Article
Cell Biology
Rasha Msallam, Bernard Malissen, Pierre Launay, Ulrich Blank, Gregory Gautier, Jean Davoust
Summary: This study investigates the regulatory functions of mast cells (MCs) in the skin, focusing on their interaction with regulatory T lymphocytes (Tregs) and Langerhans cells (LCs) during passive cutaneous anaphylaxis (PCA) responses. The researchers found that Tregs increased their contact time with MCs during PCA, suggesting an anti-inflammatory role in preventing further MC activation.
Article
Genetics & Heredity
Anna Pretschner, Sophie Pabel, Markus Haas, Monika Heiner, Wolfgang Marwan
Summary: This study investigates dynamics of cell fate decisions through various methods, utilizing multi-nucleate cells for true time series recordings. The results reveal a highly structured network of Markov chains, providing essential information on the dynamics of regulatory events in cell differentiation.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Deepika Vatsa, Sumeet Agarwal
Summary: This paper introduces a novel gene regulatory network inference method using Probabilistic Extended Petri Net, which utilizes transition of discrete gene expression levels as evidence types to understand gene regulation processes, and evaluates the method on two datasets.
Editorial Material
Multidisciplinary Sciences
Jeffrey A. Farrell
Summary: CellOracle, a computational tool, can predict the interaction of gene networks in programming cell identity during embryonic development. This tool will contribute to a better understanding of the regulation of development.
Article
Computer Science, Information Systems
Shahid Yousaf, Hafiz Mahfooz Ul Haque, Abbas Khalid, Muhammad Adnan Hashmi, Eraj Khan
Summary: This paper proposes a context-aware intelligent decision support formalism to assist cognitively impaired individuals in managing their daily activities. By contextualizing information from the environment using a semantic knowledge-based framework, a context-aware multi-agent system can be created to autonomously plan user activities and notify users accordingly.
CMC-COMPUTERS MATERIALS & CONTINUA
(2022)
Article
Computer Science, Information Systems
Qi Guo, Wangyang Yu, Fei Hao, Yuke Zhou, Yuan Liu
Summary: This study proposes an optimized modeling solution based on Petri net synchronization theory to improve the synchronization issue in the ACC system, reducing token accumulation and enhancing reliability.
Article
Multidisciplinary Sciences
Jeremias Motte, Thomas Grueter, Anna Lena Fisse, Yesim Bulut, Zornitsa Stykova, Tineke Greiner, Elena Enax-Krumova, Min-Suk Yoon, Ralf Gold, Martin Tegenthoff, Dietrich Sturm, Kalliopi Pitarokoili
Summary: This study found that an increased corneal inflammatory cell count is associated with clinical disease activity and disability progression in CIDP patients over the following 3-6 months. A CIC count of more than 25 cells/mm² had a sensitivity of 0.73 and a specificity of 0.71 for detecting clinical disease activity, and a sensitivity of 0.77 and a specificity of 0.64 for detecting disability progression.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Olga I. Isaeva, Steven L. C. Ketelaars, Pia Kvistborg
Summary: A study has found that the recent SARS-CoV-2 variants of interest and concern have limited ability to escape memory CD8 T cell responses raised by vaccination or prior infection. Most of the recognized CD8 T cell epitopes are not altered by variant-specific mutations, and mutated epitopes show a high degree of sequence similarity with reference epitopes. However, mutated epitopes in certain variants display reduced binding affinity. Overall, the impact of mutations on CD8 T cell cross-recognition is low, primarily due to receptor binding affinity and antibody selection pressures exerted on the spike protein, unrelated to T cell immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biodiversity Conservation
Emmanouil Lempidakis, Andrew N. Ross, Luca Borger, Emily L. C. Shepard
Summary: This study provides the first assessment of the impact of flow characteristics on the distribution of seabird colonies using computational fluid dynamics. The results show that the breeding habitat selection of seabirds is influenced not only by airflows, but also by the need for shelter from wind and rain/wave action. Models of airflows and cliff orientation are effective in predicting high-quality habitat.
Article
Engineering, Industrial
Qinying Sun, Haiqun Ma
Summary: Coordination among various departments is crucial for the prevention and control of COVID-19. This study establishes a model to analyze and research the emergency collaborative process for COVID-19. By conducting simulation analysis, key stages and action lists for COVID-19 prevention and control emergency coordination are identified, and countermeasures and suggestions are proposed.
RELIABILITY ENGINEERING & SYSTEM SAFETY
(2024)
Article
Multidisciplinary Sciences
Aenne Harberts, Constantin Schmidt, Joanna Schmid, Daniel Reimers, Friedrich Koch-Nolte, Hans-Willi Mittruecker, Friederike Raczkowski
Summary: IRF4 is essential for the activation and reactivation of CD8(+) memory T cells, but does not affect their overall survival. However, the formation and maintenance of CD8(+) tissue-resident memory T cells appears to depend on IRF4.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Computer Science, Artificial Intelligence
Zheng Liu, Guisheng Fan, Huiqun Yu, Liqiong Chen
Summary: This article proposes a reliability model of microservice-based cloud application using predicate Petri net, as well as a reliability strategy for microservices, and verifies the effectiveness of the strategy through experiments.
Article
Chemistry, Analytical
Aleksandra Fedorova, Viktar Beliautsou, Armin Zimmermann
Summary: This paper presents a method using colored Petri nets to model and evaluate UAV systems. The method helps operating companies in designing near-optimal multi-drone system configurations that meet monitoring quality requirements at a reasonable cost. The model allows for estimating monitoring frequency and determining the most appropriate grouping and configuration of UAVs, monitoring schemes, air time, and maintenance periods.
Article
Multidisciplinary Sciences
Vardges Tserunyan, Stacey D. Finley
Summary: In this study, we used mathematical modeling to investigate the impact of the costimulatory molecule CD28 on the response of CAR T cell populations under different sources of variability. Our findings suggest that CD28-bearing CARs mediate a faster and more consistent population response. We also identified key kinetic parameters that influence cell response time and proposed strategies to improve response time among heterogeneous CAR T cell populations by enhancing the catalytic activity of lymphocyte-specific protein tyrosine kinase.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Polymer Science
Joel P. Joseph, Sriram Bharath Gugulothu, Dipankar Nandi, Kaushik Chatterjee
Summary: T cells play a critical role in the immune response and their activation and response can be influenced by the 3D bioprinted matrix and its stiffness. The study reveals differences between 2D and 3D cultures and the impact of matrix stiffness on T cell activation and cytokine release.
Article
Dermatology
R. A. Sabroe, F. Lawlor, C. E. H. Grattan, M. R. Ardern-Jones, A. Bewley, L. Campbell, C. Flohr, T. A. Leslie, A. M. Marsland, G. Ogg, W. A. C. Sewell, M. Hashme, L. S. Exton, M. F. Mohd Mustapa, M. C. Ezejimofor
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
M. Kwiatkowska, S. Ahmed, M. R. Ardern-Jones, L. A. Bhatti, T. O. Bleiker, A. Gavin, S. Hussain, D. W. Huws, L. Irvine, S. M. Langan, G. W. M. Millington, H. Mitchell, R. Murphy, L. Paley, C. M. Proby, C. S. Thomson, R. Thomas, C. Turner, S. Vernon, Z. C. Venables
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Angela L. Bosma, Annelie H. Musters, Manja Bloem, Louise A. A. Gerbens, Maritza A. Middelkamp-Hup, Eva Haufe, Jochen Schmitt, Sebastien Barbarot, Julien Seneschal, Delphine Staumont-Salle, Emma K. Johansson, Maria Bradley, Laura B. von Kobyletzki, Ida Vittrup, Iben Frier Ruge, Jacob P. Thyssen, Christian Vestergaard, Marina de Vega, Ignacio Garcia-Doval, Andrea Chiricozzi, Luca Stingeni, Piergiacomo Calzavara-Pinton, Michael R. Ardern-Jones, Nick J. Reynolds, Carsten Flohr, Phyllis Spuls
Summary: The TREAT Registry Taskforce is a collaborative network collecting real-world data on atopic eczema patients. This study provides an overview of the eight established TREAT registries and examines the overlap and pooling ability of their datasets. The results show that pooled analyses can be performed on multiple important domain items, enabling future comparative analyses.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Allergy
Ying Xin Teo, Peter Simon Friedmann, Marta Ewa Polak, Michael Roger Ardern-Jones
Summary: Skin tests, particularly patch tests and intradermal tests, have been reported as valuable tools in assessing drug causality in DRESS. However, the heterogeneity in methodology, results analysis, and reporting of cohorts make it impossible to determine the sensitivity and specificity of the published literature. International collaboration is needed to harmonize the methodology and reporting measures in larger hypersensitivity testing studies.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Letter
Dermatology
Michael R. Ardern-Jones, Emily E. Buchanan, Samba Njungu, Daniel O'Driscoll
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Kalum Clayton, Daniel J. Holbrook, Andres Vallejo, Gemma Porter, Sofia Sirvent, James Davies, Jenny Pople, Fei Ling Lim, Myron Christodoulides, Marta E. Polak, Michael R. Ardern-Jones
Summary: This study explores the interaction between keratinocyte proliferation and differentiation status and the skin microbiome. It is found that Staphylococcus epidermidis is significantly associated with the human epidermis and can induce epidermal inflammation and antimicrobial responses. Furthermore, it activates the expression of inflammatory mediators in other epidermal immune cell populations. Understanding the mechanisms of bacterial sensing-triggered inflammatory responses will further our understanding of microbiome dysbiosis and inflammatory skin diseases.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Michael R. Ardern-Jones, Hang T. T. Phan, Florina Borca, Matt Stammers, James Batchelor, Isabel C. Reading, Sophie V. Fletcher, Trevor Smith, Andrew S. Duncombe
Summary: Blood markers can predict mortality in COVID-19 patients, and early dexamethasone treatment can reduce mortality in high-risk patients but not in low-risk patients. The risk-benefit of dexamethasone should be carefully assessed in COVID-19 cases, and alternative approaches should be considered for low-risk patients.
Article
Dermatology
Carsten Flohr, Michael J. Cork, Michael R. Ardern-Jones, Lawrence F. Eichenfield, Sebastien Barbarot, Claire Feeney, Ricardo Rojo, Irina Lazariciu, John Nesnas
Summary: The study evaluated the response to treatment with continuous/reduced-dose abrocitinib or withdrawal and reintroduction after flare in adolescents and adults with atopic dermatitis. It found that abrocitinib was effective in preventing flare in both age groups, with no significant difference in response between adolescents and adults.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2023)
Review
Chemistry, Analytical
Alexandar Todorov, Russel Torah, Michael R. Ardern-Jones, Steve P. Beeby
Summary: Atopic dermatitis (AD) is a prevalent skin disorder, particularly in children and adolescents, with current assessment methods relying on visual examination by clinicians. However, this approach is subjective and limited. Digital sensing technologies offer a potential solution for accurate and empirical evaluation of AD, allowing for global access. This review focuses on current medical practices, alternative digital evaluation methods, and potential future technologies to develop an AD monitoring device.
Article
Multidisciplinary Sciences
Sofia Sirvent, Andres F. Vallejo, Emma Corden, Ying Teo, James Davies, Kalum Clayton, Eleanor G. Seaby, Chester Lai, Sarah Ennis, Rfeef Alyami, Gemma Douilhet, Lareb S. N. Dean, Matthew Loxham, Sarah Horswill, Eugene Healy, Graham Roberts, Nigel J. Hall, Peter S. Friedmann, Harinder Singh, Clare L. Bennett, Michael R. Ardern-Jones, Marta E. Polak
Summary: Regulation of cutaneous immunity is compromised in inflammatory skin disease, such as atopic dermatitis. A study investigating molecular crosstalk in atopic dermatitis patients exposed to house dust mite has revealed a distinct dichotomy in patient responsiveness and identified potential therapeutic targets for modulation of metallothionein expression. The presence of hub structures where Langerhans cells and T cells co-localize suggests their role in the reactivity to house dust mite.
NATURE COMMUNICATIONS
(2023)
Review
Dermatology
Margo Waters, Allison Dobry, Stephanie T. Le, Kanade Shinkai, Thomas M. Beachkofsky, Mark D. P. Davis, Arturo R. Dominguez, Daniela Kroshinsky, Alina Markova, Robert G. Micheletti, Arash Mostaghimi, Helena B. Pasieka, Misha Rosenbach, Lucia Seminario-Vidal, John Trinidad, Joerg Albrecht, Emily M. Altman, Ryan Arakaki, Michael Arden-Jones, Alina G. Bridges, Adela R. Cardones, Angad A. Chadha, Jennifer K. Chen, Steven T. Chen, Kyle Cheng, Steven Daveluy, Katherine L. DeNiro, Joanna Harp, Jesse J. Keller, Brett King, Abraham M. Korman, Eve J. Lowenstein, Erin Luxenberg, Jennifer Brescoll Mancuso, Melissa M. Mauskar, Philip Milam, Kiran Motaparthi, Caroline A. Nelson, Cuong V. Nguyen, Fnu Nutan, Alex G. Ortega-Loayza, Tejesh Patel, Sahand Rahnama-Moghadam, Sergey Rekhtman, Nathan W. Rojek, Mansi Sarihan, Sheila Shaigany, Timmie R. Sharma, Sabrina M. Shearer, Bridget E. Shields, Lindsay C. Strowd, Danielle M. Tartar, Cristina Thomas, Karolyn A. Wanat, Andrew C. Walls, Lisa C. Zaba, Carolyn M. Ziemer, Emanual Maverakis, Benjamin H. Kaffenberger
Summary: This article discusses the importance of developing a skin-directed scoring system for EN, including consistent terminology and morphologic traits, as well as identifying the most affected sites. Through a Delphi consensus exercise, it was determined that there is a need for a skin-directed scoring system for EN.
Meeting Abstract
Dermatology
M. Gooderham, B. Strober, M. Ardern-Jones, E. Guttman-Yassky, M. Levenberg, G. Chan, P. Biswas, M. Watkins
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Meeting Abstract
Dermatology
Michael Ardern-Jones, Mahreen Ameen, Marjolein de Bruin-Weller, Eric Simpson, Wing Sin Chiu, Fan Zhang, Gary Chan, Christopher Koulias, Stephan Weidinger
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Meeting Abstract
Dermatology
Mahreen Ameen, Michael Ardern-Jones, Hamish Hunter, Susanne Grond, Fan Emily Yang, Yun-Fei Chen, Robert McKenzie, Alan Irvine
BRITISH JOURNAL OF DERMATOLOGY
(2022)