Article
Immunology
Margaret M. Harnett, Felicity E. Lumb, Jenny Crowe, James Doonan, Geraldine Buitrago, Stephanie Brown, Gillian Thom, Amy MacDonald, Colin J. Suckling, Colin Selman, William Harnett
Summary: In this study, it was found that ES-62 and its analogues offer protection against age-induced pathological changes in the lungs, especially under a high calorie diet. These protective effects may be related to the modulation of cytokines and inflammatory markers by ES-62.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Bangxing Hong, Valerie Chapa, Uksha Saini, Puneet Modgil, David E. Cohn, Guangan He, Zahid H. Siddik, Anil K. Sood, Yuanqing Yan, Karuppaiyah Selvendiran, Guangsheng Pei, Zhongming Zhao, Ji Young Yoo, Balveen Kaur
Summary: This study revealed the impact of HSV-induced cisplatin retention on cancer cells, resulting in increased DNA damage and activation of antitumor immunity, as well as increased sensitivity of tumors to immune checkpoint therapy.
CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Murillo Silva, Yu Kato, Mariane B. Melo, Ivy Phung, Brian L. Freeman, Zhongming Li, Kangsan Roh, Jan W. Van Wijnbergen, Hannah Watkins, Chiamaka A. Enemuo, Brittany L. Hartwell, Jason Y. H. Chang, Shuhao Xiao, Kristen A. Rodrigues, Kimberly M. Cirelli, Na Li, Sonya Haupt, Aereas Aung, Benjamin Cossette, Wuhbet Abraham, Swati Kataria, Raiza Bastidas, Jinal Bhiman, Caitlyn Linde, Nathaniel I. Bloom, Bettina Groschel, Erik Georgeson, Nicole Phelps, Ayush Thomas, Julia Bals, Diane G. Carnathan, Daniel Lingwood, Dennis R. Burton, Galit Alter, Timothy P. Padera, Angela M. Belcher, William R. Schlef, Guido Silvestri, Ruth M. Ruprecht, Shane Crotty, Darrell J. Irvine
Summary: The research uncovered that saponin/MPLA nanoparticles have greater potency in promoting immune responses and hold promising potential in both mice and nonhuman primates.
SCIENCE IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yinghua Li, Li Li, Songyi Li, Chaying He
Summary: The study found that mifepristone affects immune homeostasis in the endometrium. Mifepristone can activate dendritic cells and enhance their ability to stimulate T cells. Additionally, mifepristone can alter the balance between Th1 and Th2 cells.
ADVANCED THERAPEUTICS
(2023)
Article
Microbiology
Parna Bhattacharya, Sreenivas Gannavaram, Nevien Ismail, Ankit Saxena, Pradeep K. Dagur, Adovi Akue, Mark KuKuruga, Hira L. Nakhasi
Summary: The study revealed that the LdCen(-/-) vaccine activates the TLR-9 signaling pathway, which enhances the immune response and provides protection against virulent L. donovani challenge.
Letter
Orthopedics
Sebastian Farr, Arnard L. van der Zwan, Erik Kommol
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2021)
Article
Pediatrics
Christina N. Steiger, Romain Dayer, Anne Tabard-Fougere, Dimitri Ceroni
Summary: Clinical examination using a standardized evaluation protocol can effectively rule out significant injuries in hyperextension injuries of long fingers, reducing unnecessary radiographic examinations and improving patient treatment efficiency.
JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Felicity E. Lumb, James Doonan, Marlene Corbet, Miguel A. Pineda, Margaret M. Harnett, William Harnett
Summary: The life cycle of A viteae cannot be completed in M shawi jirds, but L3 stage worms develop into adults and produce functional ES-62. Preliminary investigation suggests that infection can modulate myeloid responses differently in the two species.
PARASITE IMMUNOLOGY
(2021)
Article
Orthopedics
Anne Tabard-Fougere, Federico Canavese, Christina N. Steiger, Geraldo De Coulon
Summary: The purpose of this study was to investigate the incidence of complications in pediatric spastic cerebral palsy (CP) patients weighing less than 20 kg at the time of intrathecal baclofen (ITB) pump implantation and compare it with spastic CP patients weighing more than 20 kg. The study found that there was no significant difference in the rate of complications or reoperation between the two groups, but the mortality rate was higher in patients weighing less than 20 kg.
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2022)
Article
Orthopedics
B. Coulin, G. Demarco, V Spyropoulou, C. Juchler, T. Vendeuvre, C. Habre, A. Tabard-Fougere, R. Dayer, C. Steiger, D. Ceroni
Summary: K. kingae should be recognized as the primary pathogen causing OAI in children younger than 48 months old. Diagnosis of an OAI caused by K. kingae is not always obvious, as this infection may occur with a mild-to-moderate clinical and biological inflammatory response. The use of nucleic acid amplification assays has improved pathogen detection and increased the observed incidence of OAIs, especially in children aged 6-48 months.
BONE & JOINT JOURNAL
(2021)
Review
Orthopedics
Nunzio Catena, Giovanni Luigi Di Gennaro, Andrea Jester, Sergio Martinez-Alvarez, Eva Ponten, Francisco Soldado, Christina Steiger, Jiahui Choong, Paola Zarantonello, Sebastian Farr
Summary: Peripheral nerve injuries of the upper limb in children can result from fractures and soft tissue injuries. While open injuries are easier to identify and repair, closed nerve injuries may be harder to diagnose in younger children.
JOURNAL OF CHILDRENS ORTHOPAEDICS
(2021)
Article
Microbiology
Morad Mohamad, Christina Steiger, Vasiliki Spyropoulou, Benoit Coulin, Tanguy Vendeuvre, Celine Habre, Amira Dhouib, Giacomo De Marco, Romain Dayer, Dimitri Ceroni
Summary: This retrospective study evaluated osteoarticular infection in infants under 12 months old, finding that neonates and infants aged 6 to 12 months were more susceptible. Staphylococcus aureus was the main pathogen in children under 6 months, while Kingella kingae was most frequently isolated in infants aged 6 to 12 months.
FUTURE MICROBIOLOGY
(2021)
Article
Orthopedics
Sarah Naef, Christina N. Steiger, Anne Tabard-Fougere, Romain Dayer, Dimitri Ceroni
Summary: Horse-related activities, especially among young people, are associated with severe injuries that often require hospital treatment. This retrospective study analyzed epidemiological data on equestrian accidents involving children and found that horse riding injuries occur frequently and are more serious compared to other sports injuries. There is an urgent need to reassess preventive measures to reduce the incidence and severity of equestrian injuries.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2022)
Article
Immunology
Moez Chargui, Giacomo De Marco, Christina Steiger, Benoit Borner, Celine Habre, Romain Dayer, Dimitri Ceroni
Summary: The article reports a rare case of primary pyomyositis caused by Kingella kingae in a 21-month-old girl. The case illustrates that primary pyomyositis may occur during invasive infections due to K. kingae, although it is a rare manifestation. Therefore, this bacterial etiology should be considered when observing primary pyomyositis, especially in children under 4 years of age.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Microbiology
Marlene Corbet, Miguel A. Pineda, Kun Yang, Anuradha Tarafdar, Sarah McGrath, Rinako Nakagawa, Felicity E. Lumb, Colin J. Suckling, William Harnett, Margaret M. Harnett
Summary: The Hygiene Hypothesis suggests that eradication of parasitic worms and pathogens has led to increased incidence of allergic, autoimmune, and metabolic conditions worldwide. ES-62, an anti-inflammatory protein, can protect joints from disease by reprogramming stromal cells to a safe phenotype. This discovery provides potential for developing new therapies to prevent joint disease.
Article
Microbiology
Giacomo DeMarco, Moez Chargui, Benoit Coulin, Benoit Borner, Christina Steiger, Romain Dayer, Dimitri Ceroni
Summary: K. kingae is considered the main bacterial cause of osteoarticular infections in children under 48 months, presenting with mild symptoms and moderate inflammatory response. Surgical intervention is often not necessary, as the infections respond well to short antibiotic treatments.
Article
Pediatrics
Celine Cuerel, C. Habre, Christina N. Steiger, Giacomo DeMarco, Anne Tabard-Fougere, Laura Merlini, Cyril Sahyoun, Romain O. Dayer, Dimitri Ceroni
Summary: Sciatic neuropathy is rare in pediatric patients and can be caused by infectious, immune mediated, toxic, or infiltrative factors. This case study describes a 7.5-year-old male child with sciatic neuropathy due to subacute osteomyelitis. Prompt treatment with antibiotics led to rapid improvement in the child's condition.
JOURNAL OF PEDIATRIC NEUROLOGY
(2022)
Article
Immunology
Yilin Wang, Piaopiao Pan, Aneesah Khan, Caglar Cil, Miguel A. Pineda
Summary: Synovial fibroblasts play a critical role in perpetuating chronic joint inflammation in Rheumatoid Arthritis, and the level of sialic acid on their surface can change in response to extracellular signals. Desialylation of synovial fibroblasts leads to dysregulated migratory ability, activation of inflammatory phenotype, and altered expression of sialyltransferases. The findings suggest that sialic acid plays a key role in modulating homeostatic and inflammatory responses in synovial fibroblasts and contributes to local inflammation in arthritic joints.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Parasitology
Geraldine Buitrago, Margaret M. Harnett, William Harnett
Summary: Despite new treatment strategies, rheumatic disorders still have unmet clinical needs. Interestingly, there is a global inverse relationship between parasitic helminth infection and the incidence of these conditions. Parasitic worms can modulate inflammatory responses and may be used to generate novel therapies for rheumatic diseases.
TRENDS IN PARASITOLOGY
(2023)
Article
Infectious Diseases
Fortesa Mehmeti, Blaise Cochard, Celine Cuerel, Geraldo De Coulon, Romain Dayer, Christina Steiger, Dimitri Ceroni
Summary: Moraxella lacunata is a rare coccobacillus that is associated with eye and upper respiratory tract infections, as well as bone and joint tissue affinity. We report a case of subacute osteomyelitis caused by M. lacunata presenting as an osteolytic bone lesion in a child.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)