期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep38061
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资金
- Natural Sciences and Engineering Research Council of Canada [NSERC] [342150]
- Canadian Institutes of Health Research (CIHR)
- Canada Foundation for Innovation (CFI) [CIHR] [93592]
- NSERC
- Fonds de recherche du Quebec - Nature et technologies
- Zoetis Investment in Innovation Award
The pathogenesis of Streptococcus suis infection, a major swine and human pathogen, is only partially understood and knowledge on the host adaptive immune response is critically scarce. Yet, S. suis virulence factors, particularly its capsular polysaccharide (CPS), enable this bacterium to modulate dendritic cell (DC) functions and potentially impair the immune response. This study aimed to evaluate modulation of T cell activation during S. suis infection and the role of DCs in this response. S. suis-stimulated total mouse splenocytes readily produced TNF-alpha, IL-6, IFN-gamma, CCL3, CXCL9, and IL-10. Ex vivo and in vivo analyses revealed the involvement of CD4(+) T cells and a Th1 response. Nevertheless, during S. suis infection, levels of the Th1-derived cytokines TNF-alpha and IFN-gamma were very low. A transient splenic depletion of CD4(+) T cells and a poor memory response were also observed. Moreover, CD4(+) T cells secreted IL-10 and failed to up-regulate optimal levels of CD40L and CD69 in coculture with DCs. The CPS hampered release of several T cell-derived cytokines in vitro. Finally, a correlation was established between severe clinical signs of S. suis disease and impaired antibody responses. Altogether, these results suggest S. suis interferes with the adaptive immune response.
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