Article
Endocrinology & Metabolism
Zahra Hoseini, Nasser Behpour, Rastegar Hoseini
Summary: This study found that exercise training and vitamin D supplementation can improve liver function in type 2 diabetic rats and attenuate insulin resistance by upregulating Akt expression and downregulating PEPCK and G6Pase expressions.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Review
Nutrition & Dietetics
Matthew T. Stratton, Kembra Albracht-Schulte, Patrick S. Harty, Madelin R. Siedler, Christian Rodriguez, Grant M. Tinsley
Summary: This review examines the physiological responses during acute fasting, finding that short-term fasting can alter substrate metabolism within the initial 24 hours, while the impact on protein metabolism appears to be minimal. The effect of acute fasting on autophagy remains unknown.
Article
Endocrinology & Metabolism
Daniela Boschetti, Cynthia R. Muller, Anna Laura V. Americo, Bruno Vecchiatto, Luiz Felipe Martucci, Renata O. Pereira, Claudia P. Oliveira, Patricia Fiorino, Fabiana S. Evangelista, Anna Karenina Azevedo-Martins
Summary: This study examined the effects of aerobic physical exercise on obese female mice. The results showed that aerobic exercise did not reduce body weight gain, but did improve adipocyte size, exercise tolerance, and glucose metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Caitlin L. Maikawa, Andrea D'Aquino, Eric T. Vuong, Bo Su, Lei Zou, Peyton C. Chen, Leslee T. Nguyen, Anton A. A. Autzen, Joseph L. Mann, Matthew J. Webber, Eric A. Appel
Summary: This study demonstrates that modulating supramolecular PEGylation can alter the pharmacokinetics of insulin, extending its systemic exposure time.
Article
Rehabilitation
Ryan A. Gordon, Emily L. Zumbro, Todd J. Castleberry, Matthew L. Sokoloski, Matthew F. Brisebois, Christopher J. Irvine, Anthony A. Duplanty, Vic Ben-Ezra
Summary: The study found that whey protein intake significantly improved glucose responses during an oral glucose tolerance test, while vigorous-intensity aerobic exercise did not further enhance glucose responses. This suggests that whey protein may play an important role in glucose regulation.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2022)
Article
Geriatrics & Gerontology
Kazuki Hyodo, Kazuya Suwabe, Daisuke Yamaguchi, Hideaki Soya, Takashi Arao
Summary: This study compared the acute effects of intermittent and continuous light-intensity aerobic dance exercise (LADE) on mood and executive functions in older adults. Findings showed that intermittent exercise was more enjoyable and fun during exercise compared to continuous exercise, but there were similar effects on mood and executive function after both types of exercise.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Physiology
Xishuai Wang, Xuejie Yi, Donghui Tang
Summary: The study found that regular aerobic exercise can protect against high-fat diet-induced pulmonary fibrosis and improve obesity-related insulin resistance, chronic low-grade inflammation, and oxidative stress imbalance.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Psychology, Multidisciplinary
Sophie C. Andrews, Lydia Kampf, Dylan Curtin, Mark Hinder, Nicole Wenderoth, Julie C. Stout, James P. Coxon
Summary: This study found that a single bout of moderate intensity aerobic exercise can improve motor skill learning in individuals with HD gene-expansion, particularly in terms of accuracy. However, further research is needed to explore the potential neurocognitive and functional benefits of exercise for individuals with HD.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Physiology
Danny Christiansen, David J. Bishop
Summary: This study found that independent of muscle hypoxia level, BFR exercise enhances early markers of metabolic health associated with cholesterol synthesis regulation and glucose homeostasis.
Article
Clinical Neurology
Elizabeth Jansen, Mandy Miller Koop, Anson B. Rosenfeldt, Jay L. Alberts
Summary: High intensity aerobic exercise, whether forced or voluntary, significantly improves symptoms and manual dexterity in PD patients by enhancing connectivity between basal ganglia and cortical areas, leading to improved motor control and execution abilities.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Microbiology
Lidong Zhang, Hedong Lang, Li Ran, Guoliang Tian, Hui Shen, Jundong Zhu, Qianyong Zhang, Long Yi, Mantian Mi
Summary: Exercise has been found to have a positive impact on skeletal muscle performance, possibly through its effects on gene expression, grip strength, serum testosterone levels, and muscle cross-sectional area. Furthermore, exercise can alter the structure of the gut microbiota, which may be related to testosterone production.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Neurosciences
Matthew L. Racine, Janee D. Terwoord, Nathaniel B. Ketelhut, Nate P. Bachman, Jennifer C. Richards, Gary J. Luckasen, Frank A. Dinenno
Summary: The haemodynamic and ATP responses in older adults during hypoxia and exercise are impaired compared to young adults, which is likely due to reduced red blood cell ATP release. Rho-kinase inhibition improves ATP release from isolated red blood cells in older adults. This study tested whether treating older adults with a Rho-kinase inhibitor (fasudil) could improve local haemodynamic and ATP responses during hypoxia and exercise. The results showed that Rho-kinase inhibition improved blood flow and ATP responses in older adults, suggesting that it may have therapeutic implications for age-related impairments in haemodynamics and ATP responses.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Physiology
Jessica Lavier, Manon Beaumann, Steeve Menetrey, Karima Bouzourene, Nathalie Rosenblatt-Velin, Vincent Pialoux, Lucia Mazzolai, Anne-Christine Peyter, Maxime Pellegrin, Gregoire P. Millet
Summary: Hypoxic high-intensity exercise increases NO bioavailability and improves vascular function, showing promising potential for cardiovascular disease prevention.
Article
Biochemistry & Molecular Biology
Ye Jian, Shunling Yuan, Jialun Yang, Yong Lei, Xuan Li, Wenfeng Liu
Summary: Abnormalities in autophagy are associated with Alzheimer's disease, and exercise can improve this condition by activating the AdipoR1/AMPK/TFEB signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Charles Bartel, Victor S. Coswig, Gabriel Protzen, Fabricio B. Del Vecchio
Summary: This study aimed to measure the energy expenditure in taekwondo-specific high-intensity intermittent exercises. The results showed that taekwondo training has different contributions to aerobic and anaerobic metabolisms. This is important for designing training programs and adjusting exercise intensity for taekwondo athletes.
Review
Biochemical Research Methods
Aurelie Rondon, Francoise Degoul
BIOCONJUGATE CHEMISTRY
(2020)
Article
Sport Sciences
Anna Borowik, Samarmar Chacaroun, Damien Tessier, Stephane Doutreleau, Samuel Verges, Patrice Flore
JOURNAL OF SPORTS SCIENCES
(2020)
Article
Physiology
Samarmar Chacaroun, Anna Borowik, Stephane Doutreleau, Elise Belaidi, Bernard Wuyam, Renaud Tamisier, Jean-Louis Pepin, Patrice Flore, Samuel Verges
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Article
Chemistry, Medicinal
Jean-Baptiste Bequignat, Nancy Ty, Aurelie Rondon, Ludivine Taiariol, Francoise Degoul, Damien Canitrot, Mercedes Quintana, Isabelle Navarro-Teulon, Elisabeth Miot-Noirault, Claude Boucheix, Jean-Michel Chezal, Emmanuel Moreau
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Sohaib Mahri, Aurelie Rondon, Tobias Wilms, Cynthia Bosquillon, Rita Vanbever
Summary: The conjugation of rhDNase with PEG30 kDa significantly extends its residence time in mouse lungs, ideal for its mucolytic action. PEGylated rhDNase is mainly cleared through the intratracheal route, while the unconjugated form is primarily eliminated within 24 hours.
JOURNAL OF CONTROLLED RELEASE
(2021)
Letter
Sport Sciences
Samarmar Chacaroun, Stephane Doutreleau, Patrice Flore, Samuel Verges
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Review
Chemistry, Multidisciplinary
Aurelie Rondon, Sohaib Mahri, Francisco Morales-Yanez, Mireille Dumoulin, Rita Vanbever
Summary: Protein therapeutics have become an important pillar in treating various diseases, but their clinical application is often hindered by issues such as short half-life and immunogenicity. Strategies to extend the half-life of proteins are being developed through polymer chemistry, protein engineering, and fusion to other proteins, with a focus on balancing between half-life extension and maintaining therapeutic activity.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Oncology
Aurelie Rondon, Jacques Rouanet, Francoise Degoul
Summary: Monoclonal antibody-bearing radionuclides have been investigated for their potential in cancer theranostic applications, with FDA approval for only two radioimmunotherapies targeting CD20 antigens in hematologic tumors. Challenges exist in applying RIT to solid cancers, with efforts focused on improving antibody penetrance and reducing radiotoxicity. Preclinical research has shown promise for targeted radioimmunotherapy, but clinical studies in the past decade have highlighted the complexity of RIT and the need for further improvement in efficiency, particularly for solid tumors.
Article
Sport Sciences
Monique Mendelson, Samarmar Chacaroun, Sebastien Baillieul, Stephane Doutreleau, Michel Guinot, Bernard Wuyam, Renaud Tamisier, Jean-Louis Pepin, Francois Esteve, Damien Tessier, Samuel Verges, Patrice Flore
Summary: The study suggests that a 2-month supervised high volume short interval HIIT can lead to greater improvements in cardiorespiratory fitness and cardiometabolic risk compared to isocaloric moderate intensity continuous training in overweight/obese individuals. Furthermore, the long-term effects of HIIT on maintaining cardiorespiratory fitness and reducing fat masses and cholesterol levels are also observed after 4 months of autonomous exercise.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2022)
Article
Sport Sciences
Mathieu Marillier, Anna Borowik, Samarmar Chacaroun, Sebastien Baillieul, Stephane Doutreleau, Michel Guinot, Bernard Wuyam, Renaud Tamisier, Jean-Louis Pepin, Francois Esteve, Samuel Verges, Damien Tessier, Patrice Flore
Summary: This study suggests that high-intensity interval training (HIIT) improves cardiorespiratory fitness and induces positive changes in left prefrontal cortex (PFC) oxygenation and affective valence during exercise in individuals with obesity.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Nicholas L. Truex, Aureïlie Rondon, Simon L. Ro''ssler, Cameron C. Hanna, Yehlin Cho, Bin-You Wang, Coralie M. Backlund, Emi A. Lutz, Darrell J. Irvine, Bradley L. Pentelute
Summary: This study engineered an antigen peptide delivery system to improve the efficacy of vaccines by targeting dendritic cells and facilitating cytosolic delivery. The results demonstrate that this system enhances immune responses and significantly inhibits tumor growth and improves survival rates in mice.
ACS CENTRAL SCIENCE
(2023)
Meeting Abstract
Respiratory System
Mathieu Marillier, Anna Borowik, Samarmar Chacaroun, Sebastien Baillieul, Stephane Doutreleau, Michel Guinot, Bernard Wuyam, Renaud Tamisier, Jean-Louis Pepin, Francois Esteve, Samuel Verges, Damien Tessier, Patrice Flore
EUROPEAN RESPIRATORY JOURNAL
(2021)
Meeting Abstract
Respiratory System
Tobias Wilms, Sohaib Mahri, Aurelie Rondon, Cynthia Bosquillon, Rita Vanbever
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2021)
Meeting Abstract
Respiratory System
Samuel Verges, Samarmar Chacaroun, Anna Borowik, Ignacio Vega-Escamilla Y Gonzalez, Stephane Doutreleau, Bernard Wuyam, Elise Belaidi, Renaud Tamisier, Jean-Louis Pepin, Patrice Flore
EUROPEAN RESPIRATORY JOURNAL
(2020)
Meeting Abstract
Respiratory System
Samuel Verges, Samarmar Chacaroun, Anna Borowik, Stephane Doutreleau, Elise Belaidi, Bernard Wuyam, Renaud Tamisier, Jean-Louis Pepin, Patrice Flore
EUROPEAN RESPIRATORY JOURNAL
(2020)