IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner

Mutant p53 in concert with an interleukin-27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice

(2016) Denada Dibra et al.   HEPATOLOGY

Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence

(2015) Ryusaku Matsumoto et al.   PLoS One

Mesenchymal Stromal Cells Engineered to Produce IGF-I by Recombinant Adenovirus Ameliorate Liver Fibrosis in Mice

(2015) Esteban J. Fiore et al.   STEM CELLS AND DEVELOPMENT

Insulin-Like Growth Factor-I, Inflammatory Proteins, and Fibrosis in Subjects With Nonalcoholic Fatty Liver Disease

(2013) Marta Letizia Hribal et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

GH-independent IGF-I action is essential to prevent the development of nonalcoholic steatohepatitis in a GH-deficient rat model

(2012) Hitoshi Nishizawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IGF-I enhances cellular senescence via the reactive oxygen species–p53 pathway

(2012) Anastasia-Evi Handayaningsih et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Essential roles of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in the liver [Review]

(2012) Yutaka Takahashi   ENDOCRINE JOURNAL

Nonalcoholic fatty liver disease in adult hypopituitary patients with GH deficiency and the impact of GH replacement therapy

(2012) H. Nishizawa et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Meta-analysis: pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis

(2011) E. Boettcher et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Non-alcoholic fatty liver disease

(2011) Briohny W. Smith et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Evaluation and Treatment of Adult Growth Hormone Deficiency: An Endocrine Society Clinical Practice Guideline

(2011) Mark E. Molitch et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Nonalcoholic Fatty Liver Disease Is Associated with Low Circulating Levels of Insulin-Like Growth Factor-I

(2011) Franco Arturi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Targeting insulin-like growth factor axis in hepatocellular carcinoma

(2011) Jennifer Wu et al.   Journal of Hematology & Oncology

Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment

(2011) Briohny W. Smith et al.   Nature Reviews Endocrinology

Stress Signaling in the Methionine-Choline–Deficient Model of Murine Fatty Liver Disease

(2010) Russell K. Soon et al.   GASTROENTEROLOGY

Long-term mortality in nonalcoholic fatty liver disease: Is liver histology of any prognostic significance?

(2010) Paul Angulo   HEPATOLOGY

Growth hormone, the insulin-like growth factor axis, insulin and cancer risk

(2010) Peter E. Clayton et al.   Nature Reviews Endocrinology

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Mitochondrial protection by low doses of insulin-like growth factor-Iin experimental cirrhosis

(2008) Raquel Pérez et al.   WORLD JOURNAL OF GASTROENTEROLOGY