Article
Nanoscience & Nanotechnology
Muhammed A. Saad, Noha M. Eissa, Mohammed A. Ahmed, Aliaa N. ElMeshad, Goetz Laible, Ahmed S. Attia, Medhat A. Al-Ghobashy, Rania M. Abdelsalam, Muhammad Y. Al-Shorbagy
Summary: A nanoformulation containing rhMBP with RTX on its surface (Nano-rhMBP-RTX) was prepared and found to have potential neuro-protective effects on C57BL/6 mice after inducing experimental autoimmune encephalomyelitis (EAE), improving symptoms and histopathological findings.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zahra Amiri, Shahla Jalili, Mahdieh Tarahomi, Majid Eslami, Esmaeil Yazdanpanah, Rasoul Baharlou, Seyed-Alireza Esmaeili, Bahman Yousefi, Dariush Haghmorad
Summary: This study investigates the potential benefits of Curcumin in treating experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). The findings reveal that Curcumin can slow disease development and alleviate symptoms in EAE through stimulating Treg and Th2 cell polarization, providing evidence for its therapeutic role in MS.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Shishi Shen, Xi Cheng, Luyao Zhou, Yipeng Zhao, Hai Wang, Jie Zhang, Xiaobo Sun, Yuge Wang, Yaqing Shu, Yanteng Xu, Yu Tao, Mingqiang Li, Zhengqi Lu, Wei Cai, Guangjun Nie, Wei Qiu
Summary: This study developed neutrophil-derived nanovesicles (NNVs) to enhance the efficiency of myelin debris clearance in microglia for multiple sclerosis (MS) therapy. The results showed that NNVs treatment ameliorated lesional neuroinflammation and improved neurological functions and white matter integrity in a mouse model of MS. Additionally, NNVs treatment upregulated the expression of NRF2 in microglia and activated the transcription of RUBCN, leading to enhanced phagocytosis of myelin debris.
Article
Biochemistry & Molecular Biology
Laetitia Pouzol, Nadege Baumlin, Anna Sassi, Melanie Tunis, Julia Marrie, Enrico Vezzali, Herve Farine, Ulrich Mentzel, Marianne M. Martinic
Summary: Current strategies for treating demyelinating diseases like multiple sclerosis focus on anti-inflammatory or immunomodulatory drugs. The CXCR7 receptor antagonist ACT-1004-1239 shows promise in reducing disease severity, decreasing neuroinflammation, and promoting myelin repair in experimental models.
Review
Immunology
Judith Derdelinckx, Patrick Cras, Zwi N. Berneman, Nathalie Cools
Summary: Antigen-specific therapy for multiple sclerosis aims to induce tolerance to myelin-derived antigens for more effective treatment, but faces challenges from clinical trials and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ana L. Vivinetto, Clara Castanares, Constanza Garcia-Keller, Cristian Falcon, Anabela Palandri, Victoria Rozes-Salvador, Juan I. Rojas, Liliana Patrucco, Clara Monferran, Liliana Cancela, Edgardo Cristiano, Ronald L. Schnaar, Ana Lis Moyano, Pablo H. H. Lopen
Summary: The activation of MAG triggers clearance of Glutamate and induces a protective antioxidant response, safeguarding oligodendrocytes and nearby neurons from damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Immunology
Lawrence Steinman, Roberto Patarca, William Haseltine
Summary: Twenty years ago, a tribute was published in this journal to celebrate the 70th anniversary of an animal model known as experimental autoimmune encephalomyelitis (EAE). Recent research has helped explain how Epstein-Barr virus triggers multiple sclerosis through molecular mimicry. These observations bring us back to Rivers' first paper on EAE, published 90 years ago, and show the continued importance of this animal model in understanding disease mechanisms.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Clinical Neurology
Jordi Kuehne Escola, Cornelius Deuschl, Andreas Junker, Fabian Dusse, Refik Pul, Christoph Kleinschnitz, Martin Koehrmann, Benedikt Frank
Summary: We report a rare case of autoimmune disorder following COVID-19 vaccination, presenting with symptoms similar to bacterial meningomyelitis. The patient showed significant clinical improvement with appropriate treatment.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Neurosciences
Jasmin Steudler, Timothy Ecott, Daniela C. Ivan, Elisa Bouillet, Sabrina Walthert, Kristina Berve, Tobias P. Dick, Britta Engelhardt, Giuseppe Locatelli
Summary: The study found that oxidative stress is an early sign of multiple sclerosis-like inflammation, and the redox and morphological changes in mitochondria accompany neuroinflammation. This provides a new theoretical basis for the treatment of multiple sclerosis.
Review
Immunology
Jessica E. Kenison, Nikolas A. Stevens, Francisco J. Quintana
Summary: Immune tolerance is crucial for disease management, and recent breakthroughs have provided new avenues for therapeutic intervention. This article reviews the mechanisms of immune tolerance and novel methods for inducing it, while updating the progress and challenges in achieving antigen-specific immune tolerance.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tina Sepasi, Tahereh Ghadiri, Abbas Ebrahimi-Kalan, Farhad Bani, Mehdi Talebi, Reza Rahbarghazi, Sina Khodakarimi, Hanieh Beyrampour-Basmenj, Khaled Seidi, Soheil Abbaspour-Ravasjani, Mohammad-Reza Sadeghi, Amir Zarebkohan, Huile Gao
Summary: The study found that nano-formulated Fingolimod could effectively reduce inflammatory responses and improve therapeutic efficacy in a mouse model of experimental autoimmune encephalomyelitis (EAE), which is of great importance for controlling relapsing-remitting multiple sclerosis (MS).
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Immunology
Maryam J. J. Tavaf, Azita Soltanmohammadi, Simin Zargarani, Esmaeil Yazdanpanah, Bizhan Sadighimoghaddam, Bahman Yousefi, Hamid R. R. Sameni, Dariush Haghmorad
Summary: This study utilized an EAE mouse model and found that low-dose and high-dose berberine can decrease the severity of EAE and alleviate its symptoms, possibly through increasing the number and function of Treg and Th2 cells, as well as its anti-inflammatory properties.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Multidisciplinary Sciences
Xiao-Ru Ma, Xudong Zhu, Yujie Xiao, Hui-Min Gu, Shuang-Shuang Zheng, Liang Li, Fan Wang, Zhao-Jun Dong, Di-Xian Wang, Yang Wu, Chenyu Yang, Wenhong Jiang, Ke Yao, Yue Yin, Yang Zhang, Chao Peng, Lixia Gao, Zhuoxian Meng, Zeping Hu, Chong Liu, Li Li, Hou-Zao Chen, Yousheng Shu, Zhenyu Ju, Jing-Wei Zhao
Summary: Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). The authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in mouse OPCs. beta-nicotinamide mononucleotide (beta-NMN) supplement delays myelin aging and enhances remyelination in the aged mice.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Alba Sanchez-Fernandez, Stephanie Zandee, Jesus Amo-Aparicio, Marc Charabati, Alexandre Prat, Cecilia Garlanda, Elan Z. Eisenmesser, Charles A. Dinarello, Ruben Lopez-Vales
Summary: This study demonstrates that IL-37 reduces inflammation and protects against neurological deficits and myelin loss in EAE mice by acting via IL1-R5/IL1-R8. Administration of recombinant human IL-37 exerts therapeutic actions in EAE mice, but IL-37 transcripts are not up-regulated in peripheral blood mononuclear cells and brain lesions of MS patients.
Review
Chemistry, Multidisciplinary
Fatemeh Davodabadi, Mohammad Sarhadi, Javad Arabpour, Saman Sargazi, Abbas Rahdar, Ana M. Diez-Pascual
Summary: Breast cancer is a highly heterogeneous disease with four primary molecular subtypes. BC therapeutic vaccines, when used alone or combined with other immunotherapies, have emerged as a promising class of cancer immunotherapeutics. In recent years, nanomedicine has provided new opportunities to enhance the effectiveness of breast cancer vaccinations, with various nanostructures designed to efficiently deliver vaccines to breast cancer cells.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Hany H. Arab, Muhammad Y. Al-Shorbagy, Muhammed A. Saad
Summary: Dapagliflozin has a potential protective effect against experimental colitis by enhancing colonic autophagy and suppressing apoptosis through activation of AMPK/mTOR and Nrf2/HO-1 pathways, and inhibition of the HMGB1/RAGE/NF-kappa B cascade.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Pharmacology & Pharmacy
Reham A. Mohammed, Mohammed F. El-Yamany, Abdel A. Abdel-Rahman, Noha N. Nassar, Muhammad Y. Al-Shorbagy
Summary: The study suggests that in a model of brain ischemia-reperfusion injury, thalidomide exerts neuroprotection by inhibiting the pERK1/2 signaling pathway, reducing neuroinflammation and preserving neuronal function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Mohammed Gamal, Heba-Alla H. Abd-ElSalam, Ibrahim A. Naguib, Medhat A. Al-Ghobashy, Hala E. Zaazaa, M. Abdelkawy
Summary: This study aimed to develop cost-effective extraction techniques for extracting quercetin from Ginkgo biloba, and assess their greenness. The solid-phase extraction method showed the best results, and the one-step extraction process was considered more environmentally friendly.
JOURNAL OF AOAC INTERNATIONAL
(2022)
Article
Andrology
Mohammed M. Nooh, Sherine M. Rizk, Nashwa M. Saied, Sally M. Abdelazim
Summary: This study investigated the role of carnosine as an antioxidant in reproductive disorders caused by CHOP, a combination of chemotherapeutic agents commonly used in treating non-Hodgkin lymphoma. Carnosine was found to ameliorate CHOP-induced alterations without diminishing the antineoplastic action of CHOP, indicating its potential in alleviating reproductive disorders induced by chemotherapy.
Article
Nanoscience & Nanotechnology
Yasmeen Ezzeldeen, Shady Swidan, Aliaa ElMeshad, Aya Sebak
Summary: This study aimed to fabricate HK transfersomes for topical treatment of melanoma, which showed potential to alleviate the immunosuppressive characteristics of the tumor and reduce the expression of stem-like cell markers. The optimized formula exhibited a mean size of 190 nm and highly negative surface charge, with promising results both in vitro and in combination with other drugs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Dina B. Mahmoud, Walaa M. Ismail, Yassmin Moatasim, Omnia Kutkat, Aliaa N. ElMeshad, Shahira M. Ezzat, Kadriya S. El Deeb, Ahlam M. El-Fishawy, Mokhtar R. Gomaa, Ahmed Kandeil, Ahmed A. Al-Karmalawy, Mohamed A. Ali, Ahmed Mostafa
Summary: The study found that polyphenol-rich Cuphea ignea extract has the potential to combat SARS-CoV-2, and a self-nanoemulsifying formulation can enhance solubility and enable combined delivery, offering a new direction for antiviral treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tarek Mohamed Kamal Motawi, Mira Magdy William, Mohammed Mostafa Nooh, Hanan Muhammad Abd-Elgawad
Summary: This study found that avocado extract can modulate the metabolizing enzymes of cyclophosphamide and alleviate the toxicity induced by cyclophosphamide.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sherif Ashraf Fahmy, Noha Khalil Mahdy, Hadeer Al Mulla, Aliaa Nabil ElMeshad, Marwa Y. Issa, Hassan Mohamed El-Said Azzazy
Summary: This study successfully improved the water solubility and bioavailability of harmala alkaloids using a complex and nanoparticle approach, and demonstrated high antibacterial and antiviral activity.
Article
Chemistry, Multidisciplinary
Ibrahim F. Abo-Elmagd, Amr M. Mahmoud, Medhat A. Al-Ghobashy, Marianne Nebsen, Nesrine S. El Sayed, Shahira Nofal, Sameh H. Soror, Robert Todd, Salwa A. Elgebaly
Summary: CCrP is a potent cardioprotective drug with promising roles in heart transplantation surgery. The newly designed MIP sensor shows high recognition affinity and good performance for CCrP detection.
Article
Genetics & Heredity
Jingwei Wei, Brigid Brophy, Sally-Ann Cole, Jannis Moormann, Jens Boch, Gotz Laible
Summary: Genome editing allows for targeted introduction of natural sequence variants in cattle breeding, accelerating genetic gain by producing non-mosaic edited embryos with precision genotypes.
FRONTIERS IN GENETICS
(2022)
Article
Nanoscience & Nanotechnology
Muhammed A. Saad, Noha M. Eissa, Mohammed A. Ahmed, Aliaa N. ElMeshad, Goetz Laible, Ahmed S. Attia, Medhat A. Al-Ghobashy, Rania M. Abdelsalam, Muhammad Y. Al-Shorbagy
Summary: A nanoformulation containing rhMBP with RTX on its surface (Nano-rhMBP-RTX) was prepared and found to have potential neuro-protective effects on C57BL/6 mice after inducing experimental autoimmune encephalomyelitis (EAE), improving symptoms and histopathological findings.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Suleiman W. Bahouth, Mohammed M. Nooh, Salvatore Mancarella
Summary: SAP97 is a member of the MAGUK family of proteins and is expressed not only in the central nervous system but also in peripheral organs. It forms multi-protein networks at the inner leaflet of the cell membrane, which are involved in trafficking and targeting of membrane proteins and play critical roles in cellular functions.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Sarah A. A. Sideek, Hala B. B. El-Nassan, Ahmed R. R. Fares, Aliaa N. N. ElMeshad, Nermeen A. A. Elkasabgy
Summary: Curcumin is the active ingredient of turmeric and has amazing medicinal applications. It has strong antibacterial and antifungal activities and powerful wound healing ability, but its poor bioavailability, low solubility, and rapid metabolism limit its medical use. Tailoring suitable drug delivery systems for carrying curcumin can improve its pharmaceutical and pharmacological effects.
Article
Pharmacology & Pharmacy
Nasr Eldin Hussein Nasr, Aliaa Nabil ElMeshad, Ahmed Roshdy Fares
Summary: This review discusses new techniques for taste masking, including the use of nanocarrier systems such as liposomes, polymeric and solid lipid nanoparticles, polymeric micelles, submicron lipid emulsions, and nanogels. These techniques offer advantages in designing oral therapeutic delivery systems that successfully mask the taste of bitter molecules.
SCIENTIA PHARMACEUTICA
(2022)