vermont P. Dia
Summary: This study investigated the protective effect of the soy peptide lunasin in an in vivo model of susceptibility to inflammatory bowel disease (IBD) and identified its potential mechanism of action in vitro. The results showed that lunasin could reduce susceptibility to inflammation and levels of proinflammatory cytokines. Lunasin exhibited anti-inflammatory properties and decreased susceptibility to IBD in genetically susceptible mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Editorial Material
Multidisciplinary Sciences
Meaghan Roy-O'Reilly, Louise D. McCullough
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Xiurong Zhao, Shun-Ming Ting, Chin-Hsuan Liu, Guanghua Sun, Marian Kruzel, Meaghan Roy-O'Reilly, Jaroslaw Aronowski
NATURE COMMUNICATIONS
(2017)
Article
Clinical Neurology
Meaghan Roy-O'Reilly, Rodney M. Ritzel, Sarah E. Conway, Ilene Staff, Gilbert Fortunato, Louise D. McCullough
TRANSLATIONAL STROKE RESEARCH
(2017)
Article
Clinical Neurology
Xiurong Zhao, Shun-Ming Ting, Guanghua Sun, Meaghan Roy-O'Reilly, Alexis S. Mobley, Jesus Bautista Garrido, Xueping Zheng, Lidiya Obertas, Joo Eun Jung, Marian Kruzel, Jaroslaw Aronowski
Article
Neurosciences
Janhavi M. Modak, Meaghan Roy-O'Reilly, Liang Zhu, Ilene Staff, Louise D. McCullough
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2019)
Article
Immunology
Rodney M. Ritzel, Abdullah Al Mamun, Joshua Crapser, Rajkumar Verma, Anita R. Patel, Brittany E. Knight, Nia Harris, Nickolas Mancini, Meaghan Roy-O'Reilly, Bhanu Priya Ganesh, Fudong Liu, Louise D. McCullough
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Clinical Neurology
Jaroslaw Aronowski, Meaghan A. Roy-O'Reilly
Article
Geriatrics & Gerontology
Matthew D. Howe, J. Weldon Furr, Yashasvee Munshi, Meaghan A. Roy-O'Reilly, Michael E. Maniskas, Edward C. Koellhoffer, John D'Aigle, Lauren H. Sansing, Louise D. McCullough, Akihiko Urayama
Article
Cell Biology
Meaghan A. Roy-O'Reilly, Hilda Ahnstedt, Monica S. Spychala, Yashasvee Munshi, Jaroslaw Aronowski, Lauren H. Sansing, Louise D. McCullough
Article
Immunology
Hilda Ahnstedt, Anthony Patrizz, Anjali Chauhan, Meaghan Roy-O'Reilly, Joseph W. Furr, Monica S. Spychala, John D'Aigle, Frank W. Blixt, Liang Zhu, Javiera Bravo Alegria, Louise D. McCullough
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Cell Biology
Anthony Patrizz, Sarah J. Doran, Anjali Chauhan, Hilda Ahnstedt, Meaghan Roy-OReilly, Yun-Ju Lai, Gillian Weston, Sami Tarabishy, Anita R. Patel, Rajkumar Verma, Ilene Staff, Julia K. Kofler, Jun Li, Fudong Liu, Rodney M. Ritzel, Louise D. McCullough
Article
Neurosciences
Nia M. Harris, Meaghan Roy-O'Reilly, Rodney M. Ritzel, Aleah Holmes, Lauren H. Sansing, Lena M. O'Keefe, Louise D. McCullough, Anjali Chauhan
EXPERIMENTAL NEUROLOGY
(2020)
Review
Multidisciplinary Sciences
Meaghan Roy-O'Reilly, Ajitkumar Mulavara, Thomas Williams
Summary: This review summarizes the effects of long-duration spaceflight on the central nervous system, particularly on the brain structure and connectivity measured by magnetic resonance imaging. While changes to the brain have been observed after spaceflight, the impact and implications of these changes remain unclear, requiring further research to develop comprehensive monitoring and countermeasure strategies for crew health and performance in future long-duration space exploration.
Review
Oncology
Meaghan A. Roy-O'Reilly, Tyler Lanman, Amber Ruiz, David Rogawski, Brian Stocksdale, Seema Nagpal
Summary: This study reviews the current understanding of clinical presentation, pathogenesis, diagnosis, and treatment of Leptomeningeal disease (LMD) and emphasizes the need for further research in this field.
CURRENT ONCOLOGY REPORTS
(2023)
Review
Endocrinology & Metabolism
Meaghan Roy-O'Reilly, Louise D. McCullough