Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Food Science & Technology
Paulo Sergio Loubet Filho, Thais Otranto Dias, Vitoria Helena de Oliveira Teixeira Reis, Amanda Maria Tomazini Munhoz Moya, Elisvania Freitas dos Santos, Cinthia Bail Betim Cazarin
Summary: The incidence of inflammatory bowel diseases (IBD) has increased and its etiology remains unknown. Risk factors, including food intake, are associated with developing IBD. Functional foods (FF) can modulate the gut microbiota and improve the health quality of IBD patients.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Microbiology
Limin Xu, Bingdong Liu, Liujing Huang, Ze Li, Yanbo Cheng, Ye Tian, Guihua Pan, Huijun Li, Yinlan Xu, Weidong Wu, Zongbin Cui, Liwei Xie
Summary: Inflammatory bowel disease (IBD) is a global public health problem. Probiotic consortia and metabolites have been found to ameliorate the symptoms of gut inflammation and regulate microbial dysbiosis. The effect of probiotic consortia is better than that of any single probiotic strain.
MICROBIOLOGY SPECTRUM
(2022)
Article
Gastroenterology & Hepatology
Giorgos Bamias, Theresa T. Pizarro, Fabio Cominelli
Summary: This review describes the cellular and molecular immunological mechanisms of intestinal fibrosis in IBD, with a particular focus on animal models of intestinal fibrosis. Based on this research, potential future targets for antifibrotic therapies for IBD patients can be identified.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Virology
Sirine Andari, Hadi Hussein, Sukayna Fadlallah, Abdo R. Jurjus, Margret Shirinian, Jana G. Hashash, Elias A. Rahal
Summary: The study found that EBV DNA exacerbates inflammatory responses in colitis, leading to increased colonic disease activity and histologic damage. Colitis mice given EBV DNA showed enhanced expression of IL-17A, IFN gamma, and TNF alpha, with a significant decrease in the expression of the CTLA4 immunoregulatory marker.
Article
Microbiology
Lola Holcomb, Johanna M. Holman, Molly Hurd, Brigitte Lavoie, Louisa Colucci, Benjamin Hunt, Timothy Hunt, Marissa Kinney, Jahnavi Pathak, Gary M. Mawe, Peter L. Moses, Emma Perry, Allesandra Stratigakis, Tao Zhang, Grace Chen, Suzanne L. Ishaq, Yanyan Li, Hiutung Chu
Summary: Crohn's disease is an inflammatory bowel disease that can be improved through diet and gut microbial interventions. However, there are still questions regarding the impact of IBD on gut microbial location and function, the effect of diet interventions on early life gut communities, and the role of biogeography in disease mediation.
Review
Nutrition & Dietetics
Natasha Haskey, Stephanie L. Gold, Jeremiah J. Faith, Maitreyi Raman
Summary: Evidence-based dietary guidance on fiber in inflammatory bowel disease (IBD) has been limited, but recent evidence suggests that dietary fiber can improve IBD symptoms and enhance health-related quality of life. However, there is limited knowledge about the optimal types and amounts of fiber for IBD patients. Individual microbiomes also play a role, necessitating a personalized nutritional approach. This review discusses dietary fiber mechanisms, novel fiber sources, and future directions in fiber research.
Article
Gastroenterology & Hepatology
Sebastian Bruno Ulrich Jordi, Brian Matthew Lang, Bianca Auschra, Roland von Kanel, Luc Biedermann, Thomas Greuter, Philipp Schreiner, Gerhard Rogler, Niklas Krupka, Michael Christian Sulz, Benjamin Misselwitz, Stefan Begre
Summary: Patients with inflammatory bowel disease (IBD) have a higher risk of depression, which has been shown to impact disease progression. This study found that depression is a strong predictor of clinical deterioration in IBD patients, and genetic markers may play a role in this relationship.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Timon E. Adolph, Jingwan Zhang
Summary: The diet and gut microbiota play a crucial role in gut inflammation in IBD. Specific nutrients in a Western diet can trigger or worsen experimental gut inflammation in genetically susceptible individuals. Nutritional trials provide common grounds for dietary advice in pediatric and adult IBD, with exclusive enteral nutrition showing effectiveness in treating pediatric Crohn's disease.
Article
Nutrition & Dietetics
Stephan C. Bischoff, Palle Bager, Johanna Escher, Alastair Forbes, Xavier Hebuterne, Christian Lodberg Hvas, Francisca Joly, Stansilaw Klek, Zeljko Krznaric, Johann Ockenga, Stephane Schneider, Raanan Shamir, Kalina Stardelova, Darija Vranesic Bender, Nicolette Wierdsma, Arved Weimann
Summary: This guideline is an update and expansion of the ESPEN scientific guideline on Clinical Nutrition in Inflammatory Bowel Disease. It has been rearranged according to the ESPEN practical guideline and includes new recommendations on microbiota modulation. The guideline aims to provide guidance for healthcare professionals treating patients with IBD, covering various aspects of care during active disease and remission, with evidence grades, consensus rates, commentaries, and citations provided.
CLINICAL NUTRITION
(2023)
Article
Food Science & Technology
Chunxu Chen, Tianhui Li, Guijie Chen, Dan Chen, Yujia Peng, Bing Hu, Yi Sun, Xiaoxiong Zeng
Summary: Sialylated IgG is a glycoprotein in breast milk with anti-inflammatory properties. Previous research has shown that sialylated IgG can promote the growth of Bifidobacterium in the gut microbiota of healthy individuals. This study investigated the prebiotic effect of sialylated IgG on the gut microbiota of patients with inflammatory bowel disease (IBD) through in vitro fermentation.
Article
Gastroenterology & Hepatology
Genelle R. Lunken, Kevin Tsai, Alana Schick, Daniel J. Lisko, Laura Cook, Bruce A. Vallance, Kevan Jacobson
Summary: The EEN IN group demonstrated reduced colitis development compared to the chow and EEN groups, highlighting the potential benefits of EEN IN as a novel induction therapy for pediatric CD and UC patients.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Pauline Wils, Benedicte Caron, Ferdinando D'Amico, Silvio Danese, Laurent Peyrin-Biroulet
Summary: This review provides a comprehensive overview of the multifactorial etiology implicated in the chronic abdominal pain of IBD patients and highlights the necessity of pharmacological and non-pharmacological approaches for treatment. Integrating psychological support in care models of IBD can reduce disease burden and healthcare costs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Shihao Duan, Yi Yang, Yubin Cao, Pingrun Chen, Chang Liang, Yan Zhang
Summary: This study aimed to investigate the impact of anxiety and depression on the efficacy of medications and IBD-related poor outcomes in patients with inflammatory bowel disease (IBD). The results showed that anxiety and depression symptoms were significantly associated with steroid resistance and IBD-related poor outcomes. Further studies are needed to explore whether interventions for anxiety and depression can improve medication response and prognosis in IBD patients.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Sanghyun Kim, Junhyoung Byun, Semyung Jung, Byoungjae Kim, Kangwon Lee, Hanjo Jeon, Jaemin Lee, Hyuksoon Choi, Eunsun Kim, Yoontae Jeen, Hongsik Lee, Hoonjai Chun, Bora Keum, Taehoon Kim
Summary: The study found that SIRT7 plays an important role in the inflammatory response in the colon of mice, and SIRT7 inhibitors can reduce colonic inflammation, potentially playing a role in the pathogenesis of immune-mediated intestinal inflammation.