Article
Cell Biology
Shun-Ichi Yamashita, Masanao Kyuuma, Keiichi Inoue, Yuki Hata, Ryu Kawada, Masaki Yamabi, Yasuyuki Fujii, Junko Sakagami, Tomoyuki Fukuda, Kentaro Furukawa, Satoshi Tsukamoto, Tomotake Kanki
Summary: The study found that muscle disuse enhances mitophagy activity and the production of reactive oxygen species in atrophic skeletal muscles, suggesting a potential therapeutic target for disuse-induced muscle atrophy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiaobin Wen, Lixin Tang, Ruqing Zhong, Lei Liu, Liang Chen, Hongfu Zhang
Summary: The mitochondrion plays a major role in maintaining redox homeostasis and is both a source and target of reactive oxygen species (ROS). Oxidative stress, resulting from an imbalance between ROS and the antioxidative system, is linked to inflammatory bowel disease and gastrointestinal mucosal diseases. Mitophagy, the selective autophagic degradation of damaged mitochondria, can significantly alleviate oxidative damage. This review aims to explore the molecular mechanisms of mitophagy and oxidative stress regulation and their relationship in intestinal diseases, providing new insights for antioxidant research and preventing oxidative damage-related diseases.
Article
Biochemistry & Molecular Biology
Hayden W. Hyatt, Mustafa Ozdemir, Toshinori Yoshihara, Branden L. Nguyen, Rafael Deminice, Scott K. Powers
Summary: Mechanical ventilation is a life-saving intervention for critically ill patients, but it can lead to ventilator-induced diaphragm dysfunction (VIDD) due to oxidative stress activating major proteolytic systems. Calpain activation plays an essential role in VIDD development, leading to oxidative stress, muscle atrophy, and contractile dysfunction.
Review
Biochemistry & Molecular Biology
Alessandro Luciani, Matthew C. S. Denley, Larissa P. Govers, Vincenzo Sorrentino, D. Sean Froese
Summary: Mitochondria, as the powerhouse of the cell, play a crucial role in sustaining energy metabolism and homeostasis, especially in terminally differentiated cells. Dysregulation of the mitochondrial network can lead to a wide range of hereditary and acquired diseases, highlighting the importance of understanding and potentially reversing the pathophysiology of these disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Environmental Sciences
Yilong Cui, Bo Li, Jiayu Du, Siming Huo, Miao Song, Bing Shao, Ben Wang, Yanfei Li
Summary: Dibutyl phthalate (DBP), a commonly used plasticizer, causes severe damage to the brain, liver, kidney, and lung by producing excessive reactive oxygen species (ROS) upon entering the body. This study found that DBP damages osteoblast cells and activates mitophagy through the increase of ROS. Silencing the Parkin gene and N-acetylcysteine (NAC) intervention can alleviate the damage caused by DBP.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Pharmacology & Pharmacy
Junqi Huang, Rundong Wu, Linyi Chen, Ziqiang Yang, Daoguang Yan, Mingchuan Li
Summary: This review summarizes the recent findings on the mitochondrial mechanisms during anthracycline cardiotoxicity, including the production of ROS and mitochondrial damage, mitochondrial iron overload and ferroptosis, autophagy, mitophagy, and disruption of cardiac metabolism.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Hyunjung Lee, Tae Youl Ha, Chang Hwa Jung, Farida Sukma Nirmala, So-Young Park, Yang Hoon Huh, Jiyun Ahn
Summary: The study revealed that acute insulin resistance coincides with mitochondrial dysfunction in skeletal muscle, leading to impaired mitochondrial function and the development of acute insulin resistance. Improving mitochondrial function has significant potential in treating acute insulin resistance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Nutrition & Dietetics
Luchuanyang Sun, Nobuyuki Miyaji, Min Yang, Edward M. Mills, Shigeto Taniyama, Takayuki Uchida, Takeshi Nikawa, Jifeng Li, Jie Shi, Katsuyasu Tachibana, Katsuya Hirasaka
Summary: The study demonstrated that astaxanthin (AX) has protective effects on muscle atrophy by preventing loss of muscle weight and suppressing muscle fiber size decrease, hydrogen peroxide production increase, and downregulation of mitochondrial respiratory chain complexes. AX also promoted mitochondrial biogenesis and inhibited mitochondrial reactive oxygen species production and apoptosis, ultimately preventing muscle atrophy.
Review
Biochemistry & Molecular Biology
Jonathan M. Memme, Mikhaela Slavin, Neushaw Moradi, David A. Hood
Summary: Periods of muscle disuse can lead to mitochondrial changes that affect muscle health and atrophy. Research has shown that abnormalities in mitochondrial quality control pathways can cause muscle atrophy due to inactivity, highlighting the need for further investigation into how mitochondria contribute to disuse-induced muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Di Lian, Ming-Ming Chen, Hanyu Wu, Shoulong Deng, Xiaoxiang Hu
Summary: This review summarizes the sources, causes, and key role of oxidative stress in skeletal muscle, as well as its relationship with muscle homeostasis and physiopathology. It provides targets for antioxidant therapy and repair of inflammatory damage in noninflammatory muscle diseases.
Article
Orthopedics
Feng Wang, Ting Zhou, Chen Xu Zhou, Quan Bing Zhang, Hua Wang, Yun Zhou
Summary: This study investigated the effects of remobilization on skeletal muscle and the role of BNIP3-dependent mitophagy. Within the first three days of remobilization, rats exhibited decreased muscle weight-to-body weight ratio, cross-sectional area, and ATP concentration, along with increased ROS production and HIF-1a protein levels in skeletal muscle. Results also indicated sustained activation of BNIP3-dependent mitophagy during remobilization, which may contribute to skeletal muscle atrophy.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Cell Biology
Yu Ruan, Jiaqiao Hu, Yaping Che, Yanyan Liu, Zhenhuan Luo, Jin Cheng, Qi Han, He He, Qinghua Zhou
Summary: Mitochondrial dysfunction is a major factor in the development of neurological disorders. Mutations in CHCHD2 and CHCHD10, which encode proteins in the mitochondrial CHCH domain family, are associated with Parkinson's disease and amyotrophic lateral sclerosis/frontotemporal dementia. CHCHD2 and CHCHD10 interact with OMA1 to inhibit its activity, suppressing mitochondrial stress response and fusion. During mitochondria stress, CHCHD2 and CHCHD10 translocate to the cytosol and interact with eIF2a, reducing overactivation of the stress response. Knockdown of CHCHD2 and CHCHD10 leads to mitochondrial stress response, which is amplified by CCCP treatment.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Sarah K. Skinner, Angelo Solania, Dennis W. Wolan, Michael S. Cohen, Terence E. Ryan, Russell T. Hepple
Summary: The study found that mitochondrial permeability transition (MPT) is a novel mechanism of skeletal muscle atrophy, operating through the release of mROS and activation of caspase-3. The experiment demonstrated that inhibiting MPT, mROS, or caspase-3 could prevent muscle atrophy in both chemical-induced and disuse models.
Article
Biochemistry & Molecular Biology
Jiawei Mo, Zhijun Wang, Qingchun Liu, Zhenhui Li, Qinghua Nie
Summary: This study confirmed for the first time that limb immobilization could induce disuse atrophy of skeletal muscle in chickens, and oxidative stress was found to be involved in this process. RNA sequencing analysis revealed that the FOXO signaling pathway, closely related to muscle atrophy, was activated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Nengzhou Chen, Zhenkun Guo, Zhousong Luo, Fuli Zheng, Wenya Shao, Guangxia Yu, Ping Cai, Siying Wu, Huangyuan Li
Summary: Long-term exposure to paraquat may increase the risk of Parkinson's disease, with ROS-mediated mitochondrial fission contributing to excessive mitophagy, which can be significantly ameliorated by mdivi-1.
ENVIRONMENTAL POLLUTION
(2021)
Review
Geriatrics & Gerontology
Anastasia Thoma, Tania Akter-Miah, Rebecca L. Reade, Adam P. Lightfoot
Article
Biochemistry & Molecular Biology
Clare Stretton, Jamie N. Pugh, Brian McDonagh, Anne McArdle, Graeme L. Close, Malcolm J. Jackson
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Anastasia Thoma, Max Lyon, Nasser Al-Shanti, Gareth A. Nye, Robert G. Cooper, Adam P. Lightfoot
Article
Biochemistry & Molecular Biology
Malcolm J. Jackson
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Yingxue Wang, Parul Sharma, Matthew Jefferson, Weijiao Zhang, Ben Bone, Anja Kipar, David Bitto, Janine L. Coombes, Timothy Pearson, Angela Man, Alex Zhekova, Yongping Bao, Ralph A. Tripp, Simon R. Carding, Yohei Yamauchi, Ulrike Mayer, Penny P. Powell, James P. Stewart, Thomas Wileman
Summary: The study demonstrates that non-canonical autophagy in airway epithelial cells is a novel innate defense mechanism that restricts influenza virus infection and reduces lethal inflammation.
Article
Geriatrics & Gerontology
Timothy Pearson, Oskar Wendowski, Penny P. Powell
Summary: This study demonstrated that increasing SNAT2 expression in muscle cells can enhance amino acid transport and availability for protein synthesis, particularly under starvation conditions. Additionally, transfected cells showed a more significant response to 5α-dihydrotestosterone (DHT), indicating potential hormonal regulation of SNAT2 function. The findings suggest that enhancing SNAT2 expression could be a viable target in pathologies related to altered amino acid transport.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Cell Biology
Ioannis Kanakis, Moussira Alameddine, Leighton Folkes, Simon Moxon, Ioanna Myrtziou, Susan E. Ozanne, Mandy J. Peffers, Katarzyna Goljanek-Whysall, Aphrodite Vasilaki
Summary: Maternal diet can impact the development and health of offspring's skeletal muscles, with small non-coding RNAs playing a role in nutrition-associated programming. Maternal low protein diet was found to affect offspring skeletal muscle development, leading to decreased muscle fiber size in weanling offspring groups. The differential expression of multiple miRs, snoRNAs, and snRNAs suggests their involvement in key muscle-specific biological processes.
Editorial Material
Cell Biology
Ayman M. Mahmoud, Fiona L. Wilkinson, Mansur A. Sandhu, Adam P. Lightfoot
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Editorial Material
Cell Biology
Ayman M. Mahmoud, Fiona L. Wilkinson, Adam P. Lightfoot, Julia M. Dos Santos, Mansur A. Sandhu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
C. A. Staunton, E. D. Owen, K. Hemmings, A. Vasilaki, A. McArdle, R. Barrett-Jolley, M. J. Jackson
Summary: This study identified differentially expressed genes in muscle from old mice following nerve injury, suggesting potential differences in muscle response that may contribute to diminished repair ability in aged individuals.
Article
Biochemistry & Molecular Biology
Cai Astley, Chahinez Houacine, Azziza Zaabalawi, Fiona Wilkinson, Adam P. Lightfoot, Yvonne Alexander, Debra Whitehead, Kamalinder K. Singh, May Azzawi
Summary: The study demonstrates that nanostructured lipid carriers (NLCs) loaded with resveratrol (RV) have the potential to restore vascular dilator function and improve potency for antihypertensive treatment strategies. This effective delivery modality shows promising implications for sustained drug release and improved bioavailability of vasoprotective compounds.
Article
Pharmacology & Pharmacy
Azziza Zaabalawi, Lewis Renshall, Frances Beards, Adam P. Lightfoot, Hans Degens, Yvonne Alexander, Ragheb Hasan, Haris Bilal, Brigitte A. Graf, Lynda K. Harris, May Azzawi
Summary: This study investigates the use of liposome-encapsulated TMS to improve vasodilator function in patients undergoing CABG. The results demonstrate that TMS-loaded liposomes can enhance vasodilation by inhibiting CYP1B1 and reducing reactive oxygen species, and suggest the potential of TMS-loaded liposomes as a therapeutic strategy for the treatment of hypertension in CABG patients.
Article
Physiology
Yalda A. Kharaz, Katarzyna Goljanek-Whysall, Gareth Nye, Jane L. Hurst, Anne McArdle, Eithne J. Comerford
Summary: This study investigated the expression of miRs in aging murine cruciate ligaments using wild-stock house mice as a model. The findings suggest that miR-29a and miR-34a may play a role in the regulation of COL1A1 gene expression in murine CLs during aging.
PHYSIOLOGICAL REPORTS
(2022)
Article
Cell Biology
Anastasia Thoma, Kate E. Earl, Katarzyna Goljanek-Whysall, Adam P. Lightfoot
Summary: MHC I overexpression may play an important role in the development of autoimmune diseases such as myositis, possibly through the activation of the ER stress pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Physiology
Jasdeep Saini, Alessandro Faroni, Adam J. Reid, Vincent Mouly, Gillian Butler-Browne, Adam P. Lightfoot, Jamie S. McPhee, Hans Degens, Nasser Al-Shanti
Summary: Research on the neuromuscular junction (NMJ) is essential for understanding neuromuscular patho-physiology and developing new therapies for related diseases. The micro-environment surrounding the NMJ plays a crucial role in NMJ formation and maintenance by promoting the secretion of neurotrophic factors through cross-talk between muscle fibers and motor neurons. In vitro studies have shown the establishment of functional NMJs in co-culture conditions without exogenous neural growth factors, indicating a potential regenerative niche for NMJ formation and maturation.
PHYSIOLOGICAL REPORTS
(2021)