期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/srep29479
关键词
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资金
- National Natural Science Foundation of China [81200975, 31501838]
- Key projects of Provincial Natural Science Foundation of Anhui [KJ2014A112]
- Doctoral Scientific Research Foundation of Anhui Medical University [0805018101]
The role of transforming growth factor-beta (TGF-beta) signaling in cancer progression is still under debate. To determine the function of TGF-beta signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We found the ablation of TGF-beta signaling could inhibit the cancer cell proliferation, cancer stem cell population and EMT, hence suppressed the invasive cancer progression, which is similar with the result of TGF-beta receptor I inhibitor treatment. These findings recognize the roles and mechanisms of TGF-beta signaling in bladder cancer progression in vivo for the first time.
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