Article
Environmental Sciences
Xiuxia Song, Ziliang Wang, Zhaofeng Zhang, Maohua Miao, Junwei Liu, Min Luan, Jing Du, Hong Liang, Wei Yuan
Summary: The study found that prenatal exposure to BPA may alter DNA methylation levels in the placenta, providing further insight into the potential impact of BPA on fetal health.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Yingya Zhao, Pengpeng Wang, Yuhan Zhou, Bin Xia, Qingyang Zhu, Wenzhen Ge, Jialin Li, Huijing Shi, Xirong Xiao, Yunhui Zhang
Summary: This study examined the impact of prenatal PM2.5 exposure on fetal growth and placental epigenetic mechanisms in Chinese women. Results showed that increased PM2.5 exposure was associated with reduced fetal growth characteristics and aberrant changes in placental DNA methylation.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Oncology
Wan-Ru Wang, Nai-Tzu Chen, Nai-Yun Hsu, I-Ying Kuo, Hsin-Wen Chang, Jiu-Yao Wang, Huey-Jen Su
Summary: Study found a negative correlation between benzyl butyl phthalate (BBzP) in settled dust and TSLP methylation levels, which was positively associated with children's respiratory symptoms. Every unit increase in BBzP concentration led to a 1.75% decrease in TSLP methylation levels, and every percentage increase in methylation levels was associated with a 20% decrease in the risk of morning respiratory symptoms in children.
CLINICAL EPIGENETICS
(2021)
Article
Environmental Sciences
Hexing Wang, Wenyun Li, Jiaqi Yang, Yuanping Wang, Hongyi Du, Minghui Han, Linji Xu, Shuping Liu, Jianping Yi, Yue Chen, Qingwu Jiang, Gengsheng He
Summary: This study investigated the effects of gestational exposure to PFASs on fetal growth by examining DNA methylation in placenta tissue of pregnant women. The results showed that PFOS was negatively associated with LINE-1 methylation, and the mixture of PFASs was negatively associated with LINE-1 methylation and NR3C1 methylation. PFOA, PFNA, PFDA, and the PFASs mixture were negatively associated with head circumference. Stratified analysis by newborns' sex found that PFOA, PFNA, and the PFASs mixture were negatively associated with LINE-1 methylation in males, and LINE-1 methylation was negatively associated with ponderal index in females. Interactions between newborns' sex and PFOS/PFOA on IGF2 and LINE-1 methylation were statistically significant. These findings suggest that intrauterine exposure to PFASs affects placental DNA methylation and reduces fetal growth, which may be modified by sex.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Obstetrics & Gynecology
Tania L. Gonzalez, Amelia M. Schaub, Bora Lee, Jinrui Cui, Kent D. Taylor, Anna E. Dorfman, Mark O. Goodarzi, Erica T. Wang, Yii-Der Ida Chen, Jerome I. Rotter, Rimsha Hussaini, Paige M. Harakuni, Mayaal H. Khan, Stephen S. Rich, Charles R. Farber, John Williams III, Margareta D. Pisarska
Summary: This study aimed to determine whether DNA methylation alterations exist in the first-trimester human placenta between conceptions using fertility treatments and those that do not. It also assessed whether significant alterations led to changes in gene expression.
FERTILITY AND STERILITY
(2023)
Article
Environmental Sciences
Oladele A. Oluwayiose, Chelsea Marcho, Haotian Wu, Emily Houle, Stephen A. Krawetz, Alexander Suvorov, Jesse Mager, J. Richard Pilsner
Summary: Preconception exposure to DEHP in male mice resulted in differential DNA methylation in sperm, embryonic, and extra-embryonic tissues, with overlapping changes observed between F0 and F1 generations. The altered transcriptomes at E7.5 in F1 embryos included developmental gene families such as Hox, Gata, and Sox, suggesting DEHP exposure affects gene expression in developing embryos. Gene ontology analyses showed enrichment of developmental processes, highlighting the impact of DEHP exposure on sperm methylome and embryonic development.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Ekaterina N. Tolmacheva, Stanislav A. Vasilyev, Tatiana Nikitina, Ekaterina S. Lytkina, Elena A. Sazhenova, Daria Zhigalina, Oksana Yu Vasilyeva, Anton Markov, Victoria V. Demeneva, Liubov A. Tashireva, Anna A. Kashevarova, Igor N. Lebedev
Summary: The presence of an extra chromosome in the embryo can significantly affect pregnancy outcome. This study found changes in DNA methylation in miscarriages with trisomy 16, specifically hypermethylation of certain genes. These hypermethylated genes may be associated with the development of trisomy 16 miscarriages.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Carla Canicais, Sara Vasconcelos, Carla Ramalho, C. Joana Marques, Sofia Doria
Summary: Our study found increased expression of imprinted genes and epigenetic regulators in IUGR placentas, but no differences in methylation levels at the KvDMR1 or global DNA methylation and hydroxymethylation levels. This suggests that epigenetic mechanisms may play a role in IUGR etiology, providing valuable insights for potential prediction and therapeutic strategies.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Environmental Sciences
Karin Engstroem, Yumjirmaa Mandakh, Lana Garmire, Zahra Masoumi, Christina Isaxon, Ebba Malmqvist, Lena Erlandsson, Stefan R. Hansson
Summary: Exposure to ambient nitrogen oxides during early pregnancy influences DNA methylation in placentas of preeclampsia cases, leading to placental immaturity and showing sexual dimorphism. No differentially expressed genes were found in this study.
Review
Biochemistry & Molecular Biology
Jorge Valencia-Ortega, Renata Saucedo, Martha A. Sanchez-Rodriguez, Jose G. Cruz-Duran, Edgar G. Ramos Martinez
Summary: Gestational diabetes mellitus is the most common metabolic complication in pregnancy, involving various factors in its pathophysiology. Studies have observed that alterations in DNA methylation patterns and certain microRNA levels are related to the disease characteristics, highlighting the need for further research in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dayuan Shi, Xinyao Zhou, Luyao Cai, Xing Wei, Luye Zhang, Qianqian Sun, Fenhe Zhou, Luming Sun
Summary: Changes in placental DNA methylation patterns in sFGR may have functional implications for differentially methylated genes and regulatory regions. The study validates the presence of abnormally methylated CYP11A1 gene in the placenta of sFGR.
Article
Environmental Sciences
Paulina Jedynak, Lucile Broseus, Jorg Tost, Florence Busato, Stephan Gabet, Cathrine Thomsen, Amrit K. Sakhi, Isabelle Pin, Remy Slama, Johanna Lepeule, Claire Philippat
Summary: A previous study found positive associations between maternal urinary concentrations of triclosan and placental DNA methylation in male fetuses. This study aimed to validate and expand on these findings by examining triclosan exposure and placental DNA methylation in a cohort of male and female fetuses. The results confirmed associations between triclosan and certain genes in both sexes, with the majority of associations being positive and mapping to imprinted genes. The study also identified mediation effects of placental tissue heterogeneity on the associations. In conclusion, triclosan exposure is associated with placental DNA methylation, particularly in imprinted genes.
ENVIRONMENTAL POLLUTION
(2023)
Article
Reproductive Biology
Genoa R. Warner, Raquel S. Dettogni, Indrani C. Bagchi, Jodi A. Flaws, Jones B. Graceli
Summary: This study reviews the associations between phthalate exposures and dysfunctions of placental development and function, highlighting important gaps in the literature. Overall, the evidence suggests that toxicity to the placenta and maternal-fetal interface is linked to exposure to phthalates. Further research is needed to understand the mechanisms of phthalates in the placenta and to conduct additional human studies with larger sample sizes to assess placental disruption during pregnancy.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Environmental Sciences
Paulina Jedynak, Jorg Tost, Antonia M. Calafat, Ekaterina Bourova-Flin, Lucile Broseus, Florence Busato, Anne Forhan, Barbara Heude, Milan Jakobi, Joel Schwartz, Remy Slama, Daniel Vaiman, Johanna Lepeule, Claire Philippat
Summary: This study is the first to describe genome-wide modifications of placental DNA methylation in association with pregnancy exposure to phthalates. The results suggest that exposure to phthalates could affect fetal development through epigenetic mechanisms. Several differentially methylated regions associated with phthalate exposure were identified.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Obstetrics & Gynecology
Misao Nakanishi, Nobuaki Funahashi, Hideoki Fukuoka, Takao Nammo, Yuichi Sato, Hajime Yoshihara, Hajime Oishi, Mamoru Tanaka, Tetsu Yano, Shigeki Minoura, Norihiro Kato, Kazuki Yasuda
Summary: The study found a correlation between maternal and cord blood choline levels with birthweight and BMI at birth. Placental DNA methylation at the retinoid X receptor alpha (RXRA) gene was negatively associated with maternal plasma choline levels and positively associated with birthweight and BMI at birth. Additionally, RXRA methylation was inversely correlated with RXRA gene expression level.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
