Article
Immunology
Karmele Valencia, Mirari Echepare, Alvaro Teijeira, Andrea Pasquier, Cristina Bertolo, Cristina Sainz, Ibon Tamayo, Benat Picabea, Graziella Bosco, Roman Thomas, Jackeline Agorreta, Jose Maria Lopez-Picazo, Joan Frigola, Ramon Amat, Alfonso Calvo, Enriqueta Felip, Ignacio Melero, Luis M. Montuenga
Summary: Valencia et al. have identified DSTYK as a novel therapeutic target in lung cancer. Inhibition of DSTYK sensitizes lung cancer cells to T cell-mediated killing and impairs mitochondrial fitness and cytoprotective autophagy. DSTYK copy number gain predicts lack of response to immunotherapy in lung cancer patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Oncology
Tianye Li, Zhenzhen Hao, Zihan Tang, Chunting Li, Linglin Cheng, Tao Wang, Xiaojin Zhu, Yunhao He, Yongye Huang, Bing Wang
Summary: BAP31 plays an important role in the migration of lung cancer cells, and its knockdown weakens cell migration. Treatment with TGF-beta can reduce cell migration and enhance proliferation, which is downregulated after BAP31 knockdown. Moreover, BAP31 regulates multiple signaling pathways, especially the Wnt signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Yixin Wang, Lei Wang, Jia Guo, Siyao Zuo, Ziyu Wang, Shucheng Hua
Summary: The study demonstrates that MYPT1 acts as a tumor suppressor in NSCLC, with its expression level being associated with prognosis. Additionally, miR-19b-3p promotes survival and migration of NSCLC cells by targeting MYPT1 and suppressing apoptosis.
Article
Oncology
Zhiwei Chen, Hyoung Jae Lee, Hangun Kim, Sayeon Cho, Kwonseop Kim
Summary: This study reveals the role of delta-catenin in the migration and invasion of prostate cancer cells and demonstrates that it promotes these processes through the suppression of autophagy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Cell Biology
Ying-chen Xia, Jian-hua Zha, Yong-Hua Sang, Hui Yin, Guo-qiu Xu, Jie Zhen, Yan Zhang, Ben-tong Yu
Summary: Activation of AMPK by ASP4132 effectively inhibits NSCLC cell growth in vitro and in vivo, inducing apoptosis, causing mitochondrial dysfunction and autophagy. AMPK activation also leads to downstream events including mTORC1 inhibition, receptor tyrosine kinase degradation, Akt inhibition, and programmed necrosis.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Thanawat Suwatthanarak, Masayoshi Tanaka, Yoshitaka Miyamoto, Kenji Miyado, Mina Okochi
Summary: The CD9-binding peptide inhibits cancer cell migration by targeting the overexpression of CD9 protein, showing promise as a novel precision antimigratory agent for cancer therapeutics.
CHEMICAL COMMUNICATIONS
(2021)
Article
Cell Biology
Xiaona Xie, Xueding Cai, Yemeng Tang, Chunhui Jiang, Feng Zhou, Lehe Yang, Zhiguo Liu, Liangxing Wang, Haiyang Zhao, Chengguang Zhao, Xiaoying Huang
Summary: Flubendazole, a traditional anthelmintic drug, exhibits potent antitumor activity in non-small cell lung carcinoma (NSCLC) by suppressing STAT3 activity and activating autophagy. It has the potential to be a new therapeutic agent for NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Peng Kuang, An Xie, Jianxiong Deng, Jiaming Tang, Peijun Wang, Feng Yu
Summary: This study explores the role and mechanism of DIRAS3 in non-small cell lung cancer (NSCLC) cell progression. It is found that DIRAS3 is poorly expressed in NSCLC tissues and cells. Over-expression of DIRAS3 inhibits the migration and invasion of NSCLC cells, and attenuates tumor growth. Mechanistically, DIRAS3 may inhibit NSCLC cell migration and invasion by inhibiting the RAS/ERK signaling pathway.
Article
Environmental Sciences
Yiyun Liu, Yangsheng Chen, Rui Sha, Yunping Li, Tong Xu, Xiaoxu Hu, Li Xu, Qunhui Xie, Bin Zhao
Summary: The study demonstrated the important role of AhR in regulating the migration of glioblastoma, and the induction of the AhR-IL24 axis mediates the inhibition of migration in response to TCDD or FICZ treatment.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Bach D. Nguyen, Brenna L. Stevens, Daniel J. Elson, Darren Finlay, John T. Gamble, Prasad R. Kopparapu, Robyn L. Tanguay, Andrew B. Buermeyer, Nancy I. Kerkvliet, Siva K. Kolluri
Summary: This study provides a detailed characterization of 11-Cl-BBQ as a selective modulator of AhR-regulated transcription with anti-cancer actions. Treatment with 11-Cl-BBQ induces potent and sustained anti-proliferative effects in lung cancer cells by promoting G1 phase cell cycle arrest. RNA-sequencing reveals activation of p53 signaling and suppression of DNA replication pathways by 11-Cl-BBQ in an AhR-dependent manner.
Article
Chemistry, Medicinal
Fan-Fan Shang, Qing Lu, Tailiang Lin, Miaoxia Pu, Ruoxuan Xiao, Wanmei Liu, Hao Deng, Hongyan Guo, Zhe-Shan Quan, Chunyong Ding, Qing-Kun Shen
Summary: The 2-OH- and 16-OH-modified CuB derivative A11 showed potent antiproliferative activity against A549 lung cancer cells, with a much wider therapeutic window than CuB. A11 directly bound to IGF2BP1 protein, leading to decreased expression of apoptosis- and cell cycle-related proteins. In an A549 xenograft mouse model, A11 exhibited superior anticancer efficacy and in vivo safety profile compared to CuB.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Chieh-Hsin Lin, Hsin-Han Chang, Chien-Rui Lai, Hisao-Hsien Wang, Wen-Chiuan Tsai, Yu-Ling Tsai, Chih-Ying Changchien, Yu-Chen Cheng, Sheng-Tang Wu, Ying Chen
Summary: Bladder cancer (BC) recurrence can be reduced by targeting fatty acid binding protein 6 (FABP6), which plays an important role in cell growth, migration, cell cycle, autophagy, and gene expression in BC cells. Inhibition of FABP6 leads to decreased cell viability, reduced tumor progression and cell motility, and altered signaling pathways. These findings highlight the potential of targeting FABP6 for the treatment of BC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Chenxin Xu, Haixia Cao, Ying Sui, Hui Zhang, Chen Shi, Jianzhong Wu, Rong Ma, Jifeng Feng
Summary: The study revealed that CDCA4 inhibits the EMT, migration, and invasion of NSCLC by interacting with CARM1 to regulate autophagy.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Chia-Cheng Miao, Wen Hwang, Ling-Yi Chu, Li-Hao Yang, Cam-Thu Ha, Pei-Yu Chen, Ming-Han Kuo, Sheng-Chieh Lin, Ya-Yu Yang, Shuang-En Chuang, Chia-Cherng Yu, Shien-Tung Pan, Mou-Chieh Kao, Chuang-Rung Chang, Yu-Ting Chou
Summary: In this study, it was found that the key autophagy molecule MAP1LC3A/LC3A is negatively associated with histological grade and distant metastasis of lung cancer, partly due to its role in maintaining mitochondria and energy homeostasis. Basal autophagy is preferentially active in SOX2-positive lung cancer cells with high-proliferative and low-invasive properties. The findings provide insights into the crosstalk between basal autophagy and SOX2 proliferation signaling, regulating mitochondrial metabolism and determining cancer cell plasticity in lung tumor progression.
Review
Oncology
Seung-Cheol Jee, Heesun Cheong
Summary: Autophagy and mitophagy play important roles in regulating cancer progression. The regulation of autophagy and mitophagy through ubiquitination and deubiquitination of related proteins is crucial for exploiting their potential in cancer development. Understanding the mechanistic association between cancer and autophagy/mitophagy activities regulated by ubiquitin modification of autophagic proteins can lead to potential therapeutic targets for cancer treatment.
Article
Toxicology
Chi-Hao Tsai, Ching-Hao Li, Po-Lin Liao, Yu-Wen Cheng, Cheng-Hui Lin, Shih-Hsuan Huang, Jaw-Jou Kang
TOXICOLOGICAL SCIENCES
(2015)
Article
Toxicology
Cheng-Hui Lin, Po-Lin Liao, George Hsiao, Ching-Hao Li, Shih-Hsuan Huang, Chi-Hao Tsai, Man-Ru Wu, Fan-Li Lin, Jau-Der Ho, Hui-Wen Cheng, Yu-Wen Cheng
TOXICOLOGICAL SCIENCES
(2015)
Article
Toxicology
Cheng-Hui Lin, Man-Ru Wu, Ching-Hao Li, Hui-Wen Cheng, Shih-Hsuan Huang, Chi-Hao Tsai, Fan-Li Lin, Jau-Der Ho, Jaw-Jou Kang, George Hsiao, Yu-Wen Cheng
TOXICOLOGICAL SCIENCES
(2017)
Article
Multidisciplinary Sciences
Fan-Li Lin, Cheng-Hui Lin, Jau-Der Ho, Jing-Lun Yen, Hung-Ming Chang, George C. Y. Chiou, Yu-Wen Cheng, George Hsiao
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Po-Lin Liao, Cheng-Hui Lin, Ching-Hao Li, Chi-Hao Tsai, Jau-Der Ho, George C. Y. Chiou, Jaw-Jou Kang, Yu-Wen Cheng
SCIENTIFIC REPORTS
(2017)
Article
Toxicology
Ching-Hao Li, Po-Lin Liao, Ya-Ting Yang, Shih-Hsuan Huang, Cheng-Hui Lin, Yu-Wen Cheng, Jaw-Jou Kang
ARCHIVES OF TOXICOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Cheng-Hui Lin, Man-Ru Wu, Wei-Jan Huang, Diana Shu-Lian Chow, George Hsiao, Yu-Wen Cheng
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Developmental Biology
Candace S. Y. Chan, Nicolas Lonfat, Rong Zhao, Alexander E. Davis, Liang Li, Man-Ru Wu, Cheng-Hui Lin, Zhe Ji, Constance L. Cepko, Sui Wang
Article
Immunology
Zuojia Chen, Jialie Luo, Jian Li, Girak Kim, Eric S. Chen, Sheng Xiao, Scott B. Snapper, Bin Bao, Dingding An, Richard S. Blumberg, Cheng-hui Lin, Sui Wang, Jiaxin Zhong, Kuai Liu, Qiyuan Li, Chuan Wu, Vijay K. Kuchroo
Summary: Foxo1 protein regulates mucus secretion by goblet cells to maintain intestinal homeostasis. Loss of Foxo1 leads to defects in autophagy and mucus secretion by goblet cells, impacting gut microbiota and causing increased susceptibility to intestinal inflammation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Hui Lin, Yue Sun, Candace S. Y. Chan, Man-Ru Wu, Lei Gu, Alexander E. Davis, Baokun Gu, Wenlin Zhang, Bogdan Tanasa, Lei R. Zhong, Mark M. Emerson, Lu Chen, Jun B. Ding, Sui Wang
Summary: Adeno-associated viruses (AAVs) can be used as powerful tools to study specific cell types in the central nervous system (CNS). Chromatin accessibility data can be utilized to identify active cis-regulatory modules (CRMs) for AAV-based cell-type specific labeling and manipulation. Strategies such as prescreening based on cell-type-specific transcription factor binding sites (TFBSs) density and generation of synthetic CRMs can improve the efficiency of identifying active CRMs.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Cheng-Hui Lin, Young Joo Sun, Soo Hyeon Lee, Elena M. Mujica, Caitlin R. Kunchur, Man-Ru Wu, Jing Yang, Youn Soo Jung, Bryce Chiang, Sui Wang, Vinit B. Mahajan
Summary: The study presents a cost-effective and minimally invasive protocol, MI3, for delivering ODIs into the mouse vitreous. This approach provides an alternative injection method for small-eyed model organisms and expands the preclinical platforms for evaluating ODIs' efficacy, toxicity, and pharmacokinetics.
Article
Biochemical Research Methods
Young Joo Sun, Cheng-Hui Lin, Man-Ru Wu, Soo Hyeon Lee, Jing Yang, Caitlin R. Kunchur, Elena M. Mujica, Bryce Chiang, Youn Soo Jung, Sui Wang, Vinit B. Mahajan
Summary: The translation discusses the limitations of using small molecule drugs to treat eye diseases and introduces a new method, MI3, to deliver ODIs into mouse eyes. This method aims to expand ODI research to cover a wide range of human eye diseases modeled in mice.
CELL REPORTS METHODS
(2021)
Meeting Abstract
Ophthalmology
Cheng-Hui Lin, Candace Chan, Man-Ru Wu, Alexander Davis, Sui Wang
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Cell Biology
Man-Ru Wu, Cheng-Hui Lin, Jau-Der Ho, George Hsiao, Yu-Wen Cheng
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)