Article
Engineering, Biomedical
Ruyi Yang, Peng Zhao, Liyang Wang, Chenli Feng, Chen Peng, Zhexuan Wang, Yingying Zhang, Minqian Shen, Kaiwen Shi, Shijun Weng, Chunqiong Dong, Fu Zeng, Tianyun Zhang, Xingdong Chen, Shuiyuan Wang, Yiheng Wang, Yuanyuan Luo, Qingyuan Chen, Yuqing Chen, Chengyong Jiang, Shanshan Jia, Zhaofei Yu, Jian Liu, Fei Wang, Su Jiang, Wendong Xu, Liang Li, Gang Wang, Xiaofen Mo, Gengfeng Zheng, Aihua Chen, Xingtao Zhou, Chunhui Jiang, Yuanzhi Yuan, Biao Yan, Jiayi Zhang
Summary: This study demonstrates the potential of subretinally implanted gold-nanoparticle-coated titania nanowire arrays to improve visual acuity and contrast sensitivity in mice and monkeys with induced photoreceptor degeneration, offering a promising approach for the restoration of visual function in patients with photoreceptor degeneration.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Bingchuan Lu, Min Ye, Jingjing Xia, Zhenrui Zhang, Zhuo Xiong, Ting Zhang
Summary: The formation of multiscale vascular networks is essential for the construction of large-scale biomimetic cardiac tissues/organs in vitro. Electrical stimulation is applied to promote the elongation and connection of endothelial cells in engineered cardiac tissue (ECT) and achieve vascularization. The results show that electrical stimulation significantly enhances the elongation, migration, and interconnection of endothelial cells in ECT and increases the expression of related genes. Electrical stimulation also enhances the secretion of signal factors between cardiomyocytes and endothelial cells and contributes to the contractility of cardiac tissue.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Yusheng Zhang, Suping Chen, Zhanwen Xiao, Xiaoyin Liu, Chengheng Wu, Kai Wu, Amin Liu, Dan Wei, Jing Sun, Liangxue Zhou, Hongsong Fan
Summary: The novel concept of a magneto-responsive electric 3D matrix has been demonstrated to enhance neurogenesis at cellular level and in spinal cord injury through the application of an external pulsed magnetic field. This research paves the way for remote control and delivery of electricity through an extracellular niche-mimicked hydrogel network, with potential applications in neurogenesis and human-computer interaction with higher resolution.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Neurosciences
Alex R. Gogliettino, Sasidhar S. Madugula, Lauren E. Grosberg, Ramandeep S. Vilkhu, Jeff Brown, Huy Nguyen, Alexandra Kling, Pawel Hottowy, Wladyslaw Dabrowski, Alexander Sher, Alan M. Litke, E. J. Chichilnisky
Summary: Electrical stimulation of retinal ganglion cells (RGCs) with electronic implants can provide artificial vision, but current devices lack precision. This study examines the neural code and effectiveness of focal epiretinal stimulation in the central macaque retina, and suggests the possibility of reproducing high-resolution visual signals with an epiretinal implant.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Pinghui Wei, Guoge Han, Meiqin He, Yan Wang
Summary: This study aimed to investigate the changes in retinal neurotransmitters and the role of the dopamine D2 receptor (D2R) pathway in regulating myopic refractive state. The results showed that after forced occlusion for 4 weeks, dopamine (DA) and γ-aminobutyric acid (GABA) concentrations decreased, while glutamate (Glu), 3-methoxytyramine (3-MT), and glycine concentrations increased, accompanied by an increase in myopic refraction and axial length (AL). Treating with D2R antagonist sulpiride increased glycine and DA levels, while decreasing 3-MT and Glu levels, accompanied by a decrease in myopic refraction and AL. The ratio of Glu to GABA (RGG) represents the balance between excitatory and inhibitory neurotransmitters, and changes in RGG correlated with changes in AL.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Yan Xue, Jieling Li, Tianhe Jiang, Qingquan Han, Yafeng Jing, Shuo Bai, Xuehai Yan
Summary: An anisotropic and conductive hydrogel scaffold fabricated using gelatin methacryloyl (GelMA) and silver nanowire (AgNW) has shown great potential in promoting muscle repair through contact cues and electrical stimulation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Andrea Corna, Poornima Ramesh, Florian Jetter, Meng-Jung Lee, Jakob H. Macke, Guenther Zeck
Summary: This study investigated the discrimination of simple objects using sinusoidal stimulation in retinal neuroprosthetics. The results showed that spatially displaced objects could be classified based on distinct spiking activity of selected RGCs under low stimulation threshold conditions, and stimulation with low artificial contrast encoded by different stimulus amplitudes also generated RGC activity in the retina.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Assraa Hassan Jassim, McKay Cavanaugh, Jessica Stukel Shah, Rebecca Willits, Denise M. Inman
Summary: Transcorneal electrical stimulation (TES) can improve retinal or optic nerve pathology in a mouse model of glaucoma and serve as a minimally invasive treatment option. The study found that TES resulted in RGC axon protection, reduced inflammation and activation of inflammatory cells, improved energy homeostasis, and decreased cell death-associated factors.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Breanne Christie, Roksana Sadeghi, Arathy Kartha, Avi Caspi, Francesco Tenore, Roberta L. Klatzky, Gislin Dagnelie, Seth Billings
Summary: This study explores the use of sequential stimulation for producing clearer shapes in the retina, which can be used for restoring basic vision. Sequential stimulation outperforms simultaneous stimulation in simple tasks, but has limited success in more complex tasks. The selection of electrodes with similar shapes and sizes is crucial for the efficacy of sequential stimulation.
JOURNAL OF NEURAL ENGINEERING
(2022)
Review
Cell Biology
Michelle O'Hara-Wright, Sahba Mobini, Anai Gonzalez-Cordero
Summary: This article discusses recent findings in the field of bioelectricity related to the central nervous system, explores the possible mechanisms of bioelectric regulation of CNS development and function, and explores the potential of utilizing electrical stimulation as a novel technique for engineering next-generation organoid models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Food Science & Technology
Alessandro Picelli, Mirko Filippetti, Giorgio Sandrini, Cristina Tassorelli, Roberto De Icco, Nicola Smania, Stefano Tamburin
Summary: This systematic review provides a comprehensive overview of the current literature on the protocols of electrical stimulation to enhance the effect of BoNT-A injection in treating spasticity. Data on patient characteristics, electrical stimulation protocols, and outcome measures were collected and critically discussed based on the neurobiology of BoNT-A uptake.
Article
Cell Biology
Yan-hua Yang, Wei Qian, Xiao-hua Hou, Chi-bing Dai
Summary: This study investigated the influence of Bifidobacterium bifidum and Bacteroides fragilis on the regulation of enteric glial cells (EGCs) involved in intestinal inflammation. The results showed that these bacteria can affect intestinal inflammation by regulating the expression of specific genes and the secretion of cytokines in EGCs.
Article
Engineering, Biomedical
Molis Yunzab, Artemio Soto-Breceda, Matias Maturana, Stephanie Kirkby, Maximilian Slattery, Anton Newgreen, Hamish Meffin, Tatiana Kameneva, Anthony N. Burkitt, Michael Ibbotson, Wei Tong
Summary: This study proposes a stimulation strategy to preferentially stimulate individual RGCs based on their temporal electrical receptive fields (tERFs). By reconstructing the tERFs and comparing characteristics based on cell morphology and light response types, the researchers were able to preferentially stimulate individual RGCs with lower activation thresholds to their own tERFs using stimulation trains composed of tERFs obtained from different cells. This proposed stimulation strategy may improve the quality of artificial vision in the next generation of retinal prostheses.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Dorsa Haji Ghaffari, Akwasi Darkwah Akwaboah, Ehsan Mirzakhalili, James D. Weiland
Summary: Retinal prostheses aim to improve visual perception in patients with photoreceptor degeneration-induced blindness, but the current limitations in shape and letter perception are due to low spatial resolution. Research has shown that better patient outcomes are correlated with spatially separate phosphenes. By using an optimization algorithm to find optimal stimulation parameters for focal RGC activation, the time required for optimizing implant operation can be reduced.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Engineering, Biomedical
Hui Xie, Yi Wang, Zixin Ye, Shiyi Fang, Zhen Xu, Tianzhun Wu, Leanne Lai Hang Chan
Summary: Retinal prostheses can restore partial vision in patients with retinal diseases, but precise positioning remains challenging, and high impedance may not always lead to optimal cortical responses.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Neurosciences
Navvab Afrashteh, Samsoon Inayat, Mostafa Mohsenvand, Majid H. Mohajerani
Article
Multidisciplinary Sciences
Corey M. Rountree, John B. Troy, Laxman Saggere
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Nanoscience & Nanotechnology
Corey M. Rountree, Ashwin Raghunathan, John B. Troy, Laxman Saggere
MICROSYSTEMS & NANOENGINEERING
(2017)
Article
Engineering, Biomedical
Corey M. Rountree, Chen Meng, John B. Troy, Laxman Saggere
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2018)
Article
Engineering, Biomedical
Corey M. Rountree, John B. Troy, Laxman Saggere
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2020)
Article
Clinical Neurology
Samsoon Inayat, Qandeel, Mojtaba Nazariahangarkolaee, Surjeet Singh, Bruce L. Mcnaughton, Ian Q. Whishaw, Majid H. Mohajerani
Article
Instruments & Instrumentation
Corey M. Rountree, Pradeep Kumar Ramkumar, Laxman Saggere
REVIEW OF SCIENTIFIC INSTRUMENTS
(2020)
Article
Biology
Samsoon Inayat, Surjeet Singh, Arashk Ghasroddashti, Qandeel, Pramuka Egodage, Ian Q. Whishaw, Majid H. Mohajerani
Article
Engineering, Electrical & Electronic
Pradeep Kumar Ramkumar, Corey M. Rountree, Laxman Saggere, John D. Finan
Summary: This study presents a unique methodology for non-destructive dimensional characterization of SU-8 microstructures using the emitted autofluorescence radiation. The relationship between autofluorescence emission intensities and SEM-measured thicknesses of microstructures was used to accurately characterize unknown SU-8 microstructures. The results suggest a feasible and accurate non-destructive, low-cost metrological technique for characterizing SU-8 microstructures using autofluorescence emission intensities.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2021)
Article
Engineering, Biomedical
Sai Siva Kare, Corey M. Rountree, John B. Troy, John D. Finan, Laxman Saggere
Summary: The study focuses on evaluating electroosmotic flow (EOF) for delivering small quantities of glutamate to the retina as a potential strategy for treating vision loss caused by photoreceptor degenerative diseases. By constructing and testing an EOF microfluidic system, the research successfully induced excitatory and inhibitory spike rate responses in PR degenerate rat retinae, demonstrating the viability of EOF-driven chemical stimulation for retinal prosthetics.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Cell Biology
Navvab Afrashteh, Samsoon Inayat, Edgar Bermudez-Contreras, Artur Luczak, Bruce L. McNaughton, Majid H. Mohajerani
Summary: The study compared the propagation characteristics of spontaneous and evoked brain activity in response to visual, auditory, and tactile stimuli. It found that spontaneous activity showed more complex propagation trajectories, while the amplitude and speed of evoked activity were similar to spontaneous activity at low stimulus strengths but diverged at higher strengths.
Article
Ophthalmology
Corey M. Rountree, John B. Troy, Laxman Saggere
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)