Cas9-catalyzed DNA Cleavage Generates Staggered Ends: Evidence from Molecular Dynamics Simulations
出版年份 2016 全文链接
标题
Cas9-catalyzed DNA Cleavage Generates Staggered Ends: Evidence from Molecular Dynamics Simulations
作者
关键词
-
出版物
Scientific Reports
Volume 6, Issue 1, Pages -
出版商
Springer Nature
发表日期
2016-11-22
DOI
10.1038/srep37584
参考文献
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- (2016) Zhicheng Zuo et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9
- (2016) Carolin Anders et al. MOLECULAR CELL
- Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9
- (2016) Seiichi Hirano et al. MOLECULAR CELL
- Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
- (2016) Shengdar Q. Tsai et al. NATURE REVIEWS GENETICS
- Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
- (2016) F. Jiang et al. SCIENCE
- Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations
- (2016) Giulia Palermo et al. ACS Central Science
- Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
- (2015) Bernd Zetsche et al. CELL
- Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
- (2015) Chen Yu et al. Cell Stem Cell
- Systematic Parameterization of Monovalent Ions Employing the Nonbonded Model
- (2015) Pengfei Li et al. Journal of Chemical Theory and Computation
- ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
- (2015) James A. Maier et al. Journal of Chemical Theory and Computation
- Conformational control of DNA target cleavage by CRISPR–Cas9
- (2015) Samuel H. Sternberg et al. NATURE
- Small molecule–triggered Cas9 protein with improved genome-editing specificity
- (2015) Kevin M Davis et al. Nature Chemical Biology
- A Cas9-guide RNA complex preorganized for target DNA recognition
- (2015) F. Jiang et al. SCIENCE
- Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
- (2014) Hiroshi Nishimasu et al. CELL
- Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
- (2014) Carolin Anders et al. NATURE
- Assessing the performance of MM/PBSA and MM/GBSA methods. 4. Accuracies of MM/PBSA and MM/GBSA methodologies evaluated by various simulation protocols using PDBbind data set
- (2014) Huiyong Sun et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
- (2014) M. Jinek et al. SCIENCE
- Rational Design of Particle Mesh Ewald Compatible Lennard-Jones Parameters for +2 Metal Cations in Explicit Solvent
- (2013) Pengfei Li et al. Journal of Chemical Theory and Computation
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Obligate Ligation-Gated Recombination (ObLiGaRe): Custom-designed nuclease-mediated targeted integration through nonhomologous end joining
- (2012) M. Maresca et al. GENOME RESEARCH
- MMPBSA.py: An Efficient Program for End-State Free Energy Calculations
- (2012) Bill R. Miller et al. Journal of Chemical Theory and Computation
- RNA-guided genetic silencing systems in bacteria and archaea
- (2012) Blake Wiedenheft et al. NATURE
- Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
- (2012) G. Gasiunas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- An overview of the Amber biomolecular simulation package
- (2012) Romelia Salomon-Ferrer et al. Wiley Interdisciplinary Reviews-Computational Molecular Science
- Catalytic Mechanism of RNA Backbone Cleavage by Ribonuclease H from Quantum Mechanics/Molecular Mechanics Simulations
- (2011) Edina Rosta et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations
- (2010) Tingjun Hou et al. Journal of Chemical Information and Modeling
- The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
- (2010) Josiane E. Garneau et al. NATURE
- CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea
- (2010) Luciano A. Marraffini et al. NATURE REVIEWS GENETICS
- Nucleases: diversity of structure, function and mechanism
- (2010) Wei Yang QUARTERLY REVIEWS OF BIOPHYSICS
- An equivalent metal ion in one- and two-metal-ion catalysis
- (2008) Wei Yang NATURE STRUCTURAL & MOLECULAR BIOLOGY
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