Article
Dermatology
Delu Che, Bing Hang, Yazhuo Li, Kaili Li, Kaijie Wang, Hao Wang
Summary: Livin is upregulated in KCs of psoriasis patients and may regulate the expression of adhesion molecules, promoting the activation and adhesion of neutrophils.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Immunology
Wenjuan Yang, Rukun He, Hao Qu, Wenwen Lian, Yue Xue, Tao Wang, Wenlong Lin, Peishuo Zhu, Meng Xia, Lihua Lai, Qingqing Wang
Summary: FXYD3 is upregulated in the lesional skin of psoriasis patients and mice with IMQ-induced psoriasis. It promotes IL-17A signaling in keratinocytes, leading to inflammation and the expression of proinflammatory factors, exacerbating psoriasis. Targeting FXYD3 could be a potential therapeutic approach for psoriasis.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Abeer Mostafa, Dina Sabry, Nesreen Aboraia, Ahmed Fawzy, Amany A. Abou-Elalla
Summary: This study aims to clarify the unprecedented role of NEAT in psoriasis pathogenesis. The results showed that psoriasis patients have dyslipidemia, increased expression of NEAT, TNF-a, VEGF genes, and elevated levels of ROS and caspase-3. NEAT can be considered as a good diagnostic biomarker for psoriasis.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Immunology
Masahiro Kamata, Yayoi Tada
Summary: Psoriasis is an immune-mediated disease in which immune cells and skin cells interact, leading to aberrant differentiation and proliferation of keratinocytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Jing Wang, Xiangying Li, Ping Zhang, Tao Yang, Na Liu, Li Qin, Guanghui Ma, Xiaobing Li, Huiping Fan, Shuhong Huang, Ningning Dang
Summary: This study found that CHRNA5 is highly expressed in psoriatic lesional skin and regulates inflammation through the MAPK/NF-Kappa B pathway. Chrna5 knockout significantly reduces the severity of psoriasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Integrative & Complementary Medicine
Shuo Zhang, Hong-jin Li, Chun-mei Yang, Liu Liu, Xiao-ying Sun, Jiao Wang, Si-ting Chen, Yi Lu, Man-qi Hu, Ge Yan, Ya-qiong Zhou, Xiao Miao, Xin Li, Bin Li
Summary: Tripterygium wilfordii multiglycoside (TGW) improves psoriasis-like inflammation by inhibiting keratinocytes proliferation and regulating immune cells and cytokine expression. It also reduces the number of γδT17 cells in skin lesions and draining lymph nodes.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Guiming Hu, Fei Gao, Guanzhe Wang, Yan Fang, Yuanyuan Guo, Jun Zhou, Yuhan Gu, Cunzhen Zhang, Na Gao, Qiang Wen, Hailing Qiao
Summary: Although the association between CYP2D6*10 (100C>T) polymorphism and hepatocellular carcinoma (HCC) is known, the mechanism remains unclear. The study found that the TT genotype was associated with a decreased risk of HCC by 69.2% and altered protein expression in the tumor microenvironment. Additionally, high levels of ANGPTL6 were associated with increased risk and poorer prognosis of HCC, making it a promising new diagnostic and prognostic biomarker for the disease.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yixin Luo, Bingyu Pang, Junfeng Hao, Qingyang Li, Pei Qiao, Chen Zhang, Yaxing Bai, Chunying Xiao, Jiaoling Chen, Dalong Zhi, Ying Liu, Erle Dang, Gang Wang, Bing Li
Summary: The dysregulated glucose metabolism in psoriasis is influenced by the cytoskeletal protein keratin 17 (K17) and its interaction partner & alpha;-enolase (ENO1). Increased K17 expression activates the glycolytic pathway in psoriatic keratinocytes (KCs). Inhibition of ENO1 or K17-Ser44 phosphorylation suppresses glycolysis and proliferation in KCs. Modulation of the ENO1-K17-LDHA axis could be a potential therapeutic approach for psoriasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yuyue Zuo, Lei Dai, Li Li, Yuqiong Huang, Xinxin Liu, Xin Liu, Xiaoru Duan, Su Jiang, Guo-Min Deng, Hongxiang Chen
Summary: We found that ANGPTL4 was significantly increased in IMQ-induced psoriasiform skin of mice and could promote keratinocyte proliferation and inflammatory response via ERK1/2 and STAT3 dependent signaling pathways in psoriasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fabian Gendrisch, Birgit Haarhaus, Nina Krieger, Karl-Werner Quirin, Christoph M. Schempp, Ute Woelfle
Summary: Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation of keratinocytes and expression of pro-inflammatory cytokines in the epidermis. New biological drugs have been developed for systemic treatment of moderate to severe psoriasis, but there is still a need for topical treatment of mild psoriasis. In this study, natural compounds were examined for their effects on psoriasis-like keratinocytes, with Curcuma amada, Humulus lupulus, and Hypericum perforatum showing the most promising results in inhibiting the expression of certain markers associated with psoriasis. Among these plant extracts, Humulus lupulus demonstrated the most prominent anti-proliferative and anti-inflammatory effect in an ex vivo psoriasis model, suggesting its potential as a candidate for further research in clinical trials as a topical treatment for psoriasis.
Article
Medicine, Research & Experimental
Hung-Lin Chen, Chia-Hui Lo, Chi-Chun Huang, Meng-Ping Lu, Po-Yuan Hu, Chang-Shan Chen, Di-Yen Chueh, Peilin Chen, Teng-Nan Lin, Yuan-Hsin Lo, Yu-Ping Hsiao, Daniel K. Hsu, Fu-Tong Liu
Summary: The study found that the expression of galectin-7 is reduced in skin lesions of psoriasis patients, and IL-17A and TNF-alpha suppress galectin-7 expression in human keratinocytes. Galectin-7 attenuates the production of inflammatory mediators by keratinocytes via the microRNA-146a/ERK pathway when cells are stimulated with IL-17A. Fluvastatin was identified as an inducer of galectin-7 expression and showed potential in reducing IL-6 and IL-8 production induced by IL-17A.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Genetics & Heredity
Dora Antal, Agnes Por, Ilona Kovacs, Katalin Dull, Szilard Poliska, Gyula Ujlaki, Mate agoston Demeny, Attila Gabor Szollosi, Borbala Kiss, Andrea Szegedi, Peter Bai, Magdolna Szanto
Summary: This study found that PARP2 mRNA expression is increased in human psoriatic lesions. Through experiments in mouse and human cell models, we found that inhibition of PARP2 expression can alleviate psoriasis-like dermatitis by suppressing inflammation in keratinocytes through inhibition of estrogen biosynthesis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Multidisciplinary Sciences
Chan Xi, Chuanxi Xiong, Huiping Wang, Yuanjun Liu, Suju Luo
Summary: Research shows that tazarotene/acitretin and NB-UVB irradiation can inhibit the expression of MMP13 in patients with psoriasis, leading to reduced cell proliferation in HaCaT keratinocytes and decreased MMP13 expression in psoriasis mouse models.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yuanbo Li, Dandan Guo, Qianqian Wang, Aifang Li, Sugai Yin, Shuxuan Li, Yalan Li, Baiyan Wang, Tao Guo, Shuying Feng
Summary: This study investigated the effects and mechanisms of Benzoylaconitine (BAC) on TNF-a/LPS-induced HaCaT keratinocytes in a IMQ-induced mice model of psoriasis. The results showed that BAC could alleviate psoriasis symptoms by inhibiting cell proliferation, inflammatory factors release, and Th17 cells accumulation. BAC also inhibited the phosphorylation of STAT3 and inflammatory cytokines levels in TNF-a/LPS-induced HaCaT keratinocytes. These findings suggest that BAC may be a potential therapeutic agent for psoriasis treatment in clinical practice.
Article
Immunology
Hongdong Chen, Zhenjie Xu, Yuan Wang, Jianguo Xu, Ke He, Hui Wang, Xiaochun Bai, Guoan Xiang
Summary: This study investigates the roles of circVAPA and its molecular mechanisms in psoriasis. It is found that circVAPA regulates cell proliferation and inflammation of keratinocytes in psoriasis by targeting the miR-125b-5p/Sirt6 axis. These findings provide a potential therapeutic target for the treatment of psoriasis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Letter
Dermatology
Tselmeg Mijiddorj Myangat, Shoma Wada, Soichiro Sawamura, Ikko Kajihara, Toshihiro Kimura, Kayo Kashiwada-Nakamura, Katsunari Makino, Jun Aoi, Shinichi Masuguchi, Satoshi Fukushima
JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Kayo Kashiwada-Nakamura, Tselmeg Mijiddorj Myangat, Ikko Kajihara, Hisashi Kanemaru, Soichiro Sawamura, Katsunari Makino, Jun Aoi, Shinichi Masuguchi, Satoshi Fukushima
JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Hiromitsu Noguchi, Tadahiko Matsumoto, Utako Kimura, Masataro Hiruma, Rui Kano, Takashi Yaguchi, Kayo Kashiwada-Nakamura, Satoshi Fukushima
JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Atsushi Fukunaga, Satoshi Fukushima, Hiroaki Iwata, Makiko Nakahara, Rikako Sasaki, Naoko Baba, Hiroshi Matsunaka, Yumi Murakami, Masutaka Furue, Chikako Nishigori
Summary: The study investigated the potential of bioactive substances in the stratum corneum as early and sensitive indicators of sun exposure on the skin using ROC analysis. Results showed that IL-1ra/IL-1 alpha, TNF-alpha, and Bax in the stratum corneum are sensitive to sun exposure and decreased significantly after sunscreen application, indicating their potential as markers for sun damage.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Haruki Horiguchi, Tsuyoshi Kadomatsu, Shinsei Yumoto, Takeshi Masuda, Keishi Miyata, Shuji Yamamura, Michio Sato, Jun Morinaga, Sumio Ohtsuki, Hideo Baba, Toshiro Moroishi, Yuichi Oike
Summary: Tumor cell-derived ANGPTL2 promotes beta-catenin-driven intestinal tumorigenesis by upregulating OB-cadherin expression and blocking destruction complex-independent proteasomal degradation of beta-catenin proteins. It also leads to decreased cell surface integrin alpha 5 beta 1 expression.
Article
Urology & Nephrology
Yusuke Okadome, Jun Morinaga, Yoshinori Yamanouchi, Eiji Matsunaga, Hirotaka Fukami, Tsuyoshi Kadomatsu, Haruki Horiguchi, Michio Sato, Taichi Sugizaki, Manabu Hayata, Takeshi Sakaguchi, Ryo Hirayama, Tatsuhiro Ishimura, Takashige Kuwabara, Koichiro Usuku, Tatsuo Yamamoto, Masashi Mukoyama, Ryusuke Suzuki, Toshihiro Fukui, Yuichi Oike
Summary: In two cohort studies, researchers found that increased pre-operative circulating monocyte counts are associated with an increased risk of cardiac surgery-associated acute kidney injury (CSA-AKI) development.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2023)
Editorial Material
Dermatology
Takashi Inozume, Satoshi Fukushima
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Dermatology
Satoshi Fukushima, Azusa Miyashita, Haruka Kuriyama, Toshihiro Kimura, Satoru Mizuhashi, Yosuke Kubo, Satoshi Nakahara, Hisashi Kanemaru, Nobuhiro Tsuchiya, Hiroaki Mashima, Rong Zhang, Yasushi Uemura
Summary: Cancer immunotherapy is the primary treatment for unresectable cancers, but it is not a complete cure for all patients. Immune cell therapy, specifically using immune cells generated from induced pluripotent stem cells (iPSCs), shows promise for innovative cancer immunotherapy methods. iPSC-derived dendritic cells (iPS-DCs) can activate T cells, while iPSC-derived macrophages (iPS-MPs) attack cancer cells. iPSCs offer a source for genetic modification and addition of immune functions. Additionally, immortalized iPS-DCs and iPS-MPs could potentially reduce costs through mass production. This review summarizes the achievements and future prospects of cancer research using iPS-DCs and iPS-MPs.
EXPERIMENTAL DERMATOLOGY
(2023)
Letter
Dermatology
Tomohiro Ishino, Tselmeg Mijiddorj Myangat, Soichiro Sawamura, Ikko Kajihara, Shuichi Shimada, Hisashi Kanemaru, Kayo Kashiwada-Nakamura, Katsunari Makino, Shinichi Masuguchi, Satoshi Fukushima
JOURNAL OF DERMATOLOGY
(2023)
Article
Biology
Yoshitaka Murakami, Fan-Yan Wei, Yoshimi Kawamura, Haruki Horiguchi, Tsuyoshi Kadomatsu, Keishi Miyata, Kyoko Miura, Yuichi Oike, Yukio Ando, Mitsuharu Ueda, Kazuhito Tomizawa, Takeshi Chujo
Summary: A study found that a mitochondrial tRNA modification enzyme, NSUN3, is crucial for embryonic development in mice. Whole-body knockout leads to embryonic death, while heart-specific knockout causes heart aberration in older mice. The research highlights the importance of mitochondrial tRNA anticodon modification for mammalian embryonic development and demonstrates that the loss of a single mitochondrial tRNA modification can induce tissue aberration that worsens with age.
COMMUNICATIONS BIOLOGY
(2023)
Letter
Dermatology
Chiaki Obaru, Toshihiro Kimura, Manami Yamamura, Haruka Kuriyama, Kayo Kashiwada-Nakamura, Satoru Mizuhashi, Tomoyo Matsumura, Takahiro Watanabe, Toshihiro Inoue, Satoshi Fukushima
JOURNAL OF DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Chikako Senju, Yuka Nakazawa, Taichi Oso, Mayuko Shimada, Kana Kato, Michiko Matsuse, Mariko Tsujimoto, Taro Masaki, Yasushi Miyazaki, Satoshi Fukushima, Satoshi Tateishi, Atsushi Utani, Hiroyuki Murota, Katsumi Tanaka, Norisato Mitsutake, Shinichi Moriwaki, Chikako Nishigori, Tomoo Ogi
Summary: Xeroderma pigmentosum (XP) is a rare genodermatosis characterized by photosensitivity and a high risk of skin tumors due to DNA repair deficiency. This study identified two deep intronic mutations in the ERCC4/XPF gene in 17 cases of XP-F, a rare subtype of XP. These mutations result in reduced gene expression and early-onset skin cancers, highlighting the need for attention to these variants. Additionally, antisense oligonucleotides designed for these mutations can restore DNA repair capacity, suggesting potential therapeutic targets for XP-F.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Hirotaka Fukami, Jun Morinaga, Hironori Nakagami, Hiroki Hayashi, Yusuke Okadome, Eiji Matsunaga, Tsuyoshi Kadomatsu, Haruki Horiguchi, Michio Sato, Taichi Sugizaki, Keishi Miyata, Daisuke Torigoe, Masashi Mukoyama, Ryuichi Morishita, Yuichi Oike
Summary: This study assessed the durability and booster effects of an ANGPTL3 vaccine, which showed efficacy for over one year and maintained suppression of circulating triglyceride levels without major adverse effects on important organs.
Article
Biology
Haruki Horiguchi, Tsuyoshi Kadomatsu, Tomoya Yamashita, Shinsei Yumoto, Kazutoyo Terada, Michio Sato, Jun Morinaga, Keishi Miyata, Yuichi Oike
Summary: This study investigates the role of Angiopoietin-like protein 2 (ANGPTL2) in ICI-related autoimmune myocarditis and demonstrates its immunostimulatory function in promoting T cell recruitment. These findings provide insight into the mechanisms regulating irAEs and highlight the importance of cardiac myofibroblast/immune cell crosstalk in enhancing autoimmune responses.
COMMUNICATIONS BIOLOGY
(2023)