Article
Food Science & Technology
Fatima Guerrero, Andres Carmona, Maria Jose Jimenez, Teresa Obrero, Victoria Pulido, Juan Antonio Moreno, Sagrario Soriano, Alejandro Martin-Malo, Pedro Aljama
Summary: The study showed that uremic toxins cause accelerated aging in HUVECs, affecting their regenerative capacity and potential to form vascular structures. This phenomenon may contribute to endothelial dysfunction associated with CKD progression.
Article
Medicine, Research & Experimental
Ruei-Dun Teng, Chih-Hao Yang, Chi-Li Chung, Joen-Rong Sheu, Cheng-Ying Hsieh
Summary: In this study, it was found that cinchonidine exhibited superior cell-protective effects on IS-stimulated HUVECs, reversing IS-induced cell death, cellular senescence, and impaired vasculogenic activity. Cinchonidine achieved this by downregulating the p53 signaling pathway, promoting p53 degradation, and enhancing the cytoplasmic-nuclear shuttling of MDM2. This suggests that cinchonidine could be a potential cell-protective agent for rescuing IS-induced endothelial cell damage.
Article
Immunology
Georgios Lioulios, Asimina Fylaktou, Aliki Xochelli, Erasmia Sampani, Ioannis Tsouchnikas, Panagiotis Giamalis, Dimitra-Vasilia Daikidou, Vasiliki Nikolaidou, Aikaterini Papagianni, Ioannis Theodorou, Maria Stangou
Summary: End stage renal disease (ESRD) has detrimental effects on the immune system, leading to quantitative alterations of lymphocyte subpopulations. Using principal component analysis (PCA) and uniform manifold approximation and projection (UMAP), we found that ESRD patients have a more senescent immune phenotype, and dialysis prescription may play a role in determining the immunological groups within the patient cohort.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Regiane Stafim da Cunha, Paulo Cezar Gregorio, Rayana Ariane Pereira Maciel, Giane Favretto, Celia Regina Cavichiolo Franco, Jenifer Pendiuk Goncalves, Marina Luise Viola de Azevedo, Roberto Pecoits-Filho, Andrea Emilia Marques Stinghen
Summary: Uremic toxins PCS and IS contribute to endothelial dysfunction in chronic kidney disease. This study found that CREB/ATF1 is activated by PCS, IS, and US in uremic conditions and may play a relevant role in endothelial dysfunction.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Yi-Chou Hou, Yueh-Min Liu, Min-Ter Liao, Cai-Mei Zheng, Chien-Lin Lu, Wen-Chih Liu, Kuo-Chin Hung, Shyh-Min Lin, Kuo-Cheng Lu
Summary: Sarcopenia occurs more frequently in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) than in the general population. Low handgrip strength, rather than sarcopenia itself, is associated with clinical outcomes in CKD patients. The study aimed to determine whether uremic toxins influence low handgrip strength in CKD patients.
FRONTIERS IN MEDICINE
(2023)
Article
Food Science & Technology
Cindy Nguyen, Amanda J. Edgley, Darren J. Kelly, Andrew R. Kompa
Summary: This study investigates the effects of the uremic toxin indoxyl sulfate (IS) on vascular endothelial function and redox balance. The results indicate that IS impairs endothelium-dependent relaxation and increases the expression of oxidative stress markers. Inhibition of the aryl hydrocarbon receptor (AhR) could be a potential therapy for cardiovascular disease in the context of chronic kidney disease (CKD).
Article
Nutrition & Dietetics
Xuechun Lin, Wangqun Liang, Li Li, Qianqian Xiong, Shuiqing He, Jing Zhao, Xiaolei Guo, Siyun Xiang, Piwei Zhang, Hong Wang, Chenjiang Ying, Ying Yao, Xuezhi Zuo
Summary: The present study revealed that patients with end-stage renal disease (ESRD) exhibit serious accumulation of indoxyl sulfate (IS) and p-cresyl sulfate (pCS), along with significant expansion of indole-producing bacteria and p-cresol-producing bacteria, upregulation of the bacterial tryptophan metabolism pathway, and greatly increased serum IS and pCS concentrations, whereas significant decline in daily IS and pCS removal.
JOURNAL OF RENAL NUTRITION
(2022)
Article
Environmental Sciences
Gerald McGwin, Russell L. Griffin
Summary: This study aims to assess the association between paraquat exposure and the incidence of end stage renal disease (ESRD) in the United States. The results show that the incidence of ESRD increases with higher paraquat density. The study findings are consistent with previous research indicating that acute paraquat poisoning leads to a high incidence of acute kidney injury, while chronic paraquat exposure is associated with the occurrence of chronic renal disease. However, further research is needed to understand the natural progression of chronic kidney disease due to chronic paraquat exposure.
ENVIRONMENTAL HEALTH
(2022)
Article
Urology & Nephrology
Yu-jia Xi, Qiang Guo, Ran Zhang, Guo-sheng Duan, Sheng-xiao Zhang
Summary: This study identified cellular senescence-associated genes that play a crucial role in the development and progression of end-stage renal disease (ESRD) and have a close relationship with immune regulation.
Article
Medicine, General & Internal
Johannes Wild, Karsten Keller, Susanne Karbach, Julia Weinmann-Menke, Thomas Muenzel, Lukas Hobohm
Summary: The relationship between psoriasis and end-stage renal disease (ESRD) has not been clarified. The study found that ESRD patients with psoriasis were hospitalized an average of 5 years earlier than patients without psoriasis. Despite their younger age, they had a higher prevalence of severe comorbidities such as coronary artery disease and cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
George N. Coritsidis, Sean Yaphe, Ilay Rahkman, Teresa Lubowski, Carly Munro, Ti-Kuang Lee, Aaron Stern, Premila Bhat
Summary: This study investigated antibiotic prescribing practices in ESRD patients in New York State, highlighting a higher proportion of ESRD patients receiving antibiotics compared to non-ESRD patients, with some dosages not in line with current guidelines. The top infectious categories varied between ESRD and non-ESRD patients, emphasizing the need for appropriate antibiotic usage and education among healthcare providers.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Medical Laboratory Technology
Monica Faria, Maria Norberta DePinho
Summary: Chronic kidney disease (CKD) affects a significant percentage of the global population, compromising renal function and leading to the accumulation of uremic retention solutes that worsen kidney function irreversibly. Current renal replacement therapies (RRTs) such as hemodialysis only partially restore kidney function, leaving larger protein-bound uremic toxins (PBUTs) untouched, increasing the risk of cardiovascular events and mortality in CKD and ESRD patients. Various strategies are being explored to reduce PBUT concentrations, but none provide the required efficiency, safety, and cost-effectiveness to prevent CKD-related complications and decrease mortality and morbidity in ESRD patients.
TRANSLATIONAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
I-Ning Yang, Chin-Li Lu, Hung-Jen Tang, Yu-Chi Kuo, Li-Hwa Tsai, Kuan Chieh Tu, Jhi-Joung Wang, Chih-Chiang Chien
Summary: This study investigated adverse events (AEs) after ChAdOx1 nCoV-19 vaccination in end-stage renal disease patients on hemodialysis. The results showed that some patients experienced local and systemic AEs, but the clinical significance of these symptoms was minor. The SCCS analysis did not find an elevated risk of vascular access thrombosis.
Article
Food Science & Technology
Christof Ulrich, Leonie Kneser, Roman Fiedler, Julia Beckert, Susann Wildgrube, Eric Seibert, Sylvia Fick, Christoph Schaefer, Silke Markau, Bogusz Trojanowicz, Matthias Girndt
Summary: NLRP-3 inflammasome activation can lead to IL-1 beta release and pyroptosis. In this study, pyroptosis rates were significantly higher in HD patients compared to BP patients, without a significant difference in IL-1 beta levels. Uremic toxin IS may mediate pyroptosis in HD patients, with caspase-4 and/or caspase-5 playing a larger role compared to caspase-1.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rahaf AlSadi, Landon C. Aziz, Michael Bohan, Shaheen Dewji, Othmane Bouhali, Mehdi Djekidel
Summary: The study retrospectively reports on RAI treatment in thyroid cancer patients with ESRD undergoing dialysis, highlighting the challenges posed by delayed biological clearance of RAI. Adjusted dose activity and balancing scheduling between RAI therapy and dialysis are recommended to ensure closer radiation exposure in ESRD patients. Pooling data from multiple centers is suggested to establish consensus and substantiated recommendations for RAI treatment in ESRD patients.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Hyun Kyung Namgung, Hye Won Woo, Jinho Shin, Min-Ho Shin, Sang Baek Koh, Hyeon Chang Kim, Yu-Mi Kim, Mi Kyung Kim
Summary: This study aimed to develop and validate hypertension risk prediction models. The models using the Framingham hypertension risk prediction factors showed good internal calibration, but their external calibration was not ideal.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Transplantation
Chan-Young Jung, Hae-Ryong Yun, Jung Tak Park, Young Su Joo, Hyung Woo Kim, Tae-Hyun Yoo, Shin-Wook Kang, Joongyub Lee, Dong-Wan Chae, Wookyung Chung, Yong-Soo Kim, Kook-Hwan Oh, Seung Hyeok Han
Summary: In Korean patients with CKD, the coronary artery calcium score (CACS) is independently associated with adverse cardiovascular outcomes and all-cause death. High CACS is associated with higher risk, and CACS shows modest improvements in prediction performance for the primary outcome.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Oncology
Hidehiro Kaneko, Yuichiro Yano, Hokyou Lee, Hyeok-Hee Lee, Akira Okada, Yuta Suzuki, Hidetaka Itoh, Satoshi Matsuoka, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Akira Nishiyama, Koichi Node, Hyeon Chang Kim, Hideo Yasunaga, Issei Komuro
Summary: Despite limited knowledge on the association between hypertension and cardiovascular events in cancer patients, this study found that moderate to severe hypertension is associated with an increased risk of heart failure and other cardiovascular disease events in cancer patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Geriatrics & Gerontology
Jin Ryu, Sujeong Eom, Hyeon Chang Kim, Chang Oh Kim, Yumie Rhee, Seng Chan You, Namki Hong
Summary: This study aimed to develop a deep learning model based on chest X-rays to predict the presence of sarcopenia. The results showed that the model performed well in predicting muscle parameters and sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Endocrinology & Metabolism
Junghyun Noh, Min Kyong Moon, Eun-Jung Rhee, Sang Hyun Park, Hyeon Chang Kim, Byung Jin Kim, Hae Jin Kim, Seonghoon Choi, Jin Oh Na, Young Youl Hyun, Bum Joon Kim, Kyung-Do Han, In-Kyung Jeong
Summary: The study found an association between low-density lipoprotein cholesterol (LDL-C) level and cardiovascular disease (CVD) risk using the Korean National Health Insurance Service database. The risk of CVD increased from LDL-C level of 70 mg/dL in very high-risk and high-risk groups, and from 130 mg/dL in moderate-risk and low-risk groups. Adjusted hazard ratios (HRs) also showed a correlation between higher LDL-C levels and increased incidence of CVD in different risk groups.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Endocrinology & Metabolism
Min Kyong Moon, Junghyun Noh, Eun-Jung Rhee, Sang Hyun Park, Hyeon Chang Kim, Byung Jin Kim, Hae Jin Kim, Seonghoon Choi, Jin Oh Na, Young Youl Hyun, Bum Joon Kim, Kyung-Do Han, In-Kyung Jeong
Summary: This study evaluated the incidence of cardiovascular disease (CVD) and suggested LDL-C treatment goals in Korean people with type 2 diabetes mellitus (T2DM). The results showed that lowering LDL-C targets can be helpful for the primary prevention of CVD in patients with T2DM who have chronic kidney disease, hypertension, long-term diabetes, or three or more cardiovascular risk factors.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Eunji Kim, Kiho Sung, Chang Oh Kim, Yoosik Youm, Hyeon Chang Kim
Summary: This study found that social network properties have a significant impact on the risk of mortality among older adults, especially those with cognitive impairment. Therefore, encouraging older adults with poor cognitive function to participate in social activities can reduce the risk of mortality.
JOURNAL OF PREVENTIVE MEDICINE & PUBLIC HEALTH
(2023)
Article
Medical Informatics
Ji Hoon Kim, Bomgyeol Kim, Min Joung Kim, Heejung Hyun, Hyeon Chang Kim, Hyuk-Jae Chang
Summary: This study aimed to develop a prediction model using an integrated nationwide dataset to predict the transfer of patients with suspected cardiovascular emergency diseases to inappropriate hospitals at the pre-hospital stage. The model showed favorable performance with an area under the receiver operating characteristic curve of 0.813 and an area under the receiver precision-recall curve of 0.286.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Public, Environmental & Occupational Health
Eunji Kim, Ga Bin Lee, Dong Keon Yon, Hyeon Chang Kim
Summary: The prevalence of obesity among Korean adolescents has been increasing, with higher rates observed among boys and high school students. Socioeconomic disparities, particularly related to household income and parental educational attainment, are associated with obesity, with a greater impact on girls.
EPIDEMIOLOGY AND HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Sung-Ha Lee, Hyeok-Hee Lee, Kiho Sung, Yoosik Youm, Hyeon Chang Kim
Summary: This study found that group-level segregation is closely associated with cardiovascular health in older adults. The social network structure of a community may influence the health status of its members.
EPIDEMIOLOGY AND HEALTH
(2023)
Review
Peripheral Vascular Disease
Hack-Lyoung Kim, Eun Mi Lee, Shin Young Ahn, Kwang-il Kim, Hyeon Chang Kim, Ju Han Kim, Hae-Young Lee, Jang Hoon Lee, Jong-Moo Park, Eun Joo Cho, Sungha Park, Jinho Shin, Young-Kwon Kim
Summary: This review provides an update on the 2018 Korean Hypertension Society Guidelines for the management of hypertension. It highlights the importance of ambulatory and home blood pressure monitoring for diagnosis and treatment target determination. The updated guidelines recommend a target blood pressure below 130/80 mmHg for high-risk patients based on consensus and the SPRINT study. However, for conditions such as cerebral infarction and chronic kidney disease, as well as for elderly patients, the target blood pressure is generally set at <140/90 mmHg due to lack of evidence.
CLINICAL HYPERTENSION
(2023)
Article
Multidisciplinary Sciences
Do-Won Jeong, Jong-Wan Park, Kyeong Seog Kim, Jiyoung Kim, June Huh, Jieun Seo, Ye Lee Kim, Joo-Youn Cho, Kwang-Woong Lee, Junji Fukuda, Yang-Sook Chun
Summary: This study demonstrates that palmitic acid (PA) acts as a molecular checkpoint of lipid reprogramming in liver cancer cells. PA mediates the palmitoylation of PHF2, leading to ubiquitin-dependent degradation of PHF2 and reducing lipogenesis. Additionally, PHF2 functions as an E3 ubiquitin ligase and destabilizes the master transcription factor of lipogenesis, SREBP1c. The induction of PA triggers the PHF2/SREBP1c axis, which increases lipogenesis in hepatocellular carcinoma (HCC). Therefore, monitoring dietary PA levels may be important for HCC patients.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Xu Jiang, Sungyeun Bae, Deok Yong Yoon, Shin Jung Park, Jaeseong Oh, Joo-Youn Cho, Kyung-Sang Yu
Summary: The pharmacokinetics, safety, and tolerability of two formulations of empagliflozin were compared in healthy subjects. The study found that CKD-370, a cocrystal formulation, had similar PK characteristics to the reference treatment and both formulations were well tolerated.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Nutrition & Dietetics
Yujin Lee, Joo-Youn Cho, Ky Young Cho
Summary: Pediatric obesity is linked to changes in gut microbiota and its metabolites, but the impact on obesity and lifestyle interventions is still unknown. This study examined metabolomes and microbial features to understand metabolic pathways and the effects of lifestyle interventions on pediatric obesity.
Article
Pharmacology & Pharmacy
Yeonseo Jang, Jihyun Kang, Sejung Hwang, Jae-Yong Chung, Joo-Youn Cho
Summary: This study established an accurate method for the quantitation of CP-I and CP-III and applied it in a clinical pharmacology study. The method showed good linearity, precision, and accuracy, and remained stable after dilution. It can effectively monitor drug-drug interactions mediated by OATP1B.
TRANSLATIONAL AND CLINICAL PHARMACOLOGY
(2023)