Article
Oncology
Ruichao Zeng, Ahmed Mohamed, Kum Kum Khanna, Michelle M. Hill
Summary: Triple-negative breast cancer (TNBC) is a aggressive subtype of breast cancer with limited treatment options. This study identified TNBC-specific glycogenes and pathways, as well as potential therapeutic targets for further investigation. The findings suggest potential new strategies for treating TNBC.
Article
Biochemistry & Molecular Biology
Ghulam Md Ashraf, Mohd Rehan, Alhuseen O. Alsayed, Pallavi Somvanshi, Shafiul Haque
Summary: This study examines the possibility of cardiovascular medications inhibiting Galectin-3-related biological activities using bioinformatics techniques. Through clustering, molecular docking, and molecular dynamics simulation, potential chemical compounds were screened and repurposed. The results show that certain compounds have the ability to inhibit Galectin-3. Further experimental validation and animal model-based studies are needed.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Medicinal
Mujtaba Hassan, Sjors van Klaveren, Maria Hakansson, Carl Diehl, Rebeka Kovacic, Floriane Baussiere, Anders P. Sundin, Jaka Dernovsek, Bjorn Walse, Fredrik Zetterberg, Hakon Leffler, Marko Anderluh, Tihomir Tomasic, Ziga Jakopin, Ulf J. Nilsson
Summary: The study has successfully synthesized and identified a highly selective galectin-8N ligand that targets a specific amino acid, offering potential for further research and therapeutic development related to pathological implications of galectin-8.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Haoming Zhang, Xiaoyu Wang, Yanjun Wan, Liheng Liu, Jie Zhou, Pingping Li, Bailing Xu
Summary: A series of novel N-arylsulfonyl-5-aryloxy-indole-2-carboxamide derivatives were discovered as dual inhibitors of galectin-3 and galectin-8 C-terminal domain. These noncarbohydrate-based inhibitors had low micromolar level K(d) values and demonstrated potency and selectivity. The inhibitors showed the ability to inhibit migration of lung fibroblast cells and could be potential treatments for cancer and tissue fibrosis.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Cell Biology
Wenhong Li, Ana Sancho, Wen-Lu Chung, Yaron Vinik, Juergen Groll, Yehiel Zick, Ohad Medalia, Alexander D. Bershadsky, Benjamin Geiger
Summary: The study found that cells respond differently to two different extracellular adhesion molecules, and these differences can be partially reversed through experimental manipulation of small G-proteins and their downstream targets. Galectin-8 and fibronectin can act synergistically to regulate the number and length of filopodia in cells.
JOURNAL OF CELL SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Jon I. Quintana, Sandra Delgado, Reyes Nunez-Franco, F. Javier Canada, Gonzalo Jimenez-Oses, Jesus Jimenez-Barbero, Ana Arda
Summary: Gal-4 consists of two different domains that preferentially bind to A and B histo blood group antigens with different affinities. The study used NMR, ITC, and molecular modeling to investigate the binding of the N-terminal domain of Gal-4 to a group of differently presented A and B oligosaccharide antigens in solution, providing a structural-based rationale for the observed binding preferences.
FRONTIERS IN CHEMISTRY
(2021)
Article
Immunology
Ashwini Shete, Mahalakshmi Bhat, Jyoti Sawant, Supriya Deshpande
Summary: Both N- and C-CRDs of galectin-9 were found to induce HIV reactivation similar to that of the full-length protein. The two domains elicited higher cytokine responses than the full-length protein, possibly capable of mediating higher perturbations in the immune system if used for HIV reactivation. N-CRD was found to induce the development of Treg cells, whereas C-CRD inhibited the induction of Treg cells. Despite this, both domains elicited IL-10 secretory response although targeting different CD4 cell phenotypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Selena Bouffette, Iuliana Botez, Frederic De Ceuninck
Summary: This article reviews the key role of Galectin-3 (Gal-3) in cardiac, hepatic, renal, and pulmonary fibrosis and inflammation, respiratory infections caused by COVID-19, and neuroinflammatory disorders. The recent strategic breakthroughs have led to the identification of new-generation Gal-3 inhibitors with improved potency, selectivity, and bioavailability, which have shown promise as valuable tools in proof-of-concept studies in preclinical models of these diseases, particularly those in clinical stages. Critical views and suggestions to expand the therapeutic opportunities provided by this complex target are also discussed.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Fisheries
Li Wang, Qiuxia Wang, Lei Wang, Shixiu Wu, Yan Yu, Yanhong Zhang, Pei Gao, Xianghui Kong, Jinyou Ma
Summary: Galectin-9, identified from Qihe crucian carp, contains two carbohydrate recognition domains (CRDs) and can recognize and bind pathogen-associated molecular patterns (PAMPs) to initiate agglutination reactions against Gram-negative and Gram-positive bacteria. This study suggests that CaGal-9 plays an important role in immune defense against pathogenic microorganisms in Carassius auratus.
JOURNAL OF FISH DISEASES
(2021)
Article
Biology
Shiou-Ru Tzeng, Yin-Chu Tseng, Chien-Chu Lin, Chia-Ying Hsu, Shing-Jong Huang, Yi-Ting Kuo, Chung- Chang
Summary: The N-terminal domain (NTD) of LonA selectively interacts with unfolded proteins, protein aggregates, and degron-tagged proteins through two hydrophobic patches, but not with intrinsically disordered substrates. NTD also selectively binds to protein substrates when they are thermally induced to adopt unfolded conformations, enabling LonA to perform protein quality control and selectively degrade damaged proteins.
Article
Engineering, Electrical & Electronic
Romulo G. Bainy, Kleber M. Silva, Brian K. Johnson
Summary: This study introduces a current mapping strategy (CMS) formulation for the differential protection of series-compensated transmission lines, which offers flexibility and stability in protection settings. The performance of CMS is validated through computer simulations, demonstrating its reliability and effectiveness under various conditions.
ELECTRIC POWER SYSTEMS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Shang-Chuen Wu, Hau-Ming Jan, Mary L. Vallecillo-Zuniga, Matthew F. Rathgeber, Caleb S. Stowell, Kaleb L. Murdock, Kashyap R. Patel, Hirotomo Nakahara, Carter J. Stowell, Moon H. Nahm, Connie M. Arthur, Richard D. Cummings, Sean R. Stowell
Summary: Microbial glycan microarrays (MGMs) are used to study host immune factors' specificity towards microbes. However, they may not fully recapitulate the natural glycan presentation on microbes, raising the possibility of inaccurate predictions. Comparing MGM with an intact microbe microarray (MMA), Gal-8 binding on MMA accurately predicted interactions with different strains of S. pneumoniae, including its overall specificity. These findings demonstrate the antimicrobial activity of Gal-8 against distinctive strains of S. pneumoniae and the advantage of using microarray platforms with intact microbes in studying host-microbe interactions.
SCIENTIFIC REPORTS
(2023)
Article
Automation & Control Systems
Lei Ren, Xuejun Cheng
Summary: This article presents a black-box domain adaption framework for sensor time series data. It proposes a single/multi-source teacher-student learning framework to transfer knowledge from source domains to a customized target model. It also introduces a new temporal consistency loss function to maintain consistent temporal information and balance the learning difficulties of different classes.
IEEE TRANSACTIONS ON CYBERNETICS
(2023)
Article
Fisheries
Chaehyeon Lim, Seongdo Lee, Hyukjae Kwon, W. M. Gayashani Sandamalika, Jehee Lee
Summary: This study aimed to investigate the binding ability and potential role of LhGal B-like in pattern recognition receptors (PRRs) and innate immunity in redlip mullet. LhGal B-like was found to be widely expressed in various tissues, with the highest expression in the brain, gills, and muscle. It was also observed that LhGal B-like had immune-modulated expression and could bind to carbohydrates, PAMP molecules, and various bacterial strains.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Mujtaba Hassan, Floriane Baussiere, Samo Guzelj, Anders P. Sundin, Maria Hakansson, Rebeka Kovacic, Hakon Leffler, Tihomir Tomasic, Marko Anderluh, Ziga Jakopin, Ulf J. Nilsson
Summary: Galectin-8 plays a crucial role in tumor progression, antibacterial autophagy, modulation of the immune system, and bone remodeling. A hybrid compound with high selectivity for galectin-8N was identified through design and synthesis of a set of galactal derivatives. These compounds may serve as potential probes for investigations into galectin-8N pharmacology.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Chandan Kishor, Renee L. Ross, Helen Blanchard
CHEMICAL BIOLOGY & DRUG DESIGN
(2018)
Article
Chemistry, Medicinal
Mohammad H. Bohari, Xing Yu, Chandan Kishor, Brijesh Patel, Rob Marc Go, Hadieh A. Eslampanah Seyedi, Yaron Vinik, I. Darren Grice, Yehiel Zick, Helen Blanchard
Article
Biochemistry & Molecular Biology
Rahul Mishra, Xing Yu, Chandan Kishor, Gavan Holloway, Kam Lau, Mark von Itzstein, Barbara S. Coulson, Helen Blanchard
JOURNAL OF MOLECULAR RECOGNITION
(2018)
Article
Chemistry, Multidisciplinary
Kristoffer Peterson, Patrick M. Collins, Xiaoli Huang, Barbro Kahl-Knutsson, Sofia Essen, Fredrik R. Zetterberg, Stina Oredsson, Hakon Leffler, Helen Blanchard, Ulf J. Nilsson
Correction
Chemistry, Medicinal
Mohammad H. Bohari, Xing Yu, Chandan Kishor, Brijesh Patel, Rob Marc Go, Hadieh A. Eslampanah Seyedi, Yaron Vinik, I. Darren Grice, Yehiel Zick, Helen Blanchard
Article
Biochemistry & Molecular Biology
Jian Zhan, Husen Jia, Evgeny A. Semchenko, Yunqiang Bian, Amy M. Zhou, Zhixiu Li, Yuedong Yang, Jihua Wang, Sohinee Sarkar, Makrina Totsika, Helen Blanchard, Freda E. -C. Jen, Qizhuang Ye, Thomas Haselhorst, Michael P. Jennings, Kate L. Seib, Yaoqi Zhou
Article
Biochemistry & Molecular Biology
Christophe Dussouy, Chandan Kishor, Annie Lambert, Clement Lamoureux, Helen Blanchard, Cyrille Grandjean
CHEMICAL BIOLOGY & DRUG DESIGN
(2020)
Article
Virology
Karla J. Helbig, Rowena A. Bull, Rebecca Ambrose, Michael R. Beard, Helen Blanchard, Till Bocking, Brendon Chua, Agathe M. G. Colmant, Keaton M. Crosse, Damian F. J. Purcell, Johanna Fraser, Joshua A. Hayward, Stuart T. Hamilton, Matloob Husain, Robin MacDiarmid, Jason M. Mackenzie, Gregory W. Moseley, Thi H. O. Nguyen, Miguel E. Quinones-Mateu, Karl Robinson, Chaturaka Rodrigo, Julio Rodriguez-Andres, Penny A. Rudd, Anja Werno, Peter White, Paul Young, Peter Speck, Merilyn Hibma, Heidi E. Drummer, Gilda Tachedjian
Article
Chemistry, Medicinal
Brijesh Patel, Chandan Kishor, Todd A. Houston, Hadas Shatz-Azoulay, Yehiel Zick, Yaron Vinik, Helen Blanchard
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Somayeh S. Tarighat, Fei Fei, Eun Ji Joo, Hisham Abdel-Azim, Lu Yang, Huimin Geng, Khuchtumur Bum-Erdene, I. Darren Grice, Mark von Itzstein, Helen Blanchard, Nora Heisterkamp
Summary: The study demonstrated that galectin-3 in stromal cells is crucial for the migration and adhesion of BCP-ALL cells, but dispensable for their proliferation and viability. Inhibition of galectin-3 increased sensitivity of BCP-ALL cells to conventional chemotherapy, suggesting a potential combination therapy strategy to improve treatment outcomes for BCP-ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maria Raics, Alex Kalman Balogh, Chandan Kishor, Istvan Timari, Francisco J. Medrano, Antonio Romero, Rob Marc Go, Helen Blanchard, Laszlo Szilagyi, Katalin E. Kover, Krisztina Feher
Summary: In this study, the binding affinities of two selenium-containing hGal-3 inhibitors to hGal-3 were investigated using NMR spectroscopy and fluorescence anisotropy titrations. The results showed that these derivatives bind to hGal-3 at a specific site, but with weaker interaction strength.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Khuchtumur Bum-Erdene, Patrick M. Collins, Matthew W. Hugo, Somayeh S. Tarighat, Fei Fei, Chandan Kishor, Hakon Leffler, Ulf J. Nilsson, John Groffen, I. Darren Grice, Nora Heisterkamp, Helen Blanchard
Summary: In this study, novel Galectin-3 antagonists with enhanced affinity and selectivity were designed and synthesized. Experimental results demonstrated the specific inhibition of Galectin-3-induced BCP-ALL cell agglutination and decreased viability of ALL cells. Therefore, these compounds show promise as important leads for cancer therapeutics.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Peter Sunde-Brown, Ian D. Jenkins, Helen Blanchard, Todd A. Houston
Summary: Methyl a(and b)-D-3,4-anhydro-tagatofuranosides are important synthetic building blocks that can undergo regioselective ring-opening to yield products with the D-fructo configuration. A modified Mitsunobu protocol with the addition of phenol allows for the exclusive and quantitative formation of tagato products under mild conditions. This reaction mechanism involves the intermediate formation of diphenoxytriphenylphosphorane, which acts as a selective Mitsunobu reagent. An unusual Mitsunobu-induced anomerisation reaction is also observed.