期刊
SCIENTIFIC REPORTS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-03689-7
关键词
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资金
- Ministerio de Economia y Competitividad-Spain [SAF2014-55579R]
- CIBER CARDIOVASCULAR (Instituto de Salud Carlos III)
- Ministerio de Economia y Competitividad-Spain
- Pro-CNIC Foundation
- CIBER CARDIOVASCULAR (FEDER)
- [ERC-2011-AdG 294340-GENTRIS]
- [PIE-13-00041]
- [INDISNET S2011-BMD-2332]
microRNAs (miRNAs) are tightly regulated during T lymphocyte activation to enable the establishment of precise immune responses. Here, we analyzed the changes of the miRNA profiles of T cells in response to activation by cognate interaction with dendritic cells. We also studied mRNA targets common to miRNAs regulated in T cell activation. pik3r1 gene, which encodes the regulatory subunits of PI3K p50, p55 and p85, was identified as target of miRNAs upregulated after T cell activation. Using 3'UTR luciferase reporter-based and biochemical assays, we showed the inhibitory relationship between miR-132-3p upregulation and expression of the pik3r1 gene. Our results indicate that specific miRNAs whose expression is modulated during T cell activation might regulate PI3K signaling in T cells.
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