N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes

The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design

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Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor

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A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase

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Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease

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A versatile salicyl hydrazonic ligand and its metal complexes as antiviral agents

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Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors

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Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease

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Magnesium-Dependent RNA Binding to the PA Endonuclease Domain of the Avian Influenza Polymerase

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Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry

(2014) Alon Herschhorn et al.   Nature Chemical Biology

Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

(2013) Joseph D. Bauman et al.   ACS Chemical Biology

Carbamoyl Pyridone HIV-1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK1265744)

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Mutational Analysis of the Binding Pockets of the Diketo Acid Inhibitor L-742,001 in the Influenza Virus PA Endonuclease

(2013) A. Stevaert et al.   JOURNAL OF VIROLOGY

The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity

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Emerging Antiviral Strategies to Interfere with Influenza Virus Entry

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Metal-Chelating 2-Hydroxyphenyl Amide Pharmacophore for Inhibition of Influenza Virus Endonuclease

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Computation-Guided Discovery of Influenza Endonuclease Inhibitors

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Discovery of novel inhibitors of LEDGF/p75-IN protein–protein interactions

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Viral enzymes containing magnesium: Metal binding as a successful strategy in drug design

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Synthesis, Characterization, X-ray Crystallography, Acetyl Cholinesterase Inhibition and Antioxidant Activities of Some Novel Ketone Derivatives of Gallic Hydrazide-Derived Schiff Bases

(2012) Nura Suleiman Gwaram et al.   MOLECULES

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

(2012) Rebecca M. DuBois et al.   PLoS Pathogens

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

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Overview of theCCP4 suite and current developments

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Anti-Influenza Activity of Marchantins, Macrocyclic Bisbibenzyls Contained in Liverworts

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Interaction of HIV-1 Reverse Transcriptase Ribonuclease H with an Acylhydrazone Inhibitor

(2010) Qingguo Gong et al.   Chemical Biology & Drug Design

Influenza A Virus Polymerase: Structural Insights into Replication and Host Adaptation Mechanisms

(2010) Stéphane Boivin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MultiDrug-Resistant 2009 Pandemic Influenza A(H1N1) Viruses Maintain Fitness and Transmissibility in Ferrets

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Novel Inhibitors of Influenza Virus Fusion: Structure-Activity Relationship and Interaction with the Viral Hemagglutinin

(2010) E. Vanderlinden et al.   JOURNAL OF VIROLOGY

Mutational and Metal Binding Analysis of the Endonuclease Domain of the Influenza Virus Polymerase PA Subunit

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Nucleoside Monophosphate Complex Structures of the Endonuclease Domain from the Influenza Virus Polymerase PA Subunit Reveal the Substrate Binding Site inside the Catalytic Center

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Metalloproteomics, metalloproteomes, and the annotation of metalloproteins

(2009) Wolfgang Maret   Metallomics

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

(2009) Puwei Yuan et al.   NATURE

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

(2009) Alexandre Dias et al.   NATURE

Global Transmission of Oseltamivir-Resistant Influenza

(2009) Anne Moscona   NEW ENGLAND JOURNAL OF MEDICINE

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

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Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

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