Article
Biochemistry & Molecular Biology
Yu Zhang, Hsun-Ming Chang, Hua Zhu, Peter C. K. Leung
Summary: BMP2 suppresses PTX3 production through a canonical ALK2/3-mediated SMAD1/5-SMAD4-dependent signaling pathway, potentially regulating the process of endometrial decidualization in humans.
Article
Medicine, General & Internal
Yi-Hung Sun, Ying-Hsiang Chou, Chun-Hao Wang, Yi-Hsuan Hsiao, Chung-Yuan Lee, Shun-Fa Yang, Po-Hui Wang
Summary: PTX3 genetic variants are not associated with the pathogenesis, clinicopathological variables, and patient survival of uterine cervical cancer in Taiwanese women. The only independent predictor for 5 years survival is pelvic lymph node metastasis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Genetics & Heredity
Canan Eroglu Gunes, Ebru Guclu, Hasibe Vural, Ercan Kurar
Summary: The study showed that the silence of lncRNA-ZEB2NAT in breast cancer cells has significant effects on EMT, metastasis and apoptosis processes, which can inhibit cell metastasis and promote cell apoptosis.
Article
Biochemistry & Molecular Biology
Jiadi Lv, Yaoping Liu, Feiran Cheng, Jiping Li, Yabo Zhou, Tianzhen Zhang, Nannan Zhou, Cong Li, Zhenfeng Wang, Longfei Ma, Mengyu Liu, Qiang Zhu, Xiaohan Liu, Ke Tang, Jingwei Ma, Huafeng Zhang, Jing Xie, Yi Fang, Haizeng Zhang, Ning Wang, Yuying Liu, Bo Huang
Summary: Microfluidic devices can sort cancer stem cells into mechanically stiff and soft subpopulations, with soft tumor cells showing higher tumorigenicity. The upregulation of Wnt signaling protein BCL9L in soft tumor cells is associated with their stemness and tumorigenicity. These findings suggest that intrinsic softness can serve as a unique marker for highly tumorigenic and metastatic tumor cells.
Article
Medicine, General & Internal
Yuanyuan Zhang, Ning Li, Guangwen Yuan, Hongwen Yao, Die Zhang, Nan Li, Gongyi Zhang, Yangchun Sun, Wenpeng Wang, Jia Zeng, Ningzhi Xu, Mei Liu, Lingying Wu
Summary: This study found that NOD1 was highly expressed in metastatic cervical squamous cell carcinoma and was associated with poor overall survival. Overexpression of NOD1 or NOD2 promoted proliferation, invasion, and migration of cancer cells. Mechanistically, NOD1 and NOD2 exerted their oncogenic effects by activating NF-kappa b and ERK signaling pathways and enhancing IL-8 secretion. Targeting the IL-8 receptor may have therapeutic potential for patients with NOD1(high) tumors.
Article
Biotechnology & Applied Microbiology
Sisi Zhang, Yingping Xu, Qingyu Zheng
Summary: This study found that circRNA_0000285 is overexpressed in cervical cancer and miR-654-3p is downregulated. Knockdown of circRNA_0000285 suppressed cell viability and promoted apoptosis in cervical cancer cells, suggesting that circRNA_0000285 may play an important role in cervical cancer development.
Article
Biochemistry & Molecular Biology
Wenyan Yu, Wei Liu, Yuxin Feng, Chunrong Zhu
Summary: The study found that GSG2 is highly expressed in colorectal cancer tissues and cells. Knocking down GSG2 can inhibit cell proliferation, colony formation, and invasion, and induce cell apoptosis. Mechanistically, GSG2 was found to regulate multiple signaling pathways, including Myc, NF-kappa B, Snail-1, and beta-catenin signaling.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2022)
Article
Biochemistry & Molecular Biology
YuJian Xia, Jian Chen, Guangyao Liu, WeiBin Huang, XiaoJing Wei, ZheWei Wei, YuLong He
Summary: The study revealed that STIP1 is highly expressed in CRC tissues and is associated with poor overall survival. STIP1 promotes CRC cell proliferation and invasion through the STAT3 pathway, while its knockdown inhibits these functions. This suggests that STIP1 could be a potential target for CRC therapy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Immunology
Yue Tian, Ying Luo, Jing Wang
Summary: The study revealed significant down-regulation of miR-425 in cervical cancer tissues and cell lines, with low expression associated with lower survival rate. Overexpression of miR-425 led to decreased proliferation, induction of apoptosis, and inhibition of migration and invasion in cervical cancer cells. Additionally, miR-425 targeted RAB2B and suppressed its expression, suggesting a tumor-suppressive role and therapeutic potential in cervical cancer management.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Oncology
Tiantian Zhang, George Zhang, Xiang Chen, Zhengming Chen, Anthony Lin, Cheryl Zhang, Lisa K. Torres, Sandi Bajrami, Tuo Zhang, Guoan Zhang, Jenny Z. Xiang, Erika M. Hissong, Yao-Tseng Chen, Yi Li, Yi-Chieh Nancy Du
Summary: Low-dose carbon monoxide (CO) inhibits cancer cell migration and adhesion, prevents cancer metastasis, and improves patient survival.
Article
Medicine, Research & Experimental
Fei Liu, Yong Zhang, Yue Dong, Peifang Ning, Yanni Zhang, Han Sun, Guang Li
Summary: The study indicates that high expression of AURKA in human colorectal cancer is associated with poor prognosis following radiotherapy. Silencing AURKA significantly increases cell sensitivity to radiation, inhibits cell migration, induces apoptosis, and arrests the cell cycle.
Article
Oncology
Tian Liang, Tong Lu, Weiwei Jia, Runze Li, Min Jiang, Yu Jiao, Yuchen Wang, Shanshan Cong, Xinyan Jiang, Lina Dong, Yingyu Zhou, Guangmei Zhang, Dan Xiao
Summary: This study elucidated the role and downstream mechanism of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the process of pyroptosis in cervical cancer cells. The findings demonstrated that lncRNA MALAT1 was upregulated in cervical carcinoma cells and its knockdown induced pyroptosis-mediated cell death, while its overexpression blocked lipopolysaccharide-induced pyroptosis. The study also identified the involvement of the microRNA-124/sirtuin 1 axis in mediating the effects of lncRNA MALAT1 on cervical cancer cell pyroptosis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Oncology
Wenfeng Liu, Zuoli Wu, Lijuan Wang, Qijun Wang, Xiuhua Sun, Shufeng Niu
Summary: The study revealed that TRIM11 upregulation in cervical cancer is associated with poor prognosis, its knockdown inhibits cell proliferation, migration, and invasion while inducing apoptosis. TRIM11 might modulate cervical cancer progression by influencing the PI3K/AKT pathway.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Ziyi Zhao, Jinhao Zeng, Qiang Guo, Kunming Pu, Yi Yang, Nianzhi Chen, Gang Zhang, Maoyuan Zhao, Qiao Zheng, Jianyuan Tang, Qiongying Hu
Summary: Berberine was found to inhibit tumor growth and stemness in colorectal cancer stem-like cells by decreasing m(6)A methylation, regulating FTO, and downregulating beta-catenin. This led to decreased cell proliferation, induced cell cycle arrest, reduced colony formation, and increased chemosensitivity, ultimately inhibiting malignant behaviors in colorectal CSCs.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Chi Chi, Wenjie Hou, Yi Zhang, Jie Chen, Zongji Shen, Youguo Chen, Min Li
Summary: In this study, it was found that the long non-coding RNA PDHB-AS is down-regulated in cervical cancer cells. Overexpression of PDHB-AS can suppress malignant behaviors of cervical cancer cells. PDHB-AS functions as a tumor suppressor by inhibiting the Wnt/β-catenin pathway, and it also interacts with other molecules such as miR-4536-5p, miR-582-5p, and DKK1 to regulate cisplatin resistance and tumor growth in cervical cancer. These findings suggest the therapeutic potential of PDHB-AS as a target for cervical cancer treatment.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Chen-Yi Liao, Ting-Chien Wu, Shun-Fa Yang, Jinghua Tsai Chang
Summary: N-acetylcysteine (NAC) can act as both an antioxidant and a pro-oxidant. The effect of NAC on cell proliferation varies depending on the antioxidant activity of the cells. The sensitivity of cells to NAC is determined by their intracellular ROS levels.
Article
Ophthalmology
Chia-Chen Lin, Chia-Yi Lee, Jing-Yang Huang, Sheng-Min Hsu, Jia-Horung Hung, Shun-Fa Yang
Summary: This study provides an in-depth analysis of the trends in DR, DME, and related comorbidities in patients with T2DM. It shows that the prevalence and incidence of DR and PDR decreased over time, while the prevalence and incidence of DME increased. Additionally, the percentage of patients with hyperlipidaemia increased in all forms of DR, while the percentage of patients with ESRD increased only in DME.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Environmental Sciences
Chung-Yuan Lee, Yung-Chuan Ho, Chiao-Wen Lin, Min-Chieh Hsin, Po-Hui Wang, Ya-Cheng Tang, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Ophthalmology
Hsiang-Wen Chien, Chia-Yi Lee, Jing-Yang Huang, Hung-Chi Chen, Kai Wang, Shun-Fa Yang
Summary: This study, using the National Health Insurance Research Database of Taiwan, found a relationship between congenital cytomegalovirus (CMV) infection and late-onset keratitis. Severe congenital CMV infection was found to be significantly correlated with late-onset keratitis in individuals with congenital CMV infection.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Oncology
Hung-Ju Chien, Chung-Jung Liu, Tsung-Ho Ying, Pei-Ju Wu, Jiunn-Wei Wang, Yi-Hsuan Ting, Yi-Hsien Hsieh, Shih-Chiang Wang
Summary: This study aimed to evaluate Timosaponin AIII (TSAIII) as a potential therapeutic approach for cervical cancer. The results showed that TSAIII suppresses cell migration, invasion, p38 activation, and uPA expression in cervical cancer. Additionally, TSAIII demonstrated antimetastatic properties and inhibited the growth of cervical cancer stem cells. These findings suggest that TSAIII may be a potential auxiliary therapy for cervical cancer.
Article
Cell Biology
Chu-Che Lee, Jen-Pi Tsai, Hsiang-Lin Lee, Yung-Jen Chen, Yong-Syuan Chen, Yi-Hsien Hsieh, Jin-Cherng Chen
Summary: In this study, Timosaponin AIII (TSAIII) was found to inhibit the growth of glioma cells by inducing cell death, mitochondrial dysfunction, and autophagy activation. The results suggest that TSAIII exhibits antitumor effects and may have potential as a therapy for glioma.
Article
Chemistry, Medicinal
Je-Chiuan Ye, Yih-Shou Hsieh, Pei-Ni Chen, Jer-Yuh Liu, Yi-Hsien Hsieh
Summary: Our study shows that PKCa regulates the PA and MMPs systems in liver cancer cells through the p38 MAPK signaling pathway, promoting cell progression. MMP-1 and u-PA play critical roles in this pathway, and targeting these genes may be a potential treatment approach for liver cancer.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Environmental Sciences
Pei-Ju Wu, Hui-Ling Chiou, Yi-Hsien Hsieh, Chia-Liang Lin, Hsiang-Lin Lee, I-Chun Liu, Tsung-Ho Ying
Summary: Licoricidin, an active compound of Glycyrrhiza uralensis, was found to significantly inhibit cell viability and induce apoptosis in cervical cancer cells. It also triggered endoplasmic reticulum stress and upregulated the protein expression of GRP78 (Bip), CHOP, and IRE1 alpha, ultimately leading to immunogenic cell death. These findings suggest that Licoricidin may be a potential inducer of immunotherapy in advanced cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tsai-Yi Tseng, Chien-Hsing Lee, Hsiang-Lin Lee, Chien-Yu Su, Cheng-Yen Kao, Jen-Pi Tsai, Yi-Hsien Hsieh
Summary: Licochalcone A (LicA) is a potent anti-inflammatory, antioxidant, and anticarcinogenic substance that shows therapeutic potential against renal cell carcinoma (RCC). LicA limits cell growth, induces cell cycle arrest, promotes autophagy and LC3B expression, and inhibits migration and invasion of RCC cells. The chemotherapeutic effects of LicA on RCC are mediated through the activation of LC3B expression, ultimately modulating the FAK/Src signaling pathway-mediated Sp1 expression.
Article
Environmental Sciences
Kuan-Chun Hsueh, Po-Chung Ju, Yi-Hsien Hsieh, Shih-Chi Su, Chao-Bin Yeh, Chiao-Wen Lin
Summary: HO-3867 triggers cell cycle arrest and apoptotic responses in liver cancer, possibly involving p38-mediated activation of caspase cascades.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Tsai-Kun Wu, Tung-Wei Hung, Yong-Syuan Chen, Ying-Ru Pan, Yi-Hsien Hsieh, Jen-Pi Tsai
Summary: Corosolic acid inhibits the migration and invasion of renal cell carcinoma cells by reducing MMP2 expression and stimulating ERK1/2 phosphorylation.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wen-Chun Sun, Chia-Liang Lin, Tzong-Huei Lee, Chia-Hao Chang, Ann-Zhi Ong, Yen-Hsiu Yeh, Chen-Lin Yu, Guang-Wei Chen, Yi-Hsien Hsieh, Shih-Wei Wang
Summary: In this study, Chaetoglobosin A (ChA) was identified as a potent and selective antitumor agent in human colorectal cancer (CRC). ChA inhibited CRC cell growth and induced apoptotic cell death through mitochondrial intrinsic and caspase-dependent pathways. The expression of Heme oxygenase-1 (HO-1) was found to be associated with ChA-induced cell death, and inhibition of HO-1 increased the sensitivity of CRC cells to ChA.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Jia-Sin Yang, Chia-Hsuan Chou, Yi-Hsien Hsieh, Peace Wun-Ang Lu, Ya-Chiu Lin, Shun-Fa Yang, Ko-Hsiu Lu
Summary: The study found that Morin can suppress the migration and invasion capabilities of human osteosarcoma cells, playing an anti-metastatic role by reducing uPA expression. Therefore, Morin may be a potential drug candidate for the treatment of human osteosarcoma.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Huang-Ming Hu, Hsiang-Lin Lee, Chung-Jung Liu, Yi-Hsien Hsieh, Yong-Syuan Chen, Kuan-Chun Hsueh
Summary: The study found that MTA2 regulates HCC progression through the MTA2-FAK-MMP7 pathway. PTK7, as a downstream factor of MTA2, affects the migration and invasion abilities of HCC cells by regulating MMP7 expression. The expression level of PTK7 is correlated with tumor stage, grade, and overall survival in HCC patients, and may have diagnostic value for HCC patients.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Hsueh-Ju Lu, Chun-Yi Chuang, Mu-Kuan Chen, Chun-Wen Su, Wei-En Yang, Chia-Ming Yeh, Kuan-Ming Lai, Chih-Hsin Tang, Chiao-Wen Lin, Shun-Fa Yang
Summary: ALDH7A1 polymorphisms and expression levels are associated with oral cancer development and prognosis, affecting pathological features, cell migration, and patient outcomes.