Article
Dermatology
Xuefen Wu, Bingxia Ming, Tong Wu, Rongfen Gao, Peng Hu, Jungen Tang, Jixin Zhong, Fang Zheng, Lingli Dong
Summary: IL-33/ST2 axis plays a crucial role in the fibrotic disorder of SSc by promoting fibroblast activation, and IL-33/ST2 blockade could be a potential novel strategy to inhibit fibrosis progression in SSc patients.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Rheumatology
Maya Malaab, Ludivine Renaud, Naoko Takamura, Kip D. Zimmerman, Willian A. da Silveira, Paula S. Ramos, Sandra Haddad, Marc Peters-Golden, Loka R. Penke, Bethany Wolf, Gary Hardiman, Carl D. Langefeld, Thomas A. Medsger, Carol A. Feghali-Bostwick
Summary: Our study identified distinct molecular features in dermal fibroblasts of systemic sclerosis patients, including dysregulated transcription factors and microRNAs, suggesting a role for epigenetic dysregulation in disease susceptibility. This highlights the potential for using epigenetic modifiers as future therapies in systemic sclerosis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Soichiro Sawamura, Katsunari Makino, Maho Ide, Shuichi Shimada, Ikko Kajihara, Takamitsu Makino, Masatoshi Jinnin, Satoshi Fukushima
Summary: In patients with systemic sclerosis (SSc), the levels of alpha 2(I) collagen are higher than alpha 1(I) collagen in fibroblasts. Further investigation of the overall regulatory mechanisms of type I collagen may help to understand the aberrant collagen metabolism in SSc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Katarzyna Gaweda-Walerych, Dawid Walerych, Mariusz Berdynski, Emanuele Buratti, Cezary Zekanowski
Summary: The study showed that parkin downregulation is associated with PGRN silencing in fibroblasts from FTLD patients, leading to a decrease in its downstream targets MFN2 and VDAC1. While TDP-43 overexpression can rescue PRKN levels, it fails to do so in FTLD cells with PGRN pathogenic variants, suggesting TDP-43 loss-of-function may contribute to PRKN decrease.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Dermatology
Zhuzhen Zhang, Ilja Kruglikov, Shangang Zhao, Zhenzhen Zi, Christy M. Gliniak, Na Li, May-yun Wang, Qingzhang Zhu, Christine M. Kusminski, Philipp E. Scherer
Summary: Study found that dermal adipocytes can modulate the structure of the dermis through regulating extracellular matrix production in dermal fibroblasts, with involvement of fatty acids released by dermal adipocytes.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Atsuto Naruke, Rei Nakano, Junichi Nunomura, Yoko Suwabe, Masumi Nakano, Shinichi Namba, Taku Kitanaka, Nanako Kitanaka, Hiroshi Sugiya, Tomohiro Nakayama
Summary: Fibroblasts play a significant role in autoimmune skin diseases by producing and secreting cytokines under inflammatory conditions, particularly by inducing the expression of the chemokine IL-8 through IL-1β. Understanding the signaling pathways involved, such as MAPK signaling mediated by Tpl2, is crucial for the pathogenesis of autoimmune diseases like atopic dermatitis.
Article
Biology
Minmin Song, Guangfeng Zhao, Haixiang Sun, Simin Yao, Zhenhua Zhou, Peipei Jiang, Qianwen Wu, Hui Zhu, Huiyan Wang, Chenyan Dai, Jingmei Wang, Ruotian Li, Yun Cao, Haining Lv, Dan Liu, Jianwu Dai, Yan Zhou, Yali Hu
Summary: Emerging evidence suggests a crucial role of circRNAs in regulating pathological processes, with circPTPN12 identified as a factor in endometrial fibrosis pathology. Dysfunction of the circPTPN12 pathway contributes to the pathogenesis of endometrial fibrosis.
Article
Cardiac & Cardiovascular Systems
William W. Du, Jindong Xu, Weining Yang, Nan Wu, Feiya Li, Le Zhou, Sheng Wang, Xiangmin Li, Alina T. He, Kevin Y. Du, Kaixuan Zeng, Jian Ma, Juanjuan Lyu, Chao Zhang, Chi Zhou, Katarina Maksimovic, Burton B. Yang
Summary: The upregulation of circNlgn in patients with cardiac disease leads to cardiac overload. The novel peptide Nlgn173 binds to nuclear structural proteins and regulators, ultimately contributing to cardiac fibrosis and heart disease. Therapeutic implications may be derived from understanding this dysregulation mechanism.
CIRCULATION RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Takako Ooshio, Masahiro Yamamoto, Kiyonaga Fujii, Bing Xin, Kenji Watanabe, Masanori Goto, Yoko Okada, Akira Suzuki, Josef M. Penninger, Hiroshi Nishina, Yuji Nishikawa
Summary: This study found that MKK7 plays an important role in the repair processes following liver parenchymal destruction, possibly through modulation of hepatocyte-extracellular matrix interactions. While dispensable for the regenerative proliferation of hepatocytes, MKK7 deficiency affected tissue repair and regenerative responses in the altered tissue microenvironment.
Article
Dermatology
Zhixing Jiang, Chen Chen, Sen Yang, Hang He, Xiaoxia Zhu, Minrui Liang
Summary: The chemokine CXCL4 is associated with anti-angiogenic properties and plays a role in systemic sclerosis (SSc) related pulmonary arterial hypertension (PAH). Elevated levels of circulating CXCL4 were found in SSc patients and correlated with peripheral vasculopathy, with potential effects on endothelial cell dysfunction and angiogenesis. The study suggests that CXCL4 may contribute to peripheral vasculopathy in SSc through downregulating Fli-1 via c-Abl signaling in endothelial cells.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sullim Lee, Taesu Jang, Ki Hyun Kim, Ki Sung Kang
Summary: 3,5,7-trimethoxyflavone (6) isolated from black ginger has the potential to inhibit matrix metalloproteinase-1 secretion induced by tumor necrosis factor-alpha, attenuate oxidative stress and inflammatory response, and suppress the expression of pro-inflammatory cytokines in normal human dermal fibroblasts.
Article
Cell Biology
Yuji Shiozaki, Shinobu Miyazaki-Anzai, Audrey L. Keenan, Makoto Miyazaki
Summary: Amino acid deficiency can mimic starvation to induce FAM134B2 expression, with MEF2D and NR4A1 identified as critical transcription factors involved. Integrated signal response and mTOR signals do not contribute to the induction of FAM134B2 under amino acid deficiency.
Article
Biochemistry & Molecular Biology
Kang Sub Kim, Ranhee Kim, So-Ri Son, Ki Sung Kang, Dae Sik Jang, Sullim Lee
Summary: In this study, a hot water extract from Morus alba fruits and its constituent oddioside A were found to inhibit the secretion of MMP-1, increase collagen, and suppress the phosphorylation of MAPKs. These findings suggest that Morus alba may be a potential agent to prevent inflammation-related skin aging and other skin disorders.
Article
Pharmacology & Pharmacy
Ying Jiang, Feifei Hu, Ming Li, Qiao Li
Summary: This study demonstrates that tanshinone IIA (TAN IIA) can inhibit skin fibrosis in systemic sclerosis (SSc) by modulating the TGF-beta/Smad and MAPK/ERK signaling pathways. TAN IIA significantly improves skin thickness and collagen deposition in a mouse model of SSc, and inhibits the proliferation of skin fibroblasts derived from SSc patients by inducing cell cycle arrest and promoting apoptosis.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hung Manh Phung, Sullim Lee, Sukyung Hong, Sojung Lee, Kiwon Jung, Ki Sung Kang
Summary: The study demonstrated the skin protective effects of polymethoxyflavones against oxidative stress and inflammation-induced damage in human dermal fibroblasts. Among the tested compounds, 5,7,4' trimethoxyflavone was identified as the most potent constituent in preventing TNF-alpha-induced HDF damage, inhibiting MMP-1 production, stimulating COLIA1 expression, and suppressing ROS and pro-inflammatory mediators in HDFs. The findings suggest that TMF may be a potential agent for preventing skin aging and dermatological disorders related to oxidative stress and inflammation.