期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/srep34234
关键词
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资金
- Transdisciplinary Research in Cancer of the Lung (TRICL) Study on behalf of the Genetic Associations and Mechanisms in Oncology (GAME-ON) Network [U19-CA148127]
- Canadian Cancer Society Research Institute [020214]
- Ontario Institute of Cancer
- Cancer Care Ontario Chair Award
- Cancer Research UK [C1298/A8780, C1298/A8362]
- NCRN
- HEAL
- Sanofi-Aventis
- NIH [5R01CA055769, 5R01CA127219, 5R01CA133996, 5R01CA121197, U19CA148127, P50 CA70907, R01CA121197, R01CA127219, U19 CA148127, R01 CA55769, K07CA160753, HHSN268200782096C]
- Roy Castle Lung Cancer Foundation, UK
- Deutsche Krebshilfe [70-2919]
- Helmholtz-DAAD fellowship [A/07/97379]
- GSF - German Federal Ministry of Education, Science, Research and Technology
- State of Bavaria
- National Genome Research Network (NGFN)
- DFG [BI576/2-1, BI 576/2-2]
- Helmholtzgemeinschaft (HGF)
- Federal office for Radiation Protection [BfS: STSch4454]
- Institut National du Cancer, France
- European Community [LSHG-CT-2005-512113]
- Norwegian Cancer Association
- Functional Genomics Programme of Research Council of Norway
- European Regional Development Fund
- State Budget of the Czech Republic (RECAMO) [CZ.1.05/2.1.00/03.0101]
- US National Cancer Institute, NIH [R01 CA111703, UO1 CA63673]
- Fred Hutchinson Cancer Research Center
- US National Cancer Institute [R01 CA092039]
- FP7 grant [REGPOT245536]
- Estonian Government [SF0180142s08]
- EU RDF in the frame of Centre of Excellence in Genomics
- Estoinian Research Infrastructure's Roadmap
- University of Tartu [SP1GVARENG]
- IARC
- Intramural Research Program of NIH, NCI, Division of Cancer Epidemiology and Genetics
- US Public Health Service from the NCI [N01-CN-45165, N01-RC-45035, N01-RC-37004]
- NCI [NO1-CN-25514, NO1-CN-25522, NO1-CN-25515, NO1-CN-25512, NO1-CN-25513, NO1-CN-25516, NO1-CN-25511, NO1-CN-25524, NO1-CN-25518, NO1-CN-75022, NO1-CN-25476, NO1-CN-25404]
- American Cancer Society
- NIH Genes, Environment and Health Initiative (GEI) [HG-06-033-NCI-01, RO1HL091172-01, U01HG004438, NIH HHSN268200782096C, U01 HG004446]
- CPRIT grant [RP100443]
- NIH (National Cancer Institute) [CA092824, CA090578, CA074386]
- GENADDICT [LSHMCT-2004-005166]
- National Institutes of Health [R01-DA017932]
- Duke Cancer Institute as part of the P30 Cancer Center Support Grant [NIH CA014236]
- Duke Cancer Institute
- Duke Cancer Institute, Duke University Medical Center
- Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University
- LUNGevity Foundation
- [U01 HG007033]
Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium in populations of European ancestry. Previously unreported significant SNPs (P value < 1 x 10(-7)) were further validated in two additional independent lung cancer GWAS datasets from Harvard University and deCODE. In the final meta-analysis of all eight GWAS datasets with 17,153 cases and 239,337 controls, a novel risk SNP rs114020893 in the lncRNA NEXN-AS1 region at 1p31.1 remained statistically significant (odds ratio = 1.17; 95% confidence interval = 1.11-1.24; P = 8.31 x 10(-9)). In further in silico analysis, rs114020893 was predicted to change the secondary structure of the lncRNA. Our finding indicates that SNP rs114020893 of NEXN-AS1 at 1p31.1 may contribute to lung cancer susceptibility.
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