Article
Neurosciences
Artur Schneider, Christian Zimmermann, Mansour Alyahyay, Florian Steenbergen, Thomas Brox, Ilka Diester
Summary: This study presents a versatile framework for capturing the 3D motion of freely definable body points and reveals multiplexing of information in the motor cortex neurons of freely moving rats. The framework allows for analysis of specific behaviors of interest by removing the influence of certain body movements.
Article
Optics
Guo Heng, Qian Chen, Wei Qin, Weizhi Qi, Lei Xi
Summary: The research team successfully extended ORPAM to experiments with freely moving mice using a detachable head-mounted probe. The lightweight probe with a large field of view is capable of providing stable and high-quality images.
Article
Chemistry, Analytical
Yuhling Wang, Tsung-Sheng Chu, Yan-Ren Lin, Chia-Hui Tsao, Chia-Hua Tsai, Tzong-Rong Ger, Li-Tzong Chen, Wun-Shaing Wayne Chang, Lun-De Liao
Summary: The study introduces a miniaturized head-mounted scanning photoacoustic imaging (hmPAI) system for real-time imaging of cortical dynamics in awake and freely moving rats, demonstrating its utility in evaluating brain function and natural behavior simultaneously.
Article
Multidisciplinary Sciences
Jokubas Ausra, Mingzheng Wu, Xin Zhang, Abraham Vazquez-Guardado, Patrick Skelton, Roberto Peralta, Raudel Avila, Thomas Murickan, Chad R. Haney, Yonggang Huang, John A. Rogers, Yevgenia Kozorovitskiy, Philipp Gutruf
Summary: Wireless, battery-free, and fully subdermally implantable optogenetic tools have the potential to revolutionize neurobiological research in freely moving animals, but current devices still have issues with invasive stimulus delivery causing damage during implantation, as well as power delivery constraints limiting the size of operational arenas.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Mihaly Voroslakos, Peter C. Petersen, Balazs Voroslakos, Gyorgy Buzsaki
Summary: The study introduces a novel 3D printed head-gear system consisting of a recoverable stainless steel microdrive and a plastic head cap system, which allows researchers to reuse silicon probes with ease, reducing cost and complexity while providing detailed procedural instructions.
Article
Neurosciences
Philip R. L. Parker, Elliott T. T. Abe, Emmalyn S. P. Leonard, Dylan M. Martins, Cristopher M. Niell
Summary: This study used single-unit electrophysiology in freely moving mice to map spatiotemporal receptive fields based on gaze-corrected visual input. The results showed that a significant fraction of neurons in the mouse V1 are tuned for eye and head position, and these signals are integrated with visual responses through a multiplicative mechanism.
Article
Engineering, Biomedical
Evgenii Kim, Eloise Anguluan, Jeungeun Kum, Jorge Sanchez-Casanova, Tae Young Park, Jae Gwan Kim, Hyungmin Kim
Summary: A wireless, wearable tFUS system was developed to achieve ultrasound brain stimulation in freely behaving animals. The system showed safety and efficacy in animal experiments, especially in stroke rehabilitation.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Neurosciences
Connar Stanley James Westgate, Ida Marchen Egerod Israelsen, Christina Kamp-Jensen, Rigmor Hojland Jensen, Sajedeh Eftekhari
Summary: Glucocorticoids reduce intracranial pressure (ICP) but do not modify its diurnal rhythm. This suggests that ICP disturbances may be a consequence of glucocorticoid therapy.
FLUIDS AND BARRIERS OF THE CNS
(2023)
Article
Multidisciplinary Sciences
Svenja Melbaum, Eleonora Russo, David Eriksson, Artur Schneider, Daniel Durstewitz, Thomas Brox, Ilka Diester
Summary: Conservation of the neural code is important in training brain-computer interfaces. The authors demonstrate cross-subject generalization in decoding unconstrained behavior from the sensorimotor cortex through alignment of neural manifolds. This study reveals the coupling of neurons with behavior and a gradient from the premotor to the primary sensory cortex.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Alexander Tarnavsky Eitan, Shirly Someck, Mario Guilermo Zajac, Eran Socher, Eran Stark
Summary: A novel current source chip was designed for integrated neural activity detection and light stimulation control, successfully achieving linear control of mu LEDs implanted in the mouse brain. The system offers high spatial, temporal, and amplitude resolution, providing a rich variety of stimulation patterns for research purposes.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2021)
Article
Biochemical Research Methods
Alexandr Klioutchnikov, Damian J. Wallace, Juergen Sawinski, Kay-Michael Voit, Yvonne Groemping, Jason N. D. Kerr
Summary: A lightweight three-photon miniature microscope has been developed to image neuronal activity in the cortex of freely moving mice. The microscope allows access to all cortical layers while the mice freely behave in a fully lit environment. By comparing activity in cortical layer 4 and layer 6, the study shows that neuronal activity is differentially modulated by lit and dark conditions during free exploration.
Article
Computer Science, Information Systems
Joana Barreto, Cesar Peixoto, Silvia Cabral, Andrew Mark Williams, Filipe Casanova, Bruno Pedro, Antonio P. Veloso
Summary: The use of IMUS for biomechanical analysis offers advantages over 2D/3D video-based analysis, particularly in analyzing movement in a natural performance environment and providing coaches with real-time access to detailed data for feedback optimization. Evaluation of the IMUS Xsens MVN Link system demonstrated its validity in providing useful data for training feedback.
Article
Biochemical Research Methods
Arne Monsees, Kay-Michael Voit, Damian J. Wallace, Juergen Sawinski, Edyta Charyasz, Klaus Scheffler, Jakob H. Macke, Jason N. D. Kerr
Summary: To understand the relationship between neural activity and skeletal kinematics, this study developed a videography-based method to quantify the three-dimensional kinematics of the skeletal system in freely behaving rats and mice. The anatomically defined skeleton model was constrained using anatomical principles and joint motion limits, enabling accurate reconstruction of complex decision-making behaviors at the level of skeletal kinematics.
Article
Biochemistry & Molecular Biology
Nikolas Perentos, Marino Krstulovic, A. Jennifer Morton
Summary: Sheep, as a practical large animal species, were used for in vivo brain function studies in naturalistic settings. The experiments demonstrated that sheep are excellent for longitudinal studies requiring large-brained mammals and/or large-scale recordings across distributed neuronal networks. This suggests that sheep can be safely used for studying neural encoding of decision-making and spatial-mapping in naturalistic environments, as well as the neural basis of intra- and inter-species social interactions.
Article
Multidisciplinary Sciences
Julian Gerson, Murat Kaan Erdal, Matthew H. McDonough, Kyle L. Ploense, Philippe Dauphin-Ducharme, Kevin M. Honeywell, Kaylyn K. Leung, Netzahualcoyotl Arroyo-Curras, Jenny M. Gibson, Nicole A. Emmons, Wendy Meiring, Joao P. Hespanha, Kevin W. Plaxco, Tod E. Kippin
Summary: In this study, electrochemical aptamer-based sensors were used to achieve real-time measurement of drug concentrations in the brains of freely moving rats. The results showed that the sensors can provide high-resolution, seconds-resolved neuropharmacokinetics and concentration-response relations of individual subjects. Additionally, a closed-loop feedback-controlled drug delivery system was employed to maintain stable intracranial drug levels.
Article
Multidisciplinary Sciences
Jimena Laura Frontera, Hind Baba Aissa, Romain William Sala, Caroline Mailhes-Hamon, Ioana Antoaneta Georgescu, Clement Lena, Daniela Popa
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Benedicte Oules, Christina Philippeos, Joe Segal, Matthieu Tihy, Matteo Vietri Rudan, Ana-Maria Cujba, Philippe A. Grange, Sven Quist, Ken Natsuga, Lydia Deschamps, Nicolas Dupin, Giacomo Donati, Fiona M. Watt
NATURE COMMUNICATIONS
(2020)
Article
Dermatology
M. Tihy, S. Menzinger, R. Andre, E. Laffitte, L. Toutous-Trellu, G. Kaya
Summary: This study provided detailed clinical and histopathological characterization of cutaneous reactions after mRNA COVID-19 vaccination, finding that generalized erythematous rash or purpura were the most common clinical presentations, and drug-reaction-like pattern was the most common histological finding. Proper clinicopathological classification is important for early diagnosis and management of these reactions.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Editorial Material
Neurosciences
Jimena L. Frontera, Clement Lena
Summary: The study demonstrates that transient activation of the cerebello-thalamo-cortical pathway is sufficient to initiate conditioned movement in operant conditioning.
Article
Chemistry, Analytical
Romain Fayat, Viviana Delgado Betancourt, Thibault Goyallon, Mathieu Petremann, Pauline Liaudet, Vincent Descossy, Lionel Reveret, Guillaume P. Dugue
Summary: Inertial sensors are increasingly being used in rodent research to estimate head orientation and tilt, with the potential for accurate tilt estimates during movement when combined with sensor calibration and appropriate filter and parameter choices. Additionally, these sensors can be applied in studying vestibular functions and behavioral analysis in rodents.
Article
Biochemistry & Molecular Biology
Beat Moeckli, Vaihere Delaune, Julien Prados, Matthieu Tihy, Andrea Peloso, Graziano Oldani, Thomas Delmi, Florence Slits, Quentin Gex, Laura Rubbia-Brandt, Nicolas Goossens, Stephanie Lacotte, Christian Toso
Summary: The global obesity epidemic particularly affects women of reproductive age. Offspring of obese mothers have an increased risk of liver disease, but the molecular mechanisms involved remain unknown. Through genomic analysis of mice, researchers found that pathways related to metabolism, the immune system, clotting cascade, and cell cycle were consistently dysregulated in the offspring of obese mothers.
Article
Neurosciences
Marco N. Pompili, Ralitsa Todorova
Summary: The study demonstrates the inability of standard methods to distinguish between sleep and freezing when both behaviors are present. It proposes using smoothed cortical spindle power to detect sleep epochs and shows the effectiveness of this method in discriminating between sleep and freezing.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Biochemistry & Molecular Biology
Fanny Demars, Ralitsa Todorova, Gabriel Makdah, Antonin Forestier, Marie-Odile Krebs, Bill P. Godsil, Therese M. Jay, Sidney I. Wiener, Marco N. Pompili
Summary: Current treatments for trauma-related disorders are ineffective for many patients. This study modeled individual differences in post-therapy fear relapse using an ethologically relevant trauma recovery paradigm. The results suggest that post-trauma behavioral phenotypes and gene expression patterns are associated with fear relapse susceptibility, which may be important for future treatment development.
Article
Multidisciplinary Sciences
Berenice Coutant, Jimena Laura Frontera, Elodie Perrin, Adele Combes, Thibault Tarpin, Fabien Menardy, Caroline Mailhes-Hamon, Sylvie Perez, Bertrand Degos, Laurent Venance, Clement Lena, Daniela Popa
Summary: The authors demonstrated that opto-stimulation of Purkinje cells can prevent and alleviate levodopa-induced dyskinesia by normalizing brain activity in a wide motor network. This finding suggests that cerebellar stimulation may be a valuable treatment for levodopa-induced dyskinesia.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Hind Baba Aissa, Romain W. Sala, Elena Laura Georgescu Margarint, Jimena Laura Frontera, Andres Pablo Varani, Fabien Menardy, Assunta Pelosi, Denis Herve, Clement Lena, Daniela Popa
Summary: The study found that in the DYT25 dystonia model, the excitability of the cerebello-thalamic pathways increased in the presymptomatic state, and asymptomatic mice after the first dystonic episode exhibited higher excitability, which persisted after cerebellar theta-burst stimulation. Stimulation administered during symptomatic states reduced cerebello-thalamic excitability and alleviated dystonic symptoms.
Article
Multidisciplinary Sciences
Jimena L. Frontera, Romain W. Sala, Ioana A. Georgescu, Hind Baba Aissa, Marion N. d'Almeida, Daniela Popa, Clement Lena
Summary: This study reveals the important role of the cerebellum in fear extinction in mice. The cerebellar fastigial nucleus projects to the mediodorsal thalamic nucleus, which is connected to the dorsomedial prefrontal cortex. Inhibition of this pathway impairs fear extinction and increases the activity of mediodorsal thalamic neurons. The cerebellum also modulates thalamo-prefrontal cortex interactions during fear extinction.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Antoine Ghestem, Marco N. Pompili, Matthias Dipper-Wawra, Pascale P. Quilichini, Christophe Bernard, Maeva Ferraris
Summary: Researchers have developed a new prosthesis for long-term electrophysiological recordings in rats, including those with epilepsy. The new design successfully protected the probes from strong mechanical stress and allowed for the safe retrieval of probes, with a retrieval and reuse success rate of 91%.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Gastroenterology & Hepatology
Laurent Spahr, Nicolas Lanthier, Mathieu Tihy, Jean-Louis Frossard, Laura Rubbia-Brandt, Nicolas Goossens
Summary: MIC is an acute, noninflammatory, potentially severe alcoholic liver injury that mimics ASH, but compared to ASH, patients with MIC have a lower fibrosis stage and a distinct gene expression profile.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Neurosciences
Maxime Levesque, HongYing Gao, Carla Southward, J. M. Pierre Langlois, Clement Lena, Richard Courtemanche
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2020)
Review
Physiology
Stephanie Trouche, Marco N. Pompili, Gabrielle Girardeau
CURRENT OPINION IN PHYSIOLOGY
(2020)