Article
Oncology
Shivani Kumar, Lois Holloway, Miriam Boxer, Mei Ling Yap, Phillip Chlap, Daniel Moses, Shalini Vinod
Summary: This study compared the differences in GTV delineation of lung cancer using MRI and PET versus CT and PET. The results showed similar interobserver variability between MRI and PET, but there were significant differences between MRI and CT delineated volumes.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Chemistry, Analytical
Christian Baker, Miguel Xochicale, Fang-Yu Lin, Sunish Mathews, Francois Joubert, Dzhoshkun I. I. Shakir, Richard Miles, Charles A. A. Mosse, Tianrui Zhao, Weidong Liang, Yada Kunpalin, Brian Dromey, Talisa Mistry, Neil J. J. Sebire, Edward Zhang, Sebastien Ourselin, Paul C. C. Beard, Anna L. L. David, Adrien E. E. Desjardins, Tom Vercauteren, Wenfeng Xia
Summary: Ultrasound needle tracking is an essential tool for minimally-invasive procedures. This study presents a new real-time ultrasound needle tracking system for guidance of fetal interventions, demonstrating its accuracy and clinical compatibility.
Article
Oncology
Aurora Rosvoll Groendahl, Yngve Mardal Moe, Christine Kiran Kaushal, Bao Ngoc Huynh, Espen Rusten, Oliver Tomic, Eivor Hernes, Bettina Hanekamp, Christine Undseth, Marianne Gronlie Guren, Eirik Malinen, Cecilia Marie Futsaether
Summary: This study evaluated the applicability of deep learning for automatic delineation of the gross tumor volume in ASCC patients, comparing the effects of single and multimodality image combinations. Training a 2D U-Net CNN model resulted in high Dice scores for both datasets of 86 and 36 patients. The highest performance was observed with a multimodal combination of PET and ceCT.
Article
Engineering, Biomedical
Sarah Latus, Johanna Sprenger, Maximilian Neidhardt, Julia Schaedler, Alexandra Ron, Antonia Fitzek, Matthias Schlueter, Philipp Breitfeld, Axel Heinemann, Klaus Pueschel, Alexander Schlaefer
Summary: This study introduces a method to detect ruptures in complex OCT data without the need for additional guidance or measurements, achieving high accuracy on different types of phantoms and ex-situ tissues.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cedric Draulans, Robin De Roover, Uulke A. van der Heide, Linda Kerkmeijer, Robert J. Smeenk, Floris Pos, Wouter V. Vogel, James Nagarajah, Marcel Janssen, Sofie Isebaert, Frederik Maes, Cindy Mai, Raymond Oyen, Steven Joniau, Martina Kunze-Busch, Karolien Goffin, Karin Haustermans
Summary: Threshold-based contouring using SOSTs trained with GTV(majority) achieved accuracy comparable to manual contours in delineating GTV(histo). Median SOSTs were found to be 41 SUV% for 68Ga-PSMA-11 PET and 44 SUV% for 18F-PSMA-1007 PET, forming a basis for tracer-specific window leveling.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jialin Shi, Xiaofeng Ding, Xien Liu, Yan Li, Wei Liang, Ji Wu
Summary: Automating CTV delineation using deep learning can improve efficiency and quality, but challenges arise due to the unique shape and margin characteristics of CTV. The proposed RA-CTVNet algorithm addresses these challenges and shows potential for enhancing CTV contour accuracy.
Article
Chemistry, Multidisciplinary
Melissa Y. Lucero, Amanda K. East, Christopher J. Reinhardt, Adam C. Sedgwick, Shengzhang Su, Michael C. Lee, Jefferson Chan
Summary: Photoacoustic imaging using near infrared I light has limitations due to interference from endogenous biomolecules, prompting the development of NIR-II imaging agents for improved sensitivity. The study introduced APNO-1080 as a NIR-II nitric oxide-responsive probe, demonstrating enhanced sensitivity and deep-tissue imaging capabilities in vitro and in vivo models of cancer.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Physics, Multidisciplinary
Li Wang, Yong Jie Wang, Sanming Song, Fang Li
Summary: Fiber optic sensors, with their advantages such as small size, easy networking, and immunity to electromagnetic interference, are expected to be an important measurement tool in ocean observation. Various fiber optic sensors based on different measurement principles have been developed and extensively researched, showing promising prospects for their application in physical ocean observation.
FRONTIERS IN PHYSICS
(2021)
Article
Oncology
Liang Zhao, Shanyu Chen, Sijia Chen, Yizhen Pang, Yaqing Dai, Shenping Hu, Li'e Lin, Lirong Fu, Long Sun, Hua Wu, Haojun Chen, Qin Lin
Summary: This study compared Ga-68-FAPI and F-18-FDG PET/CT in imaging locally advanced esophageal cancer and evaluated the potential usefulness of Ga-68-FAPI PET/CT in radiotherapy planning. Ga-68-FAPI PET showed significantly higher radiotracer uptake in primary tumors compared to F-18-FDG PET, suggesting its advantage in target volume delineation.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Anuj K. Yadav, Michael C. Lee, Melissa Y. Lucero, Shengzhang Su, Christopher J. Reinhardt, Jefferson Chan
Summary: NO's role in tumors is context-dependent, and the development of BL660-NO as an ABS probe for NIR bioluminescence imaging has provided valuable insights into the impact of diet on tumor progression.
ACS CENTRAL SCIENCE
(2022)
Article
Computer Science, Artificial Intelligence
Marzieh Ghahramani, Nabiollah Shiri
Summary: This study proposes a method based on neural networks and algorithms to classify and diagnose brain tumors quickly and accurately using MRI images. The method goes through preprocessing, feature extraction, and classification steps, extracting features using grey-level co-occurrence matrix and statistical analysis, and reducing errors through optimized algorithms. Experimental results show that the method has high accuracy and fast speed for medical image classification.
IET IMAGE PROCESSING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Isaac Shiri, Hossein Arabi, Amirhossein Sanaat, Elnaz Jenabi, Minerva Becker, Habib Zaidi
Summary: This study evaluated the performance of different deep learning algorithms in HNC PET image segmentation, finding that cross-entropy for Res-Net, Dense-VNet, and Dice plus XEnt for NN-UNet were reliable networks. The networks showed similar performance in terms of Dice similarity and PET image metrics, with good reproducibility in SUVmax quantification error and shape features.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Julius C. Holzschuh, Michael Mix, Juri Ruf, Tobias Hoelscher, Joerg Kotzerke, Alexis Vrachimis, Paul Doolan, Harun Ilhan, Ioana M. Marinescu, Simon K. B. Spohn, Tobias Fechter, Dejan Kuhn, Peter Bronsert, Christian Gratzke, Radu Grosu, Sophia C. Kamran, Pedram Heidari, Thomas S. C. Ng, Arda Koenik, Anca-Ligia Grosu, Constantinos Zamboglou
Summary: A deep learning model was created to accurately delineate the intraprostatic gross tumor volume (GTV) in PSMA-PET, achieving fast segmentation with high diagnostic accuracy comparable to manual experts.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Hang Min, Jason Dowling, Michael G. Jameson, Kirrily Cloak, Joselle Faustino, Mark Sidhom, Jarad Martin, Michael Cardoso, Martin A. Ebert, Annette Haworth, Phillip Chlap, Jeremiah de Leon, Megan Berry, David Pryor, Peter Greer, Shalini K. Vinod, Lois Holloway
Summary: This study proposes a clinical target volume (CTV) delineation quality assurance (QA) framework based on deep learning (DL) for MRI-guided prostate radiotherapy. The method utilizes a 3D dropblock ResUnet++ to generate multiple segmentation predictions and uses logistic regression classifier to classify manual delineation. The results show that this method generates fewer false positive detections at a faster processing speed.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Seung Kwan Kim, Dong-Joon Lee, Sun Do Lim, Young-Pyo Hong, No-Weon Kang
Summary: The method described enables precise alignment of the slow axis of PMF with the extraordinary axis of LiTaO3, optimizing the electro-optic effect associated with LiTaO3 and polarization for greater stability of the fabricated PMF sensing probe. This results in about 3 times enhancement in long term stability compared to a conventional single mode fiber probe, with an overall angular uncertainty of 1 degree when the fiber optic components have polarization angle tolerance of 1 degree.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Patrick K. Capon, Jiawen Li, Aimee J. Horsfall, Suliman Yagoub, Erik P. Schartner, Asma Khalid, Rodney W. Kirk, Malcolm S. Purdey, Kylie R. Dunning, Robert A. McLaughlin, Andrew D. Abell
Summary: A new fiber functionalization architecture enables simultaneous imaging and sensing, providing significant insights into complex biological systems.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Cardiac & Cardiovascular Systems
Jiawen Li, Nicholas J. Montarello, Ayla Hoogendoorn, Johan W. Verjans, Christina A. Bursill, Karlheinz Peter, Stephen J. Nicholls, Robert A. McLaughlin, Peter J. Psaltis
Summary: This review examines emerging hybrid intracoronary imaging techniques and discusses their strengths, limitations, and potential for clinical translation, aiming to advance clinical approaches for predicting atherothrombotic events and improving the treatment of coronary atherosclerosis.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Engineering, Biomedical
Julia Walther, Jonas Golde, Marius Albrecht, Bryden C. Quirk, Loretta Scolaro, Rodney W. Kirk, Yuliia Gruda, Christian Schnabel, Florian Tetschke, Korinna Joehrens, Dominik Haim, Michaela Buckova, Jiawen Li, Robert A. McLaughlin
Summary: This study presents a highly miniaturized, handheld probe developed for rapid assessment of soft tissue using optical coherencetomography (OCT). The probe combines an all-fiber optical design with a light-weight magnetic scanning mechanism to provide easy access to the oral cavity. The results demonstrate the feasibility of using a small, lightweight probe to identify pathological features in oral soft tissue.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Instruments & Instrumentation
Rachel Lloyd, Jane Walter, Sarah Pirikahu, Gemma Cadby, Martha Hickey, David D. Sampson, Karol Karnowski, Michael J. Hackmann, Christobel Saunders, Lothar Lilge, Jennifer Stone
Summary: Mammographic breast density is a significant risk factor for breast cancer, and optical breast spectroscopy (OBS) is a promising method for measuring breast density. This study validates the participant data of OBS and confirms its effectiveness in epidemiological research.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2022)
Article
Chemistry, Multidisciplinary
Jiawen Li, Simon Thiele, Rodney W. Kirk, Bryden C. Quirk, Ayla Hoogendoorn, Yung Chih Chen, Karlheinz Peter, Stephen J. Nicholls, Johan W. Verjans, Peter J. Psaltis, Christina Bursill, Alois M. Herkommer, Harald Giessen, Robert A. McLaughlin
Summary: Multimodal microendoscopes enable simultaneous structural and molecular measurements in vivo, providing valuable insights into pathological changes associated with diseases. However, different optical imaging modalities have conflicting requirements for lens design, posing a challenge for the fabrication of miniaturized imaging probes. This study demonstrates an optical design using two-photon 3D printing to create a miniaturized lens that is optimized for both fluorescence and optical coherence tomography (OCT) imaging. The lens-in-lens design shows significant improvement in fluorescence sensitivity compared to conventional fiber-optic design approaches, and is successfully integrated into an intravascular catheter probe for simultaneous OCT and fluorescence imaging of a mouse artery in vivo.
Review
Optics
Danuta M. Sampson, Adam M. Dubis, Fred K. Chen, Robert J. Zawadzki, David D. Sampson
Summary: The visualization and assessment of retinal microvasculature are crucial in the study and treatment of eye and systemic diseases. However, the current methods and analysis of OCTA imaging lack consistency, hindering progress. This paper proposes steps to standardize OCTA imaging, including imaging protocols, data analysis methods, metrics, reporting, and clinical practice, to address these limitations.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Biochemical Research Methods
Loretta Scolaro, Dirk Lorenser, Bryden C. Quirk, Rodney W. Kirk, Louisa A. Ho, Elizabeth Thomas, Jiawen Li, Christobel M. Saunders, David D. Sampson, Rebecca O. Fuller, Robert A. McLaughlin
Summary: This article introduces a multimodal imaging needle that can differentiate cell types through simultaneous optical coherence tomography (OCT) and fluorescence imaging. By conducting experiments on ER+ and ER- breast cancer cells, it is demonstrated that this miniaturized imaging probe can successfully image live cells and differentiate cancer cells.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Neurosciences
David F. G. Sciarrone, Robert A. McLaughlin, Raden Argarini, Minh-Son To, Louise H. Naylor, Lucy M. Bolam, Howard H. Carter, Daniel J. Green
Summary: Microvascular dysfunction is observed in heart failure (HF) patients, but they are still able to dilate cutaneous microvessels in response to local heat stress, suggesting that microvascular functional regulation is the primary abnormality in HF.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Engineering, Electrical & Electronic
Karol Karnowski, Gavrielle Untracht, Michael Hackmann, Onur Cetinkaya, David Sampson
Summary: This study explores the use of a side-viewing probe combining graded-index fiber and a ball lens, which demonstrates superior performance in optical imaging. Through detailed analysis and modeling, it is shown that this probe design offers excellent performance across various numerical apertures and opens up new possibilities for broader imaging applications.
IEEE PHOTONICS JOURNAL
(2022)
Article
Multidisciplinary Sciences
Gavrielle R. Untracht, Nikolaos Dikaios, Abdullah K. Durrani, Mariam Bapir, Marinko V. Sarunic, David D. Sampson, Christian Heiss, Danuta M. Sampson
Summary: This pilot study evaluates OCTA-derived microvascular parameters in healthy individuals and patients with diabetes. It establishes reference values for different regions of the body and identifies potential biomarkers for diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Mariam Bapir, Gavrielle R. R. Untracht, Julie E. A. Hunt, John H. H. McVey, Jenny Harris, Simon S. S. Skene, Paola Campagnolo, Nikolaos Dikaios, Ana Rodriguez-Mateos, David D. D. Sampson, Danuta M. M. Sampson, Christian Heiss
Summary: Endothelial function in the femoral artery and brachial artery is similarly affected by age in healthy adults, leading to an increased susceptibility to peripheral artery disease in old age.
Article
Oncology
Rachel Lloyd, Sarah Pirikahu, Jane Walter, Gemma Cadby, Ellie Darcey, Dilukshi Perera, Martha Hickey, Christobel Saunders, Karol Karnowski, David D. Sampson, John Shepherd, Lothar Lilge, Jennifer Stone
Summary: This study examines the acceptability and performance of two alternative breast density measures, Optical Breast Spectroscopy (OBS) and Dual X-ray Absorptiometry (DXA), in women aged 18-40. The results showed that over 93% of participants deemed OBS and DXA to be acceptable. The correlation between OBS-%water + collagen and %FGV was 0.48, and age and BMI were associated with breast density measures.
BRITISH JOURNAL OF CANCER
(2023)
Review
Multidisciplinary Sciences
Brett E. Bouma, Johannes F. de Boer, David Huang, Ik-Kyung Jang, Taishi Yonetsu, Cadman L. Leggett, Rainer Leitgeb, David D. Sampson, Melissa Suter, Ben J. Vakoc, Martin Villiger, Maciej Wojtkowski
Summary: This article introduces the principles, applications, and future prospects of optical coherence tomography (OCT). By explaining the principles and origins of signals for different instrument configurations, as well as image processing and interpretation methods, the article comprehensively analyzes the application of OCT in biological and medical imaging.
NATURE REVIEWS METHODS PRIMERS
(2022)
Article
Biochemistry & Molecular Biology
Mariam Bapir, Gavrielle R. Untracht, Debbie Cooke, John H. McVey, Simon S. Skene, Paola Campagnolo, Martin B. Whyte, Nikolaos Dikaios, Ana Rodriguez-Mateos, David D. Sampson, Danuta M. Sampson, Christian Heiss
Summary: This study found that individuals with type 2 diabetes mellitus (T2DM) exhibit greater impairment in femoral artery endothelial function and dermal microcirculation. The consumption of cocoa flavanol (CF) improves endothelial function in both healthy individuals and those with T2DM, who are at increased risk of developing lower extremity peripheral artery disease (PAD) and foot ulcers.