Article
Pharmacology & Pharmacy
Lance T. Dockery, Marie-Christine Daniel
Summary: This study presents the design of dendronized gold nanoparticles coated with poly(propylene imine) dendrons for targeted drug delivery in prostate cancer cells. The dendrons enhance payload density and induce a proton sponge effect for efficient therapeutic delivery. The results showed promising cytotoxicity against PC3 cells, making it a potential system for optimization.
Article
Chemistry, Multidisciplinary
Yukiya Takayama, Kosuke Kusamori, Chihiro Tsukimori, Yosuke Shimizu, Mika Hayashi, Ikumi Kiyama, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto, Makiya Nishikawa
Summary: In this study, MSCs were modified with DOX-Lips to efficiently deliver doxorubicin to tumor cells, demonstrating significant tumor growth inhibition in murine models. The results suggest that DOX-Lip-modified MSCs could serve as an effective carrier system for targeted tumor therapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Sudipta Mallick, Ramadan Abouomar, David Rivas, Max Sokolich, Fatma Ceren Kirmizitas, Aditya Dutta, Sambeeta Das
Summary: Micro-sized magnetic particles, known as microrobots, have shown potential for biomedical applications such as drug delivery and cell manipulation. This study used microrobots to deliver anticancer drugs to cancer cells, resulting in cell death. The findings confirm the promise of microrobots as precise couriers for targeted delivery of therapeutic biomolecules for cancer therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Wei Xiong, Zhengdong Guo, Baoyan Zeng, Teng Wang, Xiaowei Zeng, Wei Cao, Daizheng Lian
Summary: This study constructed multifunctional nanoparticles for the encapsulation of dacarbazine (DTIC) and targeted therapy of malignant melanoma (MM). In vitro and in vivo experiments showed that these nanoparticles had good release properties and exhibited strong anti-tumor effects with no side effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Medicine, Research & Experimental
Jianghong Huang, Qisong Liu, Jiang Xia, Xi Chen, Jianyi Xiong, Lei Yang, Yujie Liang
Summary: This article comprehensively reviews the homing effect of stem cells in joints and highlights progress towards the targeted modification of MSCs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Devaraj Ezhilarasan, Thangavelu Lakshmi, Sreekanth Kumar Mallineni
Summary: Most anticancer drugs fail in clinical trials due to various factors, such as poor solubility and bioavailability. Polymeric nanoparticles offer controlled drug release, biocompatibility, and promising anticancer effects. Nano preparations targeting specific receptors on lung cancer cells improve drug bioavailability. However, there are challenges in route of administration, size, pharmacokinetics, and immune clearance. This review explores the potential benefits and challenges of nanoparticle-based drug delivery for lung cancer treatment.
Article
Pharmacology & Pharmacy
Qi-Rui Li, Hua-Zhen Xu, Rong-Cheng Xiao, Yan Liu, Jun-Ming Tang, Jian Li, Ting-Ting Yu, Bin Liu, Liu-Gen Li, Mei-Fang Wang, Ning Han, Yong-Hong Xu, Chao Wang, Naoki Komatsu, Li Zhao, Xing-Chun Peng, Tong-Fei Li, Xiao Chen
Summary: This study demonstrates the concept of tumor-targeted drug delivery mediated by platelets. Platelets loaded with doxorubicin attached to nanodiamonds can efficiently and effectively deliver the drug to tumor cells, resulting in inhibition of cell proliferation and apoptosis. Platelets also exhibit prolonged blood circulation time and excellent tumor distribution, making them promising carriers for nano-drug delivery to tumors.
Article
Pharmacology & Pharmacy
Fangfang Jin, Qian Zeng, Husun Qian, Dian Zhang, Yu Wei, Yange Wang, Chengsen Chai, Wei Cheng, Shijia Ding, Tingmei Chen
Summary: A dual-targeted aptamer-decorated DNA hydrogel system (DTA-H) is reported for efficient, stable, and targeted delivery of drugs, showing significant potential for cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Youkabed Kazemi, Sadegh Dehghani, Fatemeh Soltani, Khalil Abnous, Mona Alibolandi, Seyed Mohammad Taghdisi, Mohammad Ramezani
Summary: Nanomaterial-based drug delivery using HA-targeted nanocarrier loaded with DOX showed promising anti-cancer effects in both in vitro and in vivo studies. The smart nanosystem demonstrated controlled drug release in response to ATP content and improved cytotoxicity and cellular uptake. The HA-targeted formulation enhanced survival rate and tumor inhibition in tumor-bearing mice compared to free DOX.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Biophysics
Shuang Fu, Yinan Zhao, Jiao Sun, Ting Yang, Defu Zhi, Enxia Zhang, Fangli Zhong, Yuhong Zhen, Shufen Zhang, Shubiao Zhang
Summary: RGD-modified liposomes showed excellent active targeting ability for integrin ?v?3 receptors and enhanced DOX release due to their pH-sensitivity, resulting in significant antitumor efficacy with low toxicity. This new approach provides a potential avenue for improved tumor therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Medicine, Research & Experimental
Lianlian Fan, Anhui Wei, Zihui Gao, Xupeng Mu
Summary: Nanodrug delivery systems face challenges of weak drug targeting, immune system clearance, and low biocompatibility. Cell membrane, especially Mesenchymal stem cell (MSC) membrane, can be used as a drug coating material to overcome these limitations. MSC membrane-coated nanoparticles have potential applications in tumor treatment, inflammatory disease, tissue regeneration, and other fields. This review summarizes recent progress in the use of MSC membrane-coated nanoparticles for therapy and drug delivery, aiming to provide guidance for future design and clinical application of membrane carriers.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nanoscience & Nanotechnology
Mei Tian, Yunfei Lian, Jing Gao, Fengxiang Yu, Ge Song, Jin Cao, Juan Li, Aftab Ullah, Xueyong Qi
Summary: In this study, magnetic drug-loaded nanoparticles were constructed and precisely delivered to tumor sites by umbilical cord mesenchymal stem cells. In vitro experiments showed that stem cells could transport magnetic drug-loaded nanoparticles to induce robust apoptosis in tumor cells.
SCIENCE OF ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Saikat Ghosh, Ankit Javia, Saritha Shetty, Denish Bardoliwala, Kuntal Maiti, Shubhadeep Banerjee, Ajay Khopade, Ambikanandan Misra, Krutika Sawant, Subhas Bhowmick
Summary: Triple negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC) are aggressive solid tumors characterized by low survival rates, high relapse incidence, tumor heterogeneity, genetic mutations, generation of cancer-stem cells, immune-resistance and chemoresistance. Emerging opportunities for effective treatment include pharmacological targets and gene-based modulation combined with nano-formulation approaches.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Giorgiana Negrea, Valentin-Florian Rauca, Marta Szilvia Meszaros, Laura Patras, Lavinia Luput, Emilia Licarete, Vlad-Alexandru Toma, Alina Porfire, Dana Muntean, Alina Sesarman, Manuela Banciu
Summary: This study proposes a novel combination therapy that selectively targets both tumor-associated macrophages and melanoma cells, leading to strong inhibition of tumor growth and modulation of the tumor-immune microenvironment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Valentina Cocce, Mara Bonelli, Silvia La Monica, Roberta Alfieri, Luisa Doneda, Eleonora Martegani, Giulio Alessandri, Costanza Annamaria Lagrasta, Aldo Gianni, Valeria Sordi, Francesco Petrella, Leda Roncoroni, Francesca Paino, Augusto Pessina
Summary: Malignant pleural mesothelioma, an asbestos-related tumor, has poor response to chemotherapy. Adult mesenchymal stromal cells derived from bone marrow or adipose tissue can be a good model for cell-based therapy, and using Paclitaxel-loaded mesenchymal stromal cells inhibits mesothelioma cell proliferation more effectively than Paclitaxel alone. In vivo studies using a minimal amount of 106 mesenchymal stromal cells loaded with Paclitaxel showed the same efficacy as systemic administration of Paclitaxel, supporting the use of mesenchymal stromal cells as a drug delivery system for solid tumors.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Li Duan, Xiao Xu, Limei Xu, Hongfei Chen, Xingfu Li, Murad Alahdal, Yin Xiao, Yujie Liang, Jiang Xia
Summary: Osteoarthritis is a degenerative disease that affects the quality of life in the elderly population, with no ideal treatment strategies currently available. Studies have suggested that exosomes may play an important role in the treatment of osteoarthritis.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Rheumatology
Murad Alahdal, Hui Zhang, Rongxiang Huang, Wei Sun, Zhiqin Deng, Li Duan, Hongwei Ouyang, Daping Wang
Summary: Dendritic cells have been found to play a potential role in the pathogenesis of osteoarthritis, with studies showing increased expression of toll-like receptors and secretion of inflammatory cytokines by DCs derived from OA patients. Strategies involving tolerogenic plasmacytoid DCs injections are suggested for treating OA inflammations.
Article
Multidisciplinary Sciences
Zhiqin Deng, Xiaotian Hu, Murad Alahdal, Jianquan Liu, Zhe Zhao, Xiaoqiang Chen, Junxiong Xie, Li Duan, Daping Wang, Wencui Li
Summary: This study aimed to explore and validate the mechanisms of hub genes in osteoarthritis through bioinformatics analysis and experimental validation. The findings confirmed significant expression changes in key genes in osteoarthritis, highlighting their crucial roles in the pathogenesis of the disease.
Article
Oncology
Murad Alahdal, Deshun Sun, Li Duan, Hongwei Ouyang, Manyi Wang, Jianyi Xiong, Daping Wang
Summary: A new mathematical model was established to identify sensitive targets in the kynurenine pathway in pancreatic adenocarcinoma, and these targets were confirmed through gene and protein expression responses. The model showed high predictive accuracy and reliability, providing evidence for potential treatment targets in PDAC.
Review
Cell Biology
Rongxiang Huang, Zhang Hui, Sun Wei, Duan Li, Wencui Li, Wang Daping, Murad Alahdal
Summary: IRE1 plays a crucial role in regulating the unfolded protein response in the endoplasmic reticulum, affecting cell fate through endonuclease activation. Different levels of IRE1α can impact chondrocyte survival and apoptosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Murad Aladal, Wei You, Rongxiang Huang, Jianghong Huang, Zhiqin Deng, Li Duan, Daping Wang, Wencui Li, Wei Sun
Summary: This article explores the potential of fibronectin 1 (FN1) in cartilage tissue engineering, highlighting its role in promoting chondrocyte differentiation and inhibiting apoptosis. It suggests that further research on FN1 could provide new insights and advanced applications in treating osteoarthritis and cartilage degeneration.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Yu Xiao, Zhiqin Deng, Yongshen Li, Baoting Wei, Xiaoqiang Chen, Zhe Zhao, Yingjie Xiu, Meifang Hu, Murad Alahdal, Zhenhan Deng, Daping Wang, Jianquan Liu, Wencui Li
Summary: In this study, potential biomarkers for predicting the prognosis of breast cancer were identified through the analysis of gene expression data. ANLN and UBE2T were found to be upregulated in breast cancer and their upregulation was associated with a poor prognosis. Furthermore, their upregulation was associated with the prevalence of specific immune cells.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Dinh Hoa Hoang, Corey Morales, Ivan Rodriguez Rodriguez, Melissa Valerio, Jiamin Guo, Min-Hsuan Chen, Xiwei Wu, David Horne, Varsha Gandhi, Lisa S. Chen, Bin Zhang, Vinod Pullarkat, Steven T. Rosen, Guido Marcucci, Ralf Buettner, Le Xuan Truong Nguyen
Summary: Treatment failures in acute myeloid leukemia (AML) are often attributed to the persistence of leukemia stem cells (LSCs) which are resistant to conventional treatments. The combination of venetoclax (VEN) and 8-chloro-adenosine (8-Cl-Ado) targets LSCs by inhibiting ribosomal RNA synthesis and mitochondrial metabolism, reducing LSC survival. This combination shows promise as a therapeutic approach for patients with relapsed AML.
Correction
Medicine, Research & Experimental
Murad Alahdal, Wei You, Rongxiang Huang, Jianghong Huang, Zhiqin Deng, Li Duan, Daping Wang, Wencui Li, Wei Sun
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Oncology
Murad Alahdal, Eyad Elkord
Summary: This article introduces the current outcomes of immunopathology and immunotherapeutic applications of immune cell-derived exosomes in COVID-19, as well as new perspectives to develop novel patterns of engineered exosomes triggering novel anti-SARS-CoV-2 immune responses.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Murad Alahdal, Eyad Elkord
Summary: The exhaustion of immune cells in COVID-19 is a serious concern and the dysregulation of immune cell functionality may lead to inflammation and cytokine storm, which explains the failure of vaccines to induce sufficient antiviral responses. Understanding the processes of immune cell over-activation and exhaustion is crucial for developing novel immune intervention strategies.
CLINICAL IMMUNOLOGY
(2022)
Review
Multidisciplinary Sciences
Abdo Meyiah, Murad Alahdal, Eyad Elkord
Summary: Macrophages type 2 (M2) have significant impact on the pathogenesis of gastro-intestinal cancers (GIC) by promoting tumor progression, invasion, and metastasis. The exosomal non-coding RNAs (Exos-ncRNAs) derived from M2 have been found to play crucial roles in the modulation of GIC tumor microenvironment (TME), mainly promoting drug resistance and immunosuppression.
Review
Oncology
Murad Alahdal, Roshane A. Perera, Marcio Covas Moschovas, Vipul Patel, Ranjan J. Perera
Summary: Prostate cancer (PCa) is becoming more common, and early detection is crucial. The PSA test is widely used but has limitations. Therefore, there is a need to develop accurate diagnostic biomarkers for PCa. Recent studies have found significant differences and clinical benefits in liquid biopsies using non-coding RNA, ctDNA/ctRNA, exosomes, and metabolomic biomarkers for diagnosing, prognosticating, and monitoring therapy response in PCa patients.
MOLECULAR THERAPY-ONCOLYTICS
(2023)
Review
Oncology
Murad Alahdal, Eyad Elkord
Summary: Standardising clinical predictive biomarkers for assessing the response to immunotherapy is challenging. Early monitoring of key non-coding RNA (ncRNA) biomarkers may help in predicting the clinical efficacy of cancer immunotherapy. Further studies are needed to elaborate on the potential ncRNA biomarkers for predicting early clinical responses to immunotherapy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Hui Zhang, Jianghong Huang, Murad Alahdal
Summary: This article provides a comprehensive overview of the potential of hydrogel bioprinting and exosome-based therapy in the treatment of osteoarthritis (OA). Combining immune regulatory exosomes with three-dimensional bioprinting hydrogel holds promise for immunomodulating cartilage tissue and treating OA. It emphasizes the potential of three-dimensional bioprinting hydrogel loaded with chondrogenic stimuli agents for OA treatment, serving as a basis for further research.
BIOMEDICINE & PHARMACOTHERAPY
(2023)