Article
Gastroenterology & Hepatology
Na Li, Peiguang Ma, Yalan Li, Xuekai Shang, Xinmei Nan, Lei Shi, Xiao Han, Jiajing Liu, Yanfei Hong, Qiuyi Li, Jiaqi Cui, Junxiang Li, Guiying Peng
Summary: Intestinal microbiota dysbiosis and metabolic disruption are well-known triggers of ulcerative colitis. However, their role in regulating ILC3s, which are crucial for intestinal health, has not been explored. This study found that the microbiota structure of severe UC patients differed from those with mild UC, moderate UC, and healthy controls. Microbes producing secondary bile acids decreased with the worsening of UC, and there was a strong positive correlation between them. The study also showed that microbiota-mediated inflammatory modulation increased with disease severity, leading to reduced ILC3 percentage and down-regulated bile acid receptor expressions.
Article
Microbiology
Hao-Yu Liu, Antoine Giraud, Cedric Seignez, David Ahl, Feilong Guo, John Sedin, Tomas Walden, Jee-Hwan Oh, Jan Peter van Pijkeren, Lena Holm, Stefan Roos, Stefan Bertilsson, Mia Phillipson
Summary: The study shows that oral administration of the probiotic bacterium Limosilactobacillus reuteri R2LC increases the numbers and effector functions of B cell subsets, leading to enhanced IgA production, altered intestinal microbiota, and protection against inflammation.
Article
Biotechnology & Applied Microbiology
Yujiao Cheng, Yan Ren, Wenhui Wang, Wangdong Zhang
Summary: Aggregated Lymphoid Nodules Area (ALNA), consisting of Reticular Mucosal Folds Region (RMFR) and Longitudinal Mucosal Folds Region (LMFR), exhibits histological properties similar to Peyer's patches (PPs). Proteomic analysis revealed a high degree of similarity in the immune-related proteins expressed in ALNA and PPs, indicating comparable functions in mucosal immune responses.
Article
Gastroenterology & Hepatology
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen-Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen
Summary: This study found that reduced levels of Lactobacillus reuteri and short-chain fatty acids (SCFAs) were associated with hepatocellular carcinoma (HCC) development. Acetate reduced IL-17A production in hepatic ILC3s by inhibiting histone deacetylase activity. Tumor-infiltrating ILC3s correlated with prognosis in HCC patients, which may be mediated by acetate. Modifying bacteria, changing SCFAs, reducing IL-17A-producing ILC3 infiltration, and combining with immune checkpoint inhibitors may contribute to the clinical treatment of HCC.
Article
Multidisciplinary Sciences
Sisi Lin, Subhajit Mukherjee, Juanjuan Li, Weiliang Hou, Chao Pan, Jinyao Liu
Summary: The oral delivery of camouflaged probiotics can induce mucosal immune responses, regulate the gut microbiota, maintain gut homeostasis, and provide defense against external threats. Studies show that this approach effectively prevents intestinal barrier breakdown, bacterial translocation, and systemic inflammation.
Article
Immunology
Chaoyue Zheng, Zhen Lu, Haisi Wu, Lulu Cui, Jiacheng Bi, Xiaochun Wan
Summary: The study found that exogenous oxidative stress can inhibit IL-33-induced ILC2 response and airway inflammation, reducing the increase of ILC2 population and recruitment of eosinophils.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Physiology
Jinwei Zhang, Yang Shen, Guitao Yang, Jing Sun, Chuang Tang, Hao Liang, Jideng Ma, Xiaoqian Wu, Haoran Cao, Meng Wu, Yuchun Ding, Mingzhou Li, Zuohua Liu, Liangpeng Ge
Summary: This study analyzed the impact of commensal microbiota on the host's mucosal immunity. It found that the absence of commensal microbiota led to smaller Peyer's patches in the gastrointestinal tract, particularly regarding B and T cells. Gene expression analysis revealed that commensal microbiota plays an important role in the development of mucosal immunity in the intestine. Overall, this study revealed the regulatory mechanisms of commensal microbiota in the host's Peyer's patches and emphasized the importance of early microbial colonization for mucosal immunity development.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ramon A. Lujan, Sophia M. Vrba, Heather D. Hickman
Summary: Before the adaptive immune response, innate antiviral cells, including conventional natural killer cells (cNK) and tissue-resident ILCs (ILC1s), respond to a wide range of viruses to limit replication and virus-induced pathology. While cNK cells lyse virus-infected cells, ILC1s respond with the production of antiviral cytokines and can even induce an antiviral state in uninfected tissue. Mounting evidence suggests that ILC1s may have enhanced secondary responses to viral infections.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Food Science & Technology
Ce Qi, Huayu Tu, Yuning Zhao, Jingbo Zhou, Jie Chen, Haiting Hu, Renqiang Yu, Jin Sun
Summary: This study demonstrates that supplementing maternal mice with the breast milk-derived probiotic Fn041 during late pregnancy and lactation can prevent atopic dermatitis in offspring. The probiotic directly induces anti-AD immune responses by promoting the absorption and metabolism of retinol in Peyer's patches, and indirectly strengthens the mucosal barrier and increases the abundance of specific anti-AD bacteria in the cecum.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ying Kong, Han-Dong Li, Dan Wang, Xiaolin Gao, Chunsheng Yang, Minshu Li, Ting Chang, Qiang Liu
Summary: The study found a correlation between the reduction of ILC2 and disease severity in neuromyelitis optica spectrum disorder (NMOSD), and expanding ILC2 could alleviate the pathological conditions.
Review
Immunology
Takahiro Matsuyama, Hiromi Matsuyama, Yoichi Dotake, Koichi Takagi, Kentaro Machida, Hiromasa Inoue
Summary: T helper type 2 cells and group 2 innate lymphoid cells play a crucial role in asthma, particularly in airway eosinophilic inflammation. These cells are activated by cytokines released by airway epithelial cells and produce high levels of type 2 cytokines. ILC2s induce airway inflammation independently of antigens and may contribute to steroid resistance. Biologics targeting these cytokines and/or their receptors have shown promise in reducing asthma exacerbations and improving lung function and quality of life in asthmatic patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Laura Schaefer, Humberto Hernandez, Rosalind A. Coats, Zhiyuan Yu, Stephen C. Pflugfelder, Robert A. Britton, Cintia de Paiva
Summary: Dry eye is a common ocular inflammatory disorder characterized by tear film instability and reduced tear production. The interaction between the intestinal microbiota and the ocular surface, mediated by microbially produced small molecules such as butyrate, plays a potential role in maintaining ocular surface homeostasis. In this study, it was found that the SCFA transporter SLC5A8 is expressed in murine conjunctival and corneal epithelium, and pretreatment with phenylbutyrate (PBA) reduced inflammation in corneal epithelial cultures and dendritic cells. The protective effect of PBA requires SLC5A8. Oral treatment with tributyrin, a prodrug form of butyrate, reduced inflammation at the ocular surface in mice undergoing desiccating stress, partially through the involvement of SLC5A8.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Timothy C. Borbet, Miranda B. Pawline, Jackie Li, Melody L. Ho, Yue Sandra Yin, Xiaozhou Zhang, Ekaterina Novikova, Katelyn Jackson, Briana J. Mullins, Victoria E. Ruiz, Marcus J. Hines, Xue-Song Zhang, Anne Mueller, Sergei B. Koralov, Martin J. Blaser
Summary: During postnatal development, the use of antibiotics can disrupt the maturing microbiome and the host immune system, with long-lasting effects on germinal center formation and intestinal immunoglobulin A (IgA) production. The timing of antibiotic exposure, particularly during the early-life stage, has a significant impact on Peyer's patch development and immune cell abundance. Bifidobacterium longum has been found to be associated with germinal center frequency and introducing this probiotic strain can partially restore the immunological deficits caused by early-life antibiotic use.
Review
Immunology
Laura Mathae, Fumio Takei, Itziar Martinez-Gonzalez
Summary: Group 2 innate lymphoid cells (ILC2s) are present in mucosal and non-mucosal tissues in both mice and humans, and are involved in initiating type 2 inflammation. Recent studies have shown that ILC2s have the ability to circulate between different organs during inflammation and may play roles in mediating multiple type 2 diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Takahiro Matsuyama, Kentaro Machida, Keiko Mizuno, Hiromi Matsuyama, Yoichi Dotake, Masahiro Shinmura, Koichi Takagi, Hiromasa Inoue
Summary: Asthma is characterized by chronic airway inflammation. Group 2 innate lymphoid cells (ILC2) play a crucial role in its pathogenesis and are involved in both steroid resistance and the induction of airway eosinophilic inflammation. Studies have shown that ILC2s induce airway inflammation through interactions with cytokines and other mediators from immune and non-immune cells, collaborating with T helper type 2 cells to organize type 2 immune responses. The increased frequencies of ILC2s in the blood and bronchoalveolar lavage fluid of asthma patients, especially in severe asthmatics, contribute to the regulation of immune response in asthma.
Article
Immunology
Sae-Hae Kim, In-Young Yang, Ju Kim, Kyung-Yeol Lee, Yong-Suk Jang
EUROPEAN JOURNAL OF IMMUNOLOGY
(2015)
Article
Immunology
Sae-Hae Kim, Ha-Yan Lee, Yong-Suk Jang
Article
Immunology
Sae-Hae Kim, Yu Na Kim, Yong-Suk Jang
JOURNAL OF IMMUNOLOGY
(2017)
Article
Immunology
Sae-Hae Kim, Yong-Suk Jang
Article
Cell Biology
Sae-Hae Kim, Yu Na Kim, Ju Kim, Yong-Suk Jang
CELLULAR IMMUNOLOGY
(2018)
Article
Immunology
Sae-Hae Kim, Byeol-Hee Cho, Kyung-Yeot Lee, Yong-Suk Jang
Article
Immunology
Sae-Hae Kim, Dae-Im Jung, In-Young Yang, Ju Kim, Kyung-Yeol Lee, Tomonori Nochi, Hiroshi Kiyono, Yong-Suk Jang
EUROPEAN JOURNAL OF IMMUNOLOGY
(2011)
Article
Immunology
Sae-Hae Kim, Dae-Im Jung, In-Young Yang, Sun-Hee Jang, Ju Kim, Thang Thua Truong, Thuc Van Pham, Ninh Uyen Truong, Kyung-Yeol Lee, Yong-Suk Jang
INTERNATIONAL IMMUNOLOGY
(2013)
Article
Immunology
Sae-Hae Kim, Ki-Weon Seo, Ju Kim, Kyung-Yeol Lee, Yong-Suk Jang
JOURNAL OF IMMUNOLOGY
(2010)
Article
Immunology
Sae-Hae Kim, In-Young Yang, Sun-Hee Jang, Ju Kim, Thang Thua Truong, Thuc Van Pham, Ninh Uyen Truong, Kyung-Yeol Lee, Yong-Suk Jang
MICROBES AND INFECTION
(2013)
Article
Cell Biology
Sae-Hae Kim, Byeol-Hee Cho, Kwang Soon Kim, Yong-Suk Jang
Summary: C5a in the Peyer's patch enhances CD8(+) T cell responses by increasing C5/C5a levels. Single-cell RNA sequencing identifies dendritic cells expressing C5aR and lysozyme as key players in CD8(+) T cell immune induction.
Review
Immunology
Sae-Hae Kim, Yong-Suk Jang
Review
Immunology
Sae-Hae Kim, Yong-Suk Jang
CLINICAL AND EXPERIMENTAL VACCINE RESEARCH
(2017)
Review
Biochemistry & Molecular Biology
Sae-Hae Kim, Yong-Suk Jang
EXPERIMENTAL AND MOLECULAR MEDICINE
(2014)