Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle

Primary defects in lipolysis and insulin action in skeletal muscle cells from type 2 diabetic individuals

(2015) Eili T. Kase et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle

(2015) Matthew A. Sanders et al.   Cell Metabolism

Defective Natriuretic Peptide Receptor Signaling in Skeletal Muscle Links Obesity to Type 2 Diabetes

(2015) Marine Coué et al.   DIABETES

Perilipin 5–Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21

(2015) Lydia-Ann L.S. Harris et al.   DIABETES

Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis

(2015) Chao Wang et al.   HEPATOLOGY

Perilipin 5 mediated lipid droplet remodelling revealed by coherent Raman imaging

(2015) Nils Billecke et al.   Integrative Biology

Adipogenic progenitors from obese human skeletal muscle give rise to functional white adipocytes that contribute to insulin resistance

(2015) C Laurens et al.   INTERNATIONAL JOURNAL OF OBESITY

The Interplay of Protein Kinase A and Perilipin 5 Regulates Cardiac Lipolysis

(2014) Nina M. Pollak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle

(2014) Rachael R. Mason et al.   Molecular Metabolism

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity

(2013) M. Bosma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

High-Fat Diet-Mediated Lipotoxicity and Insulin Resistance Is Related to Impaired Lipase Expression in Mouse Skeletal Muscle

(2013) Pierre-Marie Badin et al.   ENDOCRINOLOGY

Endurance Exercise Training Up-Regulates Lipolytic Proteins and Reduces Triglyceride Content in Skeletal Muscle of Obese Subjects

(2013) Katie Louche et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Enhanced Glucose Metabolism Is Preserved in Cultured Primary Myotubes From Obese Donors in Response to Exercise Training

(2013) Virginie Bourlier et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fatty acids regulate perilipin5 in muscle by activating PPARδ

(2013) Christian Bindesbøll et al.   JOURNAL OF LIPID RESEARCH

Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier

(2013) Nina M. Pollak et al.   JOURNAL OF LIPID RESEARCH

Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase

(2012) Siril S. Bakke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation

(2012) Kenta Kuramoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58

(2012) Pierre-Marie Badin et al.   JOURNAL OF LIPID RESEARCH

Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5

(2012) S. O. Shepherd et al.   JOURNAL OF PHYSIOLOGY-LONDON

Not only accumulation, but also saturation status of intramuscular lipids is significantly affected by PPARγ activation

(2011) A. Chabowski et al.   Acta Physiologica

Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans

(2011) P.-M. Badin et al.   DIABETES

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?

(2011) F. Amati et al.   DIABETES

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

(2011) Madeleen Bosma et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Not Just Fat: The Structure and Function of the Lipid Droplet

(2011) T. Fujimoto et al.   Cold Spring Harbor Perspectives in Biology

Interactions of Perilipin-5 (Plin5) with Adipose Triglyceride Lipase

(2010) James G. Granneman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Predictors of cardiovascular fitness in sedentary men

(2009) Marie-Ève Riou et al.   Applied Physiology Nutrition and Metabolism

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Lipid droplets as dynamic organelles connecting storage and efflux of lipids

(2008) Sven-Olof Olofsson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

(2008) C. R. Hancock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA