Metformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A

Suppression of Aurora-A-FLJ10540 signaling axis prohibits the malignant state of head and neck cancer

(2015) Chang-Han Chen et al.   Molecular Cancer

Dysregulation of Wnt-Signaling and a Candidate Set of miRNAs Underlie the Effect of Metformin on Neural Crest Cell Development

(2015) Poulomi Banerjee et al.   STEM CELLS

Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model

(2015) Devaraja Rajasekaran et al.   Oncotarget

Aurora-A signaling is activated in advanced stage of squamous cell carcinoma of head and neck cancer and requires osteopontin to stimulate invasive behavior

(2015) Chih-Yen Chien et al.   Oncotarget

Metformin impairs growth of endometrial cancer cells via cell cycle arrest and concomitant autophagy and apoptosis

(2014) Akimasa Takahashi et al.   Cancer Cell International

Metformin Sensitizes EGFR-TKI-Resistant Human Lung Cancer Cells In Vitro and In Vivo through Inhibition of IL-6 Signaling and EMT Reversal

(2014) L. Li et al.   CLINICAL CANCER RESEARCH

Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling

(2014) Y Feng et al.   Cell Death & Disease

Aurora kinase A (AURKA) expression in colorectal cancer liver metastasis is associated with poor prognosis

(2013) J A C M Goos et al.   BRITISH JOURNAL OF CANCER

Association between metformin use and improved survival in patients with laryngeal squamous cell carcinoma

(2013) Vlad C. Sandulache et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex

(2013) Y.-C. Lee et al.   JOURNAL OF CELL SCIENCE

Aurora kinases in head and neck cancer

(2013) Ranee Mehra et al.   LANCET ONCOLOGY

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis

(2013) Chung-Feng Hwang et al.   PLoS One

Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II

(2013) Barbara Salani et al.   Scientific Reports

Overexpression of Rap-1A Indicates a Poor Prognosis for Oral Cavity Squamous Cell Carcinoma and Promotes Tumor Cell Invasion via Aurora-A Modulation

(2012) Chang-Han Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage

(2012) C. Algire et al.   Cancer Prevention Research

Essential Roles of mTOR/Akt Pathway in Aurora-A Cell Transformation

(2012) Makoto Taga et al.   International Journal of Biological Sciences

Metformin in cancer: translational challenges

(2012) Ryan J O Dowling et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The Antidiabetic Drug Metformin Inhibits Gastric Cancer Cell Proliferation In Vitro and In Vivo

(2012) K. Kato et al.   MOLECULAR CANCER THERAPEUTICS

Targeting late SV40 factor: Is the achilles heel of hepatocarcinogenesis revealed?

(2012) Amir Shlomai   WORLD JOURNAL OF GASTROENTEROLOGY

Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC

(2012) Giovanni Blandino et al.   Nature Communications

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

In vitro and in vivo anti-melanoma action of metformin

(2011) Kristina Janjetovic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Late SV40 Factor (LSF) Enhances Angiogenesis by Transcriptionally Up-regulating Matrix Metalloproteinase-9 (MMP-9)

(2011) Prasanna K. Santhekadur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Met activation through a novel pathway involving osteopontin mediates oncogenesis by the transcription factor LSF

(2011) Byoung Kwon Yoo et al.   JOURNAL OF HEPATOLOGY

The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway

(2010) L.-h. Wang et al.   CANCER RESEARCH

Fibulin-3 is associated with tumour progression and a poor prognosis in nasopharyngeal carcinomas and inhibits cell migration and invasion via suppressed AKT activity

(2010) Chung-Feng Hwang et al.   JOURNAL OF PATHOLOGY

Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma

(2010) B. K. Yoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?

(2008) Vuk Stambolic et al.   BREAST CANCER RESEARCH AND TREATMENT

Expression of Aurora A (but Not Aurora B) Is Predictive of Survival in Breast Cancer

(2008) Y. Nadler et al.   CLINICAL CANCER RESEARCH

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE

Angiopoietin-1 and -2 expression in recurrent squamous cell carcinoma of the oral cavity

(2007) Chih-Yen Chien et al.   JOURNAL OF SURGICAL ONCOLOGY